HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cellsMarc A Williams
Division of Pediatric Infectious Diseases, University of California at San Diego, The School of Medicine, La Jolla 92093, USA
J Hematother Stem Cell Res 11:829-47. 2002
..Consequently, HIV-1 gp120 may actively contribute to the immunopathogenesis of AIDS...
- In vitro cytotoxic effects of stabilizing sugars within human intravenous immunoglobulin preparations against the human macrophage THP-1 cell-line
Marc A Williams
Department of Neurology, The Neuromuscular Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7881, USA
Hematology 8:285-94. 2003
..This observation was evident when preparations of IVIg were used at high concentrations but not at levels one would associate with clinically relevant doses of IVIg...
Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligandsMarc A Williams
Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, N Y, USA
J Innate Immun 2:123-43. 2010
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- Could the functional expression of HLA-G be exploited for successful stem cell transplantation and engraftment?
Marc A Williams
Department of Neurology, Neuromuscular Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7519, USA
J Hematother Stem Cell Res 12:757-8. 2003
- Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract
Tirumalai Rangasamy
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Respir Cell Mol Biol 43:276-85. 2010
..Our findings indicate that a defect in Nrf2-mediated signaling mechanisms alters the response of DCs to a common environmental allergen, which may contribute to the susceptibility to allergic diseases...
- Diesel-enriched particulate matter functionally activates human dendritic cells
Michael Porter
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 37:706-19. 2007
..Our data support the hypothesis that DEP (and to a lesser extent CEP) regulate important functional aspects of human DC, supporting an adjuvant role for this material...
- Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter
Marc A Williams
Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 181:4545-59. 2008
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- Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells
Rongbing Chen
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21212, USA
Stem Cells Dev 15:797-804. 2006
..Lysophosphatidic acid fine-tunes the effects of LPS on human myeloid DC maturation, but does not exert a dominant effect on the ability of DC to influence Th cell polarization...
Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responsesJia Guo
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY, USA
J Allergy Clin Immunol 122:195-201, 201.e1-5. 2008
..The transcription factor Yin-Yang 1 (YY-1) binds to the promoter regions of several T-cell cytokine genes, but the expression and contribution of this factor to cytokine gene expression and T-cell activation in vivo is not clear...
- Yin yang 1 is a novel regulator of pulmonary fibrosis
Xin Lin
Department of Medicine, University of Rochester Medical School, Rochester, New York 14642, USA
Am J Respir Crit Care Med 183:1689-97. 2011
..The transcription factor Yin Yang 1 (YY1) plays a role in the proliferation and differentiation of diverse cell types, but its role in fibrotic lung diseases is not known...
- TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells
Marc A Williams
University of Rochester School of Medicine and Dentistry, Division of Pulmonary and Critical Care Medicine, Rochester, New York, U S A
Biomark Insights 2:226-40. 2007
..While further studies are warranted, we suggest that alterations in TLR2 and TLR4 expression should be explored as potential biomarkers of DC exposure to environmental particulate pollution...
- Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells
Marc A Williams
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 119:488-97. 2007
..Ambient particulate matter (APM) is ubiquitous and associated with allergic diseases, but it is unknown whether APM directly activates DCs...
- Maximizing immune responses: the effects of covalent peptide linkage to beta-2-microglobulin
Stephen M Bauer
Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine, Rochester, NY 14642 8692, USA
Oncol Res 17:205-16. 2008
..We conclude that vaccines incorporating peptides covalently linked to beta2m may have future potential in the specific targeting of human malignancy...
- Neural stem cells: one of the keys to everything
Marc A Williams
J Hematother Stem Cell Res 12:591-4. 2003
- The therapeutic promise of nonembryonic stem cells--where's the beef?
Denis English
J Hematother Stem Cell Res 12:465-6. 2003
