Peter J Whorwell

Summary

Publications

  1. pmc Evaluation and management of patients with noncardiac chest pain
    C Shekhar
    Neurogastroenterology Unit, Wythenshawe Hospital, Manchester M23 9LT, UK
    Gastroenterol Res Pract 2008:708218. 2008
  2. pmc Acupuncture for irritable bowel syndrome: primary care based pragmatic randomised controlled trial
    Hugh MacPherson
    Department of Health Sciences, University of York, York, UK
    BMC Gastroenterol 12:150. 2012
  3. pmc A randomised controlled trial on hypnotherapy for irritable bowel syndrome: design and methodological challenges (the IMAGINE study)
    Carla E Flik
    Julius Centre for Health Sciences and Primary Care, University Medical Centre, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    BMC Gastroenterol 11:137. 2011
  4. doi request reprint Unraveling functional abdominal bloating and distension: the role of thoraco-abdominal accommodation and a physical sign to aid its detection
    P J Whorwell
    Department of Translational Medicine, University of Manchester, UK
    Neurogastroenterol Motil 24:301-4. 2012
  5. doi request reprint Visceral hypersensitivity in endometriosis: a new target for treatment?
    B Issa
    Department of Translational Medicine, University of Manchester, Manchester, UK
    Gut 61:367-72. 2012
  6. pmc Do probiotics improve symptoms in patients with irritable bowel syndrome?
    Peter J Whorwell
    Education and Research Centre, Wythenshawe Hospital, Manchester, UK
    Therap Adv Gastroenterol 2:37-44. 2009
  7. doi request reprint Emerging drugs for irritable bowel syndrome
    Chander Shekhar
    University of Manchester, Neurogastroenterology Unit, University Hospital of South Manchester NHS Trust, Manchester, M23 9LT, UK
    Expert Opin Emerg Drugs 14:673-85. 2009
  8. ncbi request reprint Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit
    Lesley A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gastroenterology 131:1003-10. 2006
  9. doi request reprint Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    Chander Shekhar
    Neurogastroenterology Unit, University of Manchester, Manchester, UK
    Gastroenterology 145:749-57; quiz e13-4. 2013
  10. pmc Mood color choice helps to predict response to hypnotherapy in patients with irritable bowel syndrome
    Helen R Carruthers
    Department of Medicine, University of Manchester, Manchester, UK
    BMC Complement Altern Med 10:75. 2010

Collaborators

Detail Information

Publications25

  1. pmc Evaluation and management of patients with noncardiac chest pain
    C Shekhar
    Neurogastroenterology Unit, Wythenshawe Hospital, Manchester M23 9LT, UK
    Gastroenterol Res Pract 2008:708218. 2008
    ..For the more refractory cases, behavioral treatments, such as cognitive behavioral therapy or hypnotherapy, may have to be considered...
  2. pmc Acupuncture for irritable bowel syndrome: primary care based pragmatic randomised controlled trial
    Hugh MacPherson
    Department of Health Sciences, University of York, York, UK
    BMC Gastroenterol 12:150. 2012
    ..The purpose of the study was to evaluate the effectiveness of acupuncture for irritable bowel syndrome in primary care when provided as an adjunct to usual care...
  3. pmc A randomised controlled trial on hypnotherapy for irritable bowel syndrome: design and methodological challenges (the IMAGINE study)
    Carla E Flik
    Julius Centre for Health Sciences and Primary Care, University Medical Centre, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    BMC Gastroenterol 11:137. 2011
    ..The IMAGINE-study is therefore designed to assess the overall benefit of hypnotherapy in IBS as well as comparing the efficacy of individual versus group hypnotherapy in treating this condition...
  4. doi request reprint Unraveling functional abdominal bloating and distension: the role of thoraco-abdominal accommodation and a physical sign to aid its detection
    P J Whorwell
    Department of Translational Medicine, University of Manchester, UK
    Neurogastroenterol Motil 24:301-4. 2012
    ....
  5. doi request reprint Visceral hypersensitivity in endometriosis: a new target for treatment?
    B Issa
    Department of Translational Medicine, University of Manchester, Manchester, UK
    Gut 61:367-72. 2012
    ..Irritable bowel syndrome (IBS) is also common in this setting, and it was speculated that the visceral hypersensitivity associated with this condition might be amplifying the symptoms of endometriosis...
  6. pmc Do probiotics improve symptoms in patients with irritable bowel syndrome?
    Peter J Whorwell
    Education and Research Centre, Wythenshawe Hospital, Manchester, UK
    Therap Adv Gastroenterol 2:37-44. 2009
    ..Issues for the future include determining which organisms are most effective, defining optimal doses, comparing methods of delivery and assessing the role of mixtures or the addition of prebiotics...
  7. doi request reprint Emerging drugs for irritable bowel syndrome
    Chander Shekhar
    University of Manchester, Neurogastroenterology Unit, University Hospital of South Manchester NHS Trust, Manchester, M23 9LT, UK
    Expert Opin Emerg Drugs 14:673-85. 2009
    ..This has resulted in a rapid withdrawal from the scene by a number of companies although with the identification of some potential new therapeutic targets, the area has not been totally abandoned...
  8. ncbi request reprint Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit
    Lesley A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gastroenterology 131:1003-10. 2006
    ..The aim of this study was to use the technique of abdominal inductance plethysmography to compare diurnal variation in girth in IBS patients and healthy volunteers, relating these changes to the sensation of bloating...
  9. doi request reprint Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    Chander Shekhar
    Neurogastroenterology Unit, University of Manchester, Manchester, UK
    Gastroenterology 145:749-57; quiz e13-4. 2013
    ..We investigated relationships between platelet-depleted plasma concentrations of serotonin, gastrointestinal symptoms, and motor-sensory function in patients with FC or IBS-C compared with healthy volunteers (controls)...
  10. pmc Mood color choice helps to predict response to hypnotherapy in patients with irritable bowel syndrome
    Helen R Carruthers
    Department of Medicine, University of Manchester, Manchester, UK
    BMC Complement Altern Med 10:75. 2010
    ..Using this instrument we have been able to classify colors into positive, neutral and negative shades and this study aimed to assess their predictive role in hypnotherapy...
  11. ncbi request reprint Bloating and distention in irritable bowel syndrome: the role of visceral sensation
    Anurag Agrawal
    Neurogastroenterology Unit, University of Manchester, Manchester, United Kingdom
    Gastroenterology 134:1882-9. 2008
    ..A number of mechanisms have been postulated for bloating and distention, but the role of visceral sensation, which is often abnormal in IBS, has not been previously investigated, and this study aimed to address this question...
  12. doi request reprint Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit
    Anurag Agrawal
    Neurogastroenterology Unit, Gastrointestinal Sciences, School of Translational Medicine, University of Manchester, Manchester, UK
    Am J Gastroenterol 104:1998-2004. 2009
    ..Because constipation is often associated with delayed gastrointestinal transit, this study aimed at establishing whether patients with delayed transit show more distension and bloating than do those with normal transit...
