Julian Schulze Zur Wiesch

Summary

Publications

  1. pmc Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection
    Julian Schulze zur Wiesch
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:1559-69. 2007
  2. ncbi request reprint Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    Joerg Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 46:339-49. 2007
  3. doi request reprint Genomic tandem repeat analysis proves laboratory-acquired brucellosis in veterinary (camel) diagnostic laboratory in the United Arab Emirates
    J Schulze zur Wiesch
    Medizinische Klinik, Bernhard Nocht Klinik für Tropenmedizin, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Germany
    Zoonoses Public Health 57:315-7. 2010
  4. pmc Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV infection: CD39 expression of FoxP3+ T regulatory cells correlates with progressive disease
    Julian Schulze zur Wiesch
    Infectious Disease Unit, Department of Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Virol 85:1287-97. 2011
  5. doi request reprint Decreased frequency of CD73+CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion
    Ilona Tóth
    1 Section Infectious Diseases, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Leukoc Biol 94:551-61. 2013
  6. pmc The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS)
    Daniel Benten
    Department of Gastroenterology and Hepatology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    BMC Gastroenterol 11:107. 2011
  7. pmc Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy
    Georg M Lauer
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Virol 79:12979-88. 2005
  8. pmc Outcomes and treatment of acute hepatitis C virus infection in a United States population
    Kathleen E Corey
    Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 4:1278-82. 2006
  9. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
  10. ncbi request reprint Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    Julian Schulze zur Wiesch
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 175:3603-13. 2005

Collaborators

Detail Information

Publications19

  1. pmc Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection
    Julian Schulze zur Wiesch
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:1559-69. 2007
    ....
  2. ncbi request reprint Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    Joerg Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 46:339-49. 2007
    ....
  3. doi request reprint Genomic tandem repeat analysis proves laboratory-acquired brucellosis in veterinary (camel) diagnostic laboratory in the United Arab Emirates
    J Schulze zur Wiesch
    Medizinische Klinik, Bernhard Nocht Klinik für Tropenmedizin, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Germany
    Zoonoses Public Health 57:315-7. 2010
    ..The case illustrates the high (airborne) infectivity of brucellosis in laboratory settings and the need to implement vigorous bio-safety measures in veterinary laboratories handling camel specimen diagnostic veterinary laboratory...
  4. pmc Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV infection: CD39 expression of FoxP3+ T regulatory cells correlates with progressive disease
    Julian Schulze zur Wiesch
    Infectious Disease Unit, Department of Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Virol 85:1287-97. 2011
    ..The data presented here reconcile the seemingly contradictory results of previous studies looking at Tregs in HIV and highlight the complexity of Treg-mediated immunoregulation during human viral infections...
  5. doi request reprint Decreased frequency of CD73+CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion
    Ilona Tóth
    1 Section Infectious Diseases, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Leukoc Biol 94:551-61. 2013
    ..These data indicate that down-regulation of CD73 on CD8(+) T cells correlates with immune activation and leads to functional deficits in HIV infection. ..
  6. pmc The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS)
    Daniel Benten
    Department of Gastroenterology and Hepatology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    BMC Gastroenterol 11:107. 2011
    ..Translocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis...
  7. pmc Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy
    Georg M Lauer
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Virol 79:12979-88. 2005
    ..These data suggest that broad CD8(+) T-cell responses alone may be insufficient to contain HCV replication, and also that early therapy is effective independent of such responses...
  8. pmc Outcomes and treatment of acute hepatitis C virus infection in a United States population
    Kathleen E Corey
    Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 4:1278-82. 2006
    ..However, the outcome of acute hepatitis C infection in United States cohorts is not well-characterized...
  9. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
    ..Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection...
  10. ncbi request reprint Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    Julian Schulze zur Wiesch
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 175:3603-13. 2005
    ..This comprehensive characterization of CD4(+) T cell epitopes in resolved HCV infection provides important information to facilitate studies of immunopathogenesis and HCV vaccine design and evaluation...
  11. ncbi request reprint Acute hepatitis C virus infection in incarcerated injection drug users
    Barbara H McGovern
    Lemuel Shattuck Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 42:1663-70. 2006
    ....
  12. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
    ....
  13. doi request reprint Sustained virological response after early antiviral treatment of acute hepatitis C virus and HIV coinfection
    Julian Schulze zur Wiesch
    Department of Medicin, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Infect Dis 49:466-72. 2009
    ..We present detailed clinical and immunological analysis of 3 individuals after concomitant infection with acute HCV and primary HIV...
  14. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
    ..Together, these data indicate that viral escape from CD8+ T cell responses occurs during human HCV infection and that acute immune selection pressure is of sufficient magnitude to influence HCV evolution...
  15. pmc Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    Arthur Y Kim
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
    Gastroenterology 140:686-696.e1. 2011
    ..We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses...
  16. ncbi request reprint The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, 149 13th St 5th Fl, Boston, MA 02129, USA
    Blood 105:1170-8. 2005
    ....
  17. pmc Prospective follow-up of patients with acute hepatitis C virus infection in Brazil
    Lia L Lewis-Ximenez
    Viral Hepatitis Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Clin Infect Dis 50:1222-30. 2010
    ..The natural outcome of infection with hepatitis C virus (HCV) varies substantially among individuals. However, little is known about host and viral factors associated with a self-limiting or chronic evolution of HCV infection...
  18. pmc Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e492. 2006
    ..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...
  19. pmc Viral sequence evolution in acute hepatitis C virus infection
    Thomas Kuntzen
    Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:11658-68. 2007
    ....