David L Williams

Summary

Publications

  1. ncbi request reprint Oxidation, antioxidants and cataract formation: a literature review
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Ophthalmol 9:292-8. 2006
  2. doi request reprint Cardiac biology and disease in invertebrates
    David Williams
    Department of Veterinary Medicine, University of Cambridge, St John s College, Cambridge CB3 0ES, UK
    Vet Clin North Am Exot Anim Pract 12:1-9, v. 2009
  3. ncbi request reprint Entropion correction by fornix-based suture placement: use of the Quickert-Rathbun technique in ten dogs
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Ophthalmol 7:343-7. 2004
  4. ncbi request reprint Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    Curr Eye Res 29:215-8. 2004
  5. doi request reprint Congenital abnormalities in production animals
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Clin North Am Food Anim Pract 26:477-86. 2010
  6. doi request reprint Immunopathogenesis of keratoconjunctivitis sicca in the dog
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, England, UK
    Vet Clin North Am Small Anim Pract 38:251-68, vi. 2008
  7. doi request reprint Preface
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Clin North Am Small Anim Pract 38:xi-xii. 2008
  8. ncbi request reprint Analysis of tear uptake by the Schirmer tear test strip in the canine eye
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Ophthalmol 8:325-30. 2005
  9. doi request reprint Oxidative stress and the eye
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK St John s College, Cambridge CB2 1TP, England, UK
    Vet Clin North Am Small Anim Pract 38:179-92, vii. 2008
  10. ncbi request reprint Aggravating factors in the development of ocular abnormalities in farmed Atlantic halibut (Hippoglossus hippoglossus)
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Vet J 172:501-5. 2006

Collaborators

  • Claudia Hartley
  • M Fred Heath
  • Shona Wilson
  • Clancy B Blair
  • Xiang Gao
  • Jing Ma
  • Gm Anantharamaiah
  • V J Adams
  • V R Simpson
  • D Burnett
  • Gordon D Brown
  • G E Haddad
  • Yan Li
  • E D Murphey
  • Philip R Tiller
  • Edward Sherwood
  • Fang Hua
  • Tuanzhu Ha
  • Chuanfu Li
  • Jim Kelley
  • Race L Kao
  • I William Browder
  • Ahmed A Sayed
  • Yeling Xia
  • Stephen T Thuahnai
  • Wei Lemaire
  • Joon Young Kim
  • Sheila Donnelly
  • John H Kalbfleisch
  • Angela N Kuntz
  • Seigo Izumo
  • John B Schweitzer
  • Julie R McMullen
  • Tetsuo Shioi
  • Juergen Luhm
  • Aiqiu Zhao
  • Olga I Lyuksutova
  • Janet A Willment
  • Gene G Kinney
  • Ariëtte van Bennekum
  • Stephen M Krause
  • Michael C Phillips
  • Douglas J Pettibone
  • Maryann Burno
  • Julie A O'Brien
  • Heather M Alger
  • Ryan E Temel
  • Young Min Choi
  • Soon Wuk Jeong
  • William Browder
  • Sandra M O'Neill
  • Colin M Stack
  • Xiang Liu
  • John P Dalton
  • Elisabeth Davioud-Charvet
  • Elias S J Arner
  • Lindsay L Califf
  • Jean Dessolin
  • Nadine Wittkopf
  • Shawna K Cook
  • Ulrich Langenkamp
  • Christoph Frohn
  • Jenny Hensel
  • Petra Koritke
  • John Kalbfleisch
  • Antje Mueller
  • Lothar Rink
  • Daniel Grant
  • Joerg M Brand
  • Holger Hennig
  • Jim L Kelley
  • Sheri Smith
  • Phu Duong
  • Denise J Bickel
  • Weihua Cui
  • David D Wisnoski
  • Delyth M Reid
  • Mark E Duggan
  • Chang Hoon Han
  • Craig W Lindsley
  • Cheng Y Lin
  • Michelle K Clements
  • Georg Schulthess
  • Marlene A Jacobson
  • Cyrille Sur
  • Moritz Werder
  • P Jeffrey Conn
  • Simon Y C Wong
  • Siamon Gordon
  • Tracy E Toliver-Kinsky

Detail Information

Publications67

  1. ncbi request reprint Oxidation, antioxidants and cataract formation: a literature review
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Ophthalmol 9:292-8. 2006
    ....
