Tsung Teh Wu

Summary

Publications

  1. ncbi request reprint Excellent interobserver agreement on grading the extent of residual carcinoma after preoperative chemoradiation in esophageal and esophagogastric junction carcinoma: a reliable predictor for patient outcome
    Tsung Teh Wu
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 31:58-64. 2007
  2. ncbi request reprint Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
    Changhyeok An
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4096
    Clin Cancer Res 11:656-63. 2005
  3. ncbi request reprint Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas
    Jae Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:4646-54. 2004
  4. ncbi request reprint The number of lymph nodes with metastasis predicts survival in patients with esophageal or esophagogastric junction adenocarcinoma who receive preoperative chemoradiation
    Yan Gu
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1017-25. 2006
  5. ncbi request reprint Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:3789-98. 2006
  6. ncbi request reprint Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation
    Lucian R Chirieac
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:1347-55. 2005
  7. ncbi request reprint Preoperative induction of CPT-11 and cisplatin chemotherapy followed by chemoradiotherapy in patients with locoregional carcinoma of the esophagus or gastroesophageal junction
    Jaffer A Ajani
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 100:2347-54. 2004
  8. ncbi request reprint Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas
    Sang Geol Kim
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Gastroenterology 124:1300-10. 2003
  9. ncbi request reprint Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma
    Julie G Izzo
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Mol Cancer Ther 5:2844-50. 2006
  10. ncbi request reprint The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation
    Kim L Wang
    Departments of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1467-74. 2006

Detail Information

Publications81

  1. ncbi request reprint Excellent interobserver agreement on grading the extent of residual carcinoma after preoperative chemoradiation in esophageal and esophagogastric junction carcinoma: a reliable predictor for patient outcome
    Tsung Teh Wu
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 31:58-64. 2007
    ..The extent of residual carcinoma is a reliable and reproducible predictor of survival; this grading system may allow a novel and early means of comparing outcomes after different neoadjuvant treatment regimens...
  2. ncbi request reprint Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
    Changhyeok An
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4096
    Clin Cancer Res 11:656-63. 2005
    ..The aim of this study was to evaluate the prognostic value of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) in gastric cancer...
  3. ncbi request reprint Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas
    Jae Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:4646-54. 2004
    ..Methylation of the p16 gene may contribute to the malignant transformation of gastric precursor lesions...
  4. ncbi request reprint The number of lymph nodes with metastasis predicts survival in patients with esophageal or esophagogastric junction adenocarcinoma who receive preoperative chemoradiation
    Yan Gu
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1017-25. 2006
    ..However, the prognostic significance of the number of LNs with residual metastasis remains unclear...
  5. ncbi request reprint Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:3789-98. 2006
    ..Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy...
  6. ncbi request reprint Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation
    Lucian R Chirieac
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:1347-55. 2005
    ....
  7. ncbi request reprint Preoperative induction of CPT-11 and cisplatin chemotherapy followed by chemoradiotherapy in patients with locoregional carcinoma of the esophagus or gastroesophageal junction
    Jaffer A Ajani
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 100:2347-54. 2004
    ..Patients with localized esophageal carcinoma often develop locoregional and distant disease recurrence. The current study investigated the outcome of a new chemotherapy combination as induction therapy before chemoradiotherapy...
  8. ncbi request reprint Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas
    Sang Geol Kim
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Gastroenterology 124:1300-10. 2003
    ..Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized...
  9. ncbi request reprint Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma
    Julie G Izzo
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Mol Cancer Ther 5:2844-50. 2006
    ..We hypothesized that activated NF-kappaB would define clinical biology irrespective of the type of chemotherapy or sequence administered...
  10. ncbi request reprint The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation
    Kim L Wang
    Departments of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1467-74. 2006
    ....
  11. ncbi request reprint Biomarkers of response to preoperative chemoradiation in esophageal cancers
    Rajyalakshmi Luthra
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Semin Oncol 33:S2-5. 2006
    ....
