Paul Winner

..This article reviews the practical diagnostic issues related to migraine in the pediatric population...

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..In this article, the diagnostic issues related to childhood periodic syndromes and migraine in the IHS 2004 revisions are reviewed...

..The aim of this study was to assess the efficacy and tolerability of sumatriptan injection in the treatment of morning migraine...

..To evaluate the long-term safety and tolerability of sumatriptan-naproxen sodium for the treatment of moderate to severe acute migraines and to assess the safety of administration of an optional second dose...

..These criteria provide the scientific basis for the study of headache, including the determination of the incidence and prevalence of pediatric migraine...

..Recent studies have revealed the increasing incidence of migraine and chronic migraine in the pediatric population...

..Further research in pediatric headaches is needed to help reveal additional pathophysiologic mechanisms and improve diagnostic criteria...

..CONCLUSIONS: This study suggests that sumatriptan may be beneficial to some adolescents and is generally well tolerated in the acute treatment of migraine in this population...

..In clinical trials evaluating sumatriptan in the treatment of moderate or severe migraine pain, the 50- and 100-mg doses have been comparably effective and well tolerated...

..Eletriptan is a potent 5-HT(1B/1D) agonist with proven efficacy in the acute treatment of migraine in adults...

..CONCLUSIONS: This post hoc subset analysis suggests that topiramate 100 and 200 mg/day, and possibly 50 mg/day, administered prophylactically for 26 weeks may reduce migraine in adolescents...

..To assess efficacy and tolerability of rizatriptan orally disintegrating tablet (ODT) for treatment of acute migraine in patients using topiramate for migraine prophylaxis...

..365), and the weekend placebo response rate was similar to that seen in adults. CONCLUSIONS: Rizatriptan 5 mg was well tolerated and effective on some measures when used in adolescents for the treatment of a migraine attack...

..Because these studies were not powered to detect statistical differences between active doses, studies to investigate this finding are warranted...

..The management of the expectations of both the patient and family are the key to a good outcome...

..CONCLUSION: Study results suggest that the triptan class of antimigraine drugs may effectively alleviate migraine in adolescents. Future research should address placebo response and earlier treatment paradigms...

..Topiramate was well tolerated in this population. Further randomized studies would be required to definitively establish the efficacy of topiramate for pediatric migraine prevention...

..In this article, the diagnostic issues related to migraine and childhood periodic syndromes in the IHS 2004 revisions are reviewed...

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..2% sumatriptan, 2.8% placebo). CONCLUSION: This trial confirmed that eletriptan 40 mg offers superior efficacy in treating migraine pain and associated symptoms and in restoring patient functioning when compared with sumatriptan 100 mg...

..Each of these drugs has a unique pharmacokinetic and pharmacodynamic profile, which may support a clinical preference for one intranasal agent over another in treating patients with specific headache features...

..4%...

..Recent advances in diagnosis, epidemiology, and treatment have improved the outcomes of children with headaches. This review summarizes some of these findings...

..Comparison of use of therapeutic gain (TG) and therapeutic ratio (TR) for relative assessments of selective 5HT(1B/1D) agonist efficacy in the acute treatment of migraine...

..The goal was to evaluate the efficacy and tolerability of zolmitriptan nasal spray in the treatment of adolescent migraine...

..Rizatriptan 5 mg was well tolerated in adolescents during short-term and long-term use...

..Furthermore, accurate information regarding the timeliness of treatment and reporting of headache-related information by adolescents is difficult...