Gene expression of adhesion molecules in pulmonary and hepatic microvascular endothelial cells during sepsisRongqian Wu
Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China
Chin J Traumatol 5:146-50. 2002
..To study the gene expression of adhesion molecules in pulmonary and hepatic microvascular endothelial cells during sepsis in mice...
- Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats
Rongqian Wu
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
Crit Care Med 35:912-8. 2007
..We therefore hypothesized that administration of AM/AMBP-1 would prevent metabolic acidosis after uncontrolled hemorrhage via down-regulation of endothelin-1...
- Ghrelin inhibits sympathetic nervous activity in sepsis
Rongqian Wu
The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA
Am J Physiol Endocrinol Metab 293:E1697-702. 2007
..Ghrelin's inhibitory effect on TNF-alpha production in sepsis is partially because of its modulation of the overstimulated sympathetic nerve activation...
Ghrelin attenuates sepsis-induced acute lung injury and mortality in ratsRongqian Wu
Department of Surgery, North Shore University Hospital, Manhasset, New York, USA
Am J Respir Crit Care Med 176:805-13. 2007
..However, it remains unknown whether ghrelin has any protective effects on severe sepsis-induced acute lung injury (ALI) and, if so, whether inhibition of NF-kappaB plays any role in it...
- The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma
Aqeel M Siddiqui
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York, USA
Crit Care Med 34:1874-82. 2006
..CONCLUSIONS: The protective effect of curcumin makes it or its analogues strong candidates as a novel therapy for sepsis. The beneficial effect of curcumin appears to be mediated by up-regulation of nuclear receptor PPAR-gamma...
- Differential expression of cytochrome P450 isoforms in the lungs of septic animals
Xiaoxuan Cui
Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
Crit Care Med 32:1186-91. 2004
....
- Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat
Yingjie Cui
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
Int J Mol Med 17:925-9. 2006
..Administration of PMB, however, prevented the downregulation of AMBP-1 expression at 20 h after CLP. Thus, AMBP-1 is downregulated in the late phase of sepsis, and LPS plays a critical role in the reduction of AMBP-1...
- Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve
Rongqian Wu
Department of Surgery, North Shore University Hospital, Manhasset, NY 11030, USA
Ann Surg 245:480-6. 2007
..To test the hypothesis that administration of ghrelin attenuates inflammatory responses in sepsis through vagal nerve stimulation...
- Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma
Michael Miksa
Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
J Immunol 179:6263-72. 2007
..We conclude that AM/AMBP-1 is protective in sepsis due to its vasoactive properties and direct anti-inflammatory effects mediated through both the cAMP-dependent pathway and Pyk-2-ERK1/2-dependent induction of PPAR-gamma...
- Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release
Mian Zhou
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
Am J Physiol Regul Integr Comp Physiol 294:R84-92. 2008
..We, therefore, conclude that LPS downregulates PPAR-gamma expression during sepsis via an increase in TNF-alpha release...
- Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis
Shinya Higuchi
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
J Surg Res 137:46-52. 2007
..We hypothesized that hemorrhage down-regulates CYP isoforms and PPAR-gamma in the liver, which plays an important role in producing tissue injury and proinflammatory responses after the subsequent sepsis (i.e., double-hit)...
- Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines
Rongqian Wu
Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
Int J Mol Med 18:339-46. 2006
..The reduction of AhR/Arnt may be the underlying mechanism for such downregulation. Inhibition of proinflammatory cytokines by curcumin may provide a novel approach to modulate the hepatic CYP function in sepsis...
- Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
Michael Miksa
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
Shock 25:586-93. 2006
..We conclude that, by providing the indispensable factor MFG-E8 for complete engulfment of apoptotic cells, these exosomes lead to an attenuation of the systemic inflammatory response and overall beneficial effect in sepsis...
- Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1
Rongqian Wu
Center for Immunology and Inflammation, Institute for Medical Research, North Shore-Long Island Jewish (LIJ) Health System, USA
Cardiovasc Res 68:318-26. 2005
..CONCLUSIONS: The improvement of tissue perfusion by ghrelin in severe sepsis appears to be mediated by downregulation of ET-1 involving a NF-kappaB-dependent pathway...
- Sympathetic excitotoxicity in sepsis: pro-inflammatory priming of macrophages by norepinephrine
Michael Miksa
Division of Surgical Research, North Shore Hospital and Long Island Jewish Medical Center, Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY 11030, USA
Front Biosci 10:2217-29. 2005
..Furthermore, we will introduce the new concept of "sympathetic excitotoxicity in sepsis" characterized by the neurogenic priming of the systemic pro-inflammatory response...
- Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis
Rongqian Wu
Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
Crit Care Med 32:1747-52. 2004
..05). CONCLUSION: Since delayed but repeated administration of human IalphaIp improves survival after CLP, this compound appears to be a useful agent for the treatment of severe sepsis...
- Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
Rongqian Wu
Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
Am J Physiol Heart Circ Physiol 287:H1296-302. 2004
..These results demonstrate that GHSR-1a expression is upregulated and vascular sensitivity to ghrelin stimulation is increased in the hyperdynamic phase of sepsis...
- Ghrelin clearance is reduced at the late stage of polymicrobial sepsis
Rongqian Wu
Division of Surgical Research, Department of Surgery, North Shore-Long Island Jewish Medical Center and New York University School of Medicine, Manhasset, NY 11030, USA
Int J Mol Med 12:777-81. 2003
..In addition, the liver also plays a role in the clearance of ghrelin, which was also reduced in late sepsis. The decreased clearance of ghrelin by the kidneys and liver may be due to renal and hepatic dysfunctions under such conditions...
- Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion
Rongqian Wu
The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
PLoS ONE 3:e2026. 2008
..In this study, we investigated the regulation of the cholinergic anti-inflammatory pathway by the novel gastrointestinal hormone, ghrelin, after gut I/R...
