Problems in early diagnosis of bladder cancer in a spinal cord injury patient: report of a case of simultaneous production of granulocyte colony stimulating factor and parathyroid hormone-related protein by squamous cell carcinoma of urinary bladderSubramanian Vaidyanathan
Regional Spinal Injuries Centre, District General Hospital, Southport PR8 6PN, UK
BMC Urol 2:8. 2002
..Typical symptoms and signs of a clinical condition may be absent in spinal cord injury (SCI) patients...
Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteinsKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, l 4 17 Mita, Minatoku, 108 0073, Tokyo, Japan
Virchows Arch 445:45-53. 2004
..PSH is a proliferation of rather fetal type-II pneumonocytes (pneumocytoma or pneumoblastoma?)...
Electron microscopy and immunohistochemistry studies of pulmonary carcinosarcomas expressing the transcription factor MEF-2 and showing significant cell-to-cell, cell-to-matrix, and epithelial-mesenchymal interactionsKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, l 4 17 Mita, Minatoku, 108 0073 Tokyo, Japan
Virchows Arch 444:542-53. 2004
....
Systemic lupus erythematosus with hepatic aneurysm, valsalva sinus aneurysm and associated polyangiitis: aneurysmal wall remodeling with dense fibrosis and calcification mediated by residual smooth muscle cellsK Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
Lupus 13:54-9. 2004
..It was suspected that the generalized polyangiitis as a complication of SLE might have involved the intrahepatic arteries and Valsalva sinus wall and subsequently generated the aneurysm...
An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cellsKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
Ultrastruct Pathol 26:185-90. 2002
....
A case of splenic lymphoma with marked diffuse nodular fibrosis and calcification, complicated with severe autoimmune hemolytic anemiaK Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
J Submicrosc Cytol Pathol 35:17-23. 2003
....
A seminal vesicle cyst complicated with a tumor like nodular mass of benign proliferating prostatic tissue: a case report with ultrastructural and immunohistochemical studiesK Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
J Submicrosc Cytol Pathol 35:209-14. 2003
..It is extremely important to differentiate between a benign proliferation and a malignant one, when the nodular mass is found in the seminal vesicle cyst...
A unique pancreatic ductal adenocarcinoma with carcinosarcomatous histology, immunohistochemical distribution of hCG-beta, and the elevation of serum alpha-feto-proteinK Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
J Submicrosc Cytol Pathol 35:343-9. 2003
....
A gastric carcinosarcoma with neuroendocrine cell differentiation and undifferentiated spindle-shaped sarcoma component possibly progressing from the conventional tubular adenocarcinoma; an immunohistochemical and ultrastructural studyKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, 1 4 17 Mita, Minatoku, Tokyo 108 0073, Japan
Virchows Arch 442:77-81. 2003
..It was speculated that the unique histology of carcinosarcoma might have progressed from the conventional type of pre-existing advanced tubular adenocarcinoma...
Pulmonary well-differentiated fetal adenocarcinoma expressing lineage-specific transcription factors (TTF-1 and GATA-6) to respiratory epithelial differentiation: an immunohistochemical and ultrastructural studyKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, 1 4 17 Mita, Minatoku, 108 0073, Tokyo, Japan
Virchows Arch 442:393-9. 2003
..In the present case, tumor cells forming the peculiar histological, molecular, and ultrastructural constructions showed partial and incomplete mimicry of the morphogenesis of respiratory epithelium...
CD10- and CD34-positive periglandular stromal cells in pulmonary benign metastasizing leiomyoma with metaplastic adenomyomatous glands: an ultrastructural and immunohistochemical studyKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, l 4 17 Mita, Minatoku, 108 0073 Tokyo, Japan
Virchows Arch 446:270-7. 2005
..Putative microenvironmental inductive roles were postulated for the periglandular stromal fibroblasts to induce a metaplastic change toward the glands from pre-existing lung epithelial cells revealing adenomyomatous features...
