Martin Westphal

Summary

Publications

  1. pmc Arginine vasopressin versus norepinephrine: will the stronger one win the race?
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care 10:144. 2006
  2. pmc Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome I 00161, Italy
    Crit Care 15:R217. 2011
  3. pmc Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 14:R232. 2010
  4. pmc Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str, 33, Muenster 48149, Germany
    Crit Care 14:R200. 2010
  5. pmc Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 13:R130. 2009
  6. pmc Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 12:R143. 2008
  7. pmc Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats
    Stefan Lauer
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert Schweitzer Str, 33, 48149 Muenster, Germany
    Crit Care 13:R109. 2009
  8. ncbi request reprint Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, USA
    Anesthesiology 102:954-61. 2005
  9. ncbi request reprint [Role of adrenomedullin in the pathogenesis and treatment of cardiovascular dysfunctions and sepsis]
    M Westphal
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum, Munster
    Anaesthesist 55:171-8. 2006
  10. doi request reprint Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 36:1196-204. 2008

Detail Information

Publications103 found, 100 shown here

  1. pmc Arginine vasopressin versus norepinephrine: will the stronger one win the race?
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care 10:144. 2006
    ..This in turn raises the question whether the quality of vasopressors should be judged by their potency...
  2. pmc Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome I 00161, Italy
    Crit Care 15:R217. 2011
    ..The primary study end point was a difference of ≥ 20% in the microvascular flow index of small vessels among groups...
  3. pmc Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 14:R232. 2010
    ..e. dobutamine). The primary end point was a difference of ≥ 20% in the microvascular flow index of small vessels (MFIs) among groups...
  4. pmc Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str, 33, Muenster 48149, Germany
    Crit Care 14:R200. 2010
    ..the mixed V(1a)R/V(2)R-agonist arginine vasopressin (AVP) or placebo in an established ovine model of septic shock...
  5. pmc Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 13:R130. 2009
    ....
  6. pmc Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 12:R143. 2008
    ..The aim of the present study was, therefore, to investigate the effects of a first-line therapy with either phenylephrine or norepinephrine on systemic and regional hemodynamics in patients with septic shock...
  7. pmc Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats
    Stefan Lauer
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert Schweitzer Str, 33, 48149 Muenster, Germany
    Crit Care 13:R109. 2009
    ....
  8. ncbi request reprint Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, USA
    Anesthesiology 102:954-61. 2005
    ....
  9. ncbi request reprint [Role of adrenomedullin in the pathogenesis and treatment of cardiovascular dysfunctions and sepsis]
    M Westphal
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum, Munster
    Anaesthesist 55:171-8. 2006
    ..The objectives of this review article are to characterize the regulative properties of AM and to discuss clinical and experimental studies which allow to judge the role of AM in the setting of cardiovascular dysfunction and sepsis...
  10. doi request reprint Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 36:1196-204. 2008
    ..Therefore, we aimed to examine the effects of selective neuronal NOS inhibition on cardiopulmonary functions and cellular injury in sheep with acute respiratory distress syndrome secondary to combined burn and smoke inhalation injury...
  11. doi request reprint Hydroxyethyl starches: different products--different effects
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Anesthesiology 111:187-202. 2009
    ..The impact of source material on structure and pharmacokinetics is highlighted, and the role of the carrier solution is critically assessed...
  12. ncbi request reprint [More than just a "PEEP-Show"]
    Martin Westphal
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Germany
    Anasthesiol Intensivmed Notfallmed Schmerzther 42:520-1. 2007
  13. ncbi request reprint Carboxyhemoglobin formation following smoke inhalation injury in sheep is interrelated with pulmonary shunt fraction
    Martin Westphal
    Department of Investigational Intensive Care Unit and Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX, USA
    Biochem Biophys Res Commun 311:754-8. 2003
    ..96 and -0.93). Although the arteriovenous COHb gradient successively decreased over time, COHb determined in venous blood underestimated the arterial content...
  14. ncbi request reprint Processing of stored packed red blood cells using autotransfusion devices decreases potassium and microaggregates: a prospective, randomized, single-blinded in vitro study
    B Westphal-Varghese
    Department of Transfusion Medicine, University of Muenster, Muenster, Germany
    Transfus Med 17:89-95. 2007
    ..e. hyperkalaemia and microvascular obstruction secondary to free cell fragments. This approach could be especially useful in patients undergoing massive transfusion and/or suffering from renal failure...
  15. ncbi request reprint Acute effects of combined burn and smoke inhalation injury on carboxyhemoglobin formation, tissue oxygenation, and cardiac performance
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, and Shriners Burns Hospital for Children, Galveston, TX, USA
    Biochem Biophys Res Commun 317:945-9. 2004
    ....
  16. ncbi request reprint Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock
    Marc O Maybauer
    Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital, 301 University Blvd, Galveston, TX 77555 0833, USA
    Intensive Care Med 33:1219-27. 2007
    ..To investigate ceftazidime in acute lung injury (ALI) and sepsis...
  17. ncbi request reprint Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston, USA
    Crit Care Med 34:2432-8. 2006
    ..To investigate the effects of recombinant human activated protein C (rhAPC) on pulmonary function in acute lung injury (ALI) resulting from smoke inhalation in association with a bacterial challenge...
  18. doi request reprint Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 38:2016-23. 2010
    ..To compare the effects of a first-line therapy of combined arginine vasopressin, levosimendan, and norepinephrine with arginine vasopressin + norepinephrine or norepinephrine alone in ovine septic shock...
  19. doi request reprint Combined recombinant human activated protein C and ceftazidime prevent the onset of acute respiratory distress syndrome in severe sepsis
    Marc O Maybauer
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555 0591, USA
    Shock 37:170-6. 2012
    ....
  20. doi request reprint Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury
    Martin Westphal
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 39:357-63. 2011
    ..To elucidate the effects of low-dose arginine vasopressin on cardiopulmonary functions and nitrosative stress using an established model of acute lung injury...
  21. ncbi request reprint Effects of titrated arginine vasopressin on hemodynamic variables and oxygen transport in healthy and endotoxemic sheep
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Muenster, Germany
    Crit Care Med 31:1502-8. 2003
    ..To determine the effects of titrated arginine vasopressin (AVP) alone or in combination with norepinephrine (NE) on hemodynamics and oxygen transport in healthy and endotoxemic sheep...
  22. doi request reprint Somatostatin infusion increases intestinal ischemia and does not improve vasoconstrictor response to norepinephrine in ovine endotoxemia
    Stefan Lauer
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Shock 30:603-9. 2008
    ..In addition, combined SOMA and NE therapy resulted in intestinal injury. Therefore, SOMA does not seem to represent a therapeutic option to treat arterial hypotension resulting from sepsis and systemic inflammatory response syndrome...
  23. ncbi request reprint Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep
    Dirk M Maybauer
    Departments of Anesthesiology and Surgery, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas, U S A
    Shock 26:489-95. 2006
    ..aeruginosa infusion. The results of this study reflect the complex pathophysiological variances of the combined injury and may provide a basis for future investigations for the treatment of this kind of injury...
  24. ncbi request reprint Continuously infused glipizide reverses the hyperdynamic circulation in ovine endotoxemia
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Shock 27:701-6. 2007
    ..From these results, we conclude that continuous glipizide infusion may represent a useful therapeutic option in the treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome...
  25. ncbi request reprint Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury
    Naoki Morita
    The University of Texas Medical Branch, Department of Anaesthesiology and Shriners Burns Hospital for Children, Galveston, Texas, USA
    Redox Rep 11:61-70. 2006
    ..We hypothesized that vitamin E supplementation (alpha-tocopherol) would attenuate acute lung injury induced by burn and smoke inhalation injury...
  26. ncbi request reprint Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555 0833, USA
    Shock 24:226-31. 2005
    ....
  27. ncbi request reprint Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasoconstriction
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 34:1428-36. 2006
    ..To examine the effects of combined burn and smoke inhalation injury on hypoxic pulmonary vasoconstriction, 3-nitrotyrosine formation, and respiratory function in adult sheep...
  28. ncbi request reprint Continuous versus bolus infusion of terlipressin in ovine endotoxemia
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Shock 28:623-9. 2007
    ..Continuous low-dose terlipressin infusion may represent a useful alternative treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome...
  29. doi request reprint Renal effects of saline-based 10% pentastarch versus 6% tetrastarch infusion in ovine endotoxemic shock
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Anesthesiology 112:936-47. 2010
    ..The current study evaluates the effects of saline-based 6% HES 130/0.4, 10% HES 200/0.5, and a balanced isotonic crystalloid on renal function and microscopic changes in ovine endotoxemic shock...
  30. ncbi request reprint Short-term effects of glipizide (an adenosine triphosphate-sensitive potassium channel inhibitor) on cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheep
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, 48161 Muenster, Germany
    Shock 26:516-21. 2006
    ..Additional studies are required to determine the effects of continuous infusion of glipizide in the presence of systemic inflammation...
  31. ncbi request reprint Hemodynamic effects of titrated norepinephrine in healthy versus endotoxemic sheep
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    J Endotoxin Res 13:53-7. 2007
    ....
  32. pmc Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
    Biochem Biophys Res Commun 377:786-91. 2008
    ..These findings suggest that ONOO(-) plays a pivotal role in the pathology of IL-2-induced pulmonary VLS, and that WW-85 may become a useful treatment option...
  33. pmc The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock
    Dirk M Maybauer
    Departments of Anesthesiology, Pathology, and Surgery, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas, USA
    Shock 35:148-55. 2011
    ..These results provide evidence that blockade of the nitric oxide-peroxynitrite pathway improves disturbances from septic shock, as demonstrated in a clinically relevant ovine experimental model...
  34. pmc The peroxynitrite catalyst WW-85 improves microcirculation in ovine smoke inhalation injury and septic shock
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, Galveston, TX 77555 0591, USA
    Burns 37:842-50. 2011
    ..05) by WW-85. These results provide evidence that WW-85 blocks NO production, thereby improving cardiovascular function and microcirculation...
  35. ncbi request reprint Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:2805-10. 2007
    ....
  36. pmc Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury
    Fiona D Saunders
    Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010
    ....
  37. doi request reprint Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str 33, 48149, Muenster, Germany
    Inflamm Res 60:429-37. 2011
    ..To test the hypothesis that a continuous infusion of the vasopressin analog terlipressin is associated with less organ dysfunction as compared to intermittent bolus infusion in an ovine sepsis model...
  38. ncbi request reprint Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch at Galveston, 610 Texas Avenue, Galveston, TX 77555 0833, USA
    Burns 31:1013-9. 2005
    ..Nitric oxide inhalation ameliorated the above-mentioned pathological changes. The results suggest that nitric oxide inhalation has potential for beneficial effect in the treatment of patients suffering from smoke inhalation...
  39. ncbi request reprint Cerebral response to norepinephrine compared with fluid resuscitation in ovine traumatic brain injury and systemic inflammation
    Henning D Stubbe
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Germany
    Crit Care Med 34:2651-7. 2006
    ..The present study investigated the cerebral effects of cerebral perfusion pressure (CPP) management performed by either fluid resuscitation or vasopressor treatment of low CPP induced by systemic inflammation...
  40. pmc Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Blvd, Galveston, TX 77555 0591, USA
    Crit Care 14:R217. 2010
    ....
  41. ncbi request reprint The inhibition of inducible nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, Pathology, Pediatrics and Surgery, University Texas Medical Branch, Galveston, TX 77555, USA
    Shock 25:522-7. 2006
    ..The results of present study show that iNOS may be partially involved in the pathogenesis of acute lung injury induced by smoke inhalation followed by bacterial instillation in the airway...
  42. ncbi request reprint Aerosolized alpha-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep
    Naoki Morita
    Department of Anaesthesiology, The University of Texas Medical Branch, Galveston, Texas 77555 0833, USA
    Shock 25:277-82. 2006
    ..Vitamin E nebulization therapy improved the clinical responses to burn and smoke inhalation-induced acute lung injury...
  43. ncbi request reprint Employing dobutamine as a useful agent to reverse the terlipressin-linked impairments in cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheep
    Katrin Bröking
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Shock 29:71-7. 2008
    ..This study provides evidence that dobutamine in a dosage of 2 microg x kg(1) x min(1) is useful to reverse the terlipressin-linked depressions in CI, DO(2)I and SvO(2) in ovine endotoxemia without obvious side effects...
  44. pmc Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 35:626-31. 2011
    ..This novel treatment strategy may represent a useful therapeutic adjunct for patients with these injuries...
  45. pmc Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep
    Naoki Morita
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555, USA
    Burns 37:465-73. 2011
    ..We hypothesized reduction of bronchial blood flow reduces exudation to the airway and ameliorates lung injury from combined burn and smoke insults (B&S injury)...
  46. doi request reprint Role of selective V1a receptor agonism in ovine septic shock
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 39:119-25. 2011
    ..arginine vasopressin or norepinephrine on cardiopulmonary hemodynamics and organ function in ovine septic shock...
  47. pmc Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis
    Sebastian Rehberg
    Investigational Intensive Care Unit, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Physiol Heart Circ Physiol 303:H1245-54. 2012
    ..Highly selective V(1a)-agonism appears to be superior to unselective vasopressin analogs for the treatment of sepsis-induced vascular dysfunction...
  48. ncbi request reprint Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis
    Henning D Stubbe
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Germany
    Crit Care Med 32:2491-5. 2004
    ..Atrial natriuretic peptide is regarded as an important regulator of pulmonary vasomotor tone and permeability. This study investigated the role of atrial natriuretic peptide in sepsis-associated pulmonary pathophysiology...
  49. ncbi request reprint Effects of manganese superoxide dismutase nebulization on pulmonary function in an ovine model of acute lung injury
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Shock 23:138-43. 2005
    ..Although Mn-SOD nebulization attenuated the loss of protein, it failed to improve lung edema and pulmonary gas exchange, thereby limiting its clinical use...
  50. ncbi request reprint Methylprednisolone reverses vasopressin hyporesponsiveness in ovine endotoxemia
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Shock 27:281-8. 2007
    ....
  51. pmc Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
    Crit Care 10:R144. 2006
    ..The purpose of the present study was to evaluate whether dobutamine may be titrated to reverse the AVP-related decrease in cardiac index (CI) and systemic oxygen delivery index (DO2I) in an established model of ovine endotoxemia...
  52. doi request reprint Effects of balanced crystalloid vs. 0.9% saline-based vs. balanced 6% tetrastarch infusion on renal function and tubular integrity in ovine endotoxemic shock
    Christian Ertmer
    Departments of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 39:783-92. 2011
    ..9% saline-based and balanced 6% tetrastarch solutions, on renal function and ultrastructural morphologic correlates of acute kidney injury in an established model of ovine endotoxemic shock...
  53. doi request reprint Effects of inhaled aerosolized iloprost and inhaled NO on pulmonary circulation and edema formation in ovine lung injury
    Christoph Hucklenbruch
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Munster, Germany
    Shock 30:75-80. 2008
    ..In contrast to iNO, the investigated dose of iloprost was ineffective to attenuate acute lung injury-induced changes in pulmonary hemodynamics and lung edema in this experimental model...
  54. ncbi request reprint Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Germany
    Shock 28:394-400. 2007
    ....
  55. ncbi request reprint The ATP-sensitive potassium-channel inhibitor glibenclamide improves outcome in an ovine model of hemorrhagic shock
    Dirk M Maybauer
    Department of Anesthesiology, University of Texas Medical Branch, and Shriners Burns Hospital for Children, Galveston, Texas 77555 0833, USA
    Shock 22:387-91. 2004
    ..7.17 +/- 0.6; 6 h, urine output 36 +/- 9 vs. 7.5 +/- 2 mL; P value less than 0.05 each). Because glibenclamide improved both hemodynamics and organ function, it may be a beneficial component in the acute treatment of hemorrhagic shock...
  56. ncbi request reprint Dopexamine reverses the vasopressin-associated impairment in tissue oxygen supply but decreases systemic blood pressure in ovine endotoxemia
    Martin Westphal
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany martin
    Anesth Analg 99:878-85, table of contents. 2004
    ..05 versus baseline), mean arterial blood pressure decreased (105 +/- 4 mm Hg versus 80 +/- 3 mm Hg) and heart rate increased (84 +/- 4 bpm versus 136 +/- 9 bpm; P < 0.001 versus AVP alone), thereby limiting its therapeutic use...
  57. doi request reprint Role of storage time of red blood cells on microcirculation and tissue oxygenation in critically ill patients
    Tim Frenzel
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 22:275-80. 2009
    ..To review the current literature on the role of storage time of transfused red blood cells on microcirculation and tissue oxygenation in critically ill patients...
  58. doi request reprint Fluid resuscitation in patients with traumatic brain injury: what is a SAFE approach?
    Hugo K Van Aken
    Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 25:563-5. 2012
    ..The purpose of the present article is to review the underlying physiology of osmolality and fluid therapy in TBI...
  59. pmc Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats
    Hendrik Freise
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
    Crit Care 13:R116. 2009
    ..Therefore, we investigated hepatic microcirculation and inflammatory response during TEA in septic rats...
  60. doi request reprint Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shock
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, 48149, Muenster, Germany
    Intensive Care Med 35:1286-96. 2009
    ..To compare the effects of first-line therapy with low-dose arginine vasopressin (AVP) or terlipressin (TP) on mesenteric blood flow, plasma AVP levels, organ function and mortality in ovine septic shock...
  61. ncbi request reprint Cerebral blood flow is not altered in sheep with Pseudomonas aeruginosa sepsis treated with norepinephrine or nitric oxide synthase inhibition
    Michael Booke
    Department of Anesthesiology, Klinikum des Main Taunus Kreises GmbH, 65812 Bad Soden am Taunus, Germany
    Anesth Analg 96:1122-8, table of contents. 2003
    ..Although detrimental vasoconstrictive effects of NE and L-NMMA, including cerebral hypoperfusion, are discussed, neither drug had any effect on cerebral perfusion during experimental hyperdynamic sepsis...
  62. ncbi request reprint Arteriovenous carboxyhemoglobin difference in critical illness: fiction or fact?
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Munster, Munster, Germany
    Biochem Biophys Res Commun 299:479-82. 2002
    ..001 each). We conclude that (a) arteriovenous COHb difference per se does not reflect critical illness and (b) measurements with an ABL 625 underestimate COHb concentrations...
  63. ncbi request reprint Terlipressin dose response in healthy and endotoxemic sheep: impact on cardiopulmonary performance and global oxygen transport
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Intensive Care Med 29:301-8. 2003
    ....
  64. ncbi request reprint Cerebral vascular and metabolic response to sustained systemic inflammation in ovine traumatic brain injury
    Henning D Stubbe
    Department of Anesthesiology and Intensive Care, University Hospital, Munster, Germany
    J Cereb Blood Flow Metab 24:1400-8. 2004
    ..Different mechanisms appear to induce cerebral vasodilation in response to inflammation and hypercapnia...
  65. ncbi request reprint Arginine vasopressin compromises gut mucosal microcirculation in septic rats
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Muenster, Germany
    Crit Care Med 32:194-200. 2004
    ..However, its effects on the microvascular networks have not been studied in detail. This study was designed to determine the effects of AVP infusion on the villus microcirculation of the septic rat ileum...
  66. ncbi request reprint Inhalational and acute lung injury
    Daniel L Traber
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX 77555 0833, USA
    Shock 24:82-7. 2005
  67. ncbi request reprint Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 22:70-5. 2004
    ..The results provide evidence that clearance of airway obstructive cast material is crucial in managing acute respiratory distress syndrome resulting from combined burn and smoke inhalation injury...
  68. ncbi request reprint Hemodynamic effects of exogenous adrenomedullin in healthy and endotoxemic sheep
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Biochem Biophys Res Commun 296:134-8. 2002
    ..Further, exogenous AM could possibly be a useful adjunct in the common setting of sepsis-associated pulmonary hypertension...
  69. ncbi request reprint Arteriovenous carboxyhemoglobin difference is not correlated to TNF-alpha, IL-6, PCT, CRP and leukocytes in critically ill patients
    Dina Eletr
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Clin Chim Acta 349:75-80. 2004
    ..We determined whether the arterial and central venous COHb concentration or their difference may be correlated to classical pro-inflammatory markers...
  70. ncbi request reprint Relevance of non-albumin colloids in intensive care medicine
    Christian Ertmer
    Department of Anaesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Street 33, 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 23:193-212. 2009
    ..Such studies are currently ongoing and their results should be awaited before drawing final conclusions on the HES preparations...
  71. ncbi request reprint Inhaled nitric oxide reduces lung edema during fluid resuscitation in ovine acute lung injury
    Henning D Stubbe
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum, 48149 Munster, Germany
    Intensive Care Med 29:1790-7. 2003
    ..Hypovolemia, however, may compromise tissue perfusion and contribute to organ dysfunction. We hypothesized that inhaled nitric oxide would reduce edema formation during fluid therapy...
  72. doi request reprint Role of levosimendan in sepsis and septic shock
    Bernardo Bollen Pinto
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 21:168-77. 2008
    ..To present the pharmacologic and biologic profile of levosimendan and discuss potential indications in the treatment of sepsis and septic shock, with a special focus on myocardial and pulmonary dysfunction...
  73. doi request reprint Inhibition of potassium channels in critical illness
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 21:105-10. 2008
    ..Pharmacological blockade of ATP-sensitive potassium channels has been proposed as a goal-directed therapeutic approach to stabilize hemodynamics in septic patients...
  74. ncbi request reprint Vasopressin analogues in the treatment of shock states: potential pitfalls
    Christian Ertmer
    Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 22:393-406. 2008
    ..Finally, platelet count, surrogate variables of hepatic dysfunction, electrolytes and osmolality should be strictly monitored in patients treated with vasopressin analogues...
  75. ncbi request reprint Vasopressin vs. terlipressin in the treatment of cardiovascular failure in sepsis
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Intensive Care Med 34:821-32. 2008
    ..We briefly describe the pathophysiology and pharmacology of septic shock relevant to the treatment with vasopressin analogues. In addition, differences in pharmacokinetics and pharmacodynamics between AVP and TP are discussed...
  76. ncbi request reprint Role of vasopressinergic V1 receptor agonists in the treatment of perioperative catecholamine-refractory arterial hypotension
    Matthias Lange
    Department of Anaesthesiology and Intensive Core, University Hospital of Muenster, Albert Schweitzes Strasse 33, D 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 22:369-81. 2008
    ..Future large-scale randomized, controlled clinical trials are warranted to evaluate the role of V1 agonists in the treatment of perioperative hypotension in more detail...
  77. ncbi request reprint Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia
    C Ertmer
    Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, D 48149 Muenster, Germany
    Br J Anaesth 99:830-6. 2007
    ....
  78. ncbi request reprint New approach to an ovine model of hypodynamic endotoxaemia
    M Westphal
    University of Munster, Department of Anaesthesiology and Intensive Care, Munster, Germany
    Eur J Anaesthesiol 21:625-31. 2004
    ....
  79. ncbi request reprint [Glycemic control in sepsis and septic shock: friend or foe?]
    B Ellger
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster, Deutschland
    Anaesthesist 57:43-8. 2008
    ..Whether or not this also holds true for patients with sepsis and septic shock is the issue of this post-hoc analysis of the database (2,748 patients) of 2 recent prospective clinical trials...
  80. ncbi request reprint [Role of ketamine in sepsis and systemic inflammatory response syndrome]
    M Lange
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum, Albert Schweitzer Str 33, 48149 Munster
    Anaesthesist 55:883-91. 2006
    ..Future studies are required to investigate the role of ketamine in the treatment of patients with sepsis and SIRS...
  81. ncbi request reprint [Vasopressin and terlipressin in sepsis and systemic inflammatory response syndrome. Effects on microcirculation, oxygen transport, metabolism and organ function]
    C Ertmer
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Munster
    Anaesthesist 54:346-56. 2005
    ..To date, vasopressin and terlipressin can, therefore, not be recommended for routine clinical use...
  82. doi request reprint [Sepsis-associated Guillain-Barré syndrome]
    S Rehberg
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Albert Schweitzer Str 33, 48149 Munster, Deutschland
    Anaesthesist 58:153-5. 2009
    ..This finding in association with limb quadriplegia led to the diagnosis of Guillain-Barré syndrome. Therapy with high-dose i.v. immunoglobulins led to a complete recovery...
  83. ncbi request reprint Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow
    D M Maybauer
    Department of Anaesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Burns Hospital for Children at Galveston, USA
    Anaesth Intensive Care 34:329-33. 2006
    ..This study suggests that institution of PEEP produces a reversible increase in EVLW that is linked to a decrease in QL...
  84. ncbi request reprint Ketamine in critical illness: another no-NO agent?
    Martin Westphal
    Crit Care Med 33:1162-3. 2005
  85. ncbi request reprint Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Italy
    Crit Care Med 34:2287-93. 2006
    ..We hypothesized that levosimendan, a new calcium sensitizer with potential pulmonary vasodilator properties, improves hemodynamics by unloading the right ventricle in patients with ARDS...
  86. ncbi request reprint Short-term effects of phenylephrine on systemic and regional hemodynamics in patients with septic shock: a crossover pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
    Shock 29:446-51. 2008
    ..Our results suggest that for the same MAP, phenylephrine causes a more pronounced hepatosplanchnic vasoconstriction as compared with NE...
  87. ncbi request reprint Is the arteriovenous carboxyhemoglobin gradient really a useful marker in systemic inflammation?
    Martin Westphal
    Chest 128:3771-2; author reply 3771-2. 2005
  88. ncbi request reprint Effects of thoracic epidural anesthesia on hemodynamics and global oxygen transport in ovine endotoxemia
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Shock 26:615-9. 2006
    ..Urinary output was increased in the TEA group as compared with the control group (P < 0.05). In this model of endotoxic shock, TEA improved renal perfusion without affecting cardiopulmonary hemodynamics and global oxygen transport...
  89. ncbi request reprint Glibenclamide dose response in patients with septic shock: effects on norepinephrine requirements, cardiopulmonary performance, and global oxygen transport
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
    Shock 28:530-5. 2007
    ..These data suggest that oral glibenclamide in doses from 10 to 30 mg fails to counteract arterial hypotension and thus to reduce norepinephrine requirements in catecholamine-dependent human septic shock...
  90. ncbi request reprint Red-cell storage and complications of cardiac surgery
    Tim Frenzel
    N Engl J Med 358:2841; author reply 2841-2. 2008
  91. ncbi request reprint Hemodynamic effects of thoracic epidural analgesia in ovine hyperdynamic endotoxemia
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital of Bern, Bern, Switzerland
    Reg Anesth Pain Med 32:311-6. 2007
    ..The objective of the present study was to assess the effects of TEA on systemic and pulmonary hemodynamics in a sepsis model of hyperdynamic endotoxemia...
  92. ncbi request reprint Terlipressin for haemodynamic support in septic patients: a double-edged sword?
    Martin Westphal
    Lancet 360:1250-1; author reply 1251. 2002
  93. ncbi request reprint Is vasopressin really superior to norepinephrine in reversing milrinone-induced vasodilation?
    Matthias Lange
    Eur J Cardiothorac Surg 30:689. 2006
  94. ncbi request reprint Continuous terlipressin infusion in patients with septic shock: less may be best, and the earlier the better?
    Andrea Morelli
    Intensive Care Med 33:1669-70. 2007
  95. ncbi request reprint Protective role of myocardial heat shock protein 70 in burn trauma: another brick in the wall?
    Martin Westphal
    Crit Care Med 32:1425-6. 2004
  96. ncbi request reprint Chronic inhibition of nitric oxide synthase and increased vascular responsiveness to vasopressin: what is the link?
    Martin Westphal
    J Hepatol 41:169-70. 2004
  97. ncbi request reprint Continuous thoracic epidural anesthesia improves gut mucosal microcirculation in rats with sepsis
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital of Bern, Bern, Switzerland
    Shock 28:610-4. 2007
    ..Additional studies are warranted to assess the microcirculatory effects of sympathetic blockade on other splanchnic organs in systemic inflammation...
  98. ncbi request reprint Combining arginine-vasopressin with catecholamines during cardiopulmonary resuscitation: mirror, mirror, on the wall, is there a best mixture at all?
    Martin Westphal
    Crit Care Med 33:2705-6. 2005
  99. ncbi request reprint Affinity of carbon monoxide to hemoglobin increases at low oxygen fractions
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Munster, Munster, Germany
    Biochem Biophys Res Commun 295:975-7. 2002
    ..This might explain why the arterio-venous COHb difference found in critically ill patients is not reproducible in healthy adults, since the latter ones are characterized by higher venous oxygen saturations...
  100. ncbi request reprint Is vasopressin increasing or decreasing mortality in patients with septic shock?
    Sebastian Rehberg
    Surg Infect (Larchmt) 9:215 author reply 216. 2008
  101. ncbi request reprint Low-dose terlipressin for hemodynamic support in sepsis and systemic inflammatory response syndrome: art for (he)art's sake or state of the art?
    Martin Westphal
    Crit Care Med 33:455-7. 2005