Andrew B West

Summary

Publications

  1. ncbi request reprint Functional association of the parkin gene promoter with idiopathic Parkinson's disease
    Andrew B West
    Laboratories of Neurogenetics, Department of Neuroscience, Mayo Clinic Jacksonville, FL 32224, USA
    Hum Mol Genet 11:2787-92. 2002
  2. ncbi request reprint Identification of a novel gene linked to parkin via a bi-directional promoter
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Biol 326:11-9. 2003
  3. ncbