T Eoin West

Summary

Publications

  1. pmc Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research
    Shevin T Jacob
    International Respiratory and Severe Illness Center INTERSECT, Department of Medicine, University of Washington, 325 9th Ave, Box 359927, Seattle, WA 98104, USA
    BMC Med 11:107. 2013
  2. doi request reprint Massive intractable hemoptysis due to idiopathic granulomatous pulmonary veno-occlusive disease
    T Eoin West
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Respir Care 58:e56-9. 2013
  3. pmc Impaired TLR5 functionality is associated with survival in melioidosis
    T Eoin West
    International Respiratory and Severe Illness Center, University of Washington, Seattle, WA 98104, USA
    J Immunol 190:3373-9. 2013
  4. pmc Murine pulmonary infection and inflammation induced by inhalation of Burkholderia pseudomallei
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Int J Exp Pathol 93:421-8. 2012
  5. pmc Fitting a square peg into a round hole: are the current Surviving Sepsis Campaign guidelines feasible for Africa?
    Shevin T Jacob
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Box 359927, 325 Ninth Avenue, Seattle, WA 98104, USA
    Crit Care 15:117. 2011
  6. pmc Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
    T Eoin West
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Am J Trop Med Hyg 83:1066-9. 2010
  7. pmc The role of NOD2 in murine and human melioidosis
    Nicolle D Myers
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195
    J Immunol 192:300-7. 2014
  8. pmc Toll-like receptor signaling in airborne Burkholderia thailandensis infection
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Infect Immun 77:5612-22. 2009
  9. doi request reprint Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis
    T Eoin West
    Department of Medicine, University of Washington, Box 359640, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Trans R Soc Trop Med Hyg 102:S119-26. 2008
  10. ncbi request reprint VgrG-5 is a Burkholderia type VI secretion system-exported protein required for multinucleated giant cell formation and virulence
    Sandra Schwarz
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Infect Immun 82:1445-52. 2014

Collaborators

Detail Information

Publications16

  1. pmc Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research
    Shevin T Jacob
    International Respiratory and Severe Illness Center INTERSECT, Department of Medicine, University of Washington, 325 9th Ave, Box 359927, Seattle, WA 98104, USA
    BMC Med 11:107. 2013
    ....
  2. doi request reprint Massive intractable hemoptysis due to idiopathic granulomatous pulmonary veno-occlusive disease
    T Eoin West
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Respir Care 58:e56-9. 2013
    ....
  3. pmc Impaired TLR5 functionality is associated with survival in melioidosis
    T Eoin West
    International Respiratory and Severe Illness Center, University of Washington, Seattle, WA 98104, USA
    J Immunol 190:3373-9. 2013
    ..This conclusion suggests a deleterious immunoregulatory effect of TLR5 that may be mediated by IL-10 and identifies this receptor as a potential therapeutic target in melioidosis...
  4. pmc Murine pulmonary infection and inflammation induced by inhalation of Burkholderia pseudomallei
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Int J Exp Pathol 93:421-8. 2012
    ..pseudomallei. This model has utility for the study of bacterial and host factors that contribute to the virulence of melioidosis...
  5. pmc Fitting a square peg into a round hole: are the current Surviving Sepsis Campaign guidelines feasible for Africa?
    Shevin T Jacob
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Box 359927, 325 Ninth Avenue, Seattle, WA 98104, USA
    Crit Care 15:117. 2011
    ..Comprehensive, evidence-based guidelines combined with innovative approaches to sepsis management in LMICs are required to make a meaningful impact on worldwide sepsis survival...
  6. pmc Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
    T Eoin West
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Am J Trop Med Hyg 83:1066-9. 2010
    ..Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection...
  7. pmc The role of NOD2 in murine and human melioidosis
    Nicolle D Myers
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195
    J Immunol 192:300-7. 2014
    ..pseudomallei. To our knowledge, these findings are the first to characterize the role of NOD2 in host defense in mammalian melioidosis. ..
  8. pmc Toll-like receptor signaling in airborne Burkholderia thailandensis infection
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Infect Immun 77:5612-22. 2009
    ..TLR signaling in B. thailandensis infection is substantially comparable to signaling induced by virulent B. pseudomallei. These studies provide additional insights into the host-pathogen interaction in pneumonic Burkholderia infection...
  9. doi request reprint Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis
    T Eoin West
    Department of Medicine, University of Washington, Box 359640, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Trans R Soc Trop Med Hyg 102:S119-26. 2008
    ..These findings demonstrate that airborne B. thailandensis infection in mice provides an accessible surrogate model of melioidosis...
  10. ncbi request reprint VgrG-5 is a Burkholderia type VI secretion system-exported protein required for multinucleated giant cell formation and virulence
    Sandra Schwarz
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Infect Immun 82:1445-52. 2014
    ..We propose a model whereby the CTD of VgrG-5-, propelled by T6SS-5-, plays a key role in inducing membrane fusion, either by the recruitment of other factors or by direct participation. ..
  11. pmc Inhalation of Francisella novicida Delta mglA causes replicative infection that elicits innate and adaptive responses but is not protective against invasive pneumonic tularemia
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Box 359640, Seattle, WA 98104 2499, USA
    Microbes Infect 10:773-80. 2008
    ..novicida. These findings establish that inhalation of F. novicida Delta mglA results in replicative infection that elicits innate and adaptive immune responses but not protective immunity against invasive pneumonic tularemia...
  12. pmc Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation
    Josephine R Chandler
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    J Bacteriol 191:5901-9. 2009
    ..We propose that the key function of the BtaR1-BtaI1 quorum-sensing system is to cause cells to gather into aggregates once a sufficient population has been established...
  13. pmc Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions
    Sandra Schwarz
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 6:e1001068. 2010
    ....
  14. pmc Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei
    Andrea Haraga
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Infect Immun 76:5402-11. 2008
    ..Therefore, we propose B. thailandensis as a useful BSL-1 model system to study the role of the Bsa TTSS during Burkholderia infection of mammalian cells and animals...
  15. pmc Activation of Toll-like receptors by Burkholderia pseudomallei
    T Eoin West
    Department of Medicine, University of Washington, Seattle, Washington, USA
    BMC Immunol 9:46. 2008
    ..We examined TLR signaling induced by B. pseudomallei, B. pseudomallei LPS, and B. pseudomallei lipid A using gain-of-function transfection assays of NF-kappaB activation and studies of TLR-deficient macrophages...
  16. pmc Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia
    Annalisa Lembo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Immunol 180:7574-81. 2008
    ..novicida, leading to protective immunity to pneumonic tularemia. This is the first report of the protective effect of a TLR ligand on resistance to F. novicida-induced pneumonic tularemia...