TNF alpha inhibition as treatment modality for certain rheumatologic and gastrointestinal diseasesMarcus W Wiedmann
Department of Internal Medicine I, St Mary Hospital, 12249 Berlin, Germany
Endocr Metab Immune Disord Drug Targets 9:295-314. 2009
..It is the goal of this review article to summarize various therapeutic indications, underlying studies, safety, and use during pregnancy, as well as future directions for anti-TNF therapies...
Case report: extreme CgA elevation under PPI confounding assessment of adrenal massM W Wiedmann
Abteilung Innere I, St Marien Krankenhaus Berlin, Gallwitzallee 123 143, 12249 Berlin, Germany
Z Gastroenterol 47:671-3. 2009
..Finally, it was discovered that continuous proton-pump inhibitor administration for gastro-oesophageal reflux disease had caused a falsely elevated CgA level...
Sudden elevation of liver enzymes in a 64-year-old patient: a case reportMarcus Wiedmann
Department of Internal Medicine II, University of Leipzig, Germany
Cases J 2:205. 2009
..In summary, clinicians should be aware about the presented rare adverse event of Helicobacter pylori eradication treatment for a close monitoring of those patients and rapid management of acute liver failure...
- Splenic rupture following endoscopic polypectomy
M W Wiedmann
Abteilung Innere I, St Marien Krankenhaus Berlin, Berlin, Germany
Z Gastroenterol 48:476-8. 2010
..CT scan revealed hematoperitoneum and splenic subcapsular hematoma. Laparotomy with splenectomy was performed because of extended splenic rupture. The postoperative course was unremarkable except late wound dehiscence...
- Molecular targeted therapy of biliary tract cancer--results of the first clinical studies
Marcus W Wiedmann
Department of Internal Medicine I, St Mary s Hospital, Gallwitzallee 123 143, Berlin, Germany
Curr Drug Targets 11:834-50. 2010
..Although early evidence of antitumor activity was seen, the results are still preliminary and require further investigations...
- Molecular targeted therapy of hepatocellular carcinoma - results of the first clinical studies
Marcus W Wiedmann
Department of Internal Medicine I, St Mary s Hospital, Gallwitzallee 123 143, 12249 Berlin, Germany
Curr Cancer Drug Targets 11:714-33. 2011
..Until now, the only agent that has to be proven to be effective in terms of survival outcome in two phase III placebo-controlled studies is sorafenib, which became the current standard for palliative treatment...
- Polo-like kinase 1 inhibition as a new therapeutic modality in therapy of cholangiocarcinoma
Stephan Thrum
Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany
Anticancer Res 31:3289-99. 2011
..BI 2536, the first compound of the chemical class of dihydropteridinones, is a highly selective and potent inhibitor of PLK1...
