Min Wu

Summary

Publications

  1. pmc Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype
    Ad J C de Groof
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    Mol Cancer 8:54. 2009
  2. ncbi request reprint Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
  3. ncbi request reprint Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells
    Xinfeng Yu
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China
    Biochem Biophys Res Commun 342:286-92. 2006
  4. pmc Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery
    Cuiling Liu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 147:506-15. 2006
  5. ncbi request reprint Significance of COX-2 expression in human esophageal squamous cell carcinoma
    Huiying Zhi
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People s Republic of China
    Carcinogenesis 27:1214-21. 2006
  6. ncbi request reprint 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells
    Zhongmin Liu
    National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, Peoples Republic of China
    Cancer Lett 230:271-83. 2005
  7. pmc Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells
    Rafat A Siddiqui
    Methodist Research Institute, Clarian Health Partners, Indianapolis, IN, USA
    Breast Cancer Res 7:R645-54. 2005
  8. ncbi request reprint Up-regulation of fibronectin in oesophageal squamous cell carcinoma is associated with activation of the Erk pathway
    Jian Zhang
    National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    J Pathol 207:402-9. 2005
  9. ncbi request reprint [Altered expression of the HSD17B4 gene in esophageal squamous cell carcinoma and loss of heterozygosity analysis]
    Xiao Dong Li
    State Key Laboratory of Molecular Oncology, Cancer Institute, CAMS and PUMC, Beijing 100021, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:270-3. 2005
  10. ncbi request reprint [Expression of MLRQ subunit gene of NADH oxidoreductase and its clinical significance in malignant tumors of digestive system]
    Tao Wang
    Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Shanghai 200433, China
    Zhonghua Yi Xue Za Zhi 85:590-2. 2005

Collaborators

  • Lian Xin Liu
  • Yu Liu
  • Rafat Siddiqui
  • Yang Xu
  • Z Suo
  • Zhihua Liu
  • Jian Zhang
  • Fang Ding
  • Qimin Zhan
  • Huiying Zhi
  • Ming Fu
  • Ming Rong Wang
  • Yan Cai
  • Xin Xu
  • Qi Min Zhan
  • Ya Ling Han
  • Chen Lin
  • Xiao Liang
  • Mei Dong
  • Tong Tong
  • Yuan Yuan Zha
  • Zhi Hua Liu
  • Yi Ling Yang
  • Yu Peng Wu
  • Aiping Luo
  • Chuannong Zhou
  • Xue Yan Zhang
  • Xiu Qin Wang
  • Xiuqin Wang
  • Wenhong Fan
  • Ad J C de Groof
  • Gilad Twig
  • Vidyalakshmi Chandramohan
  • Shanshan Lin
  • Jin Tang Dong
  • Yan Bin Feng
  • Man Li Luo
  • Yu Zhang
  • Leigh Ann Higa
  • Shibichakravarthy Kannan
  • Cuiling Liu
  • Xinfeng Yu
  • Xiao Dong Li
  • Tao Wang
  • Haiyan Lu
  • Zhongmin Liu
  • Joshua B Edel
  • Feng yi Feng
  • Hai Yan Lu
  • Hong Zhi He
  • Yong Mei Song
  • Jie Wang
  • Shunqian Jin
  • Yuntian Sun
  • Xun Zhang
  • Jia Hua Hu
  • Jin Zhou
  • Gengxi Hu
  • Jiayun Lu
  • Hai Tao Wang
  • Yujun Pan
  • Qun Wang
  • Amy L Smift
  • Mike Winer
  • Helma Pluk
  • Mariska M te Lindert
  • Frank Oerlemans
  • Marieke Willemse
  • Michiel M T van Dommelen
  • Be Wieringa
  • Jack A M Fransen
  • Orian S Shirihai
  • Gail E Sonenshein
  • Junying Yuan
  • Barbara E Corkey
  • Bénédicte F Py
  • Steve Katz
  • Sarah E Haigh
  • Brian Burke
  • Sébastien Jeay
  • Hibo Mohamed
  • Nora D Mineva
  • Zhi Zhou Shi
  • Alvaro Elorza
  • Jude T Deeney
  • William Yang
  • Stephen R Hann
  • Jakob D Wikstrom
  • Gil Walzer
  • Linsey Stiles

