James W Wheless

Summary

Publications

  1. doi request reprint Subependymal giant cell astrocytomas in patients with tuberous sclerosis complex: considerations for surgical or pharmacotherapeutic intervention
    James W Wheless
    Department of Pediatric Neurology, Neuroscience Institute and Tuberous Sclerosis Clinic, Le Bonheur Children s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA
    J Child Neurol 29:1562-71. 2014
  2. doi request reprint Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience
    James W Wheless
    University of Tennessee Health Science Center, Le Bonheur Children s Hospital, Memphis, TN, USA Electronic address
    Epilepsy Behav 41:47-52. 2014
  3. doi request reprint A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex
    James W Wheless
    Division of Pediatric Neurology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Child Neurol 28:933-6. 2013
  4. doi request reprint Clobazam: a newly approved but well-established drug for the treatment of intractable epilepsy syndromes
    James W Wheless
    LeBonheur Children s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA
    J Child Neurol 28:219-29. 2013
  5. pmc Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents
    James W Wheless
    University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Pediatr 12:108. 2012
  6. doi request reprint Treatment of refractory convulsive status epilepticus in children: other therapies
    James W Wheless
    LeBonheur Children s Hospital, University of Tennessee Health Science Center and St Jude Children s Research Hospital, Memphis, TN, USA
    Semin Pediatr Neurol 17:190-4. 2010
  7. doi request reprint Seizure emergency plans: patient results from a cross-sectional epilepsy survey
    James W Wheless
    University of Tennessee Health Science Center, Memphis, TN, USA
    Epilepsy Behav 13:489-93. 2008
  8. doi request reprint Is it time to replace the Wada test and put awake craniotomy to sleep?
    Andrew C Papanicolaou
    Department of Pediatrics, Division of Clinical Neurosciences, University of Tennessee Health Science Center, Memphis, Tennessee, U S A Neuroscience Institute, Le Bonheur Children s Hospital, Memphis, Tennessee, U S A
    Epilepsia 55:629-32. 2014
  9. doi request reprint Assessing motor function in young children with transcranial magnetic stimulation
    Shalini Narayana
    Division of Clinical Neurosciences, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee Le Bonheur Neuroscience Institute, Le Bonheur Children s Hospital, Memphis, Tennessee Department of Neurobiology and Anatomy, University of Tennessee Health Science Center, Memphis, Tennessee Electronic address
    Pediatr Neurol 52:94-103. 2015
  10. pmc Same day tri-modality functional brain mapping prior to resection of a lesion involving eloquent cortex: technical feasibility
    Asim F Choudhri
    Department of Radiology, Department of Pediatrics, Division of Clinical Neurosciences, Department of Neurosurgery, Department of Ophthalmology, Division of Neurology University of Tennessee, Health Science Center Memphis, TN, USA Le Bonheur Neuroscience Institute, Le Bonheur Children s Hospital Memphis, TN, USA
    Neuroradiol J 26:548-54. 2013

Detail Information

Publications30

  1. doi request reprint Subependymal giant cell astrocytomas in patients with tuberous sclerosis complex: considerations for surgical or pharmacotherapeutic intervention
    James W Wheless
    Department of Pediatric Neurology, Neuroscience Institute and Tuberous Sclerosis Clinic, Le Bonheur Children s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA
    J Child Neurol 29:1562-71. 2014
    ..We review the timing and use of surgery versus pharmacotherapy for the treatment of subependymal giant cell astrocytoma in patients with tuberous sclerosis complex. ..
  2. doi request reprint Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience
    James W Wheless
    University of Tennessee Health Science Center, Le Bonheur Children s Hospital, Memphis, TN, USA Electronic address
    Epilepsy Behav 41:47-52. 2014
    ..Analyses using baseline seizure frequency and VNS use as surrogates for disease severity showed that clobazam treatment of patients with less severe or severe LGS was equally efficacious...
  3. doi request reprint A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex
    James W Wheless
    Division of Pediatric Neurology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Child Neurol 28:933-6. 2013
    ..The authors formulated a novel rapamycin cream that is easy to compound and apply, does not cause local or systemic side effects, and results in a dramatic improvement of facial angiofibromas...
  4. doi request reprint Clobazam: a newly approved but well-established drug for the treatment of intractable epilepsy syndromes
    James W Wheless
    LeBonheur Children s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA
    J Child Neurol 28:219-29. 2013
    ..However, clobazam appears to display greater selectivity for receptors responsible for anticonvulsant activity than for those involved in sedation...
  5. pmc Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents
    James W Wheless
    University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Pediatr 12:108. 2012
    ..The objective of this article is to assist pediatric health care providers in the detection of the disease and in the counseling and guidance of families who have an infant with IS...
  6. doi request reprint Treatment of refractory convulsive status epilepticus in children: other therapies
    James W Wheless
    LeBonheur Children s Hospital, University of Tennessee Health Science Center and St Jude Children s Research Hospital, Memphis, TN, USA
    Semin Pediatr Neurol 17:190-4. 2010
    ..This review addresses the literature related to the use of the latter (4) treatment options. I will discuss the role of each treatment and review the evidence for it's use, along with possible side-effects...
  7. doi request reprint Seizure emergency plans: patient results from a cross-sectional epilepsy survey
    James W Wheless
    University of Tennessee Health Science Center, Memphis, TN, USA
    Epilepsy Behav 13:489-93. 2008
    ..Seizure emergency plans appear to be reserved for adults with more severe disease, but there may be clinical benefits to developing a plan for all adult patients with epilepsy...
  8. doi request reprint Is it time to replace the Wada test and put awake craniotomy to sleep?
    Andrew C Papanicolaou
    Department of Pediatrics, Division of Clinical Neurosciences, University of Tennessee Health Science Center, Memphis, Tennessee, U S A Neuroscience Institute, Le Bonheur Children s Hospital, Memphis, Tennessee, U S A
    Epilepsia 55:629-32. 2014
    ....
  9. doi request reprint Assessing motor function in young children with transcranial magnetic stimulation
    Shalini Narayana
    Division of Clinical Neurosciences, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee Le Bonheur Neuroscience Institute, Le Bonheur Children s Hospital, Memphis, Tennessee Department of Neurobiology and Anatomy, University of Tennessee Health Science Center, Memphis, Tennessee Electronic address
    Pediatr Neurol 52:94-103. 2015
    ..In such cases, passive mapping of the sensorimotor cortex is performed under sedation. We examined the feasibility of using transcranial magnetic stimulation (TMS) as a motor mapping tool in awake children younger than 3 years of age...
  10. pmc Same day tri-modality functional brain mapping prior to resection of a lesion involving eloquent cortex: technical feasibility
    Asim F Choudhri
    Department of Radiology, Department of Pediatrics, Division of Clinical Neurosciences, Department of Neurosurgery, Department of Ophthalmology, Division of Neurology University of Tennessee, Health Science Center Memphis, TN, USA Le Bonheur Neuroscience Institute, Le Bonheur Children s Hospital Memphis, TN, USA
    Neuroradiol J 26:548-54. 2013
    ....
  11. doi request reprint Variation in the topography of the speech production cortex verified by cortical stimulation and high gamma activity
    Abbas Babajani-Feremi
    aDepartment of Pediatrics, Division of Clinical Neurosciences Departments of bRadiology cNeurosurgery dPediatric Neurology eNeurobiology and Anatomy, University of Tennessee Health Science Center fNeuroscience Institute, Le Bonheur Children s Hospital, Memphis, Tennessee, USA
    Neuroreport 25:1411-7. 2014
    ....
  12. doi request reprint Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy
    James W Wheless
    LeBonheur Neuroscience Institute, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Epilepsia 50:195-205. 2009
    ..We carried out a retrospective review to better characterize the frequency of those abnormalities in IS and in children and adults treated with vigabatrin for refractory complex partial seizures (CPS)...
  13. doi request reprint Passive language mapping with magnetoencephalography in pediatric patients with epilepsy
    Mark Van Poppel
    Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Neurosurg Pediatr 10:96-102. 2012
    ..In this study the authors review a series of children with epilepsy who underwent language mapping with magnetoencephalography (MEG) while sedated or sleeping, to determine receptive language localization for presurgical evaluation...
  14. doi request reprint Amygdalar neuromelanosis intractable epilepsy without leptomeningeal involvement
    Douglas R Taylor
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Neurosurg Pediatr 12:21-4. 2013
    ..As evidenced by the lack of seizure activity following resection, the patient's quality of life greatly improved after neurological surgery. ..
  15. ncbi request reprint Treatment of pediatric epilepsy: European expert opinion, 2007
    James W Wheless
    Division of Pediatric Neurology, Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Epileptic Disord 9:353-412. 2007
    ..In such clinical situations, expert opinion can be especially helpful...
  16. doi request reprint Pediatric extratemporal epilepsy presenting with a complex auditory aura
    Dave F Clarke
    Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Epileptic Disord 10:181-6. 2008
    ..We report on one child, whose aura was a more complex auditory phenomenon, consisting of a door opening and closing, getting louder as the ictus persisted...
  17. doi request reprint Diffusion tensor imaging to evaluate commissural disconnection after corpus callosotomy
    Asim F Choudhri
    Department of Radiology, University of Tennessee Health Science Center, Memphis, TN, USA
    Neuroradiology 55:1397-403. 2013
    ..We evaluated whether diffusion tensor imaging (DTI) and diffusion tensor fiber tracking can assess the degree of callosal transection and determine which white matter pathways remain intact...
  18. doi request reprint Mesial temporal sclerosis in a cohort of children with SCN1A gene mutation
    Katherine Van Poppel
    Le Bonheur Comprehensive Epilepsy Program, Memphis, TN, USA
    J Child Neurol 27:893-7. 2012
    ..We conclude that mesial temporal sclerosis is a common finding in children with SCN1A mutations. Many of these children will have Dravet syndrome but not all...
  19. doi request reprint Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: survey of patients with epilepsy and physicians
    Collin A Hovinga
    University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Epilepsy Behav 13:316-22. 2008
    ....
  20. doi request reprint Angiocentric glioma-induced seizures in a 2-year-old child
    Stephen P Fulton
    Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Child Neurol 24:852-6. 2009
    ..Lesionectomy permitted sparing of adjacent areas of eloquent cortex, and the child is now seizure-free on monotherapy...
  21. pmc Levetiracetam as monotherapy for seizures in a neonate with acute lymphoblastic leukemia
    Davonna S Ledet
    Division of Neurology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Eur J Paediatr Neurol 14:78-9. 2010
    ..We report the successful use of levetiracetam monotherapy after Phenobarbital load in a neonate with leukemia and localization-related epilepsy...
  22. doi request reprint Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution: a safety study
    James W Wheless
    Department of Pediatrics and Neurology, University of Tennessee Health Science Center, LeBonheur Children s Medical Center, Neuroscience Institute, Memphis, Tennessee 38105, USA
    J Child Neurol 24:946-51. 2009
    ..The authors concluded that high serum levels of parenteral levetiracetam can be achieved rapidly and safely, in a small infusion volume. This finding has important implications for the treatment of status epilepticus...
  23. ncbi request reprint Corpus callosotomy: a palliative therapeutic technique may help identify resectable epileptogenic foci
    Dave F Clarke
    Department of Pediatrics, Division of Pediatric Neurology, Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Seizure 16:545-53. 2007
    ..Study limitations include its retrospective nature and cohort size. The findings, however, suggest the need for prospective, systematic, well-controlled studies of the use of corpus callostomy in this intractable patient population...
  24. ncbi request reprint Vigabatrin
    James W Wheless
    University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
    Neurotherapeutics 4:163-72. 2007
    ....
  25. doi request reprint Safety and tolerability of rufinamide in children with epilepsy: a pooled analysis of 7 clinical studies
    James W Wheless
    Department of Pediatric Neurology University of Tennessee Health Science Center, Le Bonheur Children s Medical Center Neuroscience Institute, Memphis, Tennessee 38105, USA
    J Child Neurol 24:1520-5. 2009
    ..This pooled analysis of data from pediatric patients in clinical studies of rufinamide for the treatment of seizures, mainly as adjunctive therapy, suggests a favorable safety and tolerability profile in this patient population...
  26. doi request reprint Managing severe epilepsy syndromes of early childhood
    James W Wheless
    Department of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    J Child Neurol 24:24S-32S; quiz 33S-6S. 2009
    ..Special treatment considerations for each syndrome are also highlighted to improve the management of patients with these syndromes...
  27. doi request reprint The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus
    James W Wheless
    LeBonheur Children s Medical Center, University of Tennessee, Memphis, Tennessee 38105, USA
    Epilepsia 49:74-8. 2008
    ..This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration...
  28. ncbi request reprint Intractable epilepsy: A survey of patients and caregivers
    James W Wheless
    Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    Epilepsy Behav 8:756-64. 2006
    ..Physicians must take into account medication side effects and quality-of-life issues when treating patients with epilepsy...
  29. ncbi request reprint Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States
    Kit Sing Au
    Department of Pediatrics, The University of Texas Medical School at Houston, 77030, USA
    Genet Med 9:88-100. 2007
    ..Male patients showed more frequent neurologic and eye symptoms, renal cysts, and ungual fibromas. Correlating genotypes with phenotypes should facilitate the disease management of tuberous sclerosis complex...
  30. ncbi request reprint Treatment of pediatric epilepsy: expert opinion, 2005
    James W Wheless
    Division of Pediatric Neurology, Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Child Neurol 20:S1-56; quiz S59-60. 2005
    ..In such clinical situations, expert opinion can be especially helpful...