  12. ncbi request reprint Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract
    Susan C Abraham
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 34:902-10. 2003
    ..Finally, the frequency of allelic loss on 18q suggests that a locus on 18q is involved in the molecular pathogenesis of biliary IPNs, but this locus is not DPC4...
  13. ncbi request reprint Significance of the depth of tumor invasion and lymph node metastasis in superficially invasive (T1) esophageal adenocarcinoma
    Lixia Liu
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 29:1079-85. 2005
    ....
  14. ncbi request reprint Signet-ring cell or mucinous histology after preoperative chemoradiation and survival in patients with esophageal or esophagogastric junction adenocarcinoma
    Lucian R Chirieac
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:2229-36. 2005
    ..Some adenocarcinomas have mixed patterns, including signet-ring cell and mucinous histology, but the clinical significance of these subtypes is unknown...
  15. pmc Prognostic significance of differentially expressed miRNAs in esophageal cancer
    Yuxin Hu
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX77030, USA
    Int J Cancer 128:132-43. 2011
    ..Our data indicate that further evaluation of miR-30e and miR-16-2 as prognostic biomarkers is warranted in patients with esophageal adenocarcinoma. In addition, the role of miR-34a in esophageal cancer also warrants further study...
  16. ncbi request reprint Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome
    Kim L Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Clin Cancer Res 12:4598-604. 2006
    ..However, the role of ANXA1 in esophageal adenocarcinoma is unclear. Our goal was to evaluate ANXA1 expression and determine its prognostic significance in adenocarcinoma of the esophagus and esophagogastric junction...
  17. ncbi request reprint Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors
    Mirela Stancu
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mod Pathol 16:1189-98. 2003
    ..These findings suggest that allelic loss of chromosomes 11q, 16q, and 18q in goblet cell carcinoids and ileal carcinoids may have an important role in the pathogenesis of these tumors...
  18. ncbi request reprint Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis
    Lixia Liu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1632-40. 2005
    ..044). Our study shows that in neuroendocrine tumors epigenetic alterations vary by tumor subsite and clinicopathologic features, including age of onset, histopathologic type and metastasis status...
  19. ncbi request reprint Fibromatosis of the breast and mutations involving the APC/beta-catenin pathway
    Susan C Abraham
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Hum Pathol 33:39-46. 2002
    ..The spectrum of beta-catenin and APC alterations is similar to that described for desmoid tumors of the abdomen, paraspinal region, and extremities...
  20. doi request reprint Lymphovascular invasion as a tool to further subclassify T1b esophageal adenocarcinoma
    Putao Cen
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:1020-7. 2008
    ..The authors hypothesized that LVI status would subclassify T1b cancers and facilitate new therapeutic strategies...
  21. pmc Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway
    Susan C Abraham
    Department of Pathology, Division of GI LiverPathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:953-62. 2002
    ..These results indicate that ACCs are genetically distinct from pancreatic ductal adenocarcinomas, but some cases contain genetic alterations common to histologically similar pancreatoblastomas...
  22. ncbi request reprint Frequent CpG island methylation in sporadic and syndromic gastric fundic gland polyps
    Susan C Abraham
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Clin Pathol 122:740-6. 2004
    ..87). Epigenetic alterations involving methylation of CpG islands might have a role in the development of some FGPs, particularly those with a PPI effect. They do not account for the presence or absence of a dysplastic phenotype in FGPs...
  23. ncbi request reprint Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer
    Liwei Wang
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gastric Cancer 8:18-28. 2005
    ..We evaluated the expression of nitric oxide synthase (NOS) III and its relationship with the angiogenic phenotype and expression of the transcription factor Sp1, as well as their effect on survival in patients with gastric cancer...
  24. ncbi request reprint Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response
    Jennifer Sims-Mourtada
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:6565-72. 2006
    ..However, the relationship between Hh signaling and therapeutic response is unknown...
  25. ncbi request reprint Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention
    Ashraful Hoque
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Carcinogenesis 26:785-91. 2005
    ....
  26. ncbi request reprint Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation
    Rajyalakshmi Luthra
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Clin Oncol 24:259-67. 2006
    ..Currently, however, there are no tools to help select optimum therapy. We hypothesized that gene expression profiling could provide clues and biomarkers for selection of therapy...
