Genomes and Genes


Jie Xu



  1. Hu Y, Wang J, Qian J, Kong X, Tang J, Wang Y, et al. Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer. Cancer Res. 2014;74:6890-902 pubmed publisher
    ..Taken together, our results identify a noncoding regulatory pathway for the CD44 oncogene, shedding new light on the basis for gastric cancer cell invasiveness. ..
  2. Bian Z, Miao Q, Zhong W, Zhang H, Wang Q, Peng Y, et al. Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease. J Autoimmun. 2015;63:76-87 pubmed publisher
    ..In conclusion, our findings uncover a critical negative feedback regulatory loop in which TGF-β1 induces Cthrc1, which can attenuate fibrosis by accelerating degradation of phospho-Smad3. ..
  3. Chen H, Xu J, Hong J, Tang R, Zhang X, Fang J. Long noncoding RNA profiles identify five distinct molecular subtypes of colorectal cancer with clinical relevance. Mol Oncol. 2014;8:1393-403 pubmed publisher
    ..This lncRNAs-based classification schema thus provides a molecular classification applicable to individual tumors that has implications to influence treatment decisions. ..
  4. Zhou X, Xu J. Identification of Alzheimer's disease-associated long noncoding RNAs. Neurobiol Aging. 2015;36:2925-2931 pubmed publisher
    ..Taken together, our study provides a resource for AD-associated lncRNAs for the development of lncRNA biomarkers and the identification of functional lncRNAs involved in AD pathogenesis. ..