Eileen White

Summary

Publications

  1. pmc The double-edged sword of autophagy modulation in cancer
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Clin Cancer Res 15:5308-16. 2009
  2. doi request reprint Eating to exit: autophagy-enabled senescence revealed
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 23:784-7. 2009
  3. pmc Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e41831. 2012
  4. pmc Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 27:1447-61. 2013
  5. pmc Effect of dual inhibition of apoptosis and autophagy in prostate cancer
    Ahamed Saleem
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Prostate 72:1374-81. 2012
  6. pmc Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 25:460-70. 2011
  7. pmc Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer
    Yanying Huo
    Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Cancer Discov 3:894-907. 2013
  8. pmc Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Mar Drugs 10:2300-11. 2012
  9. doi request reprint Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
    Mark Stein
    Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08901, USA
    Prostate 70:1388-94. 2010
  10. pmc Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
    J Nat Prod 74:842-6. 2011

Research Grants

  1. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2010
  2. REGULATION OF APOPTOSIS BY VIRAL TRANSFORMING PROTEINS
    Eileen White; Fiscal Year: 2001
  3. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2009

Collaborators

  • Joshua D Rabinowitz
  • Shridar Ganesan
  • Jing Fan
  • Michael May
  • Hong Li
  • Hong Cai
  • Murugesan Gounder
  • Jingmei Liu
  • Linda Patrick-Miller
  • Mohamed M Rafi
  • Susan Goodin
  • Kerry L McPhail
  • Robert S DiPaola
  • Robin Mathew
  • Jessie Yanxiang Guo
  • Kevin Bray
  • Mark Stein
  • Eric H Andrianasolo
  • Hsin Yi Chen
  • Dmitri Dvorzhinski
  • Guanghua Chen
  • Jurre J Kamphorst
  • Vassiliki Karantza
  • Liti Haramaty
  • Richard Lutz
  • Paul Falkowski
  • Bing Xia
  • Yanying Huo
  • Sandy Price
  • Urmila Santanam
  • Ahamed Saleem
  • Anne M Strohecker
  • Gizem Karsli-Uzunbas
  • Costantino Vetriani
  • Nicola Barnard
  • Irina Teplova
  • Huimei Lu
  • Sameera Kongara
  • Kurt Degenhardt
  • Anu Thalasila
  • Margarita L Ioffe
  • Wenyun Lu
  • Eric Snyder
  • Christian Bowman-Colin
  • Xin Teng
  • Tyler Jacks
  • Seena C Aisner
  • Donna Zhang
  • Jim Chen
  • Anahita Ghavami
  • Alexandria Lau
  • Richard Rosario-Passapera
  • Zhiyuan Shen
  • Roberto Droz-Rosario
  • Sonam Mehrotra
  • Johanna M S Lemons
  • Hilary A Coller
  • Celine Gelinas
  • Yi Yuan Huang
  • Mantu Bhaumik
  • Jennifer Schulte
  • Carola A Neumann
  • David Vaughn
  • Michael Carducci
  • Bruce Roth
  • George Wilding
  • Olga Kravchuk
  • Hongxia Lin
  • Fred Lozy
  • Dirk Moore
  • Yu Hui Chen
  • Chandrika Jeyamohan
  • Simantini Eddy
  • Vassiliki Karantza-Wadsworth
  • Cristina M Karp
  • Donyell Doram
  • C Karp
  • Assaf Vardi
  • Brian Beaudoin
  • K Bray
  • David J Foran
  • Venkata Garikapaty
  • Deirdre A Nelson
  • Paul E Thomas
  • D Dvorzhinski
  • Deirdre Nelson

Detail Information

Publications26

  1. pmc The double-edged sword of autophagy modulation in cancer
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Clin Cancer Res 15:5308-16. 2009
    ..This is especially critical as many current cancer therapeutics activate autophagy. Therefore, efforts to understand and modulate the autophagy pathway will provide new approaches to cancer therapy and prevention...
  2. doi request reprint Eating to exit: autophagy-enabled senescence revealed
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 23:784-7. 2009
    ..Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting...
  3. pmc Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e41831. 2012
    ..Thus, coordinate mTOR and autophagy inhibition leads to an imbalance between ROS production and defense, causing necroptosis that may enhance cancer treatment efficacy...
  4. pmc Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 27:1447-61. 2013
    ..Moreover, cancers require autophagy for distinct roles in metabolism that are oncogene- and tumor suppressor gene-specific. ..
  5. pmc Effect of dual inhibition of apoptosis and autophagy in prostate cancer
    Ahamed Saleem
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Prostate 72:1374-81. 2012
    ....
  6. pmc Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 25:460-70. 2011
    ..As cancers with Ras mutations have a poor prognosis, this "autophagy addiction" suggests that targeting autophagy and mitochondrial metabolism are valuable new approaches to treat these aggressive cancers...
  7. pmc Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer
    Yanying Huo
    Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Cancer Discov 3:894-907. 2013
    ..These results indicate that, in the face of DNA damage and oxidative stress elicited by PALB2 loss, p53 is a barrier to cancer development, whereas autophagy facilitates cell survival and tumorigenesis. ..
  8. pmc Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Mar Drugs 10:2300-11. 2012
    ..To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans...
  9. doi request reprint Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
    Mark Stein
    Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08901, USA
    Prostate 70:1388-94. 2010
    ....
  10. pmc Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
    J Nat Prod 74:842-6. 2011
    ..To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent mussel B. thermophilus...
  11. pmc Bcl-2 modulation to activate apoptosis in prostate cancer
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, NJ 08903 2681, USA
    Mol Cancer Res 7:1487-96. 2009
    ..Thus, rational targeting of both the Bcl-2 and Mcl-1 mechanisms of apoptosis resistance may be therapeutically advantageous for advanced prostate cancer...
  12. pmc A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
    Robert S DiPaola
    Department of Medicine, The Cancer Institute of New Jersey, UMDNJ RWJMS, New Brunswick NJ, USA
    J Transl Med 8:20. 2010
    ....
  13. pmc Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy
    Robert S DiPaola
    Department of Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Prostate 68:1743-52. 2008
    ..The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a means to cell death, is rapidly expanding and supportive of a new paradigm of therapeutic starvation...
  14. ncbi request reprint A novel proteomic coculture model of prostate cancer cell growth
    Dmitri Dvorzhinski
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA
    Proteomics 4:3268-75. 2004
    ..These data, therefore, demonstrate a novel coculture model for further study of agents that target proteins in pathways of paracrine or autocrine stimulated cell growth...
  15. ncbi request reprint A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation
    Mohamed M Rafi
    Department of Food Science, New Jersey Agricultural Experimentation Station, Cook College, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
    Anticancer Res 25:313-8. 2005
    ..Although initially active in clinical studies, current anti-microtubule agents are only temporarily effective and the discovery of new agents is warranted...
  16. pmc Deconvoluting the context-dependent role for autophagy in cancer
    Eileen White
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA
    Nat Rev Cancer 12:401-10. 2012
    ..Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved will be important to guide autophagy-based therapeutic intervention...
  17. pmc Role of autophagy in suppression of inflammation and cancer
    Eileen White
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Curr Opin Cell Biol 22:212-7. 2010
    ..Thus, cellular damage mitigation through autophagy is a novel mechanism of tumor suppression...
  18. pmc Apoptosis-inducing galactolipids from a cultured marine diatom, Phaeodactylum tricornutum
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
    J Nat Prod 71:1197-201. 2008
    ..The galactolipids induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by galactolipids...
  19. ncbi request reprint A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854 and Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Clin Cancer Res 12:5298-304. 2006
    ..We have applied this model to establish the role of apoptosis in epithelial solid tumor progression and in treatment response, which has provided novel opportunities for cancer therapies in humans...
  20. pmc Exploiting the bad eating habits of Ras-driven cancers
    Eileen White
    Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 27:2065-71. 2013
    ..Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy. ..
  21. pmc Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
    Robin Mathew
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Curr Opin Genet Dev 21:113-9. 2011
    ..A better understanding of how autophagy modulates cell metabolism under various cellular stresses and the consequences of this on tumorigenesis will help develop better therapeutic strategies against cancer prevention and treatment...
  22. pmc Role of autophagy in cancer prevention
    Hsin Yi Chen
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Cancer Prev Res (Phila) 4:973-83. 2011
    ..These findings revealed the concept that aggressive cancers can be addicted to autophagy for survival. In this setting, autophagy inhibition is a therapeutic strategy for established cancers...
  23. doi request reprint Autophagy-mediated tumor promotion
    Jessie Yanxiang Guo
    Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Cell 155:1216-9. 2013
    ..Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas. ..
  24. pmc Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes
    Huimei Lu
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    PLoS Genet 7:e1002291. 2011
    ..In addition, BCCIP deficiency causes excessive spontaneous chromatin bridges via the formation of SCU, which can subsequently impair chromosome segregations in mitosis and cell division...
  25. pmc Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors
    Sameera Kongara
    Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Mol Cancer Res 8:873-84. 2010
    ..High phospho(Ser73)-K8 expression may be a marker of autophagy functional status in breast tumors and, as such, could have therapeutic implications for breast cancer patients...
  26. ncbi request reprint Epothilone induced cytotoxicity is dependent on p53 status in prostate cells
    Margarita L Ioffe
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School UMDNJ, New Brunswick, New Jersey 08901, USA
    Prostate 61:243-7. 2004
    ..We hypothesized that epothilone induced cytotoxicity would be influenced by the status of p53 in prostate cells...

Research Grants12

  1. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2010
    ..We propose to establish the mechanism of autophagy and its consequence to cancer progression and therapeutic response. ..
  2. REGULATION OF APOPTOSIS BY VIRAL TRANSFORMING PROTEINS
    Eileen White; Fiscal Year: 2001
    ..The long term goal of the work is to study this important mechanism of tumor suppression. ..
  3. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2009
    ..We propose to establish the mechanism of autophagy and its consequence to cancer progression and therapeutic response. ..