  27. ncbi request reprint 2-Fluoro-2-deoxy-D-glucose positron emission tomography imaging is predictive of pathologic response and survival after preoperative chemoradiation in patients with esophageal carcinoma
    Stephen G Swisher
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:1776-85. 2004
    ..Preliminary reports suggest that FDG-PET may be predictive of the response of esophageal carcinoma patients to preoperative CRT...
  28. pmc Frequent CpG island methylation in serrated adenomas of the colorectum
    Seun Ja Park
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 162:815-22. 2003
    ..Our results indicate that CpG island methylation is common in sporadic serrated adenomas and may play an important role in their pathogenesis...
  29. ncbi request reprint Surgical pathology stage by American Joint Commission on Cancer criteria predicts patient survival after preoperative chemoradiation for localized gastric carcinoma
    Pooja R Rohatgi
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1475-82. 2006
    ..Therefore, the authors hypothesized that surgical pathology stage would be a better prognosticator of overall survival (OS) than baseline stage...
  30. ncbi request reprint Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome
    Kim L Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:658-67. 2007
    ..It is not known whether EGFR plays a similar role in esophageal and EGJ adenocarcinomas...
  31. ncbi request reprint Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation
    Zhongxing Liao
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 64:700-8. 2006
    ..To test the hypothesis that TS3'UTR polymorphisms predict outcomes in 146 Caucasian patients with esophageal adenocarcinoma treated with preoperative 5-fluorouracil-based chemoradiation...
  32. pmc Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma
    Jae Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 161:611-8. 2002
    ..Gastric adenomas or dysplasias without APC mutations but with or without MSI may have a different biological behavior, and are precursors of intestinal-type of gastric adenocarcinomas...
  33. ncbi request reprint Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma
    Julie G Izzo
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:698-707. 2007
    ..We hypothesized that CD1 A870 allele would be associated with higher CD1 protein expression, and increased genomic instability during EAC evolution, leading to more aggressive phenotype...
  34. ncbi request reprint Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer
    James C Yao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:4109-17. 2004
    ..Given the importance of Sp1 in the expression of VEGF, our data suggest that dysregulated Sp1 expression and activation play important roles in VEGF overexpression and, thus, gastric cancer development and progression...
  35. ncbi request reprint RRIG1 mediates effects of retinoic acid receptor beta2 on tumor cell growth and gene expression through binding to and inhibition of RhoA
    Zheng D Liang
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:7111-8. 2006
    ..Our findings therefore show a novel molecular pathway involving RAR-beta2 regulation of RRIG1 expression and RRIG1-RhoA interaction. An understanding of this pathway may translate into better control of human cancer...
  36. ncbi request reprint Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
    Sang Geol Kim
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Mod Pathol 16:1086-94. 2003
    ..The differences in genetic alterations but not epigenetic alterations may explain the pathogenesis and progression to malignancy of these cystic tumors of pancreas...
  37. ncbi request reprint Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers
    Madan G Luthra
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Clin Cancer Res 13:912-9. 2007
    ..In the current study, we did an in-depth investigation of the expression of 1q21-1q25 region genes to uncover the role of the EDC and its flanking genes in CTXRT response...
  38. ncbi request reprint Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression
    Julie G Izzo
    Department of Experimental Therapeutics, The Univerisity of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1200-5. 2007
    ..We hypothesized that nuclear NF-kappaB would define clinical biology even when surgery is used as primary therapy...
  39. pmc Sporadic fundic gland polyps with epithelial dysplasia : evidence for preferential targeting for mutations in the adenomatous polyposis coli gene
    Susan C Abraham
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 161:1735-42. 2002
    ..The lack of microsatellite instability in FGPs in this study and of K-ras mutations in a previous study suggests that secondary genetic alterations are rare in both dysplastic and nondysplastic FGPs...
  40. ncbi request reprint Colchicine effect in a colonic hyperplastic polyp. A lesion mimicking serrated adenoma
    Michael Torbenson
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Arch Pathol Lab Med 126:615-7. 2002
    ..Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter...
