The prognostic significance of leukemic cells clearance kinetics evaluation during the initial course of induction therapy with HAD (homoharringtonine, cytosine arabinoside, daunorubicin) in patients with de novo acute myeloid leukemiaZhijian Xiao
Department of Clinical Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
Am J Hematol 83:203-5. 2008
..The CR rate, DFS, and OS were significantly different between the two groups. We further confirmed that the percentage of RLCs at T1 or T2 is an independent prognostic factor of AML...
- Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia
Zhijian Xiao
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Leuk Res 32:1288-91. 2008
..03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients...
Cyclosporin A and thalidomide in patients with myelodysplastic syndromes: Results of a pilot studyZhijian Xiao
The 6th Department of Clinical Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
Leuk Res 35:61-5. 2011
..Therefore, CyA combined with thalidomide appears to be useful and is relatively well-tolerated for patients with MDS...
- Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China
Zhijian Xiao
Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, People s Republic of China
Leuk Lymphoma 43:1763-8. 2002
..Both antiproliferative and induced apoptosis mechanisms have been described. Further research, especially randomized trials, are required to confirm the role of indirubin and meisoindigo in the treatment of CML...
- Isochromosome 17q in patients with myelodysplastic syndromes: six new cases
Zhijian Xiao
Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China
Haematologica 88:714-5. 2003
- MEL1S, not MEL1, is overexpressed in myelodysplastic syndromes patients with t(1;3)(p36;q21)
Zhijian Xiao
Department of Clinical Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, PR China
Leuk Res 30:332-4. 2006
..Imbalance of a complete MEL1 message with a PR domain and a short MEL1 message lacking a PR domain (MEL1S) might be involved in the pathogenesis of these patients...
- Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro
Zhijian Xiao
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, 288 Nanjing Road, Tianjin 300020, China
Leuk Res 30:54-9. 2006
..This effect may contribute to the anti-leukemic effect of this drug...
- Detoxification and DNA repair genes polymorphisms and susceptibility of primary myelodysplastic syndromes in Chinese population
Lin Li
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Leuk Res 35:762-5. 2011
..In addition, the null genotype of GSTT1 was correlated MDS patients with complex aberrant karyotype (OR, 3.25; p=0.012). These potential genetic predisposition suggested their possible involvement in the multistep pathogenesis of MDS...
- TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes
Jieyu Wang
MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Leuk Res 37:305-11. 2013
..039). These data suggest ASXL1 mutations might results in dominance of the mutant clone in Chinese with MDS whereas EZH2 mutations might predict an increased risk of transformation to AML...
- Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts
Rui Cui
MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Leuk Res 36:1428-33. 2012
..These data increase our knowledge of the impact of SF3B1 mutations in persons with MDS. They indicate a similar favorable impact of SF3B1 mutation on survival in Chinese with MDS as reported for persons of European descent...
- Impacts of cytogenetic categories in the Revised International Prognostic Scoring System on the prognosis of primary myelodysplastic syndromes: results of a single-center study
Shiqiang Qu
Chinese Academy of Medical Sciences, Tianjin, China
Leuk Lymphoma 53:940-6. 2012
..001). In conclusion, the IPSS-R can effectively stratify the prognosis of MDS based on cytogenetics, but the prognostic significances of some karyotypes in the IPSS-R still need to be confirmed by larger multicenter cooperative studies...
- RAD51 and XRCC3 polymorphisms: impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBFβ-MYH11(+) acute myeloid leukemia
Liang Liu
State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Leuk Res 35:1020-6. 2011
..34, 95% CI, 1.32-4.16). These data indicate that the XRCC3-241Met variant may not be only a susceptibility factor to the AML with inv(16)/t(16;16), but also an independent poor-prognostic factor for this AML subtype...
- The effects of increased expression of DLK1 gene on the pathogenesis of myelodysplastic syndromes
Xiaotang Ma
State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Clin Lymphoma Myeloma Leuk 12:261-8. 2012
..These observations suggest that DLK1 dysfunction may contribute to the ineffective hematopoiesis of MDS...