An ultrastructural and immunohistochemical study of microcystic meningioma with emphasis on matrix proteins and connexin 26 type gap junctionsKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
Ultrastruct Pathol 28:247-53. 2004
....
An ultrastructural and immunohistochemical study of elastofibroma: CD 34, MEF-2, prominin 2 (CD133), and factor XIIIa-positive proliferating fibroblastic stromal cells connected by Cx43-type gap junctionsKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, Minato ku, Tokyo, Japan
Ultrastruct Pathol 31:209-19. 2007
..The elastofibromas might have arisen from stromal stem cell candidate populations of stromal fibroblastic cells (CD34(+), MEF2(+), prominin 2(CD133)(+), and factor XIIIa(+))...
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumorKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
Ultrastruct Pathol 31:51-61. 2007
..These similarities and differences are discussed in the context of the currently favored diagnostic fusion of hemangiopericytoma and solitary fibrous tumor...
An ultrastructural, immunohistochemical, and cytogenetical study of a monophasic pulmonary synovial sarcoma: implications of the frequent ultrastructure of oligocilia and concentric membranous bodies with positive immunostaining for VS38c and MEF2Kazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
Ultrastruct Pathol 27:235-41. 2003
....
An immunohistochemical and ultrastructural study of pancreatic microcystic serous cyst adenoma with special reference to tumor-associated microvasculature and vascular endothelial growth factor in tumor cellsKazuto Yamazaki
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
Ultrastruct Pathol 30:119-28. 2006
....
Increased E2F-1 expression via tumour cell proliferation and decreased apoptosis are correlated with adverse prognosis in patients with squamous cell carcinoma of the oesophagusK Yamazaki
Department of Pathology, Teikyo University, Ichihara Hospital, Ichihara, 3426 3 Anesaki, Ichihara City, Chiba 299 0111, Japan
J Clin Pathol 58:904-10. 2005
..Recent studies show that E2F-1 also participates in apoptosis induction in a p53 dependent or independent manner. Despite its crucial role and paradoxical effects on cell turnover, the function of E2F-1 in human cancer is unclear...
Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouseN Ichihara
Department of Animal Models for Human Disease, National Institute of Neuroscience, Tokyo, Japan
Brain Res 695:173-8. 1995
....
Lipid-rich clear-cell hepatocellular carcinoma arising in non-alcoholic steatohepatitis in a patient with diabetes mellitusH Orikasa
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
J Submicrosc Cytol Pathol 33:195-200. 2001
....
Mucosal microvilli in dry eye patients with chronic GVHDY Tatematsu
Department of Ophthalmology, The Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo, Japan
Bone Marrow Transplant 47:416-25. 2012
..These may be important factors affecting the stability of the tear-film layer and its contribution to cGVHD-related dry eye...
Cardiac sarcoma showing bone formation and neurogenic markers: report of a caseH Okita
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan
J Submicrosc Cytol Pathol 34:1-7. 2002
..Atrial sarcomas showing neural markers and bone formation are exceedingly rare, and this report adds a further exceptionally uncommon case to the literature...
A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHDY Ogawa
Departments of Ophthalmology and. Diagnostic Pathology, Institute for Advanced Medical Research, Tokyo, Japan
Invest Ophthalmol Vis Sci 42:111-9. 2001
..In addition, it is likely that stromal fibroblasts are actively involved in the pathogenic process of chronic GVHD in the lacrimal gland by producing excessive extracellular matrix components...
A unique early gastric tubular adenocarcinoma arising from a pre-existent carcinoid tumor in a patient with a more than 20-year history of type A gastritis: an immunohistochemical and ultrastructural studyS Kikuyama
Department of Surgery, Saiseikai Central Hospital, Tokyo, Japan
J Submicrosc Cytol Pathol 34:109-14. 2002
..Ultrastructurally there were no amphicrine cells in the tumor, containing both endocrine granules and mucin droplets...
Anaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathyTakuya Aoki
Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan
Virchows Arch 441:154-8. 2002
..The study illustrates the need for a comprehensive array of techniques to distinguish such rare non-synthesizing and non-secretory plasmacytomas from lymphoma...
Gap junctions and nerve terminals among stromal cells in human fallopian tube ampullary mucosaK Yamazaki
Department of Diagnostic Pathology, School of Medicine Keio University, Tokyo, Japan
J Submicrosc Cytol Pathol 30:399-408. 1998
..Similarities to the unique anatomical unit referred to as the 'neuro-reticular complex' in bone marrow tissue (Yamazaki and Allen, 1990) are discussed...
Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutationK Yamazaki
Department of Pathology, Teikyo University, Ichihara Hospital, Ichihara, 299 0111, Japan
Mol Pathol 56:336-41. 2003
....
Connexin 26 distribution in gap junctions between melanocytes in the human vestibular dark cell areaM Masuda
Department of Otorhinolaryngology, Keio University, School of Medicine, Tokyo, Japan
Anat Rec 262:137-46. 2001
..This suggested that the melanocytes in the human vestibular organ may play a role in transporting material between the endolymph and perilymph...
Laparoscopic hepatectomy for extrahepatic growing tumor. Surgical strategy based on extrahepatic growing indexS Takagi
Second Department of Surgery, Toho University, School of Medicine, 6 11 1, Omori Nishi, Ota ku, Tokyo 143 8541, Japan
Surg Endosc 16:1573-8. 2002
....
Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factorsHiroaki Kodama
Cardiovascular Center, Saiseikai Central Hospital, Tokyo, Japan
Am J Pathol 161:381-9. 2002
..These results support the concept that cardiac myxoma might arise from mesenchymal cardiomyocyte progenitor cells...
Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathyH Miura
Division of Degenerative Disease, National Institute of Neuroscience, NCNP, Tokyo, Japan
Neuropathol Appl Neurobiol 19:41-51. 1993
....
Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical studyKazuto Yamazaki
Department of Pathology, Teikyo University, Ichihara Hospital, Ichihara, Chiba, Japan
Pathol Res Pract 199:23-8. 2003
..015). The present analysis seems to support the theory that E2F-1 is upregulated in cell cycle, and its expression reflects the effector function of G1/S progression as far as pancreatic ductal carcinoma is concerned...
Donor fibroblast chimerism in the pathogenic fibrotic lesion of human chronic graft-versus-host diseaseYoko Ogawa
Institute for Advanced Medical Research, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
Invest Ophthalmol Vis Sci 46:4519-27. 2005
..Fibroblasts originating from circulating donor-derived precursors may participate in the excessive fibrosis in these patients...
Use of technetium-99m tin colloid for sentinel lymph node identification in non-small cell lung cancerHiroaki Nomori
Departments of Thoracic Surgery and Pathology, Saiseikai Central Hospital, Tokyo, Japan
J Thorac Cardiovasc Surg 124:486-92. 2002
..To test the reliability of sentinel lymph node identification in non-small cell lung cancer, sentinel nodes were localized with a radioactive colloid in patients undergoing surgery...
[F-18]Fluorodeoxyglucose positron emission tomography can predict pathological tumor stage and proliferative activity determined by Ki-67 in clinical stage IA lung adenocarcinomasKen-ichi Watanabe
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan
Jpn J Clin Oncol 36:403-9. 2006
..For c-stage IA lung adenocarcinomas showing CR > or = 0.55, mediastinoscopy or neoadjuvant chemotherapy is indicated...
Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activityT Aso
Department of Viral Oncology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
Biochem Biophys Res Commun 276:355-61. 2000
..In addition, we provide evidence that hypoxia-inducible factor (HIF)-1alpha is the ubiquitination target of both human and Drosophila VHL complexes...
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementiaT Obi
Department of Neurology, Shizuoka Institute of Epilepsy and Neurological Disorders, Tokyo, Japan
Neurology 70:238-41. 2008
Protective effect of human urinary thrombomodulin on ischemia- reperfusion injury in the canine liverH Kaneko
Second Department of Surgery, Toho University School of Medicine, Tokyo, Japan
Eur Surg Res 32:87-93. 2000
..These findings suggest that administration of thrombomodulin inhibits endothelial cell injury and coagulopathy and offers protection from liver ischemia-reperfusion injury...
Substance P-immunoreactive astrocytes in gracile sensory nervous tract of spinal cord in gracile axonal dystrophy mutant mouseK Yamazaki
Division of Animal Models for Human Disease, National Institute of Neuroscience, NCNP, Tokyo, Japan
Mol Chem Neuropathol 20:1-20. 1993
....
Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic, immunohistochemical, and p53 gene alteration analysisToshitaka Nagao
Department of Surgical Pathology, Tokyo Medical University Hospital, Tokyo, Japan
Mod Pathol 15:724-33. 2002
..Therefore, there is the possibility that such molecular-genetic events take an integral part for inducing the transformation from histologically lower to higher grade tumor during the hybrid carcinoma genesis of the salivary glands...
False-positive findings on [18F]FDG-PET caused by non-neoplastic cellular elements after neoadjuvant chemoradiotherapy for non-small cell lung cancerTakashi Ohtsuka
Department of Thoracic Surgery, Saiseikai Central Hospital, Minato ku, Tokyo 108 0073, Japan
Jpn J Clin Oncol 35:271-3. 2005
....
Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouseK Oda
Division of Degenerative Disease, National Institute of Neuroscience, NCNP, Tokyo, Japan
Neuropathol Appl Neurobiol 18:265-81. 1992
....
Postmortem diagnosis of Fabry disease with acromegaly and a unique vasculopathyMasaki Takao
Department of Pathology, Saiseikai Central Hospital, l 4 17 Mita, Minato ku, Tokyo, 108 0073, Japan
Virchows Arch 451:721-7. 2007
....
Atypical thymoma (WHO B3) with neuroendocrine differentiation: report of a caseJunichi Shiraishi
Department of Pathology, Japanese Red Cross Medical Center, 4 1 22 Hiroo, Tokyo 150 8935, Japan
Virchows Arch 449:234-7. 2006
..This is a unique case of thymoma with neuroendocrine differentiation, and to the best of our knowledge this is the first such case ever reported...
Intrathoracic lipomas: their clinicopathological behaviors are not as straightforward as expectedHiroyuki Sakurai
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan
Ann Thorac Surg 86:261-5. 2008
..Intrathoracic lipomas are a type of deep-seated lipoma, unlike subcutaneous lipomas. Due to the rarity of intrathoracic lipomas, little is known about their clinicopathological features...
Intrapulmonary localized fibrous tumor of the lung: a very unusual presentationHiroyuki Sakurai
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan
Ann Thorac Surg 86:1360-2. 2008
..We present here a rare case of entirely intrapulmonary localized fibrous tumor (ie, localized fibrous tumor of the lung), and we review the pertinent literature...
Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host diseaseYoko Ogawa
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
Invest Ophthalmol Vis Sci 44:1888-96. 2003
....
A clinicopathologic case report on macular hole associated with von Hippel-Lindau disease: a novel ultrastructural finding of wormlike, wavy tangles of filamentsMakoto Inoue
Department of Ophthalmology, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
Graefes Arch Clin Exp Ophthalmol 242:881-6. 2004
..We describe a novel ultrastructural finding observed in an epiretinal membrane excised from a patient with von Hippel-Lindau disease...
Keratocystoma of the parotid gland: a report of two cases of an unusual pathologic entityToshitaka Nagao
Department of Surgical Pathology, Tokyo Medical University Hospital, Tokyo, Japan
Mod Pathol 15:1005-10. 2002
..We believe that this lesion represents a benign cystic neoplasm rather than a malignant tumor or pseudoneoplastic metaplastic condition. It is important to recognize that this peculiar benign tumor does originate from the salivary gland...