  41. ncbi request reprint Comparison of genetic alterations in neuroendocrine tumors: frequent loss of chromosome 18 in ileal carcinoid tumors
    Gordon G Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1079-87. 2005
    ..02). Our study indicates that genetic alterations vary by tumor subsite and clinicopathologic features, and ileal carcinoid tumors have distinctive clinicopathologic and genetic profiles...
  42. ncbi request reprint Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway
    Michael Torbenson
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Mod Pathol 15:189-96. 2002
    ..Activation of the Wnt signaling pathway appears to be important in a subset of hepatic adenomas but does not result from common beta-catenin or APC mutations and does not appear to be directly linked to hormonal receptor status...
  43. ncbi request reprint Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis
    Michael Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mod Pathol 15:718-23. 2002
    ..The fundic gland polyps were histologically and genetically identical to single sporadic fundic gland polyps and demonstrated frequent somatic activating mutations in exon 3 of the beta-catenin gene...
  44. ncbi request reprint Value of endoscopic ultrasound staging in conjunction with the evaluation of lymphovascular invasion in identifying low-risk esophageal carcinoma
    Putao Cen
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:503-10. 2008
    ..It was hypothesized that endoscopic ultrasonography (EUS) in concert with detailed histopathologic evaluation would identify low-risk cancers for an appropriate but organ-preserving strategy...
  45. ncbi request reprint Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy
    Alexander A Parikh
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Gastrointest Surg 7:1082-8. 2003
    ..It may therefore provide a better therapeutic option, particularly in patients with multiple colorectal metastases...
  46. ncbi request reprint Preoperative chemo-radiation-induced ulceration in patients with esophageal cancer: a confounding factor in tumor response assessment in integrated computed tomographic-positron emission tomographic imaging
    Jeremy J Erasmus
    Department of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Thorac Oncol 1:478-86. 2006
    ..We evaluated the use of integrated computed tomography (CT)-PET among patients with esophageal cancer being considered for resection after CRT...
  47. pmc BRAF mutations in aberrant crypt foci and hyperplastic polyposis
    Robyn Beach
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030 4095, USA
    Am J Pathol 166:1069-75. 2005
    ..Our study shows that BRAF mutation status is heterogeneous among patients with multiple/large HPs and/or hyperplastic polyposis, suggesting differences in pathogenesis of HPs that indicate subsets within this phenotype...
  48. ncbi request reprint "Seedling" mesenchymal tumors (gastrointestinal stromal tumors and leiomyomas) are common incidental tumors of the esophagogastric junction
    Susan C Abraham
    Division of Anatomic Pathology, Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 31:1629-35. 2007
    ..The common occurrence of microscopic GISTs compared with the rarity of clinically manifest and malignant esophagogastric GISTs suggests that additional genetic or epigenetic alterations must happen for neoplastic progression...
  49. doi request reprint Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
    Gregor Krings
    Department of Pathology, University of California, San Francisco, San Francisco, CA, USA
    Mod Pathol 26:782-91. 2013
    ..Glypican 3 and arginase are the most reliable markers for identifying hepatocellular differentiation in this setting...
  50. ncbi request reprint Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability
    David K McGregor
    Departments of Pathology and Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 28:712-8. 2004
    ..Our results also indicate that regulation of CK20 gene expression involves molecular pathways that are altered by MSI-H...
  51. doi request reprint Paget cells in the esophagus: assessment of their histopathologic features and near-universal association with underlying esophageal adenocarcinoma
    Susan C Abraham
    Department of Pathology, M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 32:1068-74. 2008
    ..A commonality among cases with Paget cells is the presence of focal or diffuse, poorly differentiated adenocarcinoma with discohesive cells. E-cadherin alterations seem to play a less significant role...
  52. ncbi request reprint Genetic alterations in gastric adenomas of intestinal and foveolar phenotypes
    Susan C Abraham
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Mod Pathol 16:786-95. 2003
    ..Although intestinal-type and foveolar-type gastric adenomas display divergent biologic behavior, the specific genetic events accounting for these differences in morphology and biologic behavior are unclear...
