Barbara A Wible

Summary

Publications

  1. ncbi request reprint HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk
    Barbara A Wible
    ChanTest Inc, ChanXpress Inc, Cleveland, OH, 44128, USA
    J Pharmacol Toxicol Methods 52:136-45. 2005
  2. ncbi request reprint Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking
    Lu Wang
    Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, OH 44109, USA
    J Pharmacol Exp Ther 320:525-34. 2007
  3. doi request reprint An ion channel library for drug discovery and safety screening on automated platforms
    Barbara A Wible
    ChanTest Corporation, 14656 Neo Parkway, Cleveland, OH 44128, USA
    Assay Drug Dev Technol 6:765-80. 2008
  4. ncbi request reprint Pentamidine-induced long QT syndrome and block of hERG trafficking
    Yuri A Kuryshev
    Rammelkamp Center, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    J Pharmacol Exp Ther 312:316-23. 2005
  5. ncbi request reprint Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currents
    Yuri A Kuryshev
    Rammelkamp Center, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Mol Pharmacol 69:1216-25. 2006
  6. ncbi request reprint Mechanisms of arsenic-induced prolongation of cardiac repolarization
    Eckhard Ficker
    Rammelkamp Center, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Mol Pharmacol 66:33-44. 2004
  7. pmc Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons
    Patricia A Glazebrook
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44109, USA
    J Physiol 541:467-82. 2002
  8. ncbi request reprint Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis
    George Jarad
    Department of Medicine, Rammelkamp Center for Education and Research, MetroHealth Medical Center Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 277:47826-33. 2002
  9. ncbi request reprint Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells
    Barbara A Wible
    Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Biol Chem 277:17852-62. 2002
  10. pmc Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action
    Dierk Thomas
    Department of Cardiology, Medical University Hospital Heidelberg, Germany
    Br J Pharmacol 142:485-94. 2004

Collaborators

  • Arthur M Brown
  • Lu Wang
  • David Rampe
  • Aruna Basu
  • Eckhard K Ficker
  • Christoph A Karle
  • Dierk Thomas
  • Yuri A Kuryshev
  • Patricia A Glazebrook
  • Zhang Wei
  • George Jarad
  • Xiaoping Wan
  • Peter Hawryluk
  • Jiesheng Kang
  • William Reynolds
  • Kaoru Sawamura
  • Xiao Liang Chen
  • Adrienne T Dennis
  • Char Chang Shieh
  • Thanh Doan
  • John H Schild
  • John R Sedor
  • Jeffrey R Schelling
  • Diana L Kunze
  • Jay DeVore
  • Angelina N Ramirez
  • Shenaz Khan
  • Sven Kathofer
  • Karen Wu
  • Stephen L Nishimura
  • Martha Konieczkowski
  • Johann Kiehn
  • Hui Miao
  • Volker A W Kreye
  • Bingcheng Wang
  • Johannes Schenkel

Detail Information

Publications12

  1. ncbi request reprint HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk
    Barbara A Wible
    ChanTest Inc, ChanXpress Inc, Cleveland, OH, 44128, USA
    J Pharmacol Toxicol Methods 52:136-45. 2005
    ..To address the need for an inexpensive, rapid, and comprehensive assay to predict both types of hERG risk early in the drug development process, we have developed a novel antibody-based chemiluminescent assay called HERG-Lite...
  2. ncbi request reprint Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking
    Lu Wang
    Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, OH 44109, USA
    J Pharmacol Exp Ther 320:525-34. 2007
    ..Thus, cardiac glycosides are able to delay cardiac repolarization at nanomolar concentrations via hERG trafficking inhibition, and this may contribute to the complex electrocardiographic changes seen with compounds such as digitoxin...
  3. doi request reprint An ion channel library for drug discovery and safety screening on automated platforms
    Barbara A Wible
    ChanTest Corporation, 14656 Neo Parkway, Cleveland, OH 44128, USA
    Assay Drug Dev Technol 6:765-80. 2008
    ..The screening and validation processes as well as the relative advantages of different screening platforms are discussed...
  4. ncbi request reprint Pentamidine-induced long QT syndrome and block of hERG trafficking
    Yuri A Kuryshev
    Rammelkamp Center, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    J Pharmacol Exp Ther 312:316-23. 2005
    ..We propose that pentamidine, like arsenic trioxide, produces QT prolongation and torsades de pointes in patients by inhibition of hERG trafficking...
  5. ncbi request reprint Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currents
    Yuri A Kuryshev
    Rammelkamp Center, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Mol Pharmacol 69:1216-25. 2006
    ....
  6. ncbi request reprint Mechanisms of arsenic-induced prolongation of cardiac repolarization
    Eckhard Ficker
    Rammelkamp Center, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Mol Pharmacol 66:33-44. 2004
    ..Other drugs that interfere with proteins in the processing pathway of cardiac ion channels may be proarrhythmic for similar reasons...
  7. pmc Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons
    Patricia A Glazebrook
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44109, USA
    J Physiol 541:467-82. 2002
    ....
  8. ncbi request reprint Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis
    George Jarad
    Department of Medicine, Rammelkamp Center for Education and Research, MetroHealth Medical Center Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 277:47826-33. 2002
    ..We conclude that alpha(v)beta(8) integrin induction defines an unexpected role for Fas in cell migration, rather than as a cell death receptor...
  9. ncbi request reprint Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells
    Barbara A Wible
    Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Biol Chem 277:17852-62. 2002
    ..Consistent with its proapoptotic properties, KChAP prevents growth of DU145 and LNCaP tumor xenografts in nude mice, indicating that infection with Ad/KChAP might represent a novel method of cancer treatment...
  10. pmc Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action
    Dierk Thomas
    Department of Cardiology, Medical University Hospital Heidelberg, Germany
    Br J Pharmacol 142:485-94. 2004
    ....
  11. ncbi request reprint Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line
    Zhang Wei
    Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
    Chin Med J (Engl) 115:668-76. 2002
    ..To investigate the molecular mechanism of human ether-a-go-go-related gene (HERG) potassium channels regulated by protein kinase A (PKA) in a human cell line...
  12. ncbi request reprint HERG channel trafficking
    Eckhard Ficker
    Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland OH 44109, USA
    Novartis Found Symp 266:57-69; discussion 70-4, 95-9. 2005
    ..Therapeutic compounds that inhibit chaperone function produce a novel form of acquired long QT syndrome not by direct channel block but by reduced surface expression due to an acquired trafficking defect of hERG...