Detail Information

Publications47

  1. pmc Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype
    Ad J C de Groof
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    Mol Cancer 8:54. 2009
    ....
  2. ncbi request reprint Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
    ..These metabolic alterations provide a mechanistic explanation for the growth advantage and apoptotic resistance of tumor cells...
  3. ncbi request reprint Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells
    Xinfeng Yu
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China
    Biochem Biophys Res Commun 342:286-92. 2006
    ..Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450...
  4. pmc Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery
    Cuiling Liu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 147:506-15. 2006
    ..In conclusion, flow-induced dilatation in rat mesenteric arteries can be markedly enhanced by prior depletion of intracellular Ca2+ stores. Furthermore, these data are consistent with a role for H2O2 as the vasodilator involved...
  5. ncbi request reprint Significance of COX-2 expression in human esophageal squamous cell carcinoma
    Huiying Zhi
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People s Republic of China
    Carcinogenesis 27:1214-21. 2006
    ....
  6. ncbi request reprint 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells
    Zhongmin Liu
    National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, Peoples Republic of China
    Cancer Lett 230:271-83. 2005
    ..This study may have clinical applications for ESCC therapy and prevention...
  7. pmc Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells
    Rafat A Siddiqui
    Methodist Research Institute, Clarian Health Partners, Indianapolis, IN, USA
    Breast Cancer Res 7:R645-54. 2005
    ..The present study describes the synthesis, purification, characterization and evaluation of two novel anticancer conjugates, propofol-docosahexaenoate (propofol-DHA) and propofol-eicosapentaenoate (propofol-EPA)...
  8. ncbi request reprint Up-regulation of fibronectin in oesophageal squamous cell carcinoma is associated with activation of the Erk pathway
    Jian Zhang
    National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    J Pathol 207:402-9. 2005
    ..All the above data suggest that the up-regulation of FN contributes to the later stage of oesophageal carcinogenesis, and that activation of the Erk pathway may be involved in the roles of FN in ESCC...
  9. ncbi request reprint [Altered expression of the HSD17B4 gene in esophageal squamous cell carcinoma and loss of heterozygosity analysis]
    Xiao Dong Li
    State Key Laboratory of Molecular Oncology, Cancer Institute, CAMS and PUMC, Beijing 100021, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:270-3. 2005
    ..To investigate the alteration of the gene HSD17B4 in esophageal squamous cell carcinoma and its potential significance...
  10. ncbi request reprint [Expression of MLRQ subunit gene of NADH oxidoreductase and its clinical significance in malignant tumors of digestive system]
    Tao Wang
    Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Shanghai 200433, China
    Zhonghua Yi Xue Za Zhi 85:590-2. 2005
    ..To study the differential expression and possible role of MLRQ subunit gene of nicotinamide adenine dinucleotide reduced (NADH) oxidoreductase in malignant tumors of digestive system...
  11. ncbi request reprint Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway
    Min Wu
    Cellular Biochemistry Laboratory, Methodist Research Institute, Clarian Health Partners, Indianapolis, IN 46202, USA
    Int J Cancer 117:340-8. 2005
    ..05). The results suggest that inhibition of breast cancer growth in nude mice by dietary fish oil and inhibition of breast cancer cell growth in culture by treatment with DHA and EPA is mediated by activation of N-SMYase...
  12. ncbi request reprint Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells
    Shibichakravarthy Kannan
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 558203, USA
    Eur J Immunol 36:1739-52. 2006
    ..This report brings out a new role of Lyn in infectious diseases and indicates potential new targets for prevention and treatment of infections...
  13. ncbi request reprint Identification of chromosome aberrations in esophageal cancer cell line KYSE180 by multicolor fluorescence in situ hybridization
    Yu Peng Wu
    National Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China
    Cancer Genet Cytogenet 170:102-7. 2006
    ..No chromosomes 9, 13, or Y were detected. These results add significant information to the existing karyotype description of KYSE180 and provide detailed cytogenetic background data for appropriate use of the cell line...
  14. doi request reprint c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor
    Vidyalakshmi Chandramohan
    Department of Biochemistry, Boston University Medical School, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:2091-106. 2008
    ..The inhibition of FOXO3a-mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype...
  15. pmc Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
    Gilad Twig
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    EMBO J 27:433-46. 2008
    ..Together, these findings suggest that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagy...
  16. ncbi request reprint Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1
    Min Wu
    Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    J Gen Virol 88:3260-9. 2007
    ....
  17. ncbi request reprint Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma
    Yi Ling Yang
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Genes Chromosomes Cancer 47:127-36. 2008
    ..004). Our results indicate that PRKCI is an attractive target in the 3q26 amplicon and that it may serve as a molecular marker for metastasis and occult advanced tumor stages in ESCC...
