J Yakoob

Summary

Publications

  1. pmc Comparison of the virulence markers of Helicobacter pylori and their associated diseases in patients from Pakistan and Afghanistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Saudi J Gastroenterol 19:211-8. 2013
  2. pmc Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Stadium Road, Karachi, 74800, Pakistan
    BMC Gastroenterol 13:33. 2013
  3. doi request reprint Microsporidial infections due to Encephalitozoon intestinalis in non-HIV-infected patients with chronic diarrhoea
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Epidemiol Infect 140:1773-9. 2012
  4. ncbi request reprint Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndrome
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Br J Biomed Sci 69:6-10. 2012
  5. pmc Small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in Pakistan
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Saudi J Gastroenterol 17:371-5. 2011
  6. pmc Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 12:3. 2012
  7. pmc Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi, Pakistan
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    BMC Infect Dis 6:101. 2006
  8. ncbi request reprint Candida oesophagitis with hepatitis C virus: an uncommon association
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    Eur J Gastroenterol Hepatol 15:701-3. 2003
  9. pmc Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 14:1539-43. 2008
  10. doi request reprint Gastric corpus polyps associated with Proton Pump Inhibitors therapy
    Javed Yakoob
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 18:172-3. 2008

Collaborators

Detail Information

Publications50

  1. pmc Comparison of the virulence markers of Helicobacter pylori and their associated diseases in patients from Pakistan and Afghanistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Saudi J Gastroenterol 19:211-8. 2013
    ..016) in Afghans. Conclusion: Distribution of H. pylori virulence marker cagE with DU was similar in Afghan and Pakistan H. pylori strains. Chronic active inflammation was significantly associated with Pakistani H. pylori strains. ..
  2. pmc Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Stadium Road, Karachi, 74800, Pakistan
    BMC Gastroenterol 13:33. 2013
    ..The aim was to investigate the reinfection rate of H. pylori during a follow-up period of 12 months in adults who had undergone eradication therapy...
  3. doi request reprint Microsporidial infections due to Encephalitozoon intestinalis in non-HIV-infected patients with chronic diarrhoea
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Epidemiol Infect 140:1773-9. 2012
    ..Stool examination with trichrome or species-specific PCR for microsporidia may help establish the cause of chronic diarrhoea...
  4. ncbi request reprint Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndrome
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Br J Biomed Sci 69:6-10. 2012
    ..03). vacA s1 was positive in 61 (53%) with IBS-D compared to 32 (36%) in the control group (P=0.02). cagA s1 was positive in 39 (34%) with IBS-D compared to 13 (15%) in the control group (P=0.002)...
  5. pmc Small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in Pakistan
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Saudi J Gastroenterol 17:371-5. 2011
    ..The aim of this study was to determine the frequency of SIBO and lactose intolerance (LI) occurrence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) according to Rome III criteria...
  6. pmc Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 12:3. 2012
    ..pylori phosphoglucosamine mutase (glmM) and urease B (ureB) gene of H. heilmannii and H. felis. Sequencing of PCR products of H. heilmannii and H. felis was done...
  7. pmc Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi, Pakistan
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    BMC Infect Dis 6:101. 2006
    ..This cross-sectional study estimated the prevalence and identified risk factors associated with Hepatitis B surface antigen (HBsAg) and HCV antibody (anti-HCV) sero-positivity among children 1 to 15 years of age...
  8. ncbi request reprint Candida oesophagitis with hepatitis C virus: an uncommon association
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    Eur J Gastroenterol Hepatol 15:701-3. 2003
    ..Evaluation of this case provides insight into various mechanisms of immune suppression associated with HCV infection...
  9. pmc Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 14:1539-43. 2008
    ..To determine the efficacy of gastric juice polymerase chain reaction (PCR) for the detection of H pylori infection in comparison with histology and gastric antral biopsy PCR in patients on a proton pump inhibitor (PPI)...
  10. doi request reprint Gastric corpus polyps associated with Proton Pump Inhibitors therapy
    Javed Yakoob
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 18:172-3. 2008
    ..pylori was also negative. This is the first report originating from an Asian country describing Fundal Gland Polyps (FGPs) in the corpus of stomach rather than fundus in a patient on long-term PPI therapy...
  11. ncbi request reprint Low prevalence of the intact cag pathogenicity island in clinical isolates of Helicobacter pylori in Karachi, Pakistan
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Br J Biomed Sci 66:137-42. 2009
    ..001). The presence of the cagA gene does not signify presence of an intact cag-PAI. Most of the H. pylori isolates studied had partial cag-PAI with missing cagE and cagA promoter regions...
  12. pmc Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 9:87. 2009
    ..pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU)...
  13. doi request reprint Irritable bowel syndrome: is it associated with genotypes of Blastocystis hominis
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Parasitol Res 106:1033-8. 2010
    ..30), respectively. Majority of our patients had typeable B. hominis infection. The genotype of B. hominis in IBS-D was type 1 while in control genotype 3 was predominant...
  14. doi request reprint Risk factors associated with Helicobacter pylori infection treatment failure in a high prevalence area
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Epidemiol Infect 139:581-90. 2011
    ..Treatment failure was associated with younger mean age, point mutations in the 23S rRNA gene of H. pylori and vacA s1a and m1 when associated with cagA negativity...
  15. doi request reprint Blastocystis hominis and Dientamoeba fragilis in patients fulfilling irritable bowel syndrome criteria
    Javed Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    Parasitol Res 107:679-84. 2010
    ..030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR...
  16. doi request reprint Prevalences of Giardia lamblia and Cryptosporidium parvum infection in adults presenting with chronic diarrhoea
    J Yakoob
    Department of Medicine, Aga Khan University, Karachi B, Pakistan
    Ann Trop Med Parasitol 104:505-10. 2010
    ..6%) of the 167 found smear-negative (k=0.954; P<0.001). Although C. parvum was associated with chronic diarrhoea in the present study, the carriage of G. lamblia often appeared asymptomatic...
  17. ncbi request reprint Antibiotic susceptibility patterns of Helicobacter pylori and triple therapy in a high-prevalence area
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Br J Biomed Sci 67:197-201. 2010
    ..001) and A2142C mutation in five (17%; P = 0.003). In conclusion, triple therapy failure was associated with CLR-R. Metronidazole resistance exceeded that of CLR, hence it cannot be substituted for CLR in a triple therapy...
  18. doi request reprint In vitro sensitivity of Blastocystis hominis to garlic, ginger, white cumin, and black pepper used in diet
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Parasitol Res 109:379-85. 2011
    ..01 mg/ml of MTZ. However, this sensitivity did not increase as garlic concentration was increased to 0.1 mg/ml, for B. hominis cell count was 6,000 compared to 1,428 as MTZ was increased to 0.1 mg/ml...
  19. ncbi request reprint Helicobacter pylori: association with gall bladder disorders in Pakistan
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Br J Biomed Sci 68:59-64. 2011
    ..pylori. In conclusion, H. pylori DNA was demonstrated in cases of chronic cholecystitis and gall bladder carcinoma associated with cholelithiasis, but this association requires further study...
  20. ncbi request reprint Giardiasis in patients with dyspeptic symptoms
    Javed Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
    World J Gastroenterol 11:6667-70. 2005
    ..To investigate the prevalence of giardiasis in patients with dyspeptic symptoms...
  21. ncbi request reprint Comparison of biopsy-based methods for the detection of Helicobacter pylori infection
    J Yakoob
    Department of Medicine and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    Br J Biomed Sci 63:159-62. 2006
    ..Thus, the eUAB can be used as a rapid urease test. It is economical and has a sensitivity and specificity comparable to a commercially available rapid urease test to detect urease activity of H. pylori in gastric biopsy...
  22. ncbi request reprint Polymerase chain reaction in the detection of Helicobacter pylori infection
    Javed Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi 74800
    J Coll Physicians Surg Pak 14:153-6. 2004
    ..To determine the presence of Helicobacter pylori (H. pylori) infection, in patients suffering from gastritis and peptic ulcer disease by polymerase chain reaction (PCR) and correlate the results with the histological diagnosis...
  23. ncbi request reprint Genetic and phenotype changes following in vitro interactions between Helicobacter pylori strains
    Javed Yakoob
    Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China
    J Gastroenterol Hepatol 19:626-31. 2004
    ..The purpose of the present paper was to determine whether in vitro interaction between different Helicobacter pylori strains leads to changes in antibiotic susceptibility, cagA, vacAM2 and DNA fingerprint patterns...
