Zhao Hui Wu
Wu Z, Wong E, Shi Y, Niu J, Chen Z, Miyamoto S, et al
. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell. 2010;40:75-86 pubmed publisher
..Thus, ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-?B activation following genotoxic stimuli...
Wang W, Zhang B, Mani A, Wu Z, Fan Y, Li W, et al
. Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-?B Activation. J Pharmacol Exp Ther. 2018;366:184-193 pubmed publisher
Wu Z, Pfeffer L. MicroRNA regulation of F-box proteins and its role in cancer. Semin Cancer Biol. 2016;36:80-7 pubmed publisher
..The area of miRNAs and the F-box proteins that they regulate in cancer is an emerging field and will inform new strategies in cancer treatment. ..
Wu Z, Shi Y. When ubiquitin meets NF-?B: a trove for anti-cancer drug development. Curr Pharm Des. 2013;19:3263-75 pubmed
..We also focus on the recent progress of anti-cancer drug development targeting various steps of ubiquitination process, and the potential of these drugs in cancer treatment as related to their impact on NF-?B activation. ..
Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-ÎºB Activator (TANK) Inhibits Genotoxic Nuclear Factor ÎºB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher