Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancerLudmila Prudkin
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 14:41-7. 2008
..However, the expression of Fus1 protein has not been examined in a large series of lung cancers and their sequential preneoplastic lesions...
Lung cancer preneoplasiaIgnacio I Wistuba
Department of Pathology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
Annu Rev Pathol 1:331-48. 2006
....
- Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung
Ludmila Prudkin
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Mod Pathol 22:668-78. 2009
..Brain metastases showed characteristics of reversed mesenchymal-to-epithelial transition. Our findings suggest that epithelial-to-mesenchymal transition is a potential target for lung cancer chemoprevention and therapy...
- Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion
Pierre Saintigny
Department of 1Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center 5The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA
Mol Cancer Ther 11:2021-32. 2012
..EphA4 gene expression is associated with an improved outcome in patients with resected lung adenocarcinoma, possibly by affecting cancer cell migration and invasion...
- Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy
Apar Pataer
Departments of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Thorac Oncol 7:825-32. 2012
....
- Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis
Ximing Tang
Departmentsof Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 17:2434-43. 2011
..The thyroid transcription factor 1 (TITF-1) gene functions as a lineage survival gene abnormally expressed in a significant fraction of non-small cell lung cancers (NSCLC), in particular lung adenocarcinomas...
- Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas
Ximing Tang
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer Prev Res (Phila) 1:192-200. 2008
..Our findings have important implications for the development of new strategies for targeted chemoprevention and therapy in lung adenocarcinoma using EGFR inhibitors...
- Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions
Carmen Behrens
Departmentsof Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 16:34-44. 2010
..To identify the pattern of interleukin-1 receptor-associated kinase (IRAK-1) protein expression in non-small cell lung carcinoma (NSCLC) and corresponding preneoplastic lesions...
Primary oncocytic adenocarcinomas of the lung: a clinicopathologic, immunohistochemical, and molecular biologic analysis of 16 casesLuisa M Solis
Departments of Pathology, Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 133:133-40. 2010
..These cases represent an unusual variant of pulmonary adenocarcinoma...
- Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria
William D Travis
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Thorac Oncol 1:S13-9. 2006
..Advances in the pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC) have demonstrated important new prognostic features that have led to changes in classification and diagnostic criteria...
- Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells
Jie Zhang
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Cancer Prev Res (Phila) 1:201-7. 2008
....
- Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model
Seyed Javad Moghaddam
Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 2121 W Holcombe Boulevard, Suite 703F, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 40:443-53. 2009
..We conclude that COPD-like airway inflammation promotes lung carcinogenesis in a background of a G12D-activated K-ras allele in airway secretory cells...
- Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung
Ping Yuan
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 5:e9112. 2010
..The sequential pathogenesis of lung adenocarcinomas and SCCs occurs through dissimilar phases as the former tumors typically arise in the lung periphery whereas the latter normally arise near the central airway...
- A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis
Humam Kadara
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 17:1490-501. 2011
..Here, we assessed in NSCLC the prognostic efficacy of genes, which we had previously found to be differentially expressed in an in vitro model of human lung carcinogenesis...
- Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression
Young Ho Ahn
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Mol Cell Biol 31:4270-85. 2011
..We conclude that Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing PPARγ2 levels...
- High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation
Maria Ines Nunez
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Thorac Oncol 7:833-40. 2012
..Information on the protein expression of these receptors in non-small-cell lung carcinoma (NSCLC) is limited...
- Tissue platinum concentration and tumor response in non-small-cell lung cancer
Eric S Kim
The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 463, Houston, TX 77030, USA
J Clin Oncol 30:3345-52. 2012
..We assessed the effects of tissue platinum concentrations on response and survival in NSCLC...
- Histologic patterns and molecular characteristics of lung adenocarcinoma associated with clinical outcome
Luisa M Solis
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 118:2889-99. 2012
..Lung adenocarcinoma is histologically heterogeneous and has 5 distinct histologic growth patterns: lepidic, acinar, papillary, micropapillary, and solid. To date, there is no consensus regarding the clinical utility of these patterns...
- Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system
Humam Kadara
Departments of Thoracic Head and Neck MedicalOncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Prev Res (Phila) 2:702-11. 2009
..Moreover, one of those genes, UBE2C, seems to be a powerful biomarker for NSCLC survival prediction...
- HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors
Menghong Sun
Departments of Pathology, Thoracic Head and Neck Medical Oncology, Biostatistics, and Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Clin Cancer Res 15:4829-37. 2009
..To compare the characteristics of deregulation of HER receptors and their ligands between primary tumor and corresponding brain metastases of non-small cell lung carcinoma (NSCLC)...
- Biological activity of celecoxib in the bronchial epithelium of current and former smokers
Edward S Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Prev Res (Phila) 3:148-59. 2010
..Celecoxib (400 mg twice daily) was biologically active in the bronchial epithelium of current and former smokers; additional studies on the efficacy of celecoxib in non-small cell lung cancer chemoprevention may be warranted...
- High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
Nobukazu Fujimoto
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Cancer Res 65:11478-85. 2005
..Thus, lung adenocarcinoma cells that depend on EGFR for survival constitutively activate the receptor through a combination of genetic mutations and overexpression of EGFR dimeric partners and their ligands...
- Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors
Woo Young Kim
Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer 118:3993-4003. 2012
..The authors investigated the involvement of insulinlike growth factor 1 receptor (IGF-1R) signaling in primary resistance to EGFR TKIs and the molecular determinants of resistance to IGF-1R TKIs...
- Phase II trials of imatinib mesylate and docetaxel in patients with metastatic non-small cell lung cancer and head and neck squamous cell carcinoma
Anne S Tsao
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Thorac Oncol 6:2104-11. 2011
..Baseline tumor specimens, serum, and perfusion computed tomography (CT) scans were obtained for supportive evaluation...
- Immunohistochemical overexpression of platelet-derived growth factor receptor-beta (PDGFR-β) is associated with PDGFRB gene copy number gain in sarcomatoid non-small-cell lung cancer
Anne S Tsao
Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Clin Lung Cancer 12:369-74. 2011
..Further studies are warranted to determine whether PDGFR-b is a feasible therapeutic target in this population...
- SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines
Jie Zhang
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Pathol 170:366-76. 2007
..We conclude that SFKs are activated in NSCLC biopsy samples, promote the survival of EGFR-dependent NSCLC cells, and should be investigated as therapeutic targets in NSCLC patients...
- Mortality in the randomized, controlled lung intergroup trial of isotretinoin
J Jack Lee
Department of Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
Cancer Prev Res (Phila) 3:738-44. 2010
..The overall indications of this study have public health implications for treating acne in young people and other uses of retinoids in smokers...
- HER family receptor and ligand status in thymic carcinoma
Annikka Weissferdt
Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA
Lung Cancer 77:515-21. 2012
....
- KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
Erminia Massarelli
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 13:2890-6. 2007
..In contrast, KRAS mutation has been shown to predict poor response to such therapy. We tested the utility of combinations of these three markers in predicting response and survival in patients with NSCLC treated with EGFR-TKIs...
- Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation
Maria G Raso
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 15:5359-68. 2009
....
- Activating enhancer-binding protein-2β nucleolar localization predicts poor survival after stage I non-small cell lung cancer resection
Min P Kim
Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Ann Thorac Surg 92:1044-50. 2011
....
- Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer
Carmen Behrens
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Cancer Res 14:6014-22. 2008
....
- Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis
Osamu Takahashi
Department of Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Clin Cancer Res 18:1641-54. 2012
....
- Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer
Jin Soo Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer 118:2454-65. 2012
..The purpose of this study was to characterize insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) expression in patients with nonsmall cell lung cancer (NSCLC)...
- Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
Luisa M Solis
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 16:3743-53. 2010
....
- Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients
Abujiang Pataer
Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 16:5522-8. 2010
..To explore the role of PKR in human lung cancer, we evaluated the expression of PKR in tissue microarray (TMA) specimens from both non-small cell lung cancer (NSCLC) and normal human bronchial epithelium tissue...
- Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
Kentaro Iwanaga
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 68:1119-27. 2008
..Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis...
- Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung
J Matthew McDonald
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:7832-7. 2008
..The primary objective of this study was to determine whether markers of differentiation and activation of the Akt pathway are associated with metastasis in adenocarcinoma of the lung...
- Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
Lauren Averett Byers
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Discov 2:798-811. 2012
..On the basis of these results, clinical studies evaluating PARP and EZH2 inhibition, together with chemotherapy or other agents, warrant further investigation...
- G-protein coupled receptor family C, group 5, member A (GPRC5A) expression is decreased in the adjacent field and normal bronchial epithelia of patients with chronic obstructive pulmonary disease and non-small-cell lung cancer
Junya Fujimoto
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
J Thorac Oncol 7:1747-54. 2012
..The implication of GPRC5A in human lung cancer pathogenesis, including that associated with inflammatory chronic obstructive pulmonary disease (COPD), a risk factor for the malignancy, remains elusive...
- The BATTLE trial: personalizing therapy for lung cancer
Edward S Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer Discov 1:44-53. 2011
....
- A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck
Carol M Lewis
Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 18:1435-46. 2012
..To determine the disease control rate and toxicity of treating patients with aggressive cutaneous squamous cell carcinoma (CSCC) with neoadjuvant gefitinib...
- Pulmonary adenocarcinoma: a renewed entity in 2011
Humam Kadara
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Respirology 17:50-65. 2012
....
- Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin
Quanri Jin
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 67:11630-9. 2007
....
- Histologic features of low- and intermediate-grade neuroendocrine carcinoma (typical and atypical carcinoid tumors) of the lung
Koji Tsuta
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Lung Cancer 71:34-41. 2011
....
- Molecular pathogenesis of early-stage non-small cell lung cancer and a proposal for tissue banking to facilitate identification of new biomarkers
Maria Gabriela Raso
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
J Thorac Oncol 2:S128-35. 2007
..This study offers the opportunity to prospectively obtain, bank, and analyze tissue and other clinical specimens, which should facilitate the identification of new biomarkers for early detection, prognosis, and therapy in lung cancer...
- Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene
Narayan Shivapurkar
Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cancer Res 68:7448-56. 2008
..Our data constitute the first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene...
- An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
Lauren Averett Byers
Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Clin Cancer Res 19:279-90. 2013
....
- Identification and validation of differences in protein levels in normal, premalignant, and malignant lung cells and tissues using high-throughput Western Array and immunohistochemistry
Jie Shen
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 66:11194-206. 2006
..In addition, some of the proteins detected by this approach may be novel biomarkers for early detection of lung cancer and novel targets for chemoprevention or therapy...
- EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients
Ximing Tang
Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA
Cancer Res 65:7568-72. 2005
..Our findings indicate that mutation of the tyrosine kinase domain of EGFR is an early event in the pathogenesis of lung adenocarcinomas, and suggest EGFR mutations as an early detection marker and chemoprevention target...
- Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions
Ximing Tang
Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Cancer 107:2637-46. 2006
..The findings indicate that NF-kappaB activation plays an important role in lung cancer pathogenesis and is a suitable target for the development of new lung cancer therapies and chemoprevention strategies...
- Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
Marie Wislez
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Res 65:3226-35. 2005
....
- Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas
David J Stewart
M D Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 15:3881-8. 2009
..By hypomethylating genes, decitabine may up-regulate factors required for chemotherapeutic cytotoxicity. Platinum-resistant cells may have reduced expression of the copper/platinum transporter CTR1...
- Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy
Fei Yang
Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 71:5512-21. 2011
....
- Differential expression of somatostatin receptors 1-5 in neuroendocrine carcinoma of the lung
Koji Tsuta
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Pathol Res Pract 208:470-4. 2012
..Except for SSTR5, all SSTRs showed a tendency toward decreased expression in well- to poorly differentiated NECs. We believe that these findings indicate important implications for the future of SST analog therapy...
- Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method
Seung Wook Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Cancer Res 67:6565-73. 2007
..These ASF proteins may be used to detect abnormal lesions in the lung without collecting invasive biopsy specimens...
- Using the mitosis-specific marker anti-phosphohistone H3 to assess mitosis in pulmonary neuroendocrine carcinomas
Koji Tsuta
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 136:252-9. 2011
..4 was the best threshold for differentiating ACs from TCs. These values correspond to 4/10 hpf and 10/10 hpf. We showed that the PHH3-based mitosis-counting method is a reliable, easy method for counting mitoses in pulmonary NECs...
- Cystic bronchioloalveolar cell carcinoma
Bradley S Sabloff
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Thorac Imaging 20:110-4. 2005
..Knowledge of the spectrum of radiologic manifestations of BAC and correlation with clinical history are important in suggesting the diagnosis and preventing misinterpretation...
- Characterizing the molecular spatial and temporal field of injury in early-stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling
Humam Kadara
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Prev Res (Phila) 6:8-17. 2013
..03). This study highlights spatial and temporal cancer-associated expression alterations in the molecular field of injury of patients with early-stage NSCLCs after definitive surgery that warrant further validation in independent studies...
- ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion
Weiwen Long
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Invest 122:1869-80. 2012
..As such, ERK3 protein kinase may be an attractive target for therapeutic treatment of invasive lung cancer...
- Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung
Koji Tsuta
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 59:526-36. 2011
....
- Cotargeting cyclin D1 starts a new chapter in lung cancer prevention and therapy
Edward S Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
Cancer Prev Res (Phila) 4:779-82. 2011
..These results, along with closely related clinical results of the BATTLE program, support the promise of this cotargeting approach for lung cancer prevention and therapy and of cyclin D1 as a predictive, personalizing marker for it...
- Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer
Lauren Averett Byers
Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cancer Ther 9:1755-63. 2010
..In conclusion, serum CAF profiling, particularly in HPV-negative patients, may be useful for identifying those at highest risk for recurrence...
- Oncocytic neuroendocrine tumors of the lung: histopathologic spectrum and immunohistochemical analysis of 15 cases
Koji Tsuta
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 42:578-85. 2011
..Although this variant does not differ in clinical features of nononcocytic neuroendocrine tumors, histologic features of the oncocytic neuroendocrine tumor can be a potential cause of diagnostic error...
- Sox10-positive sustentacular cells in neuroendocrine carcinoma of the lung
Koji Tsuta
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 58:276-85. 2011
..The aim of this study was to analyse the significance of sustentacular cells in pulmonary neuroendocrine carcinomas (NECs)...
- Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development
Woo Young Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Res 69:7439-48. 2009
..Furthermore, the use of selective IGF-IR inhibitors may be a rational approach to controlling lung cancer...
- Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone
Yerko Borghero
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 97, Houston, TX 77030, USA
Ann Surg Oncol 15:3147-56. 2008
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- The BATTLE to personalize lung cancer prevention through reverse migration
Kathryn A Gold
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer Prev Res (Phila) 4:962-72. 2011
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- Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers
Kristy L Richards
Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 117:606-17. 2011
....
- Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma
William D Travis
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Clin Oncol 23:3279-87. 2005
..To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC)...
- Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma
Doina Ivan
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Cutan Pathol 37:231-6. 2010
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- Genetics of preneoplasia: lessons from lung cancer
Ignacio I Wistuba
Department of Pathology and Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Curr Mol Med 7:3-14. 2007
..f) Finally, the identification of deregulated molecular signaling pathways in lung cancer preneoplasias may provide a rationale for designing novel strategies for early detection and targeted chemoprevention of lung cancer...
- Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer
Jian Gu
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 12:7329-38. 2006
..0007). CONCLUSION: Hypermethylation of multiple genes exhibited significant differential effect on NSCLC patient survival. Assessment of the effect of each methylated gene on survival is needed to provide optimal prognostic value...
- Epidermal growth factor receptor abnormalities in lung cancer. Pathogenetic and clinical implications
Ludmila Prudkin
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Ann Diagn Pathol 10:306-15. 2006
..Importantly, the findings of EGFR abnormalities in lung cancer have supported the notion that different molecular mechanisms and pathways are involved in the pathogenesis of lung cancer arising in never and ever smokers...
- Methodological and practical challenges for personalized cancer therapies
Ignacio I Wistuba
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Nat Rev Clin Oncol 8:135-41. 2011
..These challenges include limitations of current biomarker development methodologies and regulatory and reimbursement policies and practices...
- Molecular pathology of thymic epithelial neoplasms
Elisabetta Kuhn
Department of Pathology Unit 85, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Hematol Oncol Clin North Am 22:443-55. 2008
..However, this progress is still limited and has not led to better tumor classifications, prognostication of outcome, and design of molecular targeted therapy...
- Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway
Dianren Xia
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 282:3507-19. 2007
..Thus, MKK4 promotes cell survival by activating phosphatidylinositol 3-kinase through an NFkappaB/PTEN-dependent pathway...
- Bronchioalveolar cell carcinoma: radiologic appearance and dilemmas in the assessment of response
Bradley S Sabloff
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Lung Cancer 6:108-12. 2004
..Other imaging modalities, such as positron emission tomography scanning, may prove helpful in assessing the metabolic response to therapy but have yet to be proven effective...
- HER Receptor Family: Novel Candidate for Targeted Therapy for Gallbladder and Extrahepatic Bile Duct Cancer
Toru Kawamoto
Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX
Gastrointest Cancer Res 1:221-7. 2007
..Tumor specimens from patients from the United States and Chile were examined for expression of HER-2/neu, EGFR, and their activated forms (p-erbB2, p-EGFR)...
- Gallbladder cancer: lessons from a rare tumour
Ignacio I Wistuba
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Nat Rev Cancer 4:695-706. 2004
..An understanding of how these risk factors contribute to the molecular basis of the disease is essential for understanding the origins of this unusual cancer...
- Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells
Ximing Tang
Molecular Biology Laboratory, Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Unit 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Res 2:685-91. 2004
..These results suggest that DAP kinase is involved in TRAIL-mediated cell apoptosis and that a demethylating agent may have a role in enhancing TRAIL-mediated apoptosis in some NSCLC cells by reactivation of DAP kinase...
- Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures
Shinichi Toyooka
Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA
Clin Cancer Res 8:2292-7. 2002
..CONCLUSIONS: We found differential FEZ1 expression in NSCLC and SCLC cell lines, and the absent expression in 3 of 6 short-term cultures of NSCLC tumors. FEZ1 may be related to tumorigenesis of lung cancer...
- Characteristic genetic alterations in lung cancer
Ignacio I Wistuba
Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
Methods Mol Med 74:3-28. 2003
....
- Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
Yanan Yang
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 3:e2220. 2008
..The signals activated by oncogenic K-ras that mediate BASC expansion have not been fully defined...
- Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
Hisayuki Shigematsu
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA
Cancer Res 65:1642-6. 2005
..EGFR, HER2, and KRAS mutations are mutually exclusive, suggesting different pathways to lung cancer in smokers and never smokers...
- Smoking molecular damage in bronchial epithelium
Ignacio I Wistuba
Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, Santiago, P.O. Box 114-D, Chile
Oncogene 21:7298-306. 2002
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- Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
Masaharu Nomura
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS Med 4:e125. 2007
..The objective of this study was to examine distributions of these three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers...
- Application of a methylation gene panel by quantitative PCR for lung cancers
Narayan Shivapurkar
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cancer Lett 247:56-71. 2007
..Our preliminary data on the analysis of sputum DNA specimens from cancer patients further support these observations...
- Histologic evaluation of bronchial squamous lesions: any role in lung cancer risk assessment?
Ignacio I Wistuba
Clin Cancer Res 11:1358-60. 2005
- Clonality of combined tumors
Jiaoti Huang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
Arch Pathol Lab Med 126:437-41. 2002
..However, in a minority of these tumors, different areas may be derived from different precursor cells...
- Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
Hisayuki Shigematsu
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
J Natl Cancer Inst 97:339-46. 2005
..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
- Mismatch repair expression in testicular cancer predicts recurrence and survival
Alfredo Velasco
Department of Urology, Pontificia Universidad Catolica de Chile, Santiago, Chile
Int J Cancer 122:1774-7. 2008
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- Aromatase expression predicts survival in women with early-stage non small cell lung cancer
Vei Mah
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1747, USA
Cancer Res 67:10484-90. 2007
..We predict that women whose lung cancers have higher levels of aromatase might be good candidates for targeted treatment with aromatase inhibitors...
- Characterizing the cancer genome in lung adenocarcinoma
Barbara A Weir
Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 450:893-8. 2007
..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
- TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma
Mauricio Moreno
Department of Gastroenterology, Pontificia Universidad Catolica de Chile, P O Box 114 D Santiago, Chile
Ann Hepatol 4:192-9. 2005
..GBC is preceded by gallstones, chronic cholecystitis and dysplastic changes of the gallbladder epithelium. The knowledge of the molecular events involved in its pathogenesis is scarce...
- Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question
Kevin M Haigis
Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Genes Dev 21:361-6. 2007
- Aberrant methylation of Reprimo in human malignancies
Takao Takahashi
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
Int J Cancer 115:503-10. 2005
..Aberrant methylation of Reprimo with loss of expression is a common event and may contribute to the pathogenesis of some types of human malignancy...
- A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
Anissa N Elayadi
Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Cancer Res 67:5889-95. 2007
..Thus, cell-specific peptides isolated from phage biopanning can be used for the discovery of cell surface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell...
- Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma
Erick Riquelme
Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, 85 Lira St Santiago 133202, Chile
Cancer Lett 250:100-6. 2007
..We conclude that epigenetic inactivation by abnormal promoter methylation is a frequent event in chromosome 3p candidate TSGs in GBC pathogenesis, especially affecting genes SEMA3B (3p21.3) and FHIT (3p14.2)...
- Mismatch repair gene expression and genetic instability in testicular germ cell tumor
Alfredo Velasco
Department of Urology, Catholic University of Chile, Santiago, Chile
Cancer Biol Ther 3:977-82. 2004
..Fifteen percent of testicular GCT exhibited loss of heterozygosity (LOH) but no MSI (LOH only tumors). Only 28, 17 or 6% of LOH only tumors exhibited low MSH2, low MLH1 or low MSH2 and low MLH1 staining respectively...
- The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer
Shinichi Toyooka
Department of Cancer and Thoracic Surgery, Okayama University, Okayama, Japan
Clin Cancer Res 13:5763-8. 2007
..In this study, we extensively investigated the impact of sex and smoking on the EGFR mutation...
