Eating to exit: autophagy-enabled senescence revealedEileen White
The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
Genes Dev 23:784-7. 2009
..Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting...
The double-edged sword of autophagy modulation in cancerEileen White
The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
Clin Cancer Res 15:5308-16. 2009
..This is especially critical as many current cancer therapeutics activate autophagy. Therefore, efforts to understand and modulate the autophagy pathway will provide new approaches to cancer therapy and prevention...
- Effect of dual inhibition of apoptosis and autophagy in prostate cancer
Ahamed Saleem
The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
Prostate 72:1374-81. 2012
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- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Jessie Yanxiang Guo
The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
Genes Dev 25:460-70. 2011
..As cancers with Ras mutations have a poor prognosis, this "autophagy addiction" suggests that targeting autophagy and mitochondrial metabolism are valuable new approaches to treat these aggressive cancers...
- Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
Kevin Bray
The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
PLoS ONE 7:e41831. 2012
..Thus, coordinate mTOR and autophagy inhibition leads to an imbalance between ROS production and defense, causing necroptosis that may enhance cancer treatment efficacy...
- Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus
Eric H Andrianasolo
Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
J Nat Prod 74:842-6. 2011
..To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent mussel B. thermophilus...
- Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
Mark Stein
Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08901, USA
Prostate 70:1388-94. 2010
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- Bcl-2 modulation to activate apoptosis in prostate cancer
Kevin Bray
The Cancer Institute of New Jersey, New Brunswick, NJ 08903 2681, USA
Mol Cancer Res 7:1487-96. 2009
..Thus, rational targeting of both the Bcl-2 and Mcl-1 mechanisms of apoptosis resistance may be therapeutically advantageous for advanced prostate cancer...
- A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
Robert S DiPaola
Department of Medicine, The Cancer Institute of New Jersey, UMDNJ RWJMS, New Brunswick NJ, USA
J Transl Med 8:20. 2010
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A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylationMohamed M Rafi
Department of Food Science, New Jersey Agricultural Experimentation Station, Cook College, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
Anticancer Res 25:313-8. 2005
..Although initially active in clinical studies, current anti-microtubule agents are only temporarily effective and the discovery of new agents is warranted...
- Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy
Robert S DiPaola
Department of Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Prostate 68:1743-52. 2008
..The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a means to cell death, is rapidly expanding and supportive of a new paradigm of therapeutic starvation...
- A novel proteomic coculture model of prostate cancer cell growth
Dmitri Dvorzhinski
The Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA
Proteomics 4:3268-75. 2004
..These data, therefore, demonstrate a novel coculture model for further study of agents that target proteins in pathways of paracrine or autocrine stimulated cell growth...
- Deconvoluting the context-dependent role for autophagy in cancer
Eileen White
The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA
Nat Rev Cancer 12:401-10. 2012
..Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved will be important to guide autophagy-based therapeutic intervention...
- Role of autophagy in suppression of inflammation and cancer
Eileen White
The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
Curr Opin Cell Biol 22:212-7. 2010
..Thus, cellular damage mitigation through autophagy is a novel mechanism of tumor suppression...
- A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis
Kurt Degenhardt
Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854 and Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
Clin Cancer Res 12:5298-304. 2006
..We have applied this model to establish the role of apoptosis in epithelial solid tumor progression and in treatment response, which has provided novel opportunities for cancer therapies in humans...
- Apoptosis-inducing galactolipids from a cultured marine diatom, Phaeodactylum tricornutum
Eric H Andrianasolo
Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
J Nat Prod 71:1197-201. 2008
..The galactolipids induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by galactolipids...
- Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
Robin Mathew
The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
Curr Opin Genet Dev 21:113-9. 2011
..A better understanding of how autophagy modulates cell metabolism under various cellular stresses and the consequences of this on tumorigenesis will help develop better therapeutic strategies against cancer prevention and treatment...
- Role of autophagy in cancer prevention
Hsin Yi Chen
The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
Cancer Prev Res (Phila) 4:973-83. 2011
..These findings revealed the concept that aggressive cancers can be addicted to autophagy for survival. In this setting, autophagy inhibition is a therapeutic strategy for established cancers...
- Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes
Huimei Lu
The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
PLoS Genet 7:e1002291. 2011
..In addition, BCCIP deficiency causes excessive spontaneous chromatin bridges via the formation of SCU, which can subsequently impair chromosome segregations in mitosis and cell division...
- Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors
Sameera Kongara
Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
Mol Cancer Res 8:873-84. 2010
..High phospho(Ser73)-K8 expression may be a marker of autophagy functional status in breast tumors and, as such, could have therapeutic implications for breast cancer patients...
- Epothilone induced cytotoxicity is dependent on p53 status in prostate cells
Margarita L Ioffe
The Cancer Institute of New Jersey, Robert Wood Johnson Medical School/UMDNJ, New Brunswick, New Jersey 08901, USA
Prostate 61:243-7. 2004
..These data provide a basis for further study of p53, and the phosphorylation status of cdc-2, as markers for epothilone sensitivity in clinical studies...
