Andreas Windemuth

Summary

Publications

  1. pmc Physiogenomic analysis of localized FMRI brain activity in schizophrenia
    Andreas Windemuth
    Genomas, Inc, Hartford, CT, 06106, USA
    Ann Biomed Eng 36:877-88. 2008
  2. doi Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
    Andreas Windemuth
    Genomas, Inc and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA
    Prog Neuropsychopharmacol Biol Psychiatry 36:213-9. 2012
  3. pmc Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients
    GUALBERTO RUANO
    Genomas Inc, Hartford, CT 06106, USA
    Biomark Med 5:439-49. 2011
  4. pmc Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Pharmacogenomics 11:959-71. 2010
  5. doi Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT, United States
    Clin Chim Acta 400:48-55. 2009
  6. pmc Mechanisms of statin-induced myalgia assessed by physiogenomic associations
    GUALBERTO RUANO
    Genetics Research Center, Hartford Hospital, Hartford, CT, USA
    Atherosclerosis 218:451-6. 2011
  7. pmc Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes
    David Villagra
    Genomas Inc, Hartford, CT, USA
    Biomark Med 5:427-38. 2011
  8. ncbi Physiogenomic association of statin-related myalgia to serotonin receptors
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
    Muscle Nerve 36:329-35. 2007
  9. doi Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing
    Joan Landino
    Integrated Psychiatric Services, Inc, North Haven, Connecticut, USA
    J Am Acad Nurse Pract 23:459-63. 2011
  10. pmc Genetic associations of brain structural networks in schizophrenia: a preliminary study
    Kanchana Jagannathan
    Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut 06106, USA
    Biol Psychiatry 68:657-66. 2010