  13. pmc The Manchester Color Wheel: validation in secondary school pupils
    Helen R Carruthers
    Department of Medical Illustration, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    BMC Med Res Methodol 12:136. 2012
    ..It also has the capacity to identify a positive frame of mind. We concluded that it might be a particularly useful instrument in adolescents and therefore this study aimed to validate it in a secondary school...
  14. doi request reprint Synesthesia, pseudo-synesthesia, and irritable bowel syndrome
    Helen R Carruthers
    Department of Translational Medicine, University of Manchester, Manchester, UK
    Dig Dis Sci 57:1629-35. 2012
    ..The purpose of this exploratory study was to ascertain whether these two conditions might be linked in any way...
  15. ncbi request reprint Effects of cilomilast, a selective phosphodiesterase 4 inhibitor, on esophageal motility and pH, and orocecal and colonic transit: two single-center, randomized, double-blind, placebo-controlled, two-part crossover studies in healthy volunteers
    Lesley A Houghton
    Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom
    Clin Ther 28:569-81. 2006
    ....
  16. ncbi request reprint Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome
    Peter J Whorwell
    Department of Medicine, University of Manchester, Manchester, UK
    Am J Gastroenterol 101:1581-90. 2006
    ..Thus, not all species will necessarily have the same therapeutic potential in a particular condition. We have preliminary evidence that Bifidobacterium infantis 35624 may have utility in irritable bowel syndrome (IBS)...
  17. doi request reprint Hypnotherapy for functional gastrointestinal disorders: a review
    Vivien Miller
    University of Manchester, Manchester, United Kingdom
    Int J Clin Exp Hypn 57:279-92. 2009
    ..These observations suggest that this form of treatment has considerable potential in aiding the management of functional gastrointestinal disorders and should be integrated into the ongoing medical care that these patients are receiving...
  18. ncbi request reprint Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome
    Wendy Atkinson
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University Hospital of South Manchester, Manchester, United Kingdom
    Gastroenterology 130:34-43. 2006
    ..The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed...
  19. doi request reprint Hypnotherapy for irritable bowel syndrome: the response of colonic and noncolonic symptoms
    Peter J Whorwell
    University of Manchester, Manchester, United Kingdom
    J Psychosom Res 64:621-3. 2008
    ....
  20. ncbi request reprint Psychological or organic vomiting
    Faiyaz Mohammed
    Department of Medicine, Wythenshawe Hospital, Manchester, UK
    Eur J Gastroenterol Hepatol 18:781-3. 2006
    ..It also raises the possibility of an additional mechanism by which achalasia could be initiated...
  21. ncbi request reprint Effective management of irritable bowel syndrome--the Manchester Model
    Peter J Whorwell
    Dept of Medicine, Wythenshawe Hospital, Manchester, UK
    Int J Clin Exp Hypn 54:21-6. 2006
    ..This paper describes how hypnotherapy has been successfully integrated into the functional gastroenterology service in Manchester...
  22. ncbi request reprint The Manchester Colour Wheel: enhancing its utility
    Helen R Carruthers
    Department of Translational Medicine, University of Manchester, Manchester, UK
    Percept Mot Skills 116:761-72. 2013
    ..These results show that adjustment of the wording of a mood-related question may allow equal response rates irrespective of the mood status of participants...
  23. pmc The Manchester Color Wheel: development of a novel way of identifying color choice and its validation in healthy, anxious and depressed individuals
    Helen R Carruthers
    Department of Medicine, University of Manchester, Manchester, UK
    BMC Med Res Methodol 10:12. 2010
    ..This was achieved by developing a simple method of presenting a series of colors to people validating it in healthy volunteers and in individuals where color choice might be distorted, namely anxiety and depression...
  24. ncbi request reprint Collagenous colitis, ulcerative colitis, coeliac disease and hyperparathyroidism in one patient: implications for the management of collagenous colitis
    Paul Smith
    Academic Department of Medicine, Wythenshawe Hospital, Manchester, UK
    Eur J Gastroenterol Hepatol 17:1239-42. 2005
    ..Furthermore, the threshold for re-investigating for the possibility of the development of ulcerative colitis may have to be lowered, particularly if symptoms change...
  25. ncbi request reprint The role of food intolerance in irritable bowel syndrome
    Richard Lea
    Medical Academic Department, Education and Research Centre, Wythenshawe Hospital, Manchester M23 9LT, United Kingdom
    Gastroenterol Clin North Am 34:247-55. 2005
    ..By further understanding the mechanisms involved in dietary intolerance, it should be possible to optimize the benefits of this approach to treatment...