  2. doi request reprint Cardiac biology and disease in invertebrates
    David Williams
    Department of Veterinary Medicine, University of Cambridge, St John s College, Cambridge CB3 0ES, UK
    Vet Clin North Am Exot Anim Pract 12:1-9, v. 2009
    ..Examining invertebrates with gene defects similar to those in human patients with heart disease, congenital or acquired, allows us to probe deeply into the aetiopathogenesis of many cardiac conditions...
  3. ncbi request reprint Entropion correction by fornix-based suture placement: use of the Quickert-Rathbun technique in ten dogs
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Ophthalmol 7:343-7. 2004
    ..Fornix-based suture placement is a novel approach to entropion correction in the dog which yields acceptable results in the majority of suitable cases without recourse to incisional surgery...
  4. ncbi request reprint Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    Curr Eye Res 29:215-8. 2004
    ..To determine, by a plaque reduction assay, the in vitro efficacy of novel antiviral agents in the treatment of feline herpes virus 1 (FHV-1) keratitis in the domestic cat (Felis felis)...
  5. doi request reprint Congenital abnormalities in production animals
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Clin North Am Food Anim Pract 26:477-86. 2010
    ..This article discusses recent research into several conditions to demonstrate the opportunities that exist for investigating such conditions both from a genetic and an environmental perspective...
  6. doi request reprint Immunopathogenesis of keratoconjunctivitis sicca in the dog
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, England, UK
    Vet Clin North Am Small Anim Pract 38:251-68, vi. 2008
    ..It is hoped that this review spurs further research into the etiopathogenic factors in canine KCS...
  7. doi request reprint Preface
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Clin North Am Small Anim Pract 38:xi-xii. 2008
  8. ncbi request reprint Analysis of tear uptake by the Schirmer tear test strip in the canine eye
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Ophthalmol 8:325-30. 2005
    ..To analyze the uptake of tears in a Schirmer tear test (STT) in vitro and in vitro...
  9. doi request reprint Oxidative stress and the eye
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK St John s College, Cambridge CB2 1TP, England, UK
    Vet Clin North Am Small Anim Pract 38:179-92, vii. 2008
    ....
  10. ncbi request reprint Aggravating factors in the development of ocular abnormalities in farmed Atlantic halibut (Hippoglossus hippoglossus)
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Vet J 172:501-5. 2006
    ....
  11. ncbi request reprint Major histocompatibility class II expression in the normal canine cornea and in canine chronic superficial keratitis
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Ophthalmol 8:395-400. 2005
    ..To compare the expression of major histocompatibility complex (MHC) class II antigen in the corneas of normal dogs and dogs affected with chronic superficial keratitis (CSK)...
  12. ncbi request reprint Prevalence of feline cataract: results of a cross-sectional study of 2000 normal animals, 50 cats with diabetes and one hundred cats following dehydrational crises
    David L Williams
    Queen s Veterinary School Small Animal Hospital, University of Cambridge, Madingley Road, Cambridge, England, CB3 0ES, UK
    Vet Ophthalmol 9:341-9. 2006
    ..In this study 2000 normal cats, 50 cats with diabetes and 100 cats with a history of dehydrational crises were examined ophthalmoscopically to determine presence of cataract...
  13. ncbi request reprint The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 OES, England, UK
    Vet Ophthalmol 9:311-6. 2006
    ..To determine the efficacy of a topical antioxidant formulation including N-acetyl carnosine in the treatment of canine cataract in a preliminary nonplacebo, controlled, unmasked study...
  14. doi request reprint Feline entropion: a case series of 50 affected animals (2003-2008)
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Vet Ophthalmol 12:221-6. 2009
    ..To evaluate the signalment, clinical signs, and etiopathogenesis of entropion in 50 cats...
  15. ncbi request reprint Intraocular oxygen tensions in normal and diseased eyes of farmed halibut
    D L Williams
    Department of Clinical Veterinary Medicine, Madingley Road, Cambridge CB3 OES, UK
    Vet J 167:81-6. 2004
    ..High levels of oxygen were demonstrated in samples of aqueous from all fish but fish with affected eyes had a statistically significantly higher partial pressure of oxygen than did fish with normal eyes...
  16. ncbi request reprint Biology and pathology of the invertebrate eye
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England
    Vet Clin North Am Exot Anim Pract 5:407-15. 2002
    ....
  17. ncbi request reprint Ocular disease in rats: a review
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Ophthalmol 5:183-91. 2002
    ..Here, ophthalmic conditions are reviewed in order to provide a survey of ocular disease in the rat both for veterinary ophthalmologists and for laboratory animal veterinarians and research workers...
  18. doi request reprint Lack of effects on lymphocyte function from chronic topical ocular cyclosporine medication: a prospective study
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Ophthalmol 13:315-20. 2010
    ..This study aimed to repeat the previous study and to compare the systemic effects of 2% cyclosporine in corn oil and 0.2% topical cyclosporine ointment (Optimmune, Intervet-Schering Plough, Welwyn, UK)...
  19. ncbi request reprint Symblepharon with aberrant protrusion of the nictitating membrane in the snowy owl (Nyctea scandiaca)
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, CB3 OES, UK
    Vet Ophthalmol 6:11-3. 2003
    ..Surgical intervention ameliorated the clinical signs, allowing vision in one bird by removal of the nictitating membranes, a technique which appeared to have no deleterious effects on the ocular surface...
  20. doi request reprint Extraocular myositis in the dog
    David L Williams
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, England, UK
    Vet Clin North Am Small Anim Pract 38:347-59, vii. 2008
    ....
  21. ncbi request reprint Biology and pathology of interactions between fungi and invertebrates
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Clin North Am Exot Anim Pract 6:289-300. 2003
    ..And yet it is hoped that it will have provided an interesting and informative (not to say exotic!) introduction to the important area of mycotic disease in exotic species...
  22. ncbi request reprint Prevalence of canine cataract: preliminary results of a cross-sectional study
    D L Williams
    Queen s Veterinary School Small Animal Hospital, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Vet Ophthalmol 7:29-35. 2004
    ..In this study 2000 dogs were examined ophthalmoscopically to determine presence of cataract...
  23. ncbi request reprint Oral biology and disease in invertebrates
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Clin North Am Exot Anim Pract 6:459-65. 2003
    ....
  24. ncbi request reprint Effect of age, gender, weight, and time of day on tear production in normal dogs
    Claudia Hartley
    The Queens Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Ophthalmol 9:53-7. 2006
    ..To investigate the effects of age, weight, gender, and of time of day on tear production in normal dogs...
  25. ncbi request reprint Lens morphometry determined by B-mode ultrasonography of the normal and cataractous canine lens
    David L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet Ophthalmol 7:91-5. 2004
    ..To determine axial lens thickness, anterior chamber depth and axial globe length in canine eyes with normal lenses and in eyes with immature, mature, congenital, posterior polar and diabetic cataract...
  26. doi request reprint Effect of bovine freeze-dried amniotic membrane (Amnisite-BA) on uncomplicated canine corneal erosion
    Joon Young Kim
    Department of Veterinary Medicine, Madingley Road, Cambridge, UK
    Vet Ophthalmol 12:36-42. 2009
    ..To evaluate the effectiveness of bovine freeze-dried amniotic membrane (FD-AM) (Amnisite-BA) in the surgical treatment of corneal ulceration in dogs...
