Zhao Hui Wu

Summary

Publications

  1. pmc ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
    Zhao Hui Wu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell 40:75-86. 2010
  2. pmc SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway
    Aarti Sethuraman
    Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
    Breast Cancer Res 18:81. 2016
  3. pmc MicroRNA regulation of F-box proteins and its role in cancer
    Zhao Hui Wu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA Center for Cancer Research, University of Tennessee Health Science Center, 19 S Manassas St, Memphis, TN 38163, USA Electronic address
    Semin Cancer Biol 36:80-7. 2016
  4. pmc When ubiquitin meets NF-κB: a trove for anti-cancer drug development
    Zhao Hui Wu
    Department of Pathology and Laboratory Medicine, Center for Adult Cancer Research, University of Tennessee Health Science Center, 19 S Manassas St, Memphis, TN 38163, USA
    Curr Pharm Des 19:3263-75. 2013
  5. pmc USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO
    Jixiao Niu
    1 Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA 2 Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA
    EMBO J 32:3206-19. 2013
  6. pmc DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion
    Jixiao Niu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 287:21783-95. 2012
  7. pmc LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
    Jixiao Niu
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, Memphis, TN, USA
    EMBO J 30:3741-53. 2011
  8. pmc NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiation
    Guangyun Tan
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:33036-47. 2012
  9. pmc MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN
    Guangyun Tan
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem Biophys Res Commun 417:546-51. 2012
  10. pmc Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells
    Meiyun Fan
    From the Departments of Pathology and Laboratory Medicine, Center for Adult Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee 38163
    J Biol Chem 288:27480-93. 2013

Collaborators

Detail Information

Publications11

  1. pmc ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
    Zhao Hui Wu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell 40:75-86. 2010
    ..Thus, ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-κB activation following genotoxic stimuli...
  2. pmc SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway
    Aarti Sethuraman
    Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
    Breast Cancer Res 18:81. 2016
    ..This study is aimed to characterize the role of SMARCE1/BAF57 in regulating metastasis of breast cancer cells...
  3. pmc MicroRNA regulation of F-box proteins and its role in cancer
    Zhao Hui Wu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA Center for Cancer Research, University of Tennessee Health Science Center, 19 S Manassas St, Memphis, TN 38163, USA Electronic address
    Semin Cancer Biol 36:80-7. 2016
    ..The area of miRNAs and the F-box proteins that they regulate in cancer is an emerging field and will inform new strategies in cancer treatment. ..
  4. pmc When ubiquitin meets NF-κB: a trove for anti-cancer drug development
    Zhao Hui Wu
    Department of Pathology and Laboratory Medicine, Center for Adult Cancer Research, University of Tennessee Health Science Center, 19 S Manassas St, Memphis, TN 38163, USA
    Curr Pharm Des 19:3263-75. 2013
    ..We also focus on the recent progress of anti-cancer drug development targeting various steps of ubiquitination process, and the potential of these drugs in cancer treatment as related to their impact on NF-κB activation...
  5. pmc USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO
    Jixiao Niu
    1 Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA 2 Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA
    EMBO J 32:3206-19. 2013
    ..Thus, by mediating USP10-dependent deubiquitination of NEMO, MCPIP1 induction serves as a negative feedback mechanism for attenuating genotoxic NF-κB activation. ..
  6. pmc DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion
    Jixiao Niu
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 287:21783-95. 2012
    ....
  7. pmc LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
    Jixiao Niu
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, Memphis, TN, USA
    EMBO J 30:3741-53. 2011
    ..Therefore, LUBAC-dependent NEMO linear ubiquitination is critical for genotoxic NF-κB activation and protects cells from DNA damage-induced apoptosis...
  8. pmc NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiation
    Guangyun Tan
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:33036-47. 2012
    ..Altogether, our data support a critical role of NF-κB-dependent up-regulation of miR-125b, which forms a negative feedback loop to repress p38α activation and promote cell survival upon UV radiation...
  9. pmc MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN
    Guangyun Tan
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem Biophys Res Commun 417:546-51. 2012
    ..Collectively, these results indicate that miR-22 is an important player in the cellular stress response upon UV radiation, which may promote cell survival via the repression of PTEN expression...
  10. pmc Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells
    Meiyun Fan
    From the Departments of Pathology and Laboratory Medicine, Center for Adult Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee 38163
    J Biol Chem 288:27480-93. 2013
    ..Taken together, these results suggest that miRNAs collectively function to promote survival of tumor cells under stress but suppress cell migration/invasion in breast cancer cells. ..
  11. pmc TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase
    Wei Wang
    From the Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee 38163
    J Biol Chem 290:13372-85. 2015
    ....