Harindra C Wijeysundera

Summary

Publications

  1. doi request reprint A population-based study to evaluate the effectiveness of multidisciplinary heart failure clinics and identify important service components
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    Circ Heart Fail 6:68-75. 2013
  2. pmc Specialized multi-disciplinary heart failure clinics in Ontario, Canada: an environmental scan
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    BMC Health Serv Res 12:236. 2012
  3. doi request reprint Achieving quality indicator benchmarks and potential impact on coronary heart disease mortality
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Can J Cardiol 27:756-62. 2011
  4. doi request reprint Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 303:1841-7. 2010
  5. doi request reprint Reflex systemic sympatho-neural response to brachial adenosine infusion in treated heart failure
    Harindra C Wijeysundera
    Mount Sinai Hospital and University Health Network Division of Cardiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Eur J Heart Fail 13:475-81. 2011
  6. doi request reprint Predicting EQ-5D utility scores from the Seattle Angina Questionnaire in coronary artery disease: a mapping algorithm using a Bayesian framework
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Med Decis Making 31:481-93. 2011
  7. doi request reprint Cost-effectiveness of specialized multidisciplinary heart failure clinics in Ontario, Canada
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Value Health 13:915-21. 2010
  8. doi request reprint Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 6:315-22. 2013
  9. ncbi request reprint The Effect of Multidisciplinary Heart Failure Clinic Characteristics on 1-Year Postdischarge Health Care Costs: A Population-based Study
    Harindra C Wijeysundera
    Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre Toronto Health Economics and Technology Assessment THETA Collaborative Institute of Health Policy, Management and Evaluation Institute for Clinical Evaluative Sciences ICES Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Med Care 52:272-9. 2014
  10. doi request reprint Predictors of normal coronary arteries at coronary angiography
    Kevin Levitt
    University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:694-700. 2013

Detail Information

Publications41

  1. doi request reprint A population-based study to evaluate the effectiveness of multidisciplinary heart failure clinics and identify important service components
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    Circ Heart Fail 6:68-75. 2013
    ..Our objectives were to compare real-world outcomes of patients with HF treated in HF clinics versus usual therapy and identify HF clinic features associated with improved outcomes...
  2. pmc Specialized multi-disciplinary heart failure clinics in Ontario, Canada: an environmental scan
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    BMC Health Serv Res 12:236. 2012
    ..Also, the service models of current clinics have not been described. It is therefore uncertain whether the efficacy of HF clinics in trials is generalizable to the HF clinics currently operating in the province...
  3. doi request reprint Achieving quality indicator benchmarks and potential impact on coronary heart disease mortality
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Can J Cardiol 27:756-62. 2011
    ..Quality indicators in coronary heart disease (CHD) measure the practice gap between optimal care and current clinical practice. However, the potential impact of achieving quality indicator benchmarks remains unknown...
  4. doi request reprint Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 303:1841-7. 2010
    ..Coronary heart disease (CHD) mortality has declined substantially in Canada since 1994...
  5. doi request reprint Reflex systemic sympatho-neural response to brachial adenosine infusion in treated heart failure
    Harindra C Wijeysundera
    Mount Sinai Hospital and University Health Network Division of Cardiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Eur J Heart Fail 13:475-81. 2011
    ..Our objectives were to determine whether a similar reflex is active in treated heart failure (HF) patients and attenuated by ARB...
  6. doi request reprint Predicting EQ-5D utility scores from the Seattle Angina Questionnaire in coronary artery disease: a mapping algorithm using a Bayesian framework
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Med Decis Making 31:481-93. 2011
    ..In its current form, however, it cannot be used in economic evaluations. The investigators sought to create a mapping algorithm that would allow translation of SAQ scores into EQ-5D utility scores...
  7. doi request reprint Cost-effectiveness of specialized multidisciplinary heart failure clinics in Ontario, Canada
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Value Health 13:915-21. 2010
    ..Specialized multidisciplinary clinics have been shown to reduce mortality in heart failure (HF). Our objective was to evaluate the cost-effectiveness of this model of care delivery...
  8. doi request reprint Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 6:315-22. 2013
    ....
  9. ncbi request reprint The Effect of Multidisciplinary Heart Failure Clinic Characteristics on 1-Year Postdischarge Health Care Costs: A Population-based Study
    Harindra C Wijeysundera
    Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre Toronto Health Economics and Technology Assessment THETA Collaborative Institute of Health Policy, Management and Evaluation Institute for Clinical Evaluative Sciences ICES Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Med Care 52:272-9. 2014
    ..Although multidisciplinary heart failure (HF) clinics are efficacious, it is not known how patient factors or HF clinic structural indicators and process measures have an impact on the cumulative health care costs...
  10. doi request reprint Predictors of normal coronary arteries at coronary angiography
    Kevin Levitt
    University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:694-700. 2013
    ..However, little is known about the clinical predictors of normal angiograms and whether this rate varies across different cardiac centers in Ontario...
  11. doi request reprint Lifetime analysis of hospitalizations and survival of patients newly admitted with heart failure
    Soohun Chun
    Institute for Clinical Evaluative Sciences, Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Circ Heart Fail 5:414-21. 2012
    ..Hospital readmissions for heart failure (HF) contribute to increased morbidity and resource burden. Predictors of hospitalization and patterns of cardiovascular events over the lifetime of patients with HF have not been elucidated...
  12. doi request reprint Long-term safety and effectiveness of drug-eluting stents for the treatment of saphenous vein grafts disease: a population-based study
    Dennis T Ko
    Division of Cardiology, Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    JACC Cardiovasc Interv 4:965-73. 2011
    ..The purpose of this study was to evaluate the long-term safety and effectiveness of drug-eluting stents (DES) for the treatment of saphenous vein graft (SVG) disease...
  13. doi request reprint Duration of preoperative β-blockade and outcomes after major elective noncardiac surgery
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:217-23. 2014
    ..Although practice guidelines recommend that perioperative β-blockade be initiated at least several days to weeks before noncardiac surgery is performed, the minimum required period of preoperative therapy is unclear...
  14. doi request reprint Insights into the contemporary management of heart failure in specialized multidisciplinary ambulatory clinics
    Lusine Abrahamyan
    Toronto Health Economics and Technology Assessment THETA Collaborative, Toronto, Ontario, Canada
    Can J Cardiol 29:1062-8. 2013
    ..Our objective was to evaluate the effect of this clinic level heterogeneity on HF patient management in Ontario, Canada...
  15. doi request reprint Canada's contribution to global research in cardiovascular diseases
    Hai V Nguyen
    Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:742-6. 2013
    ..As the burden of chronic diseases including CVD rises with Canada's aging population, the increase in Canadian research into CVD is encouraging...
  16. doi request reprint Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief
    Harindra C Wijeysundera
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 152:370-9. 2010
    ..Several meta-analyses have evaluated the efficacy of percutaneous coronary intervention (PCI) compared with medical therapy, but none has focused on angina relief...
  17. doi request reprint An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: a meta-analysis of contemporary randomized controlled trials
    Harindra C Wijeysundera
    Department of Medicine, Division of Cardiology, Schulich Heart Center, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:564-572, 572.e1-2. 2008
    ....
  18. ncbi request reprint Traditional cardiovascular risk factors and the presence of obstructive coronary artery disease in men and women
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:820-6. 2014
    ..Our main objective was to evaluate the relationship between traditional risk factors and the presence of obstructive coronary artery disease (CAD), and to explore potential differences in men vs women...
  19. ncbi request reprint Medical therapy v. PCI in stable coronary artery disease: a cost-effectiveness analysis
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada HCW, DTK
    Med Decis Making 33:891-905. 2013
    ..It remains unclear if these benefits are sufficient to offset their increased costs and small increase in adverse events...
  20. doi request reprint Prevalence and extent of obstructive coronary artery disease among patients undergoing elective coronary catheterization in New York State and Ontario