- Polymorphisms in folate-related genes: impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese
Lin Yang
State Key Laboratory of Experiment Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Leuk Lymphoma 52:1770-6. 2011
..Our study clearly demonstrates that polymorphisms in folate-related genes only modulate the susceptibility to adult ALL, but not to pediatric ALL, in Han Chinese...
- HFE genotype and iron metabolism in Chinese patients with myelodysplastic syndromes and aplastic anemia
Ling Nie
State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China
Ann Hematol 89:1249-53. 2010
..The results suggest that H63D mutations may not have clinical significance in Chinese patients with MDS and AA...
- Unique features of primary myelofibrosis in Chinese
Zefeng Xu
MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Blood 119:2469-73. 2012
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- NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotype
Yue Zhang
State Key Laboratory of Experiment Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
Leuk Res 31:109-11. 2007
..As far as we know, this is the first report of NPM1 mutation in patients with MDS in the English literature until now, and our primary data support that NPM1 mutations may be also involved in the pathogenesis of MDS...
- Neuropilin-1 in acute myeloid leukemia: expression and role in proliferation and migration of leukemia cells
Lin Lu
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
Leuk Lymphoma 49:331-8. 2008
..Inhibition of NRP-1 functions may provide a new therapeutic strategy for treatment of AML...
- Periodic oscillation of blood leukocytes, platelets, and hemoglobin in a patient with chronic eosinophilic leukemia
Zhijian Xiao
Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, PR China
Leuk Res 27:89-91. 2003
..Bone marrow hyperplasia was accompanied with the increase in peripheral WBC count, suggesting that the variation of cell production caused the cyclic oscillation...
- The successive development of acute myeloblastic leukemia, secondary non-Hodgkin's lymphoma and secondary myeloid/natural killer cell acute leukemia in a single patient
Zhijian Xiao
Department of Clinical Hematology, Chinese Academy of Medical Sciences, Tianjin, People s Republic of China
Leuk Lymphoma 45:1955-8. 2004
..The patient died of multiorgan failure 1 month after the onset of leukemia. As far as we know, no other such patient has been described in the English literature until now...
- AML1/RUNX1 fusion gene and t(5;21)(q13;q22) in a case of chronic myelomonocytic leukemia with progressive thrombocytopenia and monocytosis
Shihe Liu
Cancer Genet Cytogenet 152:172-4. 2004
Chromosome translocations and covert leukemic clones are generated during normal fetal developmentHiroshi Mori
Leukaemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
Proc Natl Acad Sci U S A 99:8242-7. 2002
..The frequency of positive cells (10(-4) to 10(-3)) indicates substantial clonal expansion of a progenitor population. These data have significant implications for the pathogenesis, natural history, and etiology of childhood leukemia...
- Tetraploidy or near-tetraploidy clones with double 8;21 translocation: a non-random additional anomaly of acute myeloid leukemia with t(8;21)(q22;q22)
Zhijian Xiao
Haematologica 90:413-4. 2005
..Some common features were revealed by this analysis...
- The Janus kinase 2 (JAK2) V617F mutation in Chinese patients with chronic myeloproliferative disorders
Zhijian Xiao
Haematologica 93:787-8. 2008
- Photoreactivity of indirubin derivatives
David Olivier
HGRL, Laboratoire de Photobiologie des Cancers, Laser Department, 44093, Nantes, France
Photochem Photobiol Sci 7:328-36. 2008
..These data could orientate further syntheses of either non-photoreactive compounds or compounds displaying both kinase inhibitory activity and strong phototoxicity...
- Reversal of P-glycoprotein-mediated multidrug resistance with small interference RNA (siRNA) in leukemia cells
Zhi Peng
The Faculty of Laboratory Medicine, Chongqing Medical University, Chongqing, China
Cancer Gene Ther 11:707-12. 2004
..These findings indicate that siRNA specifically and efficiently interferes with the expression of mdr1 and could be used as a molecularly defined therapeutic approach for MDR in the treatment of leukemia...
- In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
Joseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
Blood 99:3801-5. 2002
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