  53. ncbi request reprint Microsatellite instability in intraductal papillary neoplasms of the biliary tract
    Susan C Abraham
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mod Pathol 15:1309-17. 2002
    ....
  54. doi request reprint Reticulin loss in benign fatty liver: an important diagnostic pitfall when considering a diagnosis of hepatocellular carcinoma
    Aatur D Singhi
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 36:710-5. 2012
    ..Increased awareness of this important diagnostic pitfall will help prevent overcalling of reticulin loss when evaluating biopsies and resections of hepatic neoplasms with fatty change...
  55. ncbi request reprint Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas
    Dipen Maru
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:859-64. 2004
    ..The presence of chromosome 18q loss and DPC4 mutations in appendiceal adenocarcinomas suggests involvement of DPC4 and nearby genes on chromosome 18q (DCC and/or JV-18) in the pathogenesis of appendiceal adenocarcinomas...
  56. ncbi request reprint Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years
    James C Yao
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 23:3094-103. 2005
    ..To determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center...
  57. ncbi request reprint Drastic down-regulation of Kr├╝ppel-like factor 4 expression is critical in human gastric cancer development and progression
    Daoyan Wei
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:2746-54. 2005
    ..Collectively, our data provide first clinical and casual evidence and potential mechanism that the alteration of KLF4 expression plays a critical role in gastric cancer development and progression...
  58. ncbi request reprint Overexpression of caspase-3 in hepatocellular carcinomas
    Rajendra Persad
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 17:861-7. 2004
    ..01). Caspase-3 overexpression in HCCs by immunohistochemistry was associated with serum alpha-fetoprotein (AFP) levels (P=0.01). In conclusion, caspase-3 is frequently overexpressed in HCCs and is associated with high serum levels of AFP...
  59. doi request reprint Mucosal colonization by metastatic carcinoma in the gastrointestinal tract: a potential mimic of primary neoplasia
    Jeannelyn S Estrella
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 35:563-72. 2011
    ..In situ growth and presence of an apparent adenoma cannot be taken as prima facie evidence of a primary neoplasm...
  60. pmc Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma
    Chia Jui Yen
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:2632-40. 2008
    ..In addition, Bay 11-7082 and rapamycin may potentially be chemopreventive drugs against Barrett's esophagus-associated EAC...
  61. ncbi request reprint Increased retinoic acid receptor-beta4 correlates in vivo with reduced retinoic acid receptor-beta2 in esophageal squamous cell carcinoma
    Xiao Chun Xu
    Department of Clinical Cancer Prevention, Unit 1360, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:826-9. 2005
    ..These are the first in vivo expression patterns of RAR-beta2 and RAR-beta4 reported in humans or animals and support the in vitro data on these isoforms and their contrasting biological effects in human carcinogenesis...
  62. pmc Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations
    Susan C Abraham
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:1361-9. 2002
    ..Overexpression of p53 was limited to only 3 of 19 (15.8%) SPTs. These results emphasize the two distinct, divergent genetic pathways of neoplastic progression in pancreatic ductal and nonductal neoplasms...
  63. ncbi request reprint Clinical stage after preoperative chemoradiation is a better predictor of patient outcome than the baseline stage for localized gastric cancer
    Pooja R Patel
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:989-95. 2007
    ..The authors hypothesized that presurgical (postCTRT) stage would also correlate better with patient outcome than the baseline stage...
  64. pmc Fibrolamellar carcinomas are positive for CD68
    Hillary M Ross
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 24:390-5. 2011
    ..In sum, tumor positivity for CD68 staining was highly sensitive for fibrolamellar carcinoma and a lack of CD68 staining should suggest caution in making a diagnosis of fibrolamellar carcinoma...
  65. ncbi request reprint Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer
    Jie Huang
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 67:1589-93. 2007
    ..g., cyclin D1, phosphorylated Rb, and E2F). RRIG1-transfected sublines also inhibited tumor development in nude mice. The results of this study indicate that RRIG1 plays a role in suppressing tumorigenesis...