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 310:163-9. 2013
    ..However, the role of patient selection in these findings and their implications for detection of obstructive coronary artery disease (CAD) are largely unknown...
  21. doi request reprint Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies
    Prateek J Khatri
    University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Ann Intern Med 158:35-46. 2013
    ....
  22. doi request reprint Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 60:1876-84. 2012
    ..The study assessed the appropriateness of coronary revascularization in Ontario, Canada, and examined its association with longer-term outcomes...
  23. pmc Canadian quality indicators for percutaneous coronary interventions
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Can J Cardiol 24:899-903. 2008
    ..However, quality indicators for percutaneous coronary intervention (PCI) have not been developed in Canada...
  24. doi request reprint Rescue percutaneous coronary interventions for failed fibrinolytic therapy in ST-segment elevation myocardial infarction: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, University of Toronto, Ontario, Canada
    Am Heart J 161:764-770.e1. 2011
    ..However, limited data exist regarding the pattern of use of rescue percutaneous coronary intervention (PCI) in patients with STEMI who failed fibrinolysis, factors associated with its use, and its impact on long-term outcomes...
  25. doi request reprint Percutaneous coronary intervention with vs without on-site cardiac surgery backup: a systematic review and meta-analysis
    Mohammad I Zia
    University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:664.e9-16. 2011
    ..However, variations in outcomes suggest that assurance of optimal outcomes at each PCI centre without on-site surgery is needed...
  26. pmc Beyond case fatality rate: using potential impact fraction to estimate the effect of increasing treatment uptake on mortality
    Nicholas Mitsakakis
    Toronto Health Economics and Technology Assessment THETA Collaborative, Toronto, Canada
    BMC Med Res Methodol 13:109. 2013
    ..Due to the lack of data, rates where treatment is partially present are often used instead, introducing bias. A method that does not rely on no-treatment case fatality rate estimates is needed...
  27. pmc Comparative-effectiveness of revascularization versus routine medical therapy for stable ischemic heart disease: a population-based study
    Harindra C Wijeysundera
    Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Suite A202, Toronto, ON, M4N3M5, Canada
    J Gen Intern Med 29:1031-9. 2014
    ..Randomized studies have shown optimal medical therapy to be as efficacious as revascularization in stable ischemic heart disease (IHD). It is not known if these efficacy results are reflected by real-world effectiveness...
  28. doi request reprint The effect of percutaneous coronary intervention of chronically totally occluded coronary arteries on left ventricular global and regional systolic function
    Idan Roifman
    Sunnybrook Research Institute, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:1436-42. 2013
    ....
  29. doi request reprint Incidence, predictors, and prognostic implications of hospitalization for late bleeding after percutaneous coronary intervention for patients older than 65 years
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circ Cardiovasc Interv 3:140-7. 2010
    ..The incidence of late bleeding after PCI, its independent predictors, and its prognostic importance in clinical practice has not been fully addressed...
  30. ncbi request reprint Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    Circulation 126:1355-62. 2012
    ..Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year after drug-eluting stent implantation...
  31. doi request reprint Effectiveness of preprocedural statin therapy on clinical outcomes for patients with stable coronary artery disease after percutaneous coronary interventions
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, ON, Canada
    Circ Cardiovasc Qual Outcomes 4:459-66. 2011
    ..We aimed to evaluate the clinical effectiveness of preprocedural statin therapy in patients with stable CAD undergoing PCI...
  32. doi request reprint Coronary artery bypass graft surgery vs percutaneous interventions in coronary revascularization: a systematic review
    Saswata Deb
    Schulich Heart Centre, Division of Cardiology and Cardiac Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada2Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 310:2086-95. 2013
    ..However, the choice of the most appropriate revascularization modality is controversial in some patient subgroups...
  33. pmc Economic analysis of Heart and Stroke Foundation of Ontario's Hypertension Management Initiative
    Claire de Oliveira
    University Health Network, Toronto, ON, Canada Toronto Health Economics and Technology Assessment Collaborative, Toronto, ON, Canada
    Clinicoecon Outcomes Res 4:323-36. 2012
    ....
  34. pmc Techniques for estimating health care costs with censored data: an overview for the health services researcher
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Clinicoecon Outcomes Res 4:145-55. 2012
    ..The target audience is health service researchers without an advanced statistical background...
  35. doi request reprint Reporting and representation of ethnic minorities in cardiovascular trials: a systematic review
    Tony Zhang
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 166:52-7. 2013
    ..However, little is known about the reporting and representation of ethnic minorities in major cardiovascular trials...
  36. doi request reprint Relationship between initial treatment strategy and quality of life in patients with coronary chronic total occlusions
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    EuroIntervention 9:1165-72. 2014
    ..Our objective was to evaluate the relationship between coronary chronic total occlusion (CTO) treatment strategy and quality of life improvements...
  37. doi request reprint Economic evaluation of percutaneous left atrial appendage occlusion, dabigatran, and warfarin for stroke prevention in patients with nonvalvular atrial fibrillation
    Sheldon M Singh
    Schulich Heart Program, Toronto, ON, Canada
    Circulation 127:2414-23. 2013
    ....
  38. pmc Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
    BMC Health Serv Res 12:238. 2012
    ..The extent to which uncomplicated obesity among an otherwise healthy middle-aged population is associated with higher longitudinal health-care expenditures remains unclear...
  39. doi request reprint Rate and predictors of the conversion of abstracts presented at the Canadian Cardiovascular Congress scientific meetings to full peer-reviewed publications
    Wael Abuzeid
    Schulich Heart Center, Sunnybrook Health Sciences Center, Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:1520-3. 2013
    ..6%). Efforts should focus on several identified barriers to improve conversion of abstracts to full report publication...
  40. pmc How much are we spending? The estimation of research expenditures on cardiovascular disease in Canada
    Claire de Oliveira
    University Health Network, Toronto, ON, Canada
    BMC Health Serv Res 12:281. 2012
    ..Our objective was to estimate the magnitude of expenditures on CVD research for the public and charitable (not-for profit) sectors in Canada between 1975 and 2005...
  41. ncbi request reprint Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:422-30. 2007
    ....