Qi Wu

Summary

Publications

  1. pmc GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism
    Qi Wu
    Howard Hughes Medical Institute and Departments of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Eur J Pharmacol 660:21-7. 2011
  2. doi request reprint Deciphering a neuronal circuit that mediates appetite
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 483:594-7. 2012
  3. pmc Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    Qi Wu
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:9218-26. 2008
  4. pmc Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 137:1225-34. 2009
  5. pmc Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:3155-60. 2012
  6. pmc NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus
    Qi Wu
    Departments of Biochemistry and Pharmacology and Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195
    Proc Natl Acad Sci U S A 110:14765-70. 2013
  7. pmc Starvation after AgRP neuron ablation is independent of melanocortin signaling
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2687-92. 2008

Detail Information

Publications7

  1. pmc GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism
    Qi Wu
    Howard Hughes Medical Institute and Departments of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Eur J Pharmacol 660:21-7. 2011
    ..We also describe a compensatory mechanism that is gradually engaged after ablation of AgRP neurons that allows mice to continue eating without them...
  2. doi request reprint Deciphering a neuronal circuit that mediates appetite
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 483:594-7. 2012
    ..Thus we identify the PBN as a hub that integrates signals from several brain regions to bidirectionally modulate feeding and body weight...
  3. pmc Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    Qi Wu
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:9218-26. 2008
    ..Furthermore, glial cell activation in target areas of AgRP neurons appears to be a result of excitotoxicity...
  4. pmc Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 137:1225-34. 2009
    ..Chronic delivery of bretazenil during loss of AgRP neurons provides time to establish compensatory mechanisms that eventually allow mice to eat...
  5. pmc Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:3155-60. 2012
    ..We conclude that AgRP-expressing neurons play a critical role in mediating the metabolic syndrome and infertility of Lep(ob/ob) mice, whereas MCH-expressing neurons have only a minor role...
  6. pmc NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus
    Qi Wu
    Departments of Biochemistry and Pharmacology and Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195
    Proc Natl Acad Sci U S A 110:14765-70. 2013
    ..We suggest that the accumulation of NR2B subunits in the PBN contributes to aphagia in response to AgRP neuron ablation and may be involved in other forms of anorexia. ..
  7. pmc Starvation after AgRP neuron ablation is independent of melanocortin signaling
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2687-92. 2008
    ..These results indicate that both the appetitive and consummatory aspects of feeding become impaired in a melanocortin-independent manner after AgRP neuron ablation...