  24. ncbi request reprint Irritable bowel syndrome: in search of an etiology: role of Blastocystis hominis
    Javed Yakoob
    Departments of Medicine and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    Am J Trop Med Hyg 70:383-5. 2004
    ..001). Blastocystis hominis was frequently demonstrated in the stool samples of IBS patients; however, its significance in IBS still needs to be investigated. Stool culture has a higher positive yield for B. hominis than stool microscopy...
  25. ncbi request reprint Candida esophagitis: risk factors in non-HIV population in Pakistan
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Agha Khan University Hospital, Karachi, Pakistan
    World J Gastroenterol 9:2328-31. 2003
    ..Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital...
  26. ncbi request reprint Helicobacter pylori infection and micronutrient deficiencies
    Javed Yakoob
    Department of Medicine, Agha Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 9:2137-9. 2003
    ..In this paper H pylori infection in associated with various micronutrients deficiencies is briefly reviewed...
  27. ncbi request reprint Helicobacter pylori cagA and vacA cytotoxin genes in Changsha, China
    J Yakoob
    Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
    Br J Biomed Sci 59:150-3. 2002
    ..vacAs1 allele was carried in 82.5% (33/40) isolates, of which 52.5% (21/40) were subtype vacAs1a/m2 and 17.5% (7/40) were subtype vacAs1b/m2...
  28. ncbi request reprint Helicobacter pylori detection in Chinese subjects: a comparison of two common DNA fingerprinting methods
    J Yakoob
    Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha, PR China
    Br J Biomed Sci 58:239-43. 2001
    ..Diversity among H. pylori clinical isolates was demonstrated distinctly by both methods; however, RAPD-PCR showed greater discriminatory power in distinguishing between isolates...
  29. ncbi request reprint Antibiotic susceptibility of Helicobacter pylori in the Chinese population
    J Yakoob
    Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, People s Republic of China
    J Gastroenterol Hepatol 16:981-5. 2001
    ..pylori) strains to metronidazole, clarithromycin and tetracycline in the Chinese population, and to test the stability of antibiotic resistance in H. pylori 1 year after storage at -80 degrees C...
  30. ncbi request reprint Polycolonization of Helicobacter pylori among Chinese subjects
    J Yakoob
    Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha, Hunan, P R China
    Clin Microbiol Infect 7:187-92. 2001
    ..To investigate the situation among Chinese patients with regard to infection with multiple strains of Helicobacter pylori...
  31. ncbi request reprint In vitro susceptibility of Blastocystis hominis isolated from patients with irritable bowel syndrome
    J Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    Br J Biomed Sci 61:75-7. 2004
    ..B. hominis isolates varied in their degree of susceptibility to the three drugs studied, being greater with furazolidone than with metronidazole, and complete resistance with ciprofloxacin...
  32. ncbi request reprint Diversity of Helicobacter pylori among Chinese persons with H. pylori infection
    J Yakoob
    Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha, PR China
    APMIS 108:482-6. 2000
    ..pylori infection. PCR-RAPD fingerprinting is an efficient method of distinguishing between clinical isolates of H. pylori...
  33. pmc Role of rapid urease test and histopathology in the diagnosis of Helicobacter pylori infection in a developing country
    Javed Yakoob
    Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    BMC Gastroenterol 5:38. 2005
    ..The aim of this study was to determine the effect of commonly self-prescribed proton pump inhibitors (PPI) on the results of rapid urease test and histology for the diagnosis of H. pylori infection...
  34. ncbi request reprint Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi, Pakistan
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi, Pakistan
    World J Gastroenterol 11:3562-5. 2005
    ..To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases...
  35. doi request reprint Entamoeba species associated with chronic diarrhoea in Pakistan
    J Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Epidemiol Infect 140:323-8. 2012
    ..dispar in 19% (24/129) (P=0·117) and E. moshkovskii in 19% (24/129) (P<0·001). E. histolytica and E. moshkovskii were significantly associated with diarrhoea while E. dispar was found equally in both groups...
  36. ncbi request reprint Seroprevalence of hepatitis E and Helicobacter pylori in a low socioeconomic area of a metropolitan city in a developing country
    W Jafri
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Br J Biomed Sci 70:27-30. 2013
    ..025). H. pylori was common in children who used a non-flush toilet system (P < 0.001). Children exposed to H. pylori infection were also exposed to the risk of HEV...