  66. ncbi request reprint Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases
    Jean Nicolas Vauthey
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 24:2065-72. 2006
    ..Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome...
  67. ncbi request reprint Transhepatic ipsilateral right portal vein embolization extended to segment IV: improving hypertrophy and resection outcomes with spherical particles and coils
    David C Madoff
    Division of Diagnostic Imaging, Interventional Radiology Section, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 325, Houston, Texas 77030, USA
    J Vasc Interv Radiol 16:215-25. 2005
    ....
  68. pmc The crosstalk of mTOR/S6K1 and Hedgehog pathways
    Yan Wang
    Department of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 21:374-87. 2012
    ..Together, our results established a crosstalk between the mTOR/S6K1 and HH pathways, which provides a mechanism for SMO-independent Gli1 activation and also a rationale for combination therapy for EAC...
  69. doi request reprint Comparison of primary and metastatic malignant melanoma of the esophagus: clinicopathologic review of 10 cases
    Amy A Sanchez
    Department of Pathology, The University of Texas Medical School, Houston, Texas 77030, USA
    Arch Pathol Lab Med 132:1623-9. 2008
    ..Primary esophageal melanoma (PEM) is a rare disease and is difficult to distinguish from other esophageal malignancies and from metastatic melanoma...
  70. pmc Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line
    Hector Alvarez
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 7:1753-5. 2008
    ..The rapid dissemination of this cancer cell line to the esophageal cancer research community should help ameliorate the current scarcity of preclinical models in this disease...
  71. doi request reprint Significance of central perivenulitis in pediatric liver transplantation
    Susan C Abraham
    Department of Pathology, M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 32:1479-88. 2008
    ..CP is most common in conjunction with portal ACR, where it carries a significant risk for the development of zone 3 fibrosis and a trend toward the development of ductopenic chronic rejection...
  72. pmc Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    Yutaka Suehiro
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2560-9. 2008
    ....
  73. ncbi request reprint Epigenetic alterations in gastric carcinogenesis
    In Seon Choi
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Cell Res 15:247-54. 2005
    ....
  74. ncbi request reprint Duplication of the muscularis mucosae in Barrett esophagus: an underrecognized feature and its implication for staging of adenocarcinoma
    Susan C Abraham
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Surg Pathol 31:1719-25. 2007
    ..The 17% rate of angiolymphatic invasion and 10% rate of lymph node metastases in our patients with invasion into duplicated MM suggest that these tumors can behave aggressively despite their technically intramucosal location...
  75. ncbi request reprint For localized gastroesophageal cancer, you give chemoradiation before surgery, but then what happens?
    Jaffer A Ajani
    J Clin Oncol 25:4315-6. 2007
  76. ncbi request reprint Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma
    Xian Shu Gao
    Department of Radiation Oncology, Beijing University First Hospital, Beijing, P R China
    Int J Radiat Oncol Biol Phys 67:389-96. 2007
    ..To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma...
  77. pmc Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features
    Fumiaki Sato
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1890. 2008
    ..In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency...
  78. ncbi request reprint Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy
    Michael K Gibson
    Division of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 9:6461-8. 2003
    ..This study evaluates the role of clinical and cellular markers in predicting CR and OS in patients with esophageal cancer...
  79. ncbi request reprint Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer
    Liwei Wang
    Shanghai East Hospital Cancer Center, Tongji University, Shanghai, The People s Republic of China
    Clin Exp Metastasis 22:205-13. 2005
    ..Therefore, we provided both clinical and experimental evidence to indicate that Sp1 might impact gastric cancer development and progression through regulating angiogenesis, a critical aspect of cancer biology...
  80. ncbi request reprint Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma
    Julie G Izzo
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 24:748-54. 2006
    ..Nuclear factor kappaB (NF-kappaB), a transcriptional factor, is constitutively activated or treatment induced in esophageal cancer and may influence treatment outcomes...
  81. ncbi request reprint Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma
    Malcolm V Brock
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 9:2912-9. 2003
    ..The association of clinicopathological and biomolecular risk factors to survival and recurrence was performed using the Log-rank test and Cox proportional hazards model for multivariate analysis...