A population-based study to evaluate the effectiveness of multidisciplinary heart failure clinics and identify important service componentsHarindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
Circ Heart Fail 6:68-75. 2013
..Our objectives were to compare real-world outcomes of patients with HF treated in HF clinics versus usual therapy and identify HF clinic features associated with improved outcomes...
Specialized multi-disciplinary heart failure clinics in Ontario, Canada: an environmental scanHarindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
BMC Health Serv Res 12:236. 2012
..Also, the service models of current clinics have not been described. It is therefore uncertain whether the efficacy of HF clinics in trials is generalizable to the HF clinics currently operating in the province...
- Achieving quality indicator benchmarks and potential impact on coronary heart disease mortality
Harindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Can J Cardiol 27:756-62. 2011
..Quality indicators in coronary heart disease (CHD) measure the practice gap between optimal care and current clinical practice. However, the potential impact of achieving quality indicator benchmarks remains unknown...
- Reflex systemic sympatho-neural response to brachial adenosine infusion in treated heart failure
Harindra C Wijeysundera
Mount Sinai Hospital and University Health Network Division of Cardiology, Faculty of Medicine, University of Toronto, Ontario, Canada
Eur J Heart Fail 13:475-81. 2011
..Our objectives were to determine whether a similar reflex is active in treated heart failure (HF) patients and attenuated by ARB...
- Predicting EQ-5D utility scores from the Seattle Angina Questionnaire in coronary artery disease: a mapping algorithm using a Bayesian framework
Harindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
Med Decis Making 31:481-93. 2011
..In its current form, however, it cannot be used in economic evaluations. The investigators sought to create a mapping algorithm that would allow translation of SAQ scores into EQ-5D utility scores...
- Cost-effectiveness of specialized multidisciplinary heart failure clinics in Ontario, Canada
Harindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Value Health 13:915-21. 2010
..Specialized multidisciplinary clinics have been shown to reduce mortality in heart failure (HF). Our objective was to evaluate the cost-effectiveness of this model of care delivery...
- Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
Harindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
JAMA 303:1841-7. 2010
..Coronary heart disease (CHD) mortality has declined substantially in Canada since 1994...
- Lifetime analysis of hospitalizations and survival of patients newly admitted with heart failure
Soohun Chun
Institute for Clinical Evaluative Sciences, Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Circ Heart Fail 5:414-21. 2012
..Hospital readmissions for heart failure (HF) contribute to increased morbidity and resource burden. Predictors of hospitalization and patterns of cardiovascular events over the lifetime of patients with HF have not been elucidated...
- Long-term safety and effectiveness of drug-eluting stents for the treatment of saphenous vein grafts disease: a population-based study
Dennis T Ko
Division of Cardiology, Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
JACC Cardiovasc Interv 4:965-73. 2011
..The purpose of this study was to evaluate the long-term safety and effectiveness of drug-eluting stents (DES) for the treatment of saphenous vein graft (SVG) disease...
- Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief
Harindra C Wijeysundera
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Ann Intern Med 152:370-9. 2010
..Several meta-analyses have evaluated the efficacy of percutaneous coronary intervention (PCI) compared with medical therapy, but none has focused on angina relief...
- An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: a meta-analysis of contemporary randomized controlled trials
Harindra C Wijeysundera
Department of Medicine, Division of Cardiology, Schulich Heart Center, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
Am Heart J 156:564-572, 572.e1-2. 2008
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- Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies
Prateek J Khatri
University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Ann Intern Med 158:35-46. 2013
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- Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease
Dennis T Ko
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Sunnybrook Schulich Heart Centre, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada Electronic address
J Am Coll Cardiol 60:1876-84. 2012
..The study assessed the appropriateness of coronary revascularization in Ontario, Canada, and examined its association with longer-term outcomes...
- Canadian quality indicators for percutaneous coronary interventions
Dennis T Ko
Institute for Clinical Evaluative Sciences, Ontario, Canada
Can J Cardiol 24:899-903. 2008
..However, quality indicators for percutaneous coronary intervention (PCI) have not been developed in Canada...
- Percutaneous coronary intervention with vs without on-site cardiac surgery backup: a systematic review and meta-analysis
Mohammad I Zia
University of Toronto, Toronto, Ontario, Canada
Can J Cardiol 27:664.e9-16. 2011
..However, variations in outcomes suggest that assurance of optimal outcomes at each PCI centre without on-site surgery is needed...
- Rescue percutaneous coronary interventions for failed fibrinolytic therapy in ST-segment elevation myocardial infarction: a population-based study
Dennis T Ko
Division of Cardiology, Schulich Heart Centre, University of Toronto, Ontario, Canada
Am Heart J 161:764-770.e1. 2011
..However, limited data exist regarding the pattern of use of rescue percutaneous coronary intervention (PCI) in patients with STEMI who failed fibrinolysis, factors associated with its use, and its impact on long-term outcomes...
- Incidence, predictors, and prognostic implications of hospitalization for late bleeding after percutaneous coronary intervention for patients older than 65 years
Dennis T Ko
Institute for Clinical Evaluative Sciences, Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Circ Cardiovasc Interv 3:140-7. 2010
..The incidence of late bleeding after PCI, its independent predictors, and its prognostic importance in clinical practice has not been fully addressed...
- Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study
Duminda N Wijeysundera
Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
Circulation 126:1355-62. 2012
..Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year after drug-eluting stent implantation...
- Effectiveness of preprocedural statin therapy on clinical outcomes for patients with stable coronary artery disease after percutaneous coronary interventions
Dennis T Ko
Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, ON, Canada
Circ Cardiovasc Qual Outcomes 4:459-66. 2011
..We aimed to evaluate the clinical effectiveness of preprocedural statin therapy in patients with stable CAD undergoing PCI...
- Economic analysis of Heart and Stroke Foundation of Ontario's Hypertension Management Initiative
Claire de Oliveira
University Health Network, Toronto, ON, Canada Toronto Health Economics and Technology Assessment Collaborative, Toronto, ON, Canada
Clinicoecon Outcomes Res 4:323-36. 2012
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- Techniques for estimating health care costs with censored data: an overview for the health services researcher
Harindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Clinicoecon Outcomes Res 4:145-55. 2012
..The target audience is health service researchers without an advanced statistical background...
- Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada
David A Alter
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
BMC Health Serv Res 12:238. 2012
..The extent to which uncomplicated obesity among an otherwise healthy middle-aged population is associated with higher longitudinal health-care expenditures remains unclear...
- How much are we spending? The estimation of research expenditures on cardiovascular disease in Canada
Claire de Oliveira
University Health Network, Toronto, ON, Canada
BMC Health Serv Res 12:281. 2012
..Our objective was to estimate the magnitude of expenditures on CVD research for the public and charitable (not-for profit) sectors in Canada between 1975 and 2005...
Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trialsHarindra C Wijeysundera
Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
J Am Coll Cardiol 49:422-30. 2007
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