Zhengyuan Xia

Summary

Publications

  1. pmc Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats
    Shaoqing Lei
    Department of Pharmacology, School of Basic Medical Science, Wuhan University, Wuhan, Hubei Province, 430072, China
    Yonsei Med J 53:294-303. 2012
  2. ncbi request reprint N-acetylcysteine attenuates TNF-alpha-induced human vascular endothelial cell apoptosis and restores eNOS expression
    Zhengyuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China
    Eur J Pharmacol 550:134-42. 2006
  3. ncbi request reprint Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane
    Zhengyuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital, Wuhan University, 238 Jiefang Rd, Wuhan, 430060, PR China
    Anesth Analg 103:527-32. 2006
  4. pmc Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats
    Haobo Li
    Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 12:133. 2013
  5. doi request reprint Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats
    Ke Xuan Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, No 58, Zhongshan 2th Rd, Guangzhou, China, 510080
    Anesth Analg 107:1884-91. 2008
  6. ncbi request reprint A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol
    Tao Luo
    Department of Anesthesiology, Anesthesiology Research Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060 People s Republic of China
    Anesth Analg 103:110-6, table of contents. 2006
  7. doi request reprint Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis
    Fang Wang
    Anesthesiology Research Laboratory, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
    Can J Physiol Pharmacol 87:221-9. 2009
  8. doi request reprint PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes
    Yanan Liu
    Department of Anesthesiology, The University of Hong Kong, China
    Clin Sci (Lond) 122:161-73. 2012
  9. doi request reprint Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts
    Hui Min Liu
    Department of Anesthesiology, Anesthesiology Research Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
    J Surg Res 168:18-26. 2011
  10. doi request reprint N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes
    Tingting Wang
    Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
    Free Radic Biol Med 63:291-303. 2013

Collaborators

Detail Information

Publications52

  1. pmc Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats
    Shaoqing Lei
    Department of Pharmacology, School of Basic Medical Science, Wuhan University, Wuhan, Hubei Province, 430072, China
    Yonsei Med J 53:294-303. 2012
    ....
  2. ncbi request reprint N-acetylcysteine attenuates TNF-alpha-induced human vascular endothelial cell apoptosis and restores eNOS expression
    Zhengyuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China
    Eur J Pharmacol 550:134-42. 2006
    ..N-acetylcysteine attenuation of TNF-alpha-induced human vascular endothelial cell apoptosis is associated with the restoration of eNOS expression...
  3. ncbi request reprint Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane
    Zhengyuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital, Wuhan University, 238 Jiefang Rd, Wuhan, 430060, PR China
    Anesth Analg 103:527-32. 2006
    ..We conclude that administration of a large dose of propofol during CPB attenuates postoperative myocardial cellular damage as compared with isoflurane or small-dose propofol anesthesia...
  4. pmc Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats
    Haobo Li
    Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 12:133. 2013
    ..The present study was designed to test the hypothesis that the duration/severity of the indexed ischemia is a major determinant of the vulnerability to myocardial IRI at early stage of diabetes...
  5. doi request reprint Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats
    Ke Xuan Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, No 58, Zhongshan 2th Rd, Guangzhou, China, 510080
    Anesth Analg 107:1884-91. 2008
    ..We investigated if pretreatment with propofol, an anesthetic with antioxidant properties, could reduce ceramide production, and consequently, mucosal epithelial apoptosis induced by II/R in rats...
  6. ncbi request reprint A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol
    Tao Luo
    Department of Anesthesiology, Anesthesiology Research Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060 People s Republic of China
    Anesth Analg 103:110-6, table of contents. 2006
    ..Propofol exerts protective effects against H2O2-enhanced TNF-alpha cell toxicity by reducing oxidative injury...
  7. doi request reprint Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis
    Fang Wang
    Anesthesiology Research Laboratory, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
    Can J Physiol Pharmacol 87:221-9. 2009
    ..CGP53353, but not rottlerin, abolished or attenuated all these changes. We conclude that PKCbeta(2) plays a major role in TNF-alpha-induced human vascular endothelial cell apoptosis...
  8. doi request reprint PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes
    Yanan Liu
    Department of Anesthesiology, The University of Hong Kong, China
    Clin Sci (Lond) 122:161-73. 2012
    ..It is concluded that RBX can ameliorate myocardial hypertrophy and dysfunction in diabetes, which may represent a novel therapy in the prevention of diabetic cardiovascular complications...
  9. doi request reprint Bosentan affects 15-F2t-isoprostane adverse effects on postischemic rat hearts
    Hui Min Liu
    Department of Anesthesiology, Anesthesiology Research Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
    J Surg Res 168:18-26. 2011
    ..We hypothesized that IsoP exacerbates myocardial ischemia-reperfusion injury by stimulating ET-1 production, and that ET-1 blockade can attenuate or prevent these deleterious effects of IsoP...
  10. doi request reprint N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes
    Tingting Wang
    Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
    Free Radic Biol Med 63:291-303. 2013
    ..In conclusion, NAC and ALP prevented diabetic MI/R injury through PI3K/Akt and Jak2/STAT3 and cardiac APN may serve as a mediator via AdipoR2 in this process. ..
  11. ncbi request reprint Propofol dose-dependently reduces tumor necrosis factor-alpha-Induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and Bax expression and nitric oxide generation
    Tao Luo
    Department of Anesthesiology, Renmin Hospital, Wuhan University, Republic of China
    Anesth Analg 100:1653-9. 2005
    ..There is an inverse correlation between the ratio of Bcl-2/Bax expression and AI (P = 0.0009). These results suggest that propofol, at clinical relevant concentrations, can reduce TNF-induced HUVEC apoptosis...
  12. ncbi request reprint Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat
    Ke Xuan Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Can J Anaesth 54:366-74. 2007
    ....
  13. doi request reprint Proteomics of ischemia/reperfusion injury in rat intestine with and without ischemic postconditioning
    Yun Sheng Li
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Surg Res 164:e173-80. 2010
    ....
  14. ncbi request reprint Ginsenosides compound (shen-fu) attenuates gastrointestinal injury and inhibits inflammatory response after cardiopulmonary bypass in patients with congenital heart disease
    Zhong Yuan Xia
    Anesthesiology Research Laboratory, Renmin Hosital, Wuhan University, People s Republic of China
    J Thorac Cardiovasc Surg 130:258-64. 2005
    ....
  15. ncbi request reprint Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning
    Tingting Wang
    Department of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    Front Med 7:301-5. 2013
    ..This review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes. ..
  16. pmc Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-α: the role of PKC-β2 and NADPH oxidase
    Shaoqing Lei
    Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China Department of Anesthesiology, University of Hong Kong, Hong Kong
    Oxid Med Cell Longev 2013:678484. 2013
    ..It is concluded that nitroglycerine comprises the protective effects of propofol against TNF-α stimulation in endothelial cells, primarily through PKC-β2 dependent NADPH oxidase activation...
  17. doi request reprint TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits
    Maohua Wang
    Department of Anesthesiology, and Laboratory of Anesthesia and Intensive Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
    J Surg Res 173:153-60. 2012
    ..This study was carried out to investigate the role of capsaicin in lung IR injury in vivo...
  18. doi request reprint Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats
    Xue Hui Zhu
    Department of Pharmacology, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, PR China
    Free Radic Res 45:201-10. 2011