Collaborators

Detail Information

Publications22

  1. pmc Physiogenomic analysis of localized FMRI brain activity in schizophrenia
    Andreas Windemuth
    Genomas, Inc, Hartford, CT, 06106, USA
    Ann Biomed Eng 36:877-88. 2008
    ..The results of this study support the physiogenomic analysis of neuroimaging data to discover associations between genotype and disease-related phenotypes...
  2. doi Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
    Andreas Windemuth
    Genomas, Inc and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA
    Prog Neuropsychopharmacol Biol Psychiatry 36:213-9. 2012
    ..We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population...
  3. pmc Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients
    GUALBERTO RUANO
    Genomas Inc, Hartford, CT 06106, USA
    Biomark Med 5:439-49. 2011
    ....
  4. pmc Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Pharmacogenomics 11:959-71. 2010
    ..We hypothesized novel genetic underpinnings for variation in LDLC levels in the context of statin therapy...
  5. doi Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT, United States
    Clin Chim Acta 400:48-55. 2009
    ..The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema...
  6. pmc Mechanisms of statin-induced myalgia assessed by physiogenomic associations
    GUALBERTO RUANO
    Genetics Research Center, Hartford Hospital, Hartford, CT, USA
    Atherosclerosis 218:451-6. 2011
    ..We investigated genetic variants predictive of muscular side effects in patients treated with statins. We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia...
  7. pmc Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes
    David Villagra
    Genomas Inc, Hartford, CT, USA
    Biomark Med 5:427-38. 2011
    ..Each index considers all three genes as complementary components of a liver enzyme drug metabolism system and uniquely benchmarks innate hepatic drug metabolism reserve or alteration through CYP450 combinatory genotype scores...
  8. ncbi Physiogenomic association of statin-related myalgia to serotonin receptors
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
    Muscle Nerve 36:329-35. 2007
    ..Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients...
  9. doi Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing
    Joan Landino
    Integrated Psychiatric Services, Inc, North Haven, Connecticut, USA
    J Am Acad Nurse Pract 23:459-63. 2011
    ..To illustrate the utility of CYP450 genotyping to guide clinical psychopharmacological treatment decisions and minimize or avoid harmful and costly adverse drug reactions (ADRs)...
  10. pmc Genetic associations of brain structural networks in schizophrenia: a preliminary study
    Kanchana Jagannathan
    Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut 06106, USA
    Biol Psychiatry 68:657-66. 2010
    ..We used structural parameters as potential intermediate illness markers to investigate genomic factors derived from single nucleotide polymorphism (SNP) arrays...
  11. pmc CYP2C9 and VKORC1 genotypes in Puerto Ricans: A case for admixture-matching in clinical pharmacogenetic studies
    David Villagra
    Laboratory of Personalized Health, Genomas, Inc, Hartford, CT 06106, USA
    Clin Chim Acta 411:1306-11. 2010
    ..Accordingly, this study is aimed at investigating whether a correlation between overall genetic similarity and CYP2C9 and/or VKORC1 genotypes could be established...
  12. pmc Physiogenomic analysis of the Puerto Rican population
    GUALBERTO RUANO
    Genomas Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Pharmacogenomics 10:565-77. 2009
    ..This research was aimed at determining the frequencies of SNPs in key physiological, pharmacological and biochemical genes to infer population structure and ancestry in the Puerto Rican population...
  13. ncbi Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT 06106, USA
    Pharmacogenomics 6:865-72. 2005
    ....
  14. pmc Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
    Richard L Seip
    Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
    Nutr Metab (Lond) 5:4. 2008
    ..We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets...
  15. ncbi Somatic complications of psychotropic medications in a patient with multiple CYP2 drug metabolism deficiencies
    GUALBERTO RUANO
    Genomas Inc, Hartford, USA
    Conn Med 71:197-200. 2007
    ..DNA typing for multigene CYP2 deficiencies is diagnostically useful in individuals with histories of multiple ADRs, which could be avoided by DNA-guided individualized prescription...
  16. ncbi Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Atherosclerosis 185:65-9. 2006
    ..3+/-6.6 mg/dL versus 4.7+/-1.2 mg/dL, p<0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training...
  17. ncbi How many SNPs does a genome-wide haplotype map require?
    Richard Judson
    Genaissance Pharmaceuticals, 5 Science Park, New Haven, CT 06511, USA
    Pharmacogenomics 3:379-91. 2002
    ..Finally, we estimate the experimental effort and cost required to complete a genome-wide haplotype survey...
  18. ncbi Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels
    Jose de Leon
    University of Kentucky Mental Health Research Center at Eastern State Hospital, College of Medicine, Lexington, Kentucky 40508, United States
    Schizophr Res 98:40-6. 2008
    ..These genes may be promising candidates for studies of the direct effects of some antipsychotics on hyperlipidemia...
  19. ncbi Designing physiogenomic studies
    Theodore R Holford
    Pharmacogenomics 7:157-8. 2006
  20. ncbi New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals
    Richard Judson
    Genaissance Pharmaceuticals, 5 Science Park, New Haven, CT 06511, USA
    Atherosclerosis 177:345-51. 2004
    ..63 mg/L for subjects with zero copies of APOE4). We also tested previously reported associations between CRP levels and polymorphisms in the CRP and IL6 genes. These associations were not reproduced in our cohort...
  21. ncbi Genome-wide evaluation of the public SNP databases
    Ruhong Jiang
    Genaissance Pharmaceuticals, 5 Science Park, New Haven, CT 06511, USA
    Pharmacogenomics 4:779-89. 2003
    ..Finally, a relatively large fraction (> 40%) of SNPs in these databases were not seen in our study, which means that they are either of very low frequency, mismapped, or not polymorphic at all...
  22. pmc Integrating genomic based information into clinical warfarin (Coumadin) management: an illustrative case report
    Anthony LaSala
    Hartford Hospital, USA
    Conn Med 72:399-403. 2008
    ..This illustrative case report demonstrates the clinical importance of this new information. Clinicians need to incorporate these new genomic findings into appropriate management of warfarin dose anticoagulation...