Robert Wilke

Summary

Affiliation: UNSW
Location: Sydney, Australia
Summary:
Ophthalmology
Hereditary Retinal Dystrophies
Biomedical Engineering
Retinal Imaging
Retinal Implants, Bionic Vision, Artificial vision

Publications

  1. pmc Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy
    Katharina Agnes Wycisk
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Am J Hum Genet 79:973-7. 2006
  2. doi request reprint Early visual symptom patterns in inherited retinal dystrophies
    Elena Prokofyeva
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Ophthalmologica 226:151-6. 2011
  3. doi request reprint Spatial resolution and perception of patterns mediated by a subretinal 16-electrode array in patients blinded by hereditary retinal dystrophies
    Robert Wilke
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 52:5995-6003. 2011
  4. doi request reprint [Vision restoration with implants in retinal degenerations]
    Akos Kusnyerik
    Semmelweis Egyetem, Általános Orvostudományi Kar, Szemészeti Klinika Budapest
    Orv Hetil 152:537-45. 2011
  5. doi request reprint Restoration of useful vision up to letter recognition capabilities using subretinal microphotodiodes
    Heval Benav
    Conf Proc IEEE Eng Med Biol Soc 2010:5919-22. 2010
  6. doi request reprint A domain model of a clinical reading center - Design and implementation
    Gunnar Lotz
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Frondsbergstr 23, 72070, Germany
    Conf Proc IEEE Eng Med Biol Soc 2010:4530-3. 2010
  7. pmc Subretinal electronic chips allow blind patients to read letters and combine them to words
    Eberhart Zrenner
    Centre for Ophthalmology, University of Tubingen, Schleichstr 12, 72076 Tubingen, Germany
    Proc Biol Sci 278:1489-97. 2011
  8. pmc Structure-function correlation of the human central retina
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 5:e12864. 2010
  9. doi request reprint Basic quantitative assessment of visual performance in patients with very low vision
    Michael Bach
    Sektion Funktionelle Sehforschung, University Eye Hospital Freiburg, Freiburg, Germany
    Invest Ophthalmol Vis Sci 51:1255-60. 2010
  10. doi request reprint An epidemiological approach for the estimation of disease onset in Central Europe in central and peripheral monogenic retinal dystrophies
    Elena Prokofyeva
    Bioengineering Medical Laboratory, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:885-94. 2009

