Jing Yuan Xu

Summary

Publications

  1. Lian W, Wang X, Xie C, Tian H, Song X, Pan H, et al. Mixed-ligand copper(ii) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity. Dalton Trans. 2016;45:9073-87 pubmed publisher
    ..The biological features of mixed-ligand copper(ii) Schiff base complexes and how acetic auxiliary ligands manipulate these features are also discussed. ..
  2. Liu Y, Li A, Shao J, Xie C, Song X, Bao W, et al. Four Cu(ii) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity. Dalton Trans. 2016;45:8036-49 pubmed publisher
    ..The mechanistic studies revealed that four complexes, which induced early apoptosis, were involved in reactive oxygen species generation and DNA cleavage for their antitumor activities. ..
  3. Song X, Ma Z, Wu Y, Dai M, Wang D, Xu J, et al. New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo. Eur J Med Chem. 2019;167:377-387 pubmed publisher
    ..In vivo, Eto-Pt(IV) displayed potent antitumor activity and no observable toxicity in BALB/c nude mice bearing MCF-7 tumors. ..
  4. Song X, Liu Y, Shao J, Zhang Z, Xie C, Qiao X, et al. Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone. Eur J Med Chem. 2018;157:188-197 pubmed publisher
    ..By means of ICP-MS assay, we found complex 1 could largely accumulate in tumor cells in a short time. Additionally, complex 1 showed no cross resistance against the cisplatin-resistant cells. ..
  5. Tian H, Qiao X, Zhang Z, Xie C, Li Q, Xu J. A high performance 2-hydroxynaphthalene Schiff base fluorescent chemosensor for Al3+ and its applications in imaging of living cells and zebrafish in vivo. Spectrochim Acta A Mol Biomol Spectrosc. 2019;207:31-38 pubmed publisher
    ..Moreover, we also applied H3L for in vivo detection of Al3+ ions in living zebrafish larvae. ..
  6. Ma Z, Wang D, Song X, Wu Y, Chen Q, Zhao C, et al. Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo. Eur J Med Chem. 2018;157:1292-1299 pubmed publisher
    ..The chlorambucil moiety not only greatly assisted the passive diffusion of CLB-Pt-CLB into cells, but also produced the synergism with cisplatin in targeting DNA. ..
  7. Li A, Liu Y, Yuan L, Ma Z, Zhao C, Xie C, et al. Association of structural modifications with bioactivity in three new copper(II) complexes of Schiff base ligands derived from 5-chlorosalicylaldehyde and amino acids. J Inorg Biochem. 2015;146:52-60 pubmed publisher
  8. Zhang Z, Zhao C, Chen Q, Xu K, Qiao X, Xu J. Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent. Eur J Med Chem. 2018;155:434-444 pubmed publisher
  9. Wang Y, Ma Z, Zhang D, Deng J, Chen X, Xie C, et al. Highly selective and sensitive turn-on fluorescent sensor for detection of Al3+ based on quinoline-base Schiff base. Spectrochim Acta A Mol Biomol Spectrosc. 2018;195:157-164 pubmed publisher
    ..It is confirmed that HL1 could be used to detect Al3+ ions in real sample by fluorescence spectrometry and Al3+ ions in cells by bioimaging. ..