Hatano Y, Semi K, Hashimoto K, Lee M, Hirata A, Tomita H, et al
. Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis. 2015;36:719-29 pubmed publisher
..We herein propose that DNA demethylation exerts a tumor suppressive effect in the colon by inducing tumor cell differentiation. ..
Yamada Y, Haga H, Yamada Y. Concise review: dedifferentiation meets cancer development: proof of concept for epigenetic cancer. Stem Cells Transl Med. 2014;3:1182-7 pubmed publisher
Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, et al
. An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development. Stem Cell Reports. 2016;6:592-606 pubmed publisher
..This in vitro cancer model using sarcoma iPSCs should provide a unique platform for dissecting relationships between the cancer genome and cellular differentiation. ..
Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, et al
. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 2014;156:663-77 pubmed publisher
..These findings suggest that epigenetic regulation associated with iPSC derivation may drive development of particular types of cancer. ..
Hashimoto K, Yamada Y, Semi K, Yagi M, Tanaka A, Itakura F, et al
. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Proc Natl Acad Sci U S A. 2017;114:758-763 pubmed publisher
..Our results also imply that the transition from microadenomas to macroscopic tumors is reprogrammable, which underscores the importance of epigenetic regulation on tumor promotion. ..
Taguchi J, Yamada Y. Unveiling the Role of Senescence-Induced Cellular Plasticity. Cell Stem Cell. 2017;20:293-294 pubmed publisher
..2016; Mosteiro etÂ al., 2016; Chiche etÂ al., 2017, respectively) report crosstalk between reprogramming and senescence, providing insights on cellular plasticity in multicellular organisms. ..
Taguchi J, Yamada Y. In vivo reprogramming for tissue regeneration and organismal rejuvenation. Curr Opin Genet Dev. 2017;46:132-140 pubmed publisher
..Here, we review recent progress and future perspectives of in vivo reprogramming. ..