Rongqian Wu

Summary

Publications

  1. ncbi request reprint Gene expression of adhesion molecules in pulmonary and hepatic microvascular endothelial cells during sepsis
    Rongqian Wu
    Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China
    Chin J Traumatol 5:146-50. 2002
  2. ncbi request reprint Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 35:912-8. 2007
  3. pmc Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, New York, USA
    Am J Respir Crit Care Med 176:805-13. 2007
  4. ncbi request reprint Ghrelin inhibits sympathetic nervous activity in sepsis
    Rongqian Wu
    The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA
    Am J Physiol Endocrinol Metab 293:E1697-702. 2007
  5. ncbi request reprint The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma
    Aqeel M Siddiqui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York, USA
    Crit Care Med 34:1874-82. 2006
  6. ncbi request reprint Differential expression of cytochrome P450 isoforms in the lungs of septic animals
    Xiaoxuan Cui
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Crit Care Med 32:1186-91. 2004
  7. ncbi request reprint Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat
    Yingjie Cui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 17:925-9. 2006
  8. pmc Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, NY 11030, USA
    Ann Surg 245:480-6. 2007
  9. ncbi request reprint Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    J Immunol 179:6263-72. 2007
  10. ncbi request reprint Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Am J Physiol Regul Integr Comp Physiol 294:R84-92. 2008

Collaborators

  • Ping Wang
  • Maowen Hu
  • Mian Zhou
  • Michael Miksa
  • Weifeng Dong
  • Xiaoxuan Cui
  • H Hank Simms
  • Thanjavur S Ravikumar
  • Shinya Higuchi
  • Padmalaya Das
  • Aqeel M Siddiqui
  • Yingjie Cui
  • Asha Jacob
  • Youxin Ji
  • Derek Yang

Detail Information

Publications19

  1. ncbi request reprint Gene expression of adhesion molecules in pulmonary and hepatic microvascular endothelial cells during sepsis
    Rongqian Wu
    Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China
    Chin J Traumatol 5:146-50. 2002
    ..To study the gene expression of adhesion molecules in pulmonary and hepatic microvascular endothelial cells during sepsis in mice...
  2. ncbi request reprint Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 35:912-8. 2007
    ..We therefore hypothesized that administration of AM/AMBP-1 would prevent metabolic acidosis after uncontrolled hemorrhage via down-regulation of endothelin-1...
  3. pmc Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, New York, USA
    Am J Respir Crit Care Med 176:805-13. 2007
    ..However, it remains unknown whether ghrelin has any protective effects on severe sepsis-induced acute lung injury (ALI) and, if so, whether inhibition of NF-kappaB plays any role in it...
  4. ncbi request reprint Ghrelin inhibits sympathetic nervous activity in sepsis
    Rongqian Wu
    The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA
    Am J Physiol Endocrinol Metab 293:E1697-702. 2007
    ..Ghrelin's inhibitory effect on TNF-alpha production in sepsis is partially because of its modulation of the overstimulated sympathetic nerve activation...
  5. ncbi request reprint The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma
    Aqeel M Siddiqui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York, USA
    Crit Care Med 34:1874-82. 2006
    ..The purpose of this study was to demonstrate whether curcumin protects septic animals and, if so, whether activation of peroxisome proliferator-activated receptor (PPAR)-gamma, an anti-inflammatory nuclear receptor, plays any role...
  6. ncbi request reprint Differential expression of cytochrome P450 isoforms in the lungs of septic animals
    Xiaoxuan Cui
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Crit Care Med 32:1186-91. 2004
    ....
  7. ncbi request reprint Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat
    Yingjie Cui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 17:925-9. 2006
    ..Administration of PMB, however, prevented the downregulation of AMBP-1 expression at 20 h after CLP. Thus, AMBP-1 is downregulated in the late phase of sepsis, and LPS plays a critical role in the reduction of AMBP-1...
  8. pmc Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, NY 11030, USA
    Ann Surg 245:480-6. 2007
    ..To test the hypothesis that administration of ghrelin attenuates inflammatory responses in sepsis through vagal nerve stimulation...
  9. ncbi request reprint Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    J Immunol 179:6263-72. 2007
    ..We conclude that AM/AMBP-1 is protective in sepsis due to its vasoactive properties and direct anti-inflammatory effects mediated through both the cAMP-dependent pathway and Pyk-2-ERK1/2-dependent induction of PPAR-gamma...
  10. ncbi request reprint Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Am J Physiol Regul Integr Comp Physiol 294:R84-92. 2008
    ..We, therefore, conclude that LPS downregulates PPAR-gamma expression during sepsis via an increase in TNF-alpha release...
  11. ncbi request reprint Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis
    Shinya Higuchi
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    J Surg Res 137:46-52. 2007
    ..We hypothesized that hemorrhage down-regulates CYP isoforms and PPAR-gamma in the liver, which plays an important role in producing tissue injury and proinflammatory responses after the subsequent sepsis (i.e., double-hit)...
  12. ncbi request reprint Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 18:339-46. 2006
    ..The reduction of AhR/Arnt may be the underlying mechanism for such downregulation. Inhibition of proinflammatory cytokines by curcumin may provide a novel approach to modulate the hepatic CYP function in sepsis...
  13. ncbi request reprint Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
    Michael Miksa
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Shock 25:586-93. 2006
    ..We conclude that, by providing the indispensable factor MFG-E8 for complete engulfment of apoptotic cells, these exosomes lead to an attenuation of the systemic inflammatory response and overall beneficial effect in sepsis...
  14. ncbi request reprint Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1
    Rongqian Wu
    Center for Immunology and Inflammation, Institute for Medical Research, North Shore Long Island Jewish LIJ Health System, USA
    Cardiovasc Res 68:318-26. 2005
    ..Ghrelin downregulation heralds the hypodynamic response in severe sepsis. Therefore, we hypothesized that the administration of exogenous ghrelin improves organ blood flow by downregulation of ET-1 under such conditions...
  15. ncbi request reprint Sympathetic excitotoxicity in sepsis: pro-inflammatory priming of macrophages by norepinephrine
    Michael Miksa
    Division of Surgical Research, North Shore Hospital and Long Island Jewish Medical Center, Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Front Biosci 10:2217-29. 2005
    ..Furthermore, we will introduce the new concept of "sympathetic excitotoxicity in sepsis" characterized by the neurogenic priming of the systemic pro-inflammatory response...
  16. ncbi request reprint Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 32:1747-52. 2004
    ..We therefore hypothesized that IalphaIp and its active component bikunin are reduced in sepsis and that the delayed administration of IalphaIp also improves survival rate...
  17. ncbi request reprint Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Am J Physiol Heart Circ Physiol 287:H1296-302. 2004
    ..These results demonstrate that GHSR-1a expression is upregulated and vascular sensitivity to ghrelin stimulation is increased in the hyperdynamic phase of sepsis...
  18. ncbi request reprint Ghrelin clearance is reduced at the late stage of polymicrobial sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore Long Island Jewish Medical Center and New York University School of Medicine, Manhasset, NY 11030, USA
    Int J Mol Med 12:777-81. 2003
    ..In addition, the liver also plays a role in the clearance of ghrelin, which was also reduced in late sepsis. The decreased clearance of ghrelin by the kidneys and liver may be due to renal and hepatic dysfunctions under such conditions...
  19. pmc Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion
    Rongqian Wu
    The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 3:e2026. 2008
    ..In this study, we investigated the regulation of the cholinergic anti-inflammatory pathway by the novel gastrointestinal hormone, ghrelin, after gut I/R...