  18. ncbi request reprint Inhibition of hepatitis B virus replication by MyD88 is mediated by nuclear factor-kappaB activation
    Shanshan Lin
    Laboratory of Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Biochim Biophys Acta 1772:1150-7. 2007
    ..These results support a role for NF-kappaB activation in the inhibition of HBV replication and suggest a novel mechanism for the inhibition of HBV replication by MyD88 protein...
  19. ncbi request reprint Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells
    Min Wu
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Cancer Res 67:6278-85. 2007
    ..Thus, LOX-PP potently inhibits invasive phenotype of lung and pancreatic cancer cells, suggesting potential therapeutic applications in treatment of these cancers...
  20. ncbi request reprint Delivery of antisense oligonucleotides to leukemia cells by RNA bacteriophage capsids
    Min Wu
    Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, North Dakota, USA
    Nanomedicine 1:67-76. 2005
    ..Here we report an analysis of the uptake mechanism of this VLP system and preliminary examples of its use to deliver a number of ODNs, including some targeting p120 messenger RNAs, a biomarker overexpressed in myelogenous leukemia cells...
  21. ncbi request reprint Design of tele-educational system for interpreting dental tumor images
    Min Wu
    University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA
    J Med Syst 30:351-62. 2006
    ..The design of tele-educational system could serve as a model for self-evaluation of interpreting skills in dental tumor images as part of Continuous Medical Education (CME) in the future...
  22. ncbi request reprint CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
    Leigh Ann Higa
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Cell Biol 8:1277-83. 2006
    ..Our studies suggest that CUL4-DDB1 ligases use WDR proteins as molecular adaptors for substrate recognition, and modulate multiple biological processes through ubiquitin-dependent proteolysis...
  23. pmc Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria
    Tong Tong
    State Key Laboratory of Molecular Oncology, Chinese Academy of Medical Sciences, Cancer Institute, Beijing 100021, People s Republic of China
    Mol Cell Biol 25:4488-500. 2005
    ..These findings identify a novel link that connects stress protein Gadd45a to the apoptotic machinery and address the importance of cytoskeletal stability in apoptotic response to DNA damage...
  24. ncbi request reprint Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis
    Haiyan Lu
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    J Pharmacol Sci 97:533-40. 2005
    ..6%, P<0.0001) and decreased lung weights (38.5%, P<0.01) compared to the vehicle group. All these findings support that Z24 is a promising angiogenesis inhibitor for limiting tumor growth and metastasis...
  25. pmc High spatial resolution observation of single-molecule dynamics in living cell membranes
    Joshua B Edel
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA
    Biophys J 88:L43-5. 2005
    ..We show that optical confinement with ZMWs is a facile way to probe dynamic processes on the membrane surface...
  26. ncbi request reprint Expression of cell cycle/growth regulator genes in human hepatocellular carcinoma and adjacent normal liver tissues
    Lian Xin Liu
    Department of Surgery, The First Clinical College, Harbin Medical University, Nangang District, Harbin 150001, Heilongjiang Province, PR China
    Oncol Rep 10:1771-5. 2003
    ..The rapid and high-throughout method of profiling gene expression by cDNA array provides an overview of the key factors that may be involved in HCC. Some genes are reported for the first time in HCC...
  27. ncbi request reprint [Antitumor effect of gene gun-mediated DNA vaccine pWRG-neu immunization in C57BL/6 mice]
    Yuan Yuan Zha
    National Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
    Zhonghua Zhong Liu Za Zhi 25:320-4. 2003
    ..To investigate the inhibitory effect of DNA vaccine immunization on neu-overexpressed melanoma growth in prophylactic treatment and anti-lung-metastasis experiments in C57BL/6 mice...
  28. ncbi request reprint The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma
    Huiying Zhi
    National Lab of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100 021, People s Republic of China
    Int J Cancer 106:327-33. 2003
    ..These data suggested that AA metabolism pathway and its altered expression may contribute to esophageal squamous cell carcinogenesis...
  29. ncbi request reprint Gene expression profiles at different stages of human esophageal squamous cell carcinoma
    Jin Zhou
    National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
    World J Gastroenterol 9:9-15. 2003
    ..To characterize the gene expression profiles in different stages of carcinogenesis of esophageal epithelium...
  30. ncbi request reprint [Effect of EMP-1 gene on human esophageal cancer cell line]
    Hai Tao Wang
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, P R China
    Ai Zheng 21:229-32. 2002
    ..The authors further designed the experiment to study the effect of human EMP-1 gene on human esophageal cancer cell line in order to explain the function of this gene on the carcinogensis and progression esophageal cancer...
  31. ncbi request reprint A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy
    Yujun Pan
    Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Cancer Lett 184:179-88. 2002
    ..05). Results suggest that this new delivery system is more efficient than the traditional in vitro and in vivo retroviral vector delivery system...
  32. ncbi request reprint AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis
    Min Wu
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 277:25617-23. 2002
    ..Furthermore, AMID-induced apoptosis was independent of caspase activation and p53 and was not inhibited by Bcl-2. These findings suggest that AMID induces a novel caspase-independent apoptotic pathway...
  33. ncbi request reprint CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma
    Qun Wang
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China
    Cancer Lett 179:71-7. 2002
    ..Therefore, it suggested that CASK and Reelin were associated with tumorigenesis of esophagus and they were co-upregulated in human esophageal carcinoma...
  34. ncbi request reprint Participation of protease-activated receptor-1 in thrombin-induced microglial activation
    Zhiming Suo
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    J Neurochem 80:655-66. 2002
    ..In addition, strategies aimed at blocking thrombin signaling through PAR1 may be therapeutically valuable for diseases associated with cerebral vascular damage and significant inflammation with microglial activation...
  35. ncbi request reprint Gene expression profiles of hepatoma cell line BEL-7402
    Lian Xin Liu
    Department of Surgery, First Clinical College of Harbin Medical University, No 23 Youzheng Street, Nangang District, Harbin 150001, P R China
    Hepatogastroenterology 50:1496-501. 2003
    ..To investigate the gene expression of cancer related genes in hepatoma cell line BEL-7402 through the usage of Atlas Human Cancer Array with 588 well-characterized human genes related with cancer biology...
  36. ncbi request reprint Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand
    Jia Hua Hu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 13:361-7. 2003
    ..In summary, we provide the direct evidences that Fas ligand mediates the apoptosis of testicular germ cells induced by acute ethanol using FasL transgenic mice...
  37. ncbi request reprint Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer
    Jie Wang
    National Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking University of Medical School, Beijing 100021, China
    Cell Res 14:46-53. 2004
    ..No mutation was found in the genomic DNA of the MRP14 gene by PCR and directed DNA sequencing. Our finding suggested that the reduction of MRP14 expression is a frequent event in Chinese human esophageal cancer...
  38. ncbi request reprint [The effect and mechanism of arsenic trioxide on hepatocellular carcinoma]
    Lian Xin Liu
    Department of Surgery, The First Clinical College, Harbin Medical University, Harbin 150001, China
    Zhonghua Wai Ke Za Zhi 43:33-6. 2005
    ..To investigate the effect and mechanism of arsenic trioxide on hepatoma cell line BEL-7402 and observe the effect and best administration method of arsenic trioxide on hepatocellular carcinoma patients who were not suitable for operation...
  39. pmc Visualization of plasma membrane compartmentalization with patterned lipid bilayers
    Min Wu
    Department of Chemistry and Chemical Biology and School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:13798-803. 2004
    ..Cell activation using patterned surfaces provides unique insights into cell membrane structural organization, revealing dynamic, large-scale uncoupling of inner and outer leaflet components of lipid rafts...
  40. ncbi request reprint Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene
    Min Wu
    Department of Chemistry, New York University, New York, NY 10003, USA
    Front Biosci 9:2807-18. 2004
    ....
  41. ncbi request reprint [Development and characterization of a gemcitabine-resistant variant of human lung adenocarcinoma cell line A549]
    Mei Dong
    Department of Medical Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China
    Ai Zheng 23:667-71. 2004
    ....
  42. ncbi request reprint [Gadd45 mediated G2/M cell cycle arrest induced by BRCA1]
    Yong Mei Song
    National Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100021, PR China
    Ai Zheng 23:517-21. 2004
    ..The objective of this study was to investigate the effects of Gadd45 on the BRCA1-induced cell growth suppression...
  43. ncbi request reprint Alterations in expression, proteolysis and intracellular localizations of clusterin in esophageal squamous cell carcinoma
    Hong Zhi He
    National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    World J Gastroenterol 10:1387-91. 2004
    ..To investigate biogenesis and intracellular localizations of clusterin to elucidate the potential molecular mechanisms implicated in tumorigenesis of esophageal mucosa...
  44. ncbi request reprint Expression patterns of esophageal cancer deregulated genes in C57BL/6J mouse embryogenesis
    Jian Zhang
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    World J Gastroenterol 10:1088-92. 2004
    ....
  45. ncbi request reprint [Mechanisms of the drug resistance of a 2', 2-difluorodeoxycytide (gemcitabine)-resistant variant of the human lung adenocarcinoma cell line]
    Mei Dong
    Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
    Zhonghua Yi Xue Za Zhi 84:323-8. 2004
    ..To investigate the mechanisms of the drug resistance of gemcitabine resistance variant of the human lung adenocarcinoma cell line A549-Gem...
  46. ncbi request reprint Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation
    Zhiming Suo
    Laboratory for Alzheimer s Disease and Aging Research, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    J Neurosci 24:3444-52. 2004
    ..Together, this study not only discovered a novel link between subthreshold Abeta and GRK dysfunction, it also demonstrated that the GRK abnormality in vivo occurs at prodromal and early stages of AD...
  47. ncbi request reprint BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs
    Wenhong Fan
    Department of Radiation Oncology, Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 277:8061-7. 2002
    ..These findings indicate that BRCA1 can up-regulate its targeted genes through protein-protein interactions and provide a novel mechanism by which BRCA1 participates in transcriptional regulation...