Collaborators

Detail Information

Publications17

  1. pmc Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy
    Katharina Agnes Wycisk
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Am J Hum Genet 79:973-7. 2006
    ..Both patients share symptoms of slowly progressing cone dystrophy. These findings represent the first report of a mutation in the human CACNA2D4 gene and define a novel gene defect that causes autosomal recessive cone dystrophy...
  2. doi request reprint Early visual symptom patterns in inherited retinal dystrophies
    Elena Prokofyeva
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Ophthalmologica 226:151-6. 2011
    ..It showed that patterns of initial symptoms in IRD can provide extra clues for early differential diagnosis and inclusion of IRD patients in clinical trials...
  3. doi request reprint Spatial resolution and perception of patterns mediated by a subretinal 16-electrode array in patients blinded by hereditary retinal dystrophies
    Robert Wilke
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 52:5995-6003. 2011
    ..This device is part of the Tübingen retina implant, which also employs a light-sensitive, multiphotodiode array (MPDA). The ability to reliably recognize complex spatial percepts was investigated...
  4. doi request reprint [Vision restoration with implants in retinal degenerations]
    Akos Kusnyerik
    Semmelweis Egyetem, Általános Orvostudományi Kar, Szemészeti Klinika Budapest
    Orv Hetil 152:537-45. 2011
    ..A number of types of retinal implants can be expected to appear in clinical practice a few years after the successful conclusion of clinical trials...
  5. doi request reprint Restoration of useful vision up to letter recognition capabilities using subretinal microphotodiodes
    Heval Benav
    Conf Proc IEEE Eng Med Biol Soc 2010:5919-22. 2010
    ..Finally, we present images illustrating an approximation of how the visual perceptions might have appeared to the subjects, based on a mathematical model and patient reports...
  6. doi request reprint A domain model of a clinical reading center - Design and implementation
    Gunnar Lotz
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Frondsbergstr 23, 72070, Germany
    Conf Proc IEEE Eng Med Biol Soc 2010:4530-3. 2010
    ..Here we present our domain model for a clinical reading center, as well as its actual implementation utilizing the Nuxeo enterprise content management system...
  7. pmc Subretinal electronic chips allow blind patients to read letters and combine them to words
    Eberhart Zrenner
    Centre for Ophthalmology, University of Tubingen, Schleichstr 12, 72076 Tubingen, Germany
    Proc Biol Sci 278:1489-97. 2011
    ..These results demonstrate for the first time that subretinal micro-electrode arrays with 1500 photodiodes can create detailed meaningful visual perception in previously blind individuals...
  8. pmc Structure-function correlation of the human central retina
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 5:e12864. 2010
    ..The impact of retinal pathology detected by high-resolution imaging on vision remains largely unexplored. Therefore, the aim of the study was to achieve high-resolution structure-function correlation of the human macula in vivo...
  9. doi request reprint Basic quantitative assessment of visual performance in patients with very low vision
    Michael Bach
    Sektion Funktionelle Sehforschung, University Eye Hospital Freiburg, Freiburg, Germany
    Invest Ophthalmol Vis Sci 51:1255-60. 2010
    ..This report presents a method of comparing their efficacy at genuinely improving visual function, starting at no light perception (NLP)...
  10. doi request reprint An epidemiological approach for the estimation of disease onset in Central Europe in central and peripheral monogenic retinal dystrophies
    Elena Prokofyeva
    Bioengineering Medical Laboratory, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:885-94. 2009
    ..To study clinical patterns of disease onset in monogenic retinal dystrophies (MRD), using an epidemiological approach...
  11. doi request reprint CERKL mutations and associated phenotypes in seven Spanish families with autosomal recessive retinitis pigmentosa
    Almudena Avila-Fernandez
    Department of Genetics, Fundacion Jimenez Diaz CIBERER, Madrid, Spain
    Invest Ophthalmol Vis Sci 49:2709-13. 2008
    ..It encodes a ceramide kinase that is assumed to be involved in sphingolipid-mediated apoptosis in the retina. This is a report of the phenotypes and genotypes of persons carrying disease-causing mutations in CERKL...
  12. doi request reprint Mutation analysis identifies GUCY2D as the major gene responsible for autosomal dominant progressive cone degeneration
    Veronique B D Kitiratschky
    Molecular Genetics Laboratory, Institute for Ophthalmic Research, Centre for Ophthalmology, University Tübingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 49:5015-23. 2008
    ..The present study was a comprehensive screening of the GUCY2D gene in 27 adCD and adCRD unrelated families of these rare disorders...
  13. pmc Molecular analysis of ABCA4 and CRB1 genes in a Spanish family segregating both Stargardt disease and autosomal recessive retinitis pigmentosa
    Rosa Riveiro-Alvarez
    Genetics Department, Fundacion Jimenez Diaz CIBERER, Madrid, Spain
    Mol Vis 14:262-7. 2008
    ..It has been associated with mutations in different genes, including CRB1. The aim of this study was to determine the genetic causes for two different retinal dystrophies, STGD and early-onset arRP, both segregating in one Spanish family...
  14. ncbi request reprint Mutation screening of 299 Spanish families with retinal dystrophies by Leber congenital amaurosis genotyping microarray
    Elena Vallespin
    Department of Genetics, Fundacion Jimenez Diaz CIBERER, Madrid, Spain
    Invest Ophthalmol Vis Sci 48:5653-61. 2007
    ....
  15. ncbi request reprint Two truncating USH3A mutations, including one novel, in a German family with Usher syndrome
    Inga Ebermann
    Institute of Human Genetics, University Hospital of Cologne, Cologne, Germany
    Mol Vis 13:1539-47. 2007
    ..To identify the genetic defect in a German family with Usher syndrome (USH) and linkage to the USH3A locus...
  16. ncbi request reprint The phenotype of early-onset retinal degeneration in persons with RDH12 mutations
    Andreas Schuster
    Department of Pathophysiology of Vision and Neuroophthalmology, University Eye Hospital, Schleichstrasse 12 16, D 72076 Tubingen, Germany
    Invest Ophthalmol Vis Sci 48:1824-31. 2007
    ..To describe the retinal dystrophy phenotype associated with mutations in RDH12, the gene encoding a retinoid dehydrogenase/reductase expressed in the photoreceptor cells...
  17. doi request reprint Correlation between macular morphology and sensitivity in patients with retinitis pigmentosa and hyperautofluorescent ring
    Eva Lenassi
    Eye Hospital, University Medical Center Ljubljana, Ljubljana, Slovenia
    Invest Ophthalmol Vis Sci 53:47-52. 2012
    ....