    ..05 vs I/R group). It is concluded that non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats...
  19. doi request reprint Immediate postconditioning during reperfusion attenuates intestinal injury
    Ke Xuan Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, No 58, Zhongshan 2th Road, 510080 Guangzhou, China
    Intensive Care Med 35:933-42. 2009
    ..To test the hypothesis that immediate but not delayed ischemic postconditioning (IPo) during reperfusion attenuates intestinal injury, and that ischemic preconditioning (IPC) and IPo may confer synergy in intestinal protection...
  20. doi request reprint Ischaemic post-conditioning protects lung from ischaemia-reperfusion injury by up-regulation of haeme oxygenase-1
    Zhong Yuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, PR China
    Injury 41:510-6. 2010
    ..In this study, we hypothesised that the induction of HO-1 by IPO plays a protective role against the deleterious effects of IR in the lung...
  21. doi request reprint Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase
    Ke Xuan Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    Proteomics 10:4463-75. 2010
    ..The finding that AR may play a key in intestinal ischemic protection might offer evidences to foster the development of new therapies against intestinal I/R injury...
  22. pmc Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model
    Weifeng Yao
    Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat Sen University, NO 600 TianHe Road, Guangzhou 510630, China
    Oxid Med Cell Longev 2014:258567. 2014
    ..This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment...
  23. ncbi request reprint Effect of NO donor sodium nitroprusside on lipopolysaccharide induced acute lung injury in rats
    Zhong Yuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    Injury 38:53-9. 2007
    ..The nitric oxide (NO) donor-SNP ameliorates LPS-induced ALI, which may be related to the induction of HO-1 and the subsequent inhibition of iNOS...
  24. pmc Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling
    Shaoqing Lei
    Department of Anesthesiology, University of Hong Kong, Hong Kong, China
    Diabetes 62:2318-28. 2013
    ..Prevention of excessive PKCβ2 activation attenuated cardiac diastolic dysfunction by restoring Cav-3 expression and subsequently rescuing Akt/eNOS/NO signaling. ..
  25. doi request reprint Role of PKCzeta translocation in the development of type 2 diabetes in rats following continuous glucose infusion
    Jing fang Zhang
    Department of Pathophysiology, Medical College, Wuhan University, Wuhan, Hubei, China
    Diabetes Metab Res Rev 26:59-70. 2010
    ..We investigated the molecular mechanisms of hyperglycaemia-induced insulin resistance and type 2 diabetes in rats receiving a continuous glucose infusion (GI)...
  26. doi request reprint Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model
    Xinjin Chi
    Department of Anesthesiology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510630, China
    Pulm Pharmacol Ther 26:380-7. 2013
    ..Therefore, we hypothesized that blocking MD-2 would inhibit the TLR2/4-mediated inflammatory response and lessen ALI induced by liver transplantation...
  27. ncbi request reprint Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease
    Zhengyuan Xia
    Department of Anesthesiology, Affiliated Renmin Hospital, Wuhan University, PR China
    J Thorac Cardiovasc Surg 126:1404-10. 2003
    ..The relationship between endothelin-1 and the endothelium-derived prostacyclin (prostaglandin I2) and thromboxane A2 postoperatively is also investigated...
  28. pmc Hyperglycemia-induced inhibition of DJ-1 expression compromised the effectiveness of ischemic postconditioning cardioprotection in rats
    Min Liu
    Department of Anesthesiology, Renmin Hospital of Wuhan University, 99 Zi Yang Road, Wuhan, Hubei 430060, China
    Oxid Med Cell Longev 2013:564902. 2013
    ..Our result indicates a beneficial role of DJ-1 in myocardial ischemia reperfusion. Downregulation of cardiac DJ-1 may be responsible for the compromised diabetic heart responsiveness to IpostC cardioprotection. ..
  29. ncbi request reprint Nitric oxide and protection against cardiac ischemia
    Zhengyuan Xia
    Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Curr Pharm Des 17:1774-82. 2011
    ..These adversely affect NO-signaling, as well as the efficacy and safety of treatments with NO or NO-containing agents...
  30. pmc Differential microRNA profiling in a cellular hypoxia reoxygenation model upon posthypoxic propofol treatment reveals alterations in autophagy signaling network
    Zhuo Chen
    Department of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China
    Oxid Med Cell Longev 2013:378484. 2013
    ....
  31. pmc dbPSHP: a database of recent positive selection across human populations
    Mulin Jun Li
    Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, Guangdong 518057, China, Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, Department of Psychiatry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, State Key Laboratory in Cognitive and Brain Sciences, The University of Hong Kong, Hong Kong SAR, China and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Nucleic Acids Res 42:D910-6. 2014
    ..We also provide interactive pages for visualization and annotation of different selective signals. The database is freely available to the public and will be frequently updated...
  32. doi request reprint Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats
    Pinjie Huang
    Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, 510630, China
    Injury 43:1250-6. 2012
    ..Mast cell activation plays an important role in IIR injury. It is unknown whether IIR mediates lung injury via mast cell activation...
  33. ncbi request reprint Application of high-dose propofol during ischemia improves postischemic function of rat hearts: effects on tissue antioxidant capacity
    Zhengyuan Xia
    Centre for Anesthesia and Analgesia, Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 82:919-26. 2004
    ..We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction...
  34. ncbi request reprint Propofol preservation of myocardial function in patients undergoing coronary surgery using cardiopulmonary bypass is dose dependent
    David M Ansley
    Anesthesiology 98:1028; author reply 1028-9. 2003
  35. ncbi request reprint Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F2t-isoprostane formation
    Zhengyuan Xia
    Centre for Anesthesia and Analgesia, Department of Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC V6T IZ3, Canada
    Can J Physiol Pharmacol 81:14-21. 2003