  27. doi request reprint Welfare issues in farm animal ophthalmology
    David L Williams
    Veterinary Ophthalmology and Animal Welfare, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, England, UK
    Vet Clin North Am Food Anim Pract 26:427-35. 2010
    ..This article discusses the welfare implications of the ocular conditions covered further in the following articles and how these affect treatment of these diseases...
  28. ncbi request reprint Efficacy of topical aciclovir for the treatment of feline herpetic keratitis: results of a prospective clinical trial and data from in vitro investigations
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES
    Vet Rec 157:254-7. 2005
    ..The study shows that even though aciclovir is generally considered to lack efficacy against ocular FHV-1 infection, when used frequently it can have a beneficial effect in FHV-1 conjunctivitis and keratitis...
  29. pmc Clinical pathology accreditation: standards for the medical laboratory
    D Burnett
    Lindens Lodge, Bradford Place, Penarth CF64 1LA, UK
    J Clin Pathol 55:729-33. 2002
    ..CPA plans to introduce these standards in the UK in 2003 following extensive consultation with professional bodies, piloting in selected laboratories, and training of assessors...
  30. ncbi request reprint Chronic ocular lesions in tawny owls (Strix aluco) injured by road traffic
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES
    Vet Rec 159:148-53. 2006
    ..Cicatritial retinal lesions were not associated with high titres of antibodies to Toxoplasma species. The findings correlate with those observed in human beings with eye injuries due to high-speed blunt trauma...
  31. ncbi request reprint Ultrasonographic examination of ocular lesions in farmed halibut
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, UK
    Vet J 173:456-8. 2007
    ..A proportion of these fish were subsequently sacrificed to allow post mortem ocular evaluation with the aim of correlating ultrasonographic findings with intraocular pathological defects...
  32. ncbi request reprint Reduced tear production in three canine endocrinopathies
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES
    J Small Anim Pract 48:252-6. 2007
    ..This study aimed to measure tear production in dogs with diabetes, hypothyroidism and hyperadrenocorticism using the Schirmer tear test and to compare these results with Schirmer tear test values for a group of normal dogs...
  33. ncbi request reprint Surgical removal of a canine orbital lipoma
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES
    J Small Anim Pract 47:35-7. 2006
    ..Histopathological examination showed the mass to be a lipoma. The dog recovered uneventfully from surgery, and no recurrence has been noted after 12 months...
  34. ncbi request reprint Use of punctal occlusion in the treatment of canine keratoconjunctivitis sicca
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES
    J Small Anim Pract 43:478-81. 2002
    ..These results show that use of punctal plugs in dogs with KCS may be appropriate where other lacrimomimetic medications have been unsuccessful...
  35. ncbi request reprint Retinal dysplasia in wild otters (Lutra lutra)
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge
    Vet Rec 155:52-6. 2004
    ..The otters with dysplastic retinas had significantly lower concentrations of vitamin A and higher concentrations of dieldrin than the otters with normal retinas...
  36. ncbi request reprint Ethics of kidney transplants in cats and dogs
    David L Williams
    Vet Rec 152:663-4. 2003
  37. ncbi request reprint Fighting tooth and CLAW for more monoclonal antibodies against canine leucocyte antigens
    David L Williams
    Vet J 173:18-9. 2007
  38. ncbi request reprint Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets
    Ahmed A Sayed
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790, USA
    J Biol Chem 281:17001-10. 2006
    ..This study highlights Prx proteins as essential parasite proteins and potential new targets for anti-schistosome drug development and albumin as a novel, sacrificial oxidant scavenging protein in parasite redox regulation...
