- Functional neuroimaging studies of the amygdala in depression
Paul J Whalen
Department of Psychiatry, W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin, Madison, WI 53705, USA
Semin Clin Neuropsychiatry 7:234-42. 2002
..Furthermore, we suggest that the scope of the amygdala's involvement may go beyond its well-known role in fear to its more subtle and generalized role in modulating moment-to-moment vigilance levels...
- Contextual modulation of amygdala responsivity to surprised faces
University of Wisconsin Madison, Madison, WI 53705, USA
J Cogn Neurosci 16:1730-45. 2004
..Connectivity analyses identified candidate cortical-subcortical systems subserving this modulation...
- Human amygdala responsivity to masked fearful eye whites
Paul J Whalen
Department of Psychiatry, W M Keck Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, USA
Science 306:2061. 2004
..These data demonstrate that the amygdala is responsive to elements of...
- Stability of amygdala BOLD response to fearful faces over multiple scan sessions
W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin, WI 53705, USA
Neuroimage 25:1112-23. 2005
..Future studies might manipulate the experimental design to either amplify or attenuate this variability, according to the goals of the research...
- Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response
Jack B Nitschke
Departments of Psychiatry and Psychology, University of Wisconsin, Madison, 53705 2280, USA
Am J Psychiatry 166:302-10. 2009
..This study tested whether patients with generalized anxiety disorder have alterations in anticipatory amygdala function and whether anticipatory activity in the anterior cingulate cortex predicts treatment response...
- Human amygdala responses during presentation of happy and neutral faces: correlations with state anxiety
Leah H Somerville
W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin 53705, USA
Biol Psychiatry 55:897-903. 2004
..This study assessed amygdala response to happy and neutral facial expressions in an experimental paradigm devoid of primary negatively valenced comparison expressions...
- Selectively reduced regional cortical volumes in post-traumatic stress disorder
Scott L Rauch
Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
Neuroreport 14:913-6. 2003
..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD...
- Inverse amygdala and medial prefrontal cortex responses to surprised faces
W M Keck Laboratory for Functional Brain Imaging, Department of Psychiatry, University of Wisconsin Madison, 53705, USA
Neuroreport 14:2317-22. 2003
- The counting Stroop: a cognitive interference task
Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Nat Protoc 1:230-3. 2006
- A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder
Scott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
Psychiatry Res 122:13-9. 2003
..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders...
- Age- and gender-related changes in the normal human brain using hybrid diffusion imaging (HYDI)
Yu Chien Wu
Department of Radiology, University of Wisconsin Madison, Madison, WI, USA
Neuroimage 54:1840-53. 2011
- Brain habituation during repeated exposure to fearful and neutral faces: a functional MRI study
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Brain Res Bull 59:387-92. 2003
..These results indicate that brain regions involved in novelty detection and memory processing habituate at similar rates regardless of whether the face in focus displays an aversive emotional expression or not...
- A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder
Lisa M Shin
Department of Psychology, Tufts University, Medford, Mass, USA
Arch Gen Psychiatry 62:273-81. 2005
..Previous functional neuroimaging studies have demonstrated exaggerated amygdala responses and diminished medial prefrontal cortex responses during the symptomatic state in posttraumatic stress disorder (PTSD)...
- A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder
Paul J Whalen
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Biol Psychiatry 63:858-63. 2008
..Here, we sought to determine whether pretreatment amygdala and rostral ACC (rACC) reactivity to facial expressions could predict treatment outcomes in patients with generalized anxiety disorder (GAD)...
- The uncertainty of it all
Paul J Whalen
Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA
Trends Cogn Sci 11:499-500. 2007
..e. tones) when they occur in an unpredictable fashion. The implications of this finding for understanding the role of the amygdala in vigilance, threat assessment and anxiety are considered here...
- Differential amygdalar response to novel versus newly familiar neutral faces: a functional MRI probe developed for studying inhibited temperament
Carl E Schwartz
Developmental Psychopathology Research Group CES, Massachusetts General Hospital, Charlestown 02129, USA
Biol Psychiatry 53:854-62. 2003
..Prior neuroimaging studies of the amygdala in humans to date have focused principally on responses to emotional stimuli, primarily aversive, rather than to novelty per se...