Jianfeng Xu

Summary

Publications

  1. pmc Prostate cancer risk-associated genetic markers and their potential clinical utility
    Jianfeng Xu
    Fudan Institute of Urology, Huashan Hospital, Fudan UniversityFudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Asian J Androl 15:314-22. 2013
  2. pmc Prediction of prostate cancer from prostate biopsy in Chinese men using a genetic score derived from 24 prostate cancer risk-associated SNPs
    Haowen Jiang
    Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, P R China
    Prostate 73:1651-9. 2013
  3. pmc Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men
    Rong Na
    Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR, China
    Prostate 73:1623-35. 2013
  4. pmc Age-specific prostate specific antigen cutoffs for guiding biopsy decision in Chinese population
    Rong Na
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e67585. 2013
  5. doi request reprint Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer
    Ping Wang
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China
    Genes Chromosomes Cancer 53:98-105. 2014
  6. ncbi request reprint Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4
    Jianfeng Xu
    Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Nat Genet 44:1231-5. 2012
  7. pmc Outcomes and trends of prostate biopsy for prostate cancer in Chinese men from 2003 to 2011
    Rong Na
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 7:e49914. 2012
  8. pmc Predictive performance of prostate cancer risk in Chinese men using 33 reported prostate cancer risk-associated SNPs
    Jie Zheng
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China
    Prostate 72:577-83. 2012
  9. doi request reprint The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality
    Guanxiong Ding
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Clin Genitourin Cancer 10:251-5. 2012
  10. doi request reprint Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men
    Xiaoling Lin
    Fudan Institute of Urology, Huashan Hospital, School of Life Sciences, Fudan University, Shanghai, China
    Hum Mol Genet 21:2610-7. 2012

