Taurine in morning spot urine for the useful assessment of dietary seafood intake in Japanese children and adolescentsMari Mori
Institute for World Health Development, Mukogawa Women s University, Nishinomiya, 6638143, Japan
J Biomed Sci 17:S43. 2010
..Therefore, we presently examined the relationship of Tau excretion in the morning SU with 24U Tau for simplifying the population comparison and the follow-up of SF intake changes in the process of food education program (FEP)...
Taurine as the nutritional factor for the longevity of the Japanese revealed by a world-wide epidemiological surveyYukio Yamori
Mukogawa Women s University, Japan
Adv Exp Med Biol 643:13-25. 2009
..24-UT was negatively associated with stroke mortality. These five diet-related factors explained 61 and 49% of IHD and stroke variances in male, 63 and 36% of IHD and stroke variances in female, respectively...
Nutrition and lifestyle-related disease prevention in the futureY Yamori
Kyoto University, Japan
Clin Exp Pharmacol Physiol 31:S65. 2004
- Taurine in health and diseases: consistent evidence from experimental and epidemiological studies
Yukio Yamori
Institute for World Health Development, Mukogawa Women s University, Nishinomiya 6638143, Japan
J Biomed Sci 17:S6. 2010
..The preventive effects of T, good for health and longevity, first noted experimentally, were also proven epidemiologically in humans...
- Male cardiovascular mortality and dietary markers in 25 population samples of 16 countries
Yukio Yamori
International Center for Research on Primary Prevention of Cardiovascular Diseases, Kokusaikenju Bldg, 86 2 Shimobambacho cho, Jodoji, Sakyo ku, Kyoto, 606 8413, Japan
J Hypertens 24:1499-505. 2006
..To examine associations between various dietary markers and mortality from ischemic heart disease (IHD) and stroke...
- Worldwide epidemic of obesity: hope for Japanese diets
Yukio Yamori
International Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto, Kinjo Gakuin University, Nagoya and Mukogawa Women s University, Nishinomiya, Japan
Clin Exp Pharmacol Physiol 31:S2-4. 2004
....
- Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world
Yukio Yamori
Mukogawa Women s University Institute for World Health Development, Nishinomiya, Hyogo, 6638143, Japan
J Biomed Sci 17:S21. 2010
..We further analyzed the associations of individual T/Cr and M/Cr levels to cardiovascular risks in the present study...
- Fish and lifestyle-related disease prevention: experimental and epidemiological evidence for anti-atherogenic potential of taurine
Yukio Yamori
International Center for Research on Primary Prevention of Cardiovascular Diseases, Mukogawa Women s University, Nishinomiya, Japan
Clin Exp Pharmacol Physiol 31:S20-3. 2004
..6. Taurine may act as an immunomodulator of cytokine production, which is involved in atherogenesis...
- Cardiovascular risk factors in Tanzania: a revisit
M Njelekela
Department of Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida nihonmatsu cho, Sakyo ku, 606 8501, Kyoto, Japan
Acta Trop 79:231-9. 2001
..These data suggest that for the past decade there has been an increase in the mean levels and prevalence of selected cardiovascular risk factors in Tanzania...
- Aging and salt-loading modulate blood pressure QTLs in rats
T Mashimo
Department of Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Am J Hypertens 12:1098-104. 1999
..2). The present study provides experimental evidence that QTLs for BP could be modulated by nongenetic factors, such as aging and salt-loading...
- The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania
H Negishi
Department of Natural Environments, Graduate School of Human and Environmental Studies, Kyoto University, Japan
J Hypertens 19:529-33. 2001
....
- Lack of association between the alpha-adducin locus and essential hypertension in the Japanese population
N Kato
Graduate School of Human and Environmental Studies, Kyoto University, Japan
Hypertension 31:730-3. 1998
....
- Genetic analysis of the atrial natriuretic peptide gene in essential hypertension
N Kato
Graduate School of Human and Environmental Studies, Kyoto University, Yoshida nihonmatsu cho, Sakyo ku, Kyoto, 606 8316, Japan
Clin Sci (Lond) 98:251-8. 2000
..The pathophysiological relevance of ANP, however, needs to be further defined in relation to hypertension-associated phenotypes, and also should be examined in different ethnic groups...
- Ethnic and environmental differences in various markers of dietary intake and blood pressure among Chinese Han and three other minority peoples of China: results from the WHO Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study
L Liu
Otsuka Department of International Preventive Nutritional Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Hypertens Res 24:315-22. 2001
..Different health promotion strategies might thus be emphasized in different populations...
- Leisure-time physical activity and other factors in relation to blood pressure in Japanese-Americans in Hawaii, USA
L Liu
Otsuka Department of International Preventive Nutritional Medicine, WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Hypertens Res 24:145-51. 2001
..In conclusion, the results further emphasize that the health benefits of LTPA, control of body weight, and reduction in salt intake should continually receive strong attention in population-based high BP control...
- Phytoestrogens attenuate oxidative DNA damage in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
K Mizutani
Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
J Hypertens 18:1833-40. 2000
....
- Increased oxidative DNA damage in stroke-prone spontaneously hypertensive rats
H Negishi
Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Clin Exp Pharmacol Physiol 26:482-4. 1999
..3. Stroke-prone spontaneously hypertensive rats were exposed to DNA damage by oxidative stress at the early stage when they developed severe hypertension, but this increase in DNA damage was not the secondary effect of hypertension...
- G protein beta3 subunit variant and essential hypertension in Japanese
N Kato
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Hypertension 32:935-8. 1998
..However, further investigation is required to answer the question of whether the lack of association reflects ethnic differences in the nature of genetic susceptibility loci...
- Protective effect of inducible type nitric oxide synthase against intracellular oxidative stress caused by advanced glycation end-products in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
K Mizutani
Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
J Hypertens 18:1071-9. 2000
....
- Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats
W Pan
Department of Environmental Preservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
J Nutr 131:1154-8. 2001
....
- Determinants of hyperleptinaemia in an African population
M Njelekela
Department of Human and Environmental Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan
East Afr Med J 80:195-9. 2003
..In MO women, the high leptin concentrations did not reflect the amount of adipose stores...
- Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC study
Y Yamori
Department of Environmental Preservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Hypertens Res 24:453-7. 2001
..A strong and inverse association between population levels of taurine excretion and IHD mortality was observed...
- Nitric oxide deficiency induces myocardial infarction in hypercholesterolaemic stroke-prone spontaneously hypertensive rats
K Ikeda
Otsuka Department of International Preventive Nutritional Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Clin Exp Pharmacol Physiol 24:344-8. 1997
..5. These results suggest that nitric oxide deficiency induces myocardial infarction in hypercholesterolaemic SHRSP. These NO-deficient hypercholesterolaemic SHRSP offer a new model of myocardial infarction in rats...
- Implications from and for food cultures for cardiovascular diseases: Japanese food, particularly Okinawan diets
Y Yamori
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Asia Pac J Clin Nutr 10:144-5. 2001
..Biomarkers for fish and soy intake and intervention studies indicate that these foods, along with seaweed and green vegetables are candidates for chronic non-communicable disease prevention...
- Different associations of blood pressure with 24-hour urinary sodium excretion among pre- and post-menopausal women. WHO Cardiovascular Diseases and Alimentary Comparison (WHO-CARDIAC) Study
Y Yamori
Department of Life Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Japan
J Hypertens 19:535-8. 2001
....
- Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP)
K Mizutani
Department of Environmental Preservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
J Nutr Sci Vitaminol (Tokyo) 45:95-106. 1999
..In conclusion, EWP attenuated the elevation of blood pressure in SHRSP possibly by increasing the vasorelaxation activity. The aortic fragility and elasticity were also improved in EWP-fed SHRSP...
- Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats
K Mizutani
Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Clin Exp Pharmacol Physiol 28:55-9. 2001
....
- Antihypertensive effect of cattle bone collagen-derived peptides in ovariectomized stroke-prone spontaneously hypertensive rats
K Mizutani
Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
Clin Exp Pharmacol Physiol 27:416-7. 2000
..4. These results indicate that CBC peptides may prevent increases in blood pressure in ovariectomized SHRSP by a possible mechanism of an inhibitory action against ACE...
- Changes in stroke mortality rates for 1950 to 1997: a great slowdown of decline trend in Japan
L Liu
Otsuka Department of International Preventive Nutritional Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Stroke 32:1745-9. 2001
..Stroke is the second leading cause of death in Japan. We sought to examine changes in stroke mortality rates by age, sex, and birth cohorts from 1950 to 1997...
- Identification of quantitative trait loci for serum cholesterol levels in stroke-prone spontaneously hypertensive rats
N Kato
Graduate School of Human and Environmental Studies, University of Kyoto, Kyoto, Japan
Arterioscler Thromb Vasc Biol 20:223-9. 2000
..Further work, however, is required to clarify whether the cholesterol trait is related to the etiology of stroke or has been retained by chance through the inbreeding process in SHRSP...
- Nutritional variation and cardiovascular risk factors in Tanzania--rural-urban difference
Marina Njelekela
Department of Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
S Afr Med J 93:295-9. 2003
..Dietary determinants of serum TC were meat, fish and green vegetable consumption. CONCLUSION: Differences in dietary habits contributed significantly to the urban-rural-pastoral variations in CVD risk pattern in Tanzania...
- Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation
H Negishi
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Neurosci Lett 306:206-8. 2001
..These results suggest that neuronal damage following ischemia and recirculation is, in part, caused by the increase in hydroxyl radicals during ischemia and recirculation...
- Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats
T Noguchi
Graduate School of Human and Environmental Studies, Kyoto University, Japan
Hypertens Res 24:735-42. 2001
....
- Implication of hypertensive rat models for primordial nutritional prevention of cardiovascular diseases
Y Yamori
Graduate School of Human and Environmental Studies, Kyoto University, Japan
Clin Exp Pharmacol Physiol 26:568-72. 1999
..7. Experimental findings in SHRSP as well as epidemiological studies on nutrition and CVD indicate the future avenue towards 'predictive-preventive medicine' for CVD...
- Soy isoflavones improve bone metabolism in postmenopausal Japanese women
Mari Mori
Resarch Institute for Production Development, Kyoto, Japan
Clin Exp Pharmacol Physiol 31:S44-6. 2004
..05 vs before) in them. The reduction rate of Dpd in ISO group was also significantly greater than that in P group (P < 0.01). 5. Dietary supplementation of vitamins C 25 mg and E 5 mg did not affect urinary Dpd...
- Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women
Mari Mori
Resarch Institute for Production Development, Mukogawa Women s University, Japan
Clin Exp Pharmacol Physiol 31:S39-41. 2004
..Enough ISO supplementation may contribute to the risk reduction of osteoporosis and obesity and, thus to overall health promotion in menopausal women...
- Diet-related factors, educational levels and blood pressure in a Chinese population sample: findings from the Japan-China Cooperative Research Project
Yukio Yamori
World Health Organization Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto, Japan
Hypertens Res 25:559-64. 2002
..The results emphasize that education plays an important role in public health for the control of high BP in the Chinese population...
- Effect of a soybean product on serum lipid levels in female university students
Kyoko Takahashi
Department of Food Science and Nutrition, Mukogawa Women s University, Nishinomiya, Japan
Clin Exp Pharmacol Physiol 31:S42-3. 2004
..001) from 242 +/- 17 to 220 +/- 25 mg/dL in Group A. 3. Dietary intake of soy protein for 4 weeks could be effective in reducing CHD risk among Japanese female students with a high plasma cholesterol level...
- Obesity and lipid profiles in middle aged men and women in Tanzania
M A Njelekela
Department of Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Japan
East Afr Med J 79:58-64. 2002
....
- Evaluation of the poly(ADP-ribose) polymerase gene in human stroke
N Kato
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
Atherosclerosis 148:345-52. 2000
....
- Soybean isoflavones reduce postmenopausal bone resorption in female Japanese immigrants in Brazil: a ten-week study
Yukio Yamori
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto, Japan
J Am Coll Nutr 21:560-3. 2002
..In this study, we carried out an intervention study to explore the effects of dietary isoflavone on bone metabolism...
- Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats
Hiroko Negishi
College of Human Life and Environment, Kinjo Gakuin University, Nagoya 463 8521, Japan
J Nutr 134:38-42. 2004
..Furthermore, because the amounts of polyphenols used in this experiment correspond to those in approximately 1 L of tea, the regular consumption of black and green tea may also provide some protection against hypertension in humans...
- Prevalence of obesity and dyslipidemia in middle-aged men and women in Tanzania, Africa: relationship with resting energy expenditure and dietary factors
Marina Njelekela
Department of Human and Environmental Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606 8501, Japan
J Nutr Sci Vitaminol (Tokyo) 48:352-8. 2002
..001) and fish (p < 0.05), and a lower REE (p < 0.05). These findings suggest that unhealthy diet and lower energy expenditure are important contributors to obesity and dyslipidemia in Tanzania...
- Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells
H Yoshida
Graduate School of Human and Environmental Studies, Kyoto University, Japan
Biosci Biotechnol Biochem 65:1211-3. 2001
..These results indicate that glycitein suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor...
- Inverse relationship between urinary markers of animal protein intake and blood pressure in Chinese: results from the WHO Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study
Longjian Liu
Otsuka Department of International Preventive Nutritional Medicine, WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto University, Sakyo ku, Japan
Int J Epidemiol 31:227-33. 2002
....
- Serum lipid effects of a monounsaturated (palmitoleic) fatty acid-rich diet based on macadamia nuts in healthy, young Japanese women
Junko Hiraoka-Yamamoto
Frontier Health Science, Mukogawa Women s University, Nishinomiya, Japan
Clin Exp Pharmacol Physiol 31:S37-8. 2004
....
- Caffeic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II in stroke-prone spontaneously hypertensive rats
Peng-Gao Li
Frontier Health Science, School of Human Environmental Sciences, Mukogawa Women's University, Nishinomiya, Japan
Hypertens Res 28:369-77. 2005
....
- Pontine hypoplasia in children with periventricular leukomalacia
S Yoshida
Department of Radiology, Kyoto City Hospital, Kyoto, Japan
AJNR Am J Neuroradiol 29:425-30. 2008
..The present study was conducted to examine the hypothesis that the pons in patients with PVL is smaller than normal...
- Downregulation of Rac1 activation by caffeic acid in aortic smooth muscle cells
Jin Wen Xu
Frontier Health Science, School of Human Environmental Science, Mukogawa Women s University, Nishinomiya, Hyogo, 663 8179, Japan
Life Sci 76:2861-72. 2005
..These results support the hypothesis that caffeic acid reduces Rac1 GTPase protein and activity level, followed by a down-regulation of NADPH oxidase activity...
- Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats
Jin Wen Xu
Frontier Health Science, School of Human Environmental Science, Mukogawa Women s University, Nishinomiya, Japan
Hypertens Res 27:675-83. 2004
..The endothelial-protective effects of phytoestrogen may contribute to improvement of cardiovascular functions...
- Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo
Kazuhiro Kunimasa
Department of Applied Biological Science, Tokyo University of Science, Chiba Institute for World Health Development, Mukogawa Women s University, Hyogo Tokyo, Japan
Cancer Sci 101:2462-9. 2010
..9nmol) per egg. These results indicate that nobiletin is a novel antiangiogenic compound that exhibits its activity through combined inhibition of multiple angiogenic EC functions...
- Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats
Ken ichi Mizutani
Laboratory of Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
J Hypertens 20:1607-14. 2002
..To elucidate the role of AGEs in genetic hypertension, we investigated the effect of OPB-9195, a novel inhibitor of AGEs, on hypertension and oxidative damage in SHRSP...
- Comprehensive QTL analysis of serum cholesterol levels before and after a high-cholesterol diet in SHRSP
Tomoji Mashimo
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Physiol Genomics 30:95-101. 2007
..This observation is significant in establishing a new model for atherosclerosis with hypertension in rats...
- Antioxidant nutrients and hypoxia/ischemia brain injury in rodents
Katsumi Ikeda
School of Human Environmental Sciences, Mukogawa Women s University, Ikebiraki cho, Nishinomiya, Japan
Toxicology 189:55-61. 2003
..These results are important in light of an attenuation of the deleterious consequences of oxidative stress in ischemia and recirculation injury...
- Isoflavones regulate secretion of leukemia inhibitory factor and transforming growth factor {beta} and expression of glycodelin in human endometrial epithelial cells
Jin Wen Xu
Section of Pathophysiology, Department of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
J Endocrinol 196:425-33. 2008
..Overall, our findings suggest that isoflavones may alter the uterine expression of estrogen-responsive genes...
- Flax oil-mediated activation of PPAR-γ correlates with reduction of hepatic lipid accumulation in obese spontaneously hypertensive/NDmcr-cp rats, a model of the metabolic syndrome
Kanta Chechi
Department of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
Br J Nutr 104:1313-21. 2010
..These findings suggest that flax oil feeding may activate PPAR-γ-dependent pathways to alter the hepatic lipid metabolism and to increase insulin sensitivity in the obese SHR/NDmcr-cp rats...
- Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
Kazuhito Hayakawa
Yakult Central Institute for Microbiological Research, Kunitachi shi, Tokyo, Japan
Eur J Pharmacol 524:120-5. 2005
..These results suggest that a reduction in the effects induced by the renal nerves may play an important role in the hypotensive effect induced in spontaneously hypertensive rats by chronic dietary administration of GABA...
- Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women: a four-week study
Takehiko Uesugi
Fujicco Co, Ltd, Kobe, Japan
J Am Coll Nutr 21:97-102. 2002
..These effects could have the potential to reduce the risks of postmenopausal osteoporosis and of cardiovascular diseases in such women...
- Obesity, emerging risk in China: trend of increasing prevalence of obesity and its association with hypertension and hypercholesterolaemia among the Chinese
Longjian Liu
Department of Neurobiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Clin Exp Pharmacol Physiol 31:S8-10. 2004
..63 (1.57-4.40). 4. In conclusion, the results highlight the epidemic of obesity, an emerging risk in China. Great efforts must be made to alter this unwelcome trend...
- Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland
Miki Sagara
Department of Preventive Nutritional Medicine, Research Institute for Production Development
J Am Coll Nutr 23:85-91. 2004
..CONCLUSION: Dietary intakes of soy protein (at least 20 g) and isoflavones (at least 80 mg) for 5 weeks would be effective in reducing CHD risk among high-risk, middle-aged men...
- Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats
Takanori Noguchi
Human Nutrition, Kobe Gakuin University, Nishi, Kobe, Japan
Clin Exp Pharmacol Physiol 31:S24-6. 2004
....
- Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats
Yasuto Sasaki
Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, Japan
Clin Exp Pharmacol Physiol 29:963-7. 2002
..These pharmacological activities may contribute to the beneficial properties of EGb 761 observed in clinical practice...
- Proposition of a feasible protocol to evaluate salt sensitivity in a population-based setting
Norihiro Kato
Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan
Hypertens Res 25:801-9. 2002
..Based on these results, the dietary method presented here seems to be applicable for a population-based survey. Our preliminary data also suggest that PRA and ANP would be of predictive value in the salt sensitivity test...
- Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model
Norihiro Kato
Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
Hypertension 42:1191-7. 2003
..The size of the introgressed region is large, but our novel congenic strain should help delineate complex, genetic impairments underlying BP and associated vascular disease phenotypes...
- Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat
Akihiro Michihara
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan
Biol Pharm Bull 25:734-7. 2002
..These data indicate that the cholesterol synthesis in the liver of SHRSP by the reduced amount of MPD is significantly reduced...
- Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony
Norihiro Kato
Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, Toyama, Tokyo, Japan
J Hypertens 21:295-303. 2003
..To evaluate potential confounding factors in linkage analysis, we performed genome-wide screens in F2 populations derived from SHRSP and Wistar-Kyoto rats of a Japanese colony...
- Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes
Kazuo Yamagata
Division of Life Science, Graduate School of Integrated Science and Art, University of East Asia, Yamaguchi, Japan
Glia 41:199-206. 2003
..Our results also suggest that the reduced expression of GDNF caused by S1P is a factor in the stroke proneness of SHRSP...
- Effects of voluntary exercise on cerebral thrombosis and endothelial function in spontaneously hypertensive rats (SHRSP/Izm)
Yasuto Sasaki
Laboratory of Physiology, Kobe Gakuin University, Nishi ku, Kobe, Japan
Clin Exp Pharmacol Physiol 31:S47-8. 2004
..8. These results suggested that voluntary exercise decreased thrombotic tendency by increasing NO level through enhanced expression of eNOS mRNA and antioxidative effects...
- Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats
Ken ichi Mizutani
Research Institute, National Cardiovascular Center, Suita, Japan
Hypertens Res 25:135-40. 2002
..The increased expression of KYNU in SHR is thought to decrease the KYN level. KYNU seems to be one of the genes that contributes to hypertension in SHR...
- Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver
Akihiro Michihara
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan
Biol Pharm Bull 26:1484-6. 2003
..These data show for the first time that probucol decreases the level of an enzyme involved in cholesterol biosynthesis other than HMG-CoA reductase...
- Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats
Kazuhito Hayakawa
Yakult Central Institute for Microbiological Research, Tokyo, Japan
Br J Nutr 92:411-7. 2004
..The present results suggest that low-dose oral GABA has a hypotensive effect in SHR/Izm and that the hypotensive effect of FMG is due to GABA...
- Nutritional prevention on hypertension, cerebral hemodynamics and thrombosis in stroke-prone spontaneously hypertensive rats
Takanori Noguchi
Laboratory for Behavioral Genetics, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Japan
Cell Mol Neurobiol 24:599-638. 2004
..Our results indicate that those treatments are beneficial in the prevention of hypertension and stroke and that the nutritional science is very important for "prediction and prevention medicine."..
- Nitric oxide reduces astrocytic lactate production and induces neuronal vulnerability in stroke-prone spontaneously hypertensive rats
Kazuo Yamagata
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University NUBS, Kameino, Fujisawa, Kanagawa, Japan
Glia 56:387-93. 2008
..These results indicated that the neurons and astrocytes of SHRSP differed in responsiveness to SNP from those of WKY. This difference might explain the deficiency of energy and vulnerability to SNP of the neurons of SHRSP...
- Evaluation of the atrial natriuretic peptide gene in stroke
Norihiro Kato
Teikyo University School of Medicine, Tokyo, Japan
Atherosclerosis 163:279-86. 2002
..Overall results did not support the disease relevance of ANP, disagreeing with previous reports. Thus, considerable caution should be taken when one attempts to transfer findings in the animal model to humans...
- Epidemiological evidence of the association between dietary protein intake and blood pressure: a meta-analysis of published data
Longjian Liu
Geriatric Research Education and Clinical Center, and the Donald W Reynolds Department of Geriatrics, College of Medicine and University of Arkansas for Medical Sciences, Little Rock 72114, USA
Hypertens Res 25:689-95. 2002
..The evidence from longitudinal epidemiological studies was limited. Further studies will be needed to confirm the hypothesis of the inverse dietary protein-BP association...
- Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat
Hyoe Inomata
Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
Hypertens Res 28:273-81. 2005
....
- Pharmacological studies of alcohol susceptibility and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR)
Kanji Yoshimoto
Department of Legal Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Tohoku J Exp Med 201:11-22. 2003
..These results suggest that the hypertensive state causes the dysfunction in the striatum of the brain rewarding system and induces the risk for increasing alcohol consumption to compensate for the alteration of serotonergic neurons...
- Cardiovascular remodeling and metabolic abnormalities in SHRSP.Z-Lepr(fa)/IzmDmcr rats as a new model of metabolic syndrome
Takahiro Ueno
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
Hypertens Res 31:1021-31. 2008
..The phenotype of SHRSP fatty is similar to that of human metabolic syndrome, and therefore, studies of these rats may help clarify the molecular mechanisms that underlie metabolic syndrome in humans...
