John J Wixted

Summary

Publications

  1. doi request reprint Arachidonic acid, eicosanoids, and fracture repair
    John J Wixted
    Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Orthop Trauma 24:539-42. 2010
  2. pmc Secreted frizzled related protein 1 is a target to improve fracture healing
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 220:174-81. 2009
  3. pmc The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cancer Ther 9:3210-20. 2010
  4. pmc Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
  5. pmc Biomechanical investigation of a novel ratcheting arthrodesis nail
    Jeremy J McCormick
    Department of Orthopaedic Surgery, University of Massachusetts, Medical Center, Worcester, Massachusetts 01655, USA
    J Orthop Surg Res 5:74. 2010
  6. pmc Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor
    John J Wixted
    Department of Orthopedic Surgery and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 221:31-9. 2009
  7. doi request reprint Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study
    Jason A Silva
    Department of Orthopedics, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Injury 41:S85-9. 2010
  8. doi request reprint An improved murine femur fracture device for bone healing studies
    Joseph E Marturano
    Department of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 41:1222-8. 2008

Collaborators

Detail Information

Publications8

  1. doi request reprint Arachidonic acid, eicosanoids, and fracture repair
    John J Wixted
    Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Orthop Trauma 24:539-42. 2010
    ..This article reviews recent investigations into the potential role of leukotrienes as negative regulators of fracture healing and potential pharmacologic use of medications that block this effect...
  2. pmc Secreted frizzled related protein 1 is a target to improve fracture healing
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 220:174-81. 2009
    ..Thus, developing an antagonist to specifically inhibit sFRP1 represents a safe target for stimulating fracture repair and bone formation in metabolic bone disorders, osteoporosis and aging...
  3. pmc The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cancer Ther 9:3210-20. 2010
    ..Vorinostat treatment reduces tumor growth in bone and accompanying osteolytic disease as a result of decreased tumor burden in bone. However, vorinostat can promote osteopenia throughout the skeleton independent of tumor cell activity...
  4. pmc Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
    ..Thus, our studies define a novel role of Runx2 in up-regulating the vicious cycle of metastatic bone disease, in addition to Runx2 regulation of genes related to progression of tumor metastasis...
  5. pmc Biomechanical investigation of a novel ratcheting arthrodesis nail
    Jeremy J McCormick
    Department of Orthopaedic Surgery, University of Massachusetts, Medical Center, Worcester, Massachusetts 01655, USA
    J Orthop Surg Res 5:74. 2010
    ..abstract:..
  6. pmc Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor
    John J Wixted
    Department of Orthopedic Surgery and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 221:31-9. 2009
    ....
  7. doi request reprint Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study
    Jason A Silva
    Department of Orthopedics, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Injury 41:S85-9. 2010
    ..Test the biomechanical properties of femurs that have undergone reaming with the Reamer Irrigator Aspirator (RIA) device with an aim to prove no difference in torsional strength between matched pairs...
  8. doi request reprint An improved murine femur fracture device for bone healing studies
    Joseph E Marturano
    Department of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 41:1222-8. 2008
    ..Maintaining kinetic energy parameters within suggested ranges may also aid in ensuring accuracy and reproducibility...