Psychostimulant dependence in a community sampleLi Tzy Wu
Center for Risk Behavior and Mental Health Research, Research Triangle Institute, North Carolina 27709 2194, USA
Subst Use Misuse 38:221-48. 2003
..To examine the prevalence of psychostimulant dependence and the characteristics associated with nonmedical users' development of dependence...
- Inhalant use and disorders among adults in the United States
Li Tzy Wu
Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, DUMC, P O Box 17969, Durham, NC 27715, USA
Drug Alcohol Depend 85:1-11. 2006
..To examine the patterns of adult inhalant use and correlates of inhalant use disorder...
- Non-prescribed use of pain relievers among adolescents in the United States
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 17969, Durham, NC 27715, USA
Drug Alcohol Depend 94:1-11. 2008
..We examined gender-specific prevalences, patterns, and correlates of non-prescribed use of pain relievers - mainly opioids - in a representative sample of American adolescents (N=18,678)...
- Alcohol use disorders and the use of treatment services among college-age young adults
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, P O Box 17969, Durham, NC 27715, USA
Psychiatr Serv 58:192-200. 2007
..This breakdown of young adults had not been addressed previously...
- Misuse of methamphetamine and prescription stimulants among youths and young adults in the community
Li Tzy Wu
Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2213 Elba Street, Civitan Building, Room 240 Duke University Medical Center, Durham, NC 27710, USA
Drug Alcohol Depend 89:195-205. 2007
..Gender differences in the prevalence and characteristics of misuse of methamphetamine (meth) and prescription stimulants were examined in a representative US sample of youths and young adults aged 16-25 (N=24,409)...
- Psychiatric disorders in inhalant users: results from The National Epidemiologic Survey on Alcohol and Related Conditions
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke University Medical Center, Duke Clinical Research Institute DCRI, Durham, NC 27715, USA
Drug Alcohol Depend 88:146-55. 2007
..To examine the prevalence and correlates of mood, anxiety, and personality disorders among lifetime inhalant users...
- Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths
Li Tzy Wu
Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, DUMC, P O Box 17969, Durham, NC 27715, USA
Drug Alcohol Depend 84:102-13. 2006
..S. civilian population that included multiethnic urban, suburban, and rural youths aged 16-23 (N=19,084)...
- Use of alcohol treatment and mental health services among adolescents with alcohol use disorders
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA
Psychiatr Serv 57:84-92. 2006
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- Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
Am J Addict 17:304-11. 2008
..Illicit methadone use among patients in maintenance programs is infrequent; however, a number of factors may increase risk of illicit use...
- A dimensional approach to understanding severity estimates and risk correlates of marijuana abuse and dependence in adults
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Int J Methods Psychiatr Res 21:117-33. 2012
..Elevated rates of MUDs among African Americans and Hispanics require research to elucidate risk factors and improve assessments of MUDs for different racial/ethnic groups...
- The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health
Dan G Blazer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Psychiatry 166:1162-9. 2009
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- Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
Am J Addict 18:206-18. 2009
..Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V...
- Is inhalant use a risk factor for heroin and injection drug use among adolescents in the United States?
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
Addict Behav 32:265-81. 2007
..We examined whether inhalant use was associated with heroin and injection drug use (IDU) among adolescents aged 12 to 17 in the United States...
- How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
J Addict Med 5:28-35. 2011
..To study substance use and psychiatric disorders among prescription opioid users, heroin users, and non-opioid drug users in a national sample of adults...
- Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27710, USA
J Subst Abuse Treat 38:S70-9. 2010
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- An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University, Duke University Medical Center, Durham, North Carolina 27710, USA
J Stud Alcohol Drugs 70:414-25. 2009
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- The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Addict 18:452-61. 2009
..The recent resurgence in ecstasy use among adults underscores the need to monitor trends in its use...
- Alcohol and drug use disorders among adults in emergency department settings in the United States
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Ann Emerg Med 60:172-80.e5. 2012
..We examine past-year substance use and substance use disorders (alcohol, 9 drug classes) among adult ED users. Prevalences of substance use and substance use disorders among ED nonusers are calculated for reference purposes...
- Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
J Psychiatr Res 46:360-9. 2012
..To address an urgent need for screening of substance use problems in medical settings, we examined substance-specific dependence criteria as potential brief screeners for the detection of patients with a substance use disorder (SUD)...
- Substance use disorders and comorbid Axis I and II psychiatric disorders among young psychiatric patients: findings from a large electronic health records database
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
J Psychiatr Res 45:1453-62. 2011
..21%); children, females, and blacks had elevated odds of inpatient psychiatric treatment. Collectively, results add clinical evidence on treatment needs and diagnostic patterns for understudied diagnoses...
- Early outcomes following low dose naltrexone enhancement of opioid detoxification
Paolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
Am J Addict 18:109-16. 2009
..Further studies are needed to test the utility of this approach in easing the transition from detoxification to various follow-up treatment modalities designed to address opioid dependence...
- An item response theory analysis of DSM-IV criteria for hallucinogen abuse and dependence in adolescents
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Addict Behav 35:273-7. 2010
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- Problem drinking and low-dose naltrexone-assisted opioid detoxification
Paolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, North Carolina 27705, USA
J Stud Alcohol Drugs 72:507-13. 2011
..In a secondary analysis of these data, we sought to determine whether problem drinking affects detoxification outcomes and whether symptoms are influenced by VLNTX use...
- Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Am Acad Child Adolesc Psychiatry 48:563-72. 2009
..To examine the psychometric properties of diagnostic criteria for prescription analgesic opioid use disorders (OUDs) and to identify background predictors of a latent continuum for OUD liability...
- The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal
Paolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Am J Drug Alcohol Abuse 38:200-5. 2012
..Very low-dose naltrexone (VLNTX) has been shown to attenuate withdrawal intensity and noradrenaline release following opioid agonist taper, suggesting a combination with clonidine may result in improved safety and efficacy...
- The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
Addict Behav 34:654-61. 2009
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- Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives
Paolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Curr Drug Abuse Rev 5:52-63. 2012
..Future studies should also test new pharmacological mechanisms to help reduce physical dependence, and identify individualized approaches, including the use of pharmacogenetics and long-acting opioid agonist and antagonist formulations...
- Substance use disorders among inhalant users: results from the National Epidemiologic Survey on alcohol and related conditions
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 2218 Elder Street, 2B, DUMC Box 3419, Durham, NC 27710, USA
Addict Behav 33:968-73. 2008
..To assess the prevalence, correlates, and age of onset of DSM-IV substance use disorders (SUDs) among adult inhalant users...
- Racial/ethnic variations in substance-related disorders among adolescents in the United States
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Arch Gen Psychiatry 68:1176-85. 2011
..While young racial/ethnic groups are the fastest growing population in the United States, data about substance-related disorders among adolescents of various racial/ethnic backgrounds are lacking...
- The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health
Dan G Blazer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 17:237-45. 2009
..To estimate the prevalence, distribution, and correlates of drug use among middle aged and elderly persons in the United States and to compare with alcohol use in this age group...
Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependencePaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
J Clin Psychopharmacol 27:468-74. 2007
..The present study evaluated whether the augmentation with low-dose NTX during the post-detoxification treatment of opioid dependence would improve outcomes...
- Use of item response theory and latent class analysis to link poly-substance use disorders with addiction severity, HIV risk, and quality of life among opioid-dependent patients in the Clinical Trials Network
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
Drug Alcohol Depend 118:186-93. 2011
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- Hallucinogen-related disorders in a national sample of adolescents: the influence of ecstasy/MDMA use
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Drug Alcohol Depend 104:156-66. 2009
..To present the prevalence and correlates of hallucinogen use disorders (HUDs: abuse or dependence) and subthreshold dependence...
- The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample
Dan G Blazer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Am J Geriatr Psychiatry 19:685-94. 2011
..To estimate 1-year prevalence and correlates of alcohol abuse, dependence, and subthreshold dependence (diagnostic orphans) among middle-aged and elderly persons in the United States...
- Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA Electronic address
Gen Hosp Psychiatry 35:74-82. 2013
..The objective was to identify a potential core set of brief screeners for the detection of individuals with a substance use disorder (SUD) in medical settings...
- Patterns of tobacco use and tobacco-related psychiatric morbidity and substance use among middle-aged and older adults in the United States
Dan G Blazer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Aging Ment Health 16:296-304. 2012
..To examine prevalence of tobacco use and identify psychiatric symptoms and substance use correlates of tobacco use comparing adults 50-64 years of age with those 65+ years of age (N = 10,891)...
- Treatment use and barriers among adolescents with prescription opioid use disorders
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham 27710, USA
Addict Behav 36:1233-9. 2011
..This study examined national trends, patterns, correlates, and barriers to substance abuse treatment use by adolescents aged 12-17 years who met at least one of the past-year criteria for prescription opioid abuse or dependence (N=1788)...
- Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health
Dan G Blazer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Geriatr Soc 57:1252-7. 2009
..To estimate the frequency, distribution, and correlates of nonprescription use of pain relievers by middle-aged and elderly persons in the United States...
- Prescription pain reliever abuse and dependence among adolescents: a nationally representative study
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC 27710, USA
J Am Acad Child Adolesc Psychiatry 47:1020-9. 2008
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Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
J Psychiatr Res 42:1213-9. 2008
..However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans...
- Hallucinogen use disorders among adult users of MDMA and other hallucinogens
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina 27710, USA
Am J Addict 17:354-63. 2008
..Subthreshold hallucinogen dependence is relatively prevalent and represents a clinically important subgroup that warrants future research and consideration in a major diagnostic classification system...
- Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial
Paolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
Addict Biol 14:204-13. 2009
..Further studies should explore the use of VLNTX, combined with full and partial opioid agonist medications, in detoxification and long-term treatment of opioid dependence...
- Subtypes of nonmedical opioid users: results from the national epidemiologic survey on alcohol and related conditions
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Drug Alcohol Depend 112:69-80. 2010
..To identify subtypes of nonmedical opioid users, gender variations in psychiatric disorders, and quality of life in a representative sample of adults...
- Trends in nonheroin opioid abuse admissions: 1992-2004
Kathleen S Peindl
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
J Opioid Manag 3:215-23. 2007
..This study examines trends for treatment admissions for nonheroin opioid abuse from 1992 to 2004...
- Using electronic health records data to assess comorbidities of substance use and psychiatric diagnoses and treatment settings among adults
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
J Psychiatr Res 47:555-63. 2013
..To examine prevalences of substance use disorders (SUD) and comprehensive patterns of comorbidities among psychiatric patients ages 18-64 years (N = 40,099) in an electronic health records (EHR) database...
- The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) study
Li Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC 27710, USA
Drug Alcohol Depend 103:114-23. 2009
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- Illicit and nonmedical drug use among older adults: a review
Li Tzy Wu
Duke University Medical Center, Durham, NC 27710, USA
J Aging Health 23:481-504. 2011
..7 million in 2020. The authors provide a review of epidemiological findings for this understudied area of research by focusing on illicit drug use disorders and nonmedical use of prescription drugs among adults aged 50+ years...
- The impact of the CONSORT statement on reporting of randomized clinical trials in psychiatry
Changsu Han
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
Contemp Clin Trials 30:116-22. 2009
..Although the overall quality of reporting on psychiatric RCTs generally improved after publication of the CONSORT statement, reporting the details of randomization, blinding, and obtaining informed consent remain insufficient...
- Substance abuse among individuals with intellectual disabilities
Shawna L Carroll Chapman
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Res Dev Disabil 33:1147-56. 2012
..Research is needed to better gauge the magnitude of substance use problems, identify prevention strategies, and specify treatment components that meet the unique needs of individuals with ID...
- Psychiatric symptoms and substance use disorders in a nationally representative sample of American adolescents involved with foster care
Daniel J Pilowsky
Department of Psychiatry, Columbia College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Adolesc Health 38:351-8. 2006
..To ascertain the prevalence of psychiatric symptoms and substance use disorders among adolescents with a lifetime history of foster care placement, using data from a nationally representative sample of U.S. adolescents...
- Substance use, dependence, and service utilization among the US uninsured nonelderly population
Li Tzy Wu
RTI International, Research Triangle Park, NC 12194, USA
Am J Public Health 93:2079-85. 2003
..We examined the prevalence and correlates of substance use, dependence, and service utilization among uninsured persons aged 12 to 64 years...
- Private health insurance coverage for substance abuse and mental health services, 1995 to 1998
Li Tzy Wu
Center for Risk Behavior and Mental Health Research at RTI International, Research Triangle Park, North Carolina 27709, USA
Psychiatr Serv 55:180-2. 2004
..Untreated addictive and psychiatric problems are costly to society. Underinsurance among socially disadvantaged subgroups deserves greater attention from researchers and policy makers...
- Injection drug use among stimulant users in a national sample
Li Tzy Wu
Center for Risk Behavior and Mental Health Research, RTI International, P G Box 12194, Research Triangle Park, NC 27709 2194, USA
Am J Drug Alcohol Abuse 30:61-83. 2004
..Factors related to the cessation of illicit drug use and substance abuse service utilization were also determined among a subsample of stimulant users who reported IDU...
- Inhalant abuse and dependence among adolescents in the United States
Li Tzy Wu
RTI International, Research Triangle Park, NC 27709, USA
J Am Acad Child Adolesc Psychiatry 43:1206-14. 2004
..To examine the patterns of inhalant use and correlates of the progression from inhalant use to abuse and dependence among adolescents aged 12 to 17...
- High prevalence of substance use disorders among adolescents who use marijuana and inhalants
Li Tzy Wu
Center for Risk Behavior and Mental Health Research, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
Drug Alcohol Depend 78:23-32. 2005
..We examined the association between the use of inhalants, marijuana, and other drugs and recent DSM-IV substance use disorders among adolescents aged 12-17 years...
- Alcohol dependence and use of treatment services among women in the community
Li Tzy Wu
Center for Risk Behavior and Mental Health Research, RTI International, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
Am J Psychiatry 161:1790-7. 2004
..This study examined the extent and characteristics of alcohol dependence and the perceived need for and use of alcohol treatment services among women compared with men in a nonclinical sample of adults 18-64 years of age...
- Use of nitrite inhalants ("poppers") among American youth
Li Tzy Wu
RTI International, Research Triangle Park, North Carolina 27709 2194, USA
J Adolesc Health 37:52-60. 2005
..We examined the patterns and correlates of nitrite inhalant use among adolescents aged 12 to 17 years...
- Use of substance abuse treatment services by persons with mental health and substance use problems
Li Tzy Wu
Center for Risk Behavior and Mental Health Research, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA
Psychiatr Serv 54:363-9. 2003
..This study provided population estimates of mental syndromes and substance use problems and examined whether the co-occurrence of mental health and substance use problems was associated with the use of substance abuse treatment services...
- Cocaine use and the occurrence of panic attacks in the community: a case-crossover approach
Li-Tzy Wu
Department of Mental Health, Johns Hopkins Bloomberg, School of Public Health, Baltimore, MD, USA
Subst Use Misuse 40:285-97. 2005
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- Use of substance abuse services by young uninsured american adults
Li Tzy Wu
Behavioral Health Research Division of RTI International, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709, USA
Psychiatr Serv 56:946-53. 2005
..This study examined the prevalence and correlates of substance abuse service use among uninsured young adults aged 18 to 34 years (N=24,282)...
- Inhalant use among incarcerated adolescents in the United States: prevalence, characteristics, and correlates of use
Matthew O Howard
School of Social Work, 325 Pittsboro, CB 3550, The University of North Carolina at Chapel Hill, NC 27599, USA
Drug Alcohol Depend 93:197-209. 2008
..To characterize patterns and correlates of inhalant use among incarcerated youth...