  39. ncbi request reprint Healthy herpetology: the role of the veterinarian in reptile prophylaxis
    David L Williams
    Vet J 175:16-7. 2008
  40. pmc Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, United States
    J Neuroimmunol 199:75-82. 2008
    ..These results suggest that TLR2 is a new target of ischemic preconditioning in the brain and preconditioning with a TLR2 specific ligand will protect the brain from I/R injury...
  41. ncbi request reprint A quantitative analysis of apolipoprotein binding to SR-BI: multiple binding sites for lipid-free and lipid-associated apolipoproteins
    Stephen T Thuahnai
    Division of GI Nutrition, Lipid Research Group, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104 4318, USA
    J Lipid Res 44:1132-42. 2003
    ..These results are consistent with the existence of more than one type of apolipoprotein binding site on SR-BI...
  42. ncbi request reprint Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7317-24. 2007
    ..These data also suggest that modulation of TLR4/PI3K/Akt-dependent signaling pathways may be a viable strategy for reducing myocardial I/R injury...
  43. doi request reprint Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
    Cardiovasc Res 78:546-53. 2008
    ..We hypothesized that activation of PI3K/Akt signalling plays a critical role in LPS-induced cardioprotection...
  44. doi request reprint Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages
    Sheila Donnelly
    Level 6, Bldg 4, University of Technology Sydney, Cnr Thomas and Harris St, Ultimo, Sydney, NSW 2007, Australia
    FASEB J 22:4022-32. 2008
    ..We propose that Prx activates macrophages as an initial step in the induction of Th2 responses by helminth parasites and is thereby a novel pathogen-associated molecular pattern...
  45. pmc Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Neuroimmunol 190:101-11. 2007
    ..These data suggest that activation of TLR4 signaling contributes to ischemia-induced hippocampal neuronal death. In addition, these data suggest that modulation of TLR4 signaling may attenuate ischemic injury in hippocampal neurons...
  46. pmc Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target
    Angela N Kuntz
    Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
    PLoS Med 4:e206. 2007
    ..Our goal was to investigate the potential of a unique, selenium-containing parasite enzyme thioredoxin glutathione reductase (TGR) as a drug target...
  47. ncbi request reprint Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host
    David L Williams
    Department of Biological Sciences, Illinois State University, Normal, IL 61790, USA
    Mol Biochem Parasitol 150:359-63. 2006
  48. ncbi request reprint A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models
    Gene G Kinney
    Neuroscience West Point, Merck Research Laboratories, West Point, PA 19486, USA
    J Pharmacol Exp Ther 313:199-206. 2005
    ..These effects are consistent with the hypothesis that allosteric potentiation of mGluR5 may provide a novel approach for development of antipsychotic agents...
  49. ncbi request reprint NF-kappaB activation is required for the development of cardiac hypertrophy in vivo
    Yuehua Li
    Dept of Surgery, James H Quillen College of Medicine, East Tennessee State University, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 287:H1712-20. 2004
    ..Our results suggest that NF-kappaB activation is required for the development of cardiac hypertrophy in vivo and that NF-kappaB could be an important target for inhibiting the development of cardiac hypertrophy in vivo...
  50. ncbi request reprint Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni
    Ahmed A Sayed
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790 4120, USA
    J Biol Chem 279:26159-66. 2004
    ....
  51. ncbi request reprint The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase
    Heather M Alger
    Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
    Mol Biochem Parasitol 121:129-39. 2002
    ..This is the first example of an organism with a redox system based exclusively on thioredoxin glutathione reductase...
  52. ncbi request reprint Myocardial protection with the non-selective endothelin receptor antagonist L-753,037 following acute coronary artery occlusion in the dog
    Stephen M Krause
    Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Cardiovasc Pharmacol 43:214-21. 2004
    ....
  53. ncbi request reprint Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614, USA
    J Immunol 172:449-56. 2004
    ..This suggests that stimulation of the PI3K pathway may be an effective approach for preventing or treating sepsis and/or septic shock...