  37. doi request reprint Helicobacter pylori infection in children: population-based age-specific prevalence and risk factors in a developing country
    W Jafri
    Department of Medicine and Pediatrics, Aga Khan University, Karachi, Pakistan
    Acta Paediatr 99:279-82. 2010
    ..We estimated the prevalence, age of acquisition and risk factors for Helicobacter pylori (H. pylori) seroprevalence in children aged 1-15 years...
  38. ncbi request reprint The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs
    Javed Yakoob
    Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    Dig Dis Sci 53:95-100. 2008
    ..8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology...
  39. ncbi request reprint Irritable bowel syndrome in health care professionals in Pakistan
    W Jafei
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 53:405-7. 2003
    ..To evaluate the symptomatology of irritable bowel syndrome (IBS) among health care professionals attending an IBS symposium in a tertiary care university hospital...
  40. ncbi request reprint Helicobacter species ribosomal DNA recovered from the liver tissue of chinese patients with primary hepatocellular carcinoma
    Xue Gong Fan
    Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People s Republic of China
    Clin Infect Dis 35:1555-7. 2002
    ..Four 16S rDNA fragments from positive PCR samples were directly sequenced. By sequence comparison, all were found to be 99% identical to the 16S rRNA of Helicobacter pylori...
  41. ncbi request reprint Frequency of NSAID induced peptic ulcer disease
    Saeed Hamid
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    J Pak Med Assoc 56:218-22. 2006
    ..To determine the frequency of peptic ulcer disease in patients on nonsteroidal anti-inflammatory drugs (NSAID)...
  42. ncbi request reprint An office-based serological test for detection of current Helicobacter pylori infection: is it useful?
    Khalid Mumtaz
    Section of Gastroenterology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    Eur J Gastroenterol Hepatol 18:85-8. 2006
    ..To compare the accuracy of a new office-based serological test for the detection of current Helicobacter pylori infection with gastric histopathology...
  43. ncbi request reprint Irritable bowel syndrome in patients evaluated for organic bowel pathology
    Wasim Jafri
    Department of Medicine, The Aga Khan University Hospital, Karachi 74800, Pakistan
    J Coll Physicians Surg Pak 14:438-9. 2004
  44. ncbi request reprint Frequency of irritable bowel syndrome in college students
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi
    J Ayub Med Coll Abbottabad 17:9-11. 2005
    ..This study was carried out to investigate the presence of irritable bowel syndrome (IBS) in college students and compare its distribution in the non-medical college and medical college students...
  45. ncbi request reprint Perception of gastroesophageal reflux disease in urban population in Pakistan
    Nadim Jafri
    Section of Gastroenterology, Department of Medicine, Aga Khan Medical University Hospital, Karachi, Pakistan
    J Coll Physicians Surg Pak 15:532-4. 2005
    ..To determine the frequency and health care seeking behavior of patients with gastroesophageal reflux symptoms using American College of Gastroenterology (ACG) questionnaire for gastroesophageal reflux disease (GERD)...
  46. doi request reprint Furazolidone, co-amoxiclav, colloidal bismuth subcitrate, and esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapy
    Zaigham Abbas
    Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Dig Dis Sci 54:1953-7. 2009
    ..On an intention-to-treat analysis, the eradication rate was 81% (42 out of 52) whereas on per-protocol basis, the eradication rate was 82.4% (42 out of 51). In conclusion, this new regimen represents a suitable second-line therapy...
  47. ncbi request reprint Irritable bowel syndrome and health seeking behaviour in different communities of Pakistan
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 57:285-7. 2007
    ..To investigate the frequency of irritable bowel syndrome (IBS) and health seeking behaviour in patients belonging to different ethnic groups and their squatter settlements in two cities of Pakistan...
  48. ncbi request reprint Phloroglucinol in irritable bowel syndrome
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:5-8. 2006
    ..To determine the efficacy and tolerability of phloroglucinol, an antispasmodic agent in the treatment of Irritable Bowel Syndrome (IBS)...
  49. ncbi request reprint Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma
    Javed Yakoob
    Department of Medicine and Pathology, The Aga Khan University, Karachi, Pakistan
    J Pak Med Assoc 59:639-41. 2009
    ..To our knowledge this is the first local report of spindle cell carcinoma occurring in the esophagus and describes its endoscopic and histopathological features with distinctive biphasic morphology...
  50. ncbi request reprint Helicobacter pylori: a diverse bacterium
    Wasim Jafri
    J Coll Physicians Surg Pak 13:553-4. 2003