Mechanisms of the antioxidant effects of nitric oxideD A Wink
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Antioxid Redox Signal 3:203-13. 2001
..This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress...
- Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress
D A Wink
Tumor Biology Section, Radiation Biology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:11147-51. 1997
..The results suggest that oxidation and nitrosation of thiols by superoxide and NO are determined by their relative fluxes and may have physiological significance...
- Regulation of transforming growth factor beta1 by nitric oxide
Y Vodovotz
Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 59:2142-9. 1999
..These results provide the first evidence that nitrosative stress influences the regulation of TGF-beta1 and raise the possibility that NO production may augment TGF-beta1 activity by modifying a naturally occurring neutralizing peptide...
- Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines: role of TNF-alpha
L C McKinney
Department of Radiation Pathophysiology and Toxicology, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA
J Leukoc Biol 64:459-66. 1998
..We conclude (1) that irradiated cells produce more NO in response to either IFN-gamma or LPS and (2) that the increase is mediated by induction of TNF-alpha...
- The role of nitric oxide chemistry in cancer treatment
D A Wink
Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Biochemistry (Mosc) 63:802-9. 1998
..This manuscript will discuss some mechanisms involved with NO and cancer treatment modalities and the potential application of these findings to cancer therapy...
- Distinction between nitrosating mechanisms within human cells and aqueous solution
M G Espey
Radiation Biology Branch, Division of Clinical Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:30085-91. 2001
..Although NO(2) was not a component of aqueous NO autoxidation, the results suggest that the intermediacy of this species may be a significant factor in the advent of either nitrosation or oxidation chemistry in biological systems...
- Mechanisms of cell death governed by the balance between nitrosative and oxidative stress
M G Espey
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 899:209-21. 2000
..We here describe how the mechanisms of cell death are interwoven in the balance between the different chemical intermediates involved in nitrosative and oxidative stress...
- A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity
K M Miranda
Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
J Inorg Biochem 79:237-40. 2000
..This report discusses several examples of cytotoxicity involved with these stresses...
Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapyC H Switzer
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Oncogene 30:2504-13. 2011
..These results establish SET as a novel molecular target and that the inhibition of SET may have beneficial effects in cancer chemotherapy...
- Qualitative and quantitative analysis of DNA fragmentation using digital imaging
Y Vodovotz
Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Anal Biochem 250:147-52. 1997
..Integration of the areas specifically under the peaks yields a quantitative measure of apoptosis. We provide a useful, rapid, and objective means to quantitate apoptosis, using relatively inexpensive hardware and software...
- Effects of nitric oxide on reactive oxygen species production and infarction size after brain reperfusion injury
R M Pluta
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
Neurosurgery 48:884-92; discussion 892-3. 2001
..We hypothesized that, during reperfusion, exogenous nitric oxide (NO) would reduce stroke size by quenching ROS...
- A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
K M Miranda
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, Maryland 20892, USA
Nitric Oxide 5:62-71. 2001
..This report introduces a new, convenient assay for the stable oxidation products of nitrogen oxide chemistry in biological samples...
- Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion
K M Miranda
Tumor Biology Section, Radiation Biology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:1720-7. 2001
..Given that the cytotoxicity of AS is far greater than that of either NO/N2O3 or NO + O2, this study provides important new insights into the implications of the potential endogenous formation of NO- under inflammatory conditions in vivo...
- Nitric oxide enhancement of melphalan-induced cytotoxicity
J A Cook
Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Br J Cancer 76:325-34. 1997
..Our observations may give insights for improving tumour kill with melphalan using either exogenous or possibly endogenous sources of NO...
- Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase
X Zhou
Laboratory of Human Carcinogenesis, Radiation Biology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:21241-6. 2000
..Our results are consistent with the hypothesis that nitrosative stress, mediated by N(2)O(3), can result in the inhibition of norepinephrine biosynthesis and may contribute to the regulation of neurotransmission and vasodilatation...
- Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity
C H Switzer
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Oncogene 28:3837-46. 2009
..In addition to ACS-1, other dithiolethione compounds showed similar effects in reducing Akt activation, suggesting that this class of compounds may have other effects beyond chemoprevention...
- Ionizing radiation potentiates the induction of nitric oxide synthase by interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines. Role of tumor necrosis factor-alpha
L C McKinney
Department of Radiation Pathophysiology and Toxicology, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5145, USA
Ann N Y Acad Sci 899:61-8. 2000
..Radiation alone did not produce this induction, rather, it was effective as a priming signal; cells exposed to radiation produced more NO when a second signal, either IFN-gamma or LPS, was applied 24 h later...
