Zhao Hui Wu

Summary

Publications

  1. Wu Z, Wong E, Shi Y, Niu J, Chen Z, Miyamoto S, et al. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell. 2010;40:75-86 pubmed publisher
    ..Thus, ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-?B activation following genotoxic stimuli...
  2. Wang W, Zhang B, Mani A, Wu Z, Fan Y, Li W, et al. Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-?B Activation. J Pharmacol Exp Ther. 2018;366:184-193 pubmed publisher
  3. Wu Z, Pfeffer L. MicroRNA regulation of F-box proteins and its role in cancer. Semin Cancer Biol. 2016;36:80-7 pubmed publisher
    ..The area of miRNAs and the F-box proteins that they regulate in cancer is an emerging field and will inform new strategies in cancer treatment. ..
  4. Wu Z, Shi Y. When ubiquitin meets NF-?B: a trove for anti-cancer drug development. Curr Pharm Des. 2013;19:3263-75 pubmed
    ..We also focus on the recent progress of anti-cancer drug development targeting various steps of ubiquitination process, and the potential of these drugs in cancer treatment as related to their impact on NF-?B activation. ..
  5. Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher