Terry P Yamaguchi
Garriock R, Mikawa T, Yamaguchi T. Isolation and culture of mouse proepicardium using serum-free conditions. Methods. 2014;66:365-9 pubmed publisher
..This PE culture method allows for the ex vivo analysis of specific growth factors on PE and epicardial development with greater efficiency and precision than existing epicardial culture methods. ..
Garriock R, Chalamalasetty R, Kennedy M, Canizales L, Lewandoski M, Yamaguchi T. Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation. Development. 2015;142:1628-38 pubmed publisher
..Finally, we find that Wnt3a/Î²-catenin signaling directs trunk progenitors towards PMP fates; however, our data also suggest that Wnt3a positively supports a progenitor state for both mesodermal and neural progenitors. ..
Chalamalasetty R, Garriock R, Dunty W, Kennedy M, Jailwala P, Si H, et al
. Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation. Development. 2014;141:4285-97 pubmed publisher
..Our data provide new insights into how cell fate decisions are imposed by the expression of a single transcriptional regulator. ..
Ajima R, Bisson J, Helt J, Nakaya M, Habas R, Tessarollo L, et al
. DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015;408:126-39 pubmed publisher
..However, deleting Daam1 further disrupted Wnt5a homozygous-null hearts, suggesting that DAAM1 also has Wnt5a-independent roles in cardiac development. ..
Kennedy M, Chalamalasetty R, Thomas S, Garriock R, Jailwala P, Yamaguchi T. Sp5 and Sp8 recruit Î²-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016;113:3545-50 pubmed publisher
..Because Sp5 is itself directly activated by Wnt signals, we propose that Sp5 is a Wnt/Î²-catenin pathway-specific transcript on factor that functions in a feed-forward loop to robustly activate select Wnt target genes. ..
Kumar A, Chalamalasetty R, Kennedy M, Thomas S, Inala S, Garriock R, et al
. Zfp703 Is a Wnt/?-Catenin Feedback Suppressor Targeting the ?-Catenin/Tcf1 Complex. Mol Cell Biol. 2016;36:1793-802 pubmed publisher
..We propose that Zfp703 is a novel feedback suppressor of Wnt/?-catenin signaling that functions by inhibiting the association of ?-catenin with Tcf1 on Wnt response elements in target gene enhancers. ..
Chalamalasetty R, Ajima R, Garriock R, Kennedy M, Tessarollo L, Yamaguchi T. A new gain-of-function mouse line to study the role of Wnt3a in development and disease. Genesis. 2016;54:497-502 pubmed publisher
..These data indicate that the exogenously expressed Wnt3a stimulates the Wnt/?-catenin signaling pathway, as expected. The Rosa26(Wnt3a) mouse line should prove to be an invaluable tool to study the function of Wnt3a in vivo. ..