  54. ncbi request reprint Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614 1708, USA
    Crit Care Med 31:1808-18. 2003
    ..To determine whether there was a correlation between induction of polymicrobial sepsis, modulation of tissue Toll-like receptor (TLR) gene, and protein expression and survival outcome...
  55. ncbi request reprint A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors
    Wei Lemaire
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Eur J Pharmacol 450:19-28. 2002
    ..It may also be useful as a nonlabeled competitor or as a radioligand in autoradiographic studies of oxytocin receptor localization in these tissues...
  56. ncbi request reprint Glucan phosphate treatment attenuates burn-induced inflammation and improves resistance to Pseudomonas aeruginosa burn wound infection
    Olga I Lyuksutova
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, 301 University Boulevard, Galveston, TX 77555, USA
    Shock 23:224-32. 2005
    ..These studies show that glucan phosphate treatment attenuates burn-induced inflammation and increases resistance to P. aeruginosa burn wound infection in an experimental model of burn injury...
  57. ncbi request reprint The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 35:1539-47. 2005
    ....
  58. ncbi request reprint Murine immune responses to a novel schistosome egg antigen, SmEP25
    David L Williams
    Department of Biological Sciences, Illinois State University, Normal, IL 61790, USA
    Int J Parasitol 35:875-82. 2005
    ..The systematic identification of T-cell-sensitising egg components will lead to a better understanding of the processes involved in granuloma formation...
  59. ncbi request reprint Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 291:H1910-8. 2006
    ..GP administration also activates the phosphoinositide 3-kinase/Akt pathway, decreases myocardial MIF expression, and reduces cardiomyocyte apoptosis...
  60. ncbi request reprint Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Shock 25:432-9. 2006
    ..Thus, manipulation of the endogenous PI3K/Akt signaling pathway may represent a new and novel therapeutic approach to management of important diseases...
  61. ncbi request reprint Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol
    Ariëtte van Bennekum
    Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Biochemistry 44:4517-25. 2005
    ..Ezetimibe, a representative of a new class of drugs that inhibit intestinal cholesterol absorption, blocks SR-BI- and CD36-facilitated uptake of cholesterol into COS-7 cells...
  62. pmc Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio
    Juergen Luhm
    Institute of Immunology and Transfusion Medicine, Medical School, University of Lubeck, Germany
    BMC Immunol 7:5. 2006
    ..e. glucan phosphate, in the presence of lipopolysaccharide (LPS) or toxic shock syndrome toxin 1 (TSST-1)...
  63. ncbi request reprint The development of a novel mouse model of transient global cerebral ischemia
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614 0575, USA
    Neurosci Lett 400:69-74. 2006
    ....
  64. ncbi request reprint Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo
    Tuanzhu Ha
    Department of Surgery, Campus Box 70575, East Tennessee State University, Johnson City, TN 37614, USA
    Free Radic Biol Med 39:1570-80. 2005
    ..Similar results were observed in aortic-banding-induced cardiac hypertrophy in mice. Our results suggest that both NFkappaB activation and the PI3K/Akt signaling pathway participate in the development of cardiac hypertrophy in vivo...
  65. ncbi request reprint Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 338:1118-25. 2005
    ..The results demonstrate that both inhibition of the NFkappaB activation pathway and activation of the Akt signaling pathway may be responsible for the protective effect of transfection of dominant negative MyD88...
  66. ncbi request reprint Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Campus Box 70575, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 290:H985-94. 2006
    ..Blockade of MyD88 significantly reduced cardiac hypertrophy, cardiac myocyte apoptosis, and improved cardiac function in vivo...
  67. ncbi request reprint Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake
    Ryan E Temel
    Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 277:26565-72. 2002
    ..The reduced V(max) for HDL CE-selective uptake likely contributes to the severe reduction in CE accumulation in steroidogenic cells of apoA-I(-/-) mice...