The pharmacology of donepezil: a new treatment of Alzheimer's diseaseD G Wilkinson
University of Southampton, Thornhill Research Unit, Moorgreen Hospital, West End, Southampton, SO30 3JB, UK
Expert Opin Pharmacother 1:121-35. 1999
..This drug evaluation will review the basic pharmacology of donepezil and place it in context with the trial data and the author's clinical experience with the drug...
- Galantamine: a randomized, double-blind, dose comparison in patients with Alzheimer's disease
D Wilkinson
Old Age Psychiatry, Thornhill Research Unit, Moorgreen Hospital, Southampton, UK
Int J Geriatr Psychiatry 16:852-7. 2001
..To investigate whether Galantamine significantly improves the core symptoms of Alzheimer's disease (AD)...
- Prophylactic therapy with lithium in elderly patients with unipolar major depression
David Wilkinson
MARC, Elderly Mental Health Directorate, Moorgreen Hospital, Southampton
Int J Geriatr Psychiatry 17:619-22. 2002
..To compare the relapse rate of elderly depressed patients taking low dose lithium as an additional therapy with antidepressant medication to those receiving antidepressant medication alone...
Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate alzheimer's diseaseDavid Wilkinson
Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
Dement Geriatr Cogn Disord 28:244-51. 2009
..Therapeutic endpoints based on reduced clinical worsening represent clinically relevant and realistic goals for patients suffering from progressive neurodegenerative disorders such as Alzheimer's disease (AD)...
A review of the effects of memantine on clinical progression in Alzheimer's diseaseDavid Wilkinson
Memory Assessment and Research Centre MARC, Moorgreen Hospital, Southampton, UK
Int J Geriatr Psychiatry 27:769-76. 2012
..If given early, such a treatment would be expected to maximise any potential benefit. Memantine has shown clinical benefits in the key domains of AD, both as monotherapy and in combination with a cholinesterase inhibitor (ChEI)...
- Memantine and brain atrophy in Alzheimer's disease: a 1-year randomized controlled trial
David Wilkinson
Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
J Alzheimers Dis 29:459-69. 2012
..The biological relevance of cerebral atrophy was supported by a significant correlation between rate of atrophy and decline in cognitive and behavioral outcomes...
- Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease
David Wilkinson
Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
Dement Geriatr Cogn Disord 24:138-45. 2007
..Alzheimer's disease (AD) is a progressive neurodegenerative disorder and delaying disease worsening is a relevant treatment outcome...
- The long-term efficacy and tolerability of donepezil in patients with vascular dementia
David Wilkinson
Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
Int J Geriatr Psychiatry 25:305-13. 2010
..To determine the long-term tolerability and efficacy of donepezil in patients with vascular dementia (VaD)...
- Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
Clive Holmes
Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
Lancet 372:216-23. 2008
..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes...
- Abeta species removal after abeta42 immunization
James A R Nicoll
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
J Neuropathol Exp Neurol 65:1040-8. 2006
..Abeta immunotherapy can clear all Abeta species from the cortex. However, if it is to be used for treatment of established Alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study...
- Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
James A R Nicoll
Division of Clinical Neurosciences, University of Southampton, Southampton, UK
Nat Med 9:448-52. 2003
..The T-lymphocyte meningoencephalitis is likely to correspond to the side effect seen in some other patients who received AN-1792 (refs. 7-9)...
- The effect of link nurses on hospital readmission rates
Paul Anthony Ashton
Memory Assessment and Research Centre (MARC, Moorgreen Hospital, Southampton
Nurs Times 102:34-5. 2006
..This is a summary of the paper the full version can be accessed at nursingtimes.net...
- Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study
Clive Holmes
University of Southampton, School of Medicine, Community Clinical Sciences Research Division, Memory Assessment and Research Unit, Moorgreen Hospital, Southampton, UK
Int J Geriatr Psychiatry 17:305-8. 2002
..To determine whether aromatherapy with lavender oil is effective in the treatment of agitated behaviour in patients with severe dementia...
- Risperidone and rivastigmine and agitated behaviour in severe Alzheimer's disease: a randomised double blind placebo controlled study
Clive Holmes
Int J Geriatr Psychiatry 22:380-1. 2007
- Association between HIV-1 infection, the etiology of genital ulcer disease, and response to syndromic management
Prashini Moodley
Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
Sex Transm Dis 30:241-5. 2003
..04). At follow-up, 40/407 (10%) showed a decreased healing tendency, not associated with ulcer etiology or HIV-1 seropositivity. CONCLUSION: Response to syndromic management of GUD was acceptable and not associated with HIV-1 coinfection...
- Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology
Alistair Burns
University of Manchester, Manchester, UK
J Psychopharmacol 20:732-55. 2006
..Patients, their carers, and clinicians deserve to be optimistic in a field which often attracts therapeutic nihilism...
- Influence of HIV-1 coinfection on effective management of abnormal vaginal discharge
Prashini Moodley
Africa Centre for Population Studies and Reproductive Health, Faculty of Medicine, University of Natal, Durban, South Africa
Sex Transm Dis 30:1-5. 2003
..001). CONCLUSIONS: Clinical and microbiologic response to SM of the nonulcerative STIs was not affected by HIV-1 coinfection, but cure rates for bacterial vaginosis were reduced...