    ..05). We conclude that oxidant injury occurs during ischemia and reperfusion, and propofol provides dose-dependent protection primarily by enhancing tissue antioxidant capacity and reducing lipid peroxidation...
  36. ncbi request reprint Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine
    Zhixin Guo
    Faculty of Pharmaceutical Sciences, Div of Pharmacology and Toxicology, The Univ of British Columbia, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 292:H1728-36. 2007
    ..The protective effects of NAC on diabetic rat hearts may be attributable to its protection of hearts against oxidative damage induced by the increased NADPH oxidase and to its reduction in cardiac inflammatory mediators IL-6 and COX-2...
  37. ncbi request reprint Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats
    Zhixin Guo
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Metabolism 56:1363-71. 2007
    ..Despite an increase in cardiac adiponectin receptor 1 expression, there is an increased cardiac inflammatory response and a decreased GLUT4 protein expression associated with a reduction in circulating adiponectin...
  38. ncbi request reprint Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats
    Zhengyuan Xia
    Pharmaceutical Sciences, Division of Pharmacology, The University of British Columbia, 2146 East Mall, Vancouver, Canada V6T 1Z3
    Eur J Pharmacol 544:118-25. 2006
    ..These effects were attenuated, but not prevented by N-acetylcysteine treatment. N-acetylcysteine attenuation of diabetic myocardial dysfunction could be attributed to the restoration of myocardial Mn-SOD activity...
  39. ncbi request reprint Sevoflurane or desflurane anesthesia plus postoperative propofol sedation attenuates myocardial injury after coronary surgery in elderly high-risk patients
    Zhengyuan Xia
    Anesthesiology 100:1038-9; author reply 1039-40. 2004
  40. ncbi request reprint 15-F(2t)-isoprostane exacerbates myocardial ischemia-reperfusion injury of isolated rat hearts
    Zhengyuan Xia
    University of British Columbia, Department of Anesthesiology, Vancouver, BC, Canada V5Z 4E3
    Am J Physiol Heart Circ Physiol 289:H1366-72. 2005
    ..15-F(2t)-IsoP-induced endothelin-1 production during cardiac reperfusion may represent a mechanism underlying the deleterious actions of 15-F(2t)-IsoP...
  41. ncbi request reprint Endothelin A and B receptor antagonist bosentan reduces postischemic myocardial injury in the rat: critical timing of administration
    Zhengyuan Xia
    Centre for Anesthesia and Analgesia, Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 83:259-66. 2005
    ..Endothelin-1 antagonist application during early reperfusion may exacerbate postischemic myocardial dysfunction...
  42. ncbi request reprint The relationship between plasma free 15-F2t-isoprostane concentration and early postoperative cardiac depression following warm heart surgery
    David M Ansley
    Department of Anesthesia and Pharmacology, Centre for Anesthesia and Analgesia, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 126:1222-3. 2003
  43. ncbi request reprint Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F(2t)-isoprostane formation and tissue antioxidant capacity
    Zhengyuan Xia
    Centre for Anesthesia and Analgesia, Department of Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada
    Cardiovasc Res 59:113-21. 2003
    ..Experimental study has shown that myocardial ischemic tolerance is reduced during middle-age. We investigated the effect of propofol on ischemic tolerance of middle-aged rat hearts...
  44. ncbi request reprint Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes
    Prabhakara Reddy Nagareddy
    Div of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The Univ of British Columbia, 2146 East Mall, Vancouver, BC, Canada, V6T 1Z3
    Am J Physiol Heart Circ Physiol 289:H2144-52. 2005
    ....
  45. ncbi request reprint The effect of N-acetylcysteine on cardiac contractility to dobutamine in rats with streptozotocin-induced diabetes
    Xing Cheng
    Department of Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C, Canada, V6T 1Z3
    Eur J Pharmacol 519:118-26. 2005
    ..Antioxidant supplementation in diabetes reduces oxidative stress and improves cardiac function...
  46. ncbi request reprint Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats
    Zhengyuan Xia
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Division of Pharmacology, 2146 East Mall, Vancouver BC, V6T 1Z3, Canada
    Free Radic Res 40:175-84. 2006
    ..05 vs. C) and NAC normalised the changes that occurred in the diabetic rats. The protective effects may be attributable to restoration of NO bioavailability in the circulation...
  47. ncbi request reprint Effectiveness of isoflurane in inducing delayed preconditioning against myocardial infarction in vivo
    Zhengyuan Xia
    Anesthesiology 104:383-4; author reply 384-5. 2006
  48. ncbi request reprint N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats
    Prabhakara Reddy Nagareddy
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    J Cardiovasc Pharmacol 47:513-20. 2006
    ..The results suggest that nitrosative stress depress MABP and HR following diabetes. Further studies are required to elucidate the mechanisms involved in nitrosative stress mediated depression of blood pressure and heart rate...
  49. ncbi request reprint N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats
    Zhengyuan Xia
    Faculty of Pharmaceutical Sciences, Division of Pharmacology, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Cardiovasc Res 73:770-82. 2007
    ..We hypothesized that chronic treatment with the antioxidant N-acetylcysteine (NAC) would normalize oxidative stress-mediated overexpression of myocardial PKCbeta(2) and CTGF and attenuate the development of myocardial hypertrophy...
  50. ncbi request reprint Antioxidant intervention before and during myocardial ischemia may exacerbate post-ischemic myocardial dysfunction: Relationship with endothelin-1 production
    Ruqiong Nie
    Med Hypotheses 70:194-5. 2008
  51. doi request reprint Role of hydrogen peroxide in propofol restoration of microvascular function impaired by high glucose
    Zhengyuan Xia
    Anesthesiology 109:930; author reply 930-1. 2008
  52. ncbi request reprint Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat
    Ruqiong Nie
    Department of Cardiology, Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Can J Physiol Pharmacol 85:1012-9. 2007
    ..05, SM2 vs. control). It is concluded that S. miltiorrhiza could be beneficial in the treatment of myocardial ischemic injury and the timing of administration seems important...