Xie Z, Chen Y, Liao E, Jiang Y, Liu F, Pennypacker S. Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. Biochem Biophys Res Commun. 2010;397:296-300 pubmed publisher
..These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity. ..
Xie Z, Chen Y, Pennypacker S, Zhou Z, Peng D. The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis. Biochem Biophys Res Commun. 2010;398:719-22 pubmed publisher
..These data suggest that the SH3 domain, but not the catalytic domain, is required for PLC-gamma1 to mediate EGF-induced SCC4 cell mitogenesis. ..
Xie Z, Peng J, Pennypacker S, Chen Y. Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration. Biochem Biophys Res Commun. 2010;399:425-8 pubmed publisher
..These data indicate that EGF-induced cell migration is mediated by the lipase domain of PLC-gamma1 and the subsequent IP(3) generation and intracellular calcium mobilization. ..
Xie Z, Jiang Y, Liao E, Chen Y, Pennypacker S, Peng J, et al
. PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells. Oncogene. 2012;31:5090-8 pubmed publisher
..However, inhibition of the catalytic activity of PLC-?1 had little effect. These data suggest that PIKE has a critical role in EGF-induced SCC cell proliferation and may function as a proto-oncogene in SCC. ..