Pulmonary metastasis 12 years after resection of thymoma with microscopic capsule invasionHiroaki Nomori
Department of Thoracic Surgery, Saiseikai Central Hospital, 1 4 17 Mita, Minato ku, Tokyo 108 0073, Japan
Jpn J Clin Oncol 34:630-3. 2004
..Long-term follow-up is essential for the detection of recurrence after resection of a thymoma with microscopic capsular invasion, and surgery could be the best treatment for distant metastasis in case of resectable lesions...
Postmortem diagnosis of "occult" Klinefelter syndrome in a patient with chronic renal disease and liver cirrhosisKentaro Matsuoka
Department of Pathology, School of Medicine, Keio University, and Saiseikai Central Hospital, Tokyo, Japan
Arch Pathol Lab Med 126:359-61. 2002
..This report illustrates the value of postmortem laboratory investigations, particularly FISH for sex chromosomes and serum hormone analysis, for the demonstration of clinically uncertain or "occult" Klinefelter syndrome...
Intrapulmonary schwannomaTakashi Ohtsuka
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan
Jpn J Thorac Cardiovasc Surg 53:154-6. 2005
..Immunohistochemical staining demonstrated the presence of S-100 protein in the tumor cells. We present a case of intrapulmonary schwannoma and review 62 cases of primary schwannoma of the lung...
An ultrastructural and immunohistochemical study of a combined submucosal granular cell tumor and lipoma of the colon showing a unique nodule-in-nodule structure: putative implication of CD34 or prominin-2-positive stromal cells in its histopathogenesisTaisuke Mori
Virchows Arch 449:137-9. 2006
Unique follicular carcinoma of the thyroid gland with extracellular deposition of amorphous globular structures mimicking an adenoid cystic patternKazuto Yamazaki
Virchows Arch 443:690-2. 2003
Expression of p21/WAF-1, status of apoptosis and p53 mutation in esophageal squamous cell carcinoma with HPV infectionMakoto Hasegawa
Department of Surgery, Ichihara Hospital Teikyo University, School of Medicine, Ichihara, Japan
Pathol Int 52:442-50. 2002
..The data provide significant support for the hypothesis that HPV infection may play a crucial role in the oncogenesis of some ESCC...
Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 casesToshitaka Nagao
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Mod Pathol 16:1265-72. 2003
..Limited evidence suggests that p53 abnormalities in combination with HER-2/neu overexpression or loss of pRb expression may have a role in dedifferentiation of adenoid cystic carcinoma...
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insultsHirohisa Tajima
Department of Pharmacology and Neurosciences, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Neurosci Lett 324:227-31. 2002
..HN immunoreactivity was also detected in an AD brain, but little in normal brains. This study suggests that HN peptide could be produced in vivo, and would provide a novel insight into the pathophysiology of AD...
Ovarian fibroma (fibrothecoma) with extensive cystic degeneration: unusual MR imaging findings in two casesTohru Takeshita
Department of Radiology, Teikyo University School of Medicine, Ichihara Hospital, 3426-3 Anesaki, Ichihara, Chiba 299-0111, Japan
Radiat Med 23:70-4. 2005
..It should be noted that ovarian fibromas (fibrothecomas) with extensive cystic degeneration are a rare exception to the rule that solid components in a cystic adnexal mass imply malignancy...
Sarcomatoid variant of salivary duct carcinoma: clinicopathologic and immunohistochemical study of eight cases with review of the literatureToshitaka Nagao
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 122:222-31. 2004
..6 months). These results indicate that sarcomatoid SDC is a highly aggressive tumor, similar to conventional SDC...
Deficits in spatial learning and motor coordination in ADAM11-deficient miceEiki Takahashi
Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
BMC Neurosci 7:19. 2006
..To elucidate the physiological functions of ADAM11, we generated ADAM11-deficient mice by means of gene targeting...
Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonistsKazuto Yamazaki
Tsukuba Research Laboratories, Eisai Company, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki, 300 2635, Japan
Biochem Biophys Res Commun 290:1114-22. 2002
..This finding suggests that fenofibrate treatment may reduce plasma SAA concentration in patients with secondary amyloidosis...