Collaborators

Detail Information

Publications23

  1. pmc Prostate cancer risk-associated genetic markers and their potential clinical utility
    Jianfeng Xu
    Fudan Institute of Urology, Huashan Hospital, Fudan UniversityFudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Asian J Androl 15:314-22. 2013
    ..Another unique feature of this article is the inclusion of genetic association studies of PCa in Chinese and Japanese populations...
  2. pmc Prediction of prostate cancer from prostate biopsy in Chinese men using a genetic score derived from 24 prostate cancer risk-associated SNPs
    Haowen Jiang
    Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, P R China
    Prostate 73:1651-9. 2013
    ..We evaluated whether these SNPs can independently predict outcomes of prostate biopsy, and improve the predictive performance of existing clinical variables...
  3. pmc Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men
    Rong Na
    Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR, China
    Prostate 73:1623-35. 2013
    ..The objective of this study is to evaluate which of these SNPs are associated with PCa risk in Chinese men and estimate their strength of association...
  4. pmc Age-specific prostate specific antigen cutoffs for guiding biopsy decision in Chinese population
    Rong Na
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e67585. 2013
    ..Age-specific prostate specific antigen (PSA) cutoffs for prostate biopsy have been widely used in the USA and European countries. However, the application of age-specific PSA remains poorly understood in China...
  5. doi request reprint Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer
    Ping Wang
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China
    Genes Chromosomes Cancer 53:98-105. 2014
    ..33, 95% CI = 1.00 - 1.78, P = 0.05), P = 0.001. In conclusion, A combination of three previously implicated bladder cancer risk-associated SNPs is a significant predictor of genetic susceptibility to bladder cancer in Chinese...
  6. ncbi request reprint Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4
    Jianfeng Xu
    Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Nat Genet 44:1231-5. 2012
    ..These findings may advance the understanding of genetic susceptibility to prostate cancer...
  7. pmc Outcomes and trends of prostate biopsy for prostate cancer in Chinese men from 2003 to 2011
    Rong Na
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 7:e49914. 2012
    ..Prostate-specific antigen (PSA) screening is growing in popularity in China, but its impact on biopsy characteristics and outcomes are poorly understood...
  8. pmc Predictive performance of prostate cancer risk in Chinese men using 33 reported prostate cancer risk-associated SNPs
    Jie Zheng
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China
    Prostate 72:577-83. 2012
    ..In aggregate, these variants have shown potential to predict risk for PCa in European men. However, their utility for PCa risk prediction in Chinese men is unknown...
  9. doi request reprint The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality
    Guanxiong Ding
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Clin Genitourin Cancer 10:251-5. 2012
    ..Our study aimed to evaluate the association between genetic polymorphisms and the risk of PCa...
  10. doi request reprint Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men
    Xiaoling Lin
    Fudan Institute of Urology, Huashan Hospital, School of Life Sciences, Fudan University, Shanghai, China
    Hum Mol Genet 21:2610-7. 2012
    ..62 × 10(-36)). The new loci identified offer new insights into the biochemical pathways involved in determining the serum level of VitB12 and provide opportunities to better delineate the role of VitB12 in health and disease...
  11. doi request reprint Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF
    Guanxiong Ding
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Gen Physiol Biophys 32:245-50. 2013
    ..It could be induced by some factors or chemokines such as SDF-1, CXCR4, and VEGF. The possible role of PCa-MSCs in the process of PCa development needed further clarification. ..
  12. doi request reprint Systematic evaluation of bladder cancer risk-associated single-nucleotide polymorphisms in a Chinese population
    Zhicheng Ma
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Mol Carcinog 52:916-21. 2013
    ..Additional studies with larger sample sizes are needed to further confirm our results...
  13. doi request reprint Multimodal SPION-CREKA peptide based agents for molecular imaging of microthrombus in a rat myocardial ischemia-reperfusion model
    Yanan Song
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China
    Biomaterials 35:2961-70. 2014
    ..The fibrin-targeted nanoagent could be expected to have utility not only in molecular imaging of fibrin, understanding the mechanisms of microcirculation disorders, but also in targeted therapy with fibrinolytic agents...
  14. doi request reprint Olmesartan attenuates cardiac hypertrophy and improves cardiac diastolic function in spontaneously hypertensive rats through inhibition of calcineurin pathway
    Mingqiang Fu
    Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China Department of Medicine, Sahlgrenska University Hospital Sahlgrenska, Gothenburg, Sweden and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    J Cardiovasc Pharmacol 63:218-26. 2014
    ..To test whether olmesartan ameliorates cardiac diastolic dysfunction in spontaneously hypertensive rats (SHRs) through calcineurin pathway...
  15. pmc RNA sequencing reveals upregulation of RUNX1-RUNX1T1 gene signatures in clear cell renal cell carcinoma
    Zuquan Xiong
    Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai 200040, China
    Biomed Res Int 2014:450621. 2014
    ..We also confirmed the findings based on previously published gene expression microarray data. Our data shows that upregulated of the RUNX1-RUNX1T1 gene set maybe an important factor contributing to the etiology of ccRCC. ..
  16. doi request reprint PRRT2 c.649dupC mutation derived from de novo in paroxysmal kinesigenic dyskinesia
    Hong fu Li
    Department of Neurology, Huashan Hospital, Institutes of Brain Science, Shanghai Medical College, Fudan University, China
    CNS Neurosci Ther 19:61-5. 2013
    ..This might be attributed to the incomplete penetrance of c.649dupC. Alternatively, c.649dupC might derive from de novo. The aim of this study is to elucidate the possibility concerning de novo mutagenesis of PRRT2 mutations in PKD...
  17. doi request reprint Effects of CYP2C19 variant alleles on postclopidogrel platelet reactivity and clinical outcomes in an actual clinical setting in China
    Hongyi Wu
    Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital bFudan VARI Center for Genetic Epidemiology, School of Life Science, Fudan University, Shanghai, China
    Pharmacogenet Genomics 22:887-90. 2012
    ....
  18. pmc Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men
    Fang Liu
    Fudan VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China
    Cancer Sci 102:1916-20. 2011
    ..This finding provides evidence of ethnic differences and similarity in genetic susceptibility to PCa. Genome-wide association studies in Chinese men are needed to identify Chinese-specific PCa risk-associated SNP...
  19. doi request reprint Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma
    De Ke Jiang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Nat Genet 45:72-5. 2013
    ..0008 and 0.0002, respectively). We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14))...
  20. ncbi request reprint The effect of nonuniform magnetic targeting of intracoronary-delivering mesenchymal stem cells on coronary embolisation
    Zheyong Huang
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China
    Biomaterials 34:9905-16. 2013
    ..These potential complications of magnetic targeting should be thoroughly investigated and overcome before clinical application...
  21. pmc Association of prostate cancer risk with SNPs in regions containing androgen receptor binding sites captured by ChIP-On-chip analyses
    Yizhen Lu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Prostate 72:376-85. 2012
    ..Recently, using ChIP-on-chip technology, 22,447 androgen receptor (AR) binding sites have been mapped throughout the genome, greatly expanding the genomic regions potentially involved in androgen-mediated activity...
  22. doi request reprint High density lipoprotein cholesterol promotes the proliferation of bone-derived mesenchymal stem cells via binding scavenger receptor-B type I and activation of PI3K/Akt, MAPK/ERK1/2 pathways
    Jianfeng Xu
    Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Mol Cell Biochem 371:55-64. 2012
    ..The results suggested that HDL was capable of improving MSCs proliferation, in which MAPK/ERK1/2 and PI3K/Akt pathways involved and SR-BI played a critical role as well...
  23. doi request reprint Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population
    Hongyan Chen
    State Key Laboratory of Genetic Engineering, Fudan VARI Genetic Epidemiology Center and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai200433, China
    Am J Epidemiol 173:915-22. 2011
    ..33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations...