Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem studyHe Wu
Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, PR China
Brain Res 1342:111-7. 2010
..These data suggest that inflammation occurs early and persists for several days after ICH in humans and could be involved in the progression of ICH-induced secondary brain damage...
Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edemaHe Wu
Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, PR China
Neurochem Int 57:248-53. 2010
..These findings have important implications for efforts to reduce secondary brain damage after ICH...
Expression of thrombin and its associated protein in cerebellum of human and rat after intracerebral hemorrhageZhi Yi Zhang
Department of Rheumatology and Immunology, First Clinical Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China
Chin Med J (Engl) 123:2077-81. 2010
..The purpose of the study was to explore the effect of thrombin, protease nexin-1 (PN-1) and protease activated receptor-1 (PAR-1) in rat and human cerebellum after ICH...
The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhageHe Wu
Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, People s Republic of China
J Neurol Sci 270:172-83. 2008
..The expression of AQP-4 is different between human and rat. Thus, we demonstrated that the animal experimental approach was, however, not sufficient by itself and needed to be corroborated by observations on human brains...
Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edemaLikun Zan
Department of Pathology, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, PR China
Neurochem Int 58:872-9. 2011
..Dynamic temporal changes in Src and SSeCKS expression may modulate angiogenesis and cerebral edema formation after focal cerebral ischemia...
Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampusJi ping Qi
Department of Pathology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China
J Alzheimers Dis 12:335-41. 2007
..Therefore our observations provide a basis for establishing therapeutic strategies aimed at preventing ischemic insults and subsequent neurodegeneration in AD...
Efficacy of the lipid-soluble iron chelator 2,2'-dipyridyl against hemorrhagic brain injuryHe Wu
Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Neurobiol Dis 45:388-94. 2012
..Post-treatment reduced brain lesion volume and edema and improved neurologic function. These results indicate that the lipid-soluble ferrous iron chelator 2,2'-dipyridyl can reduce brain injury and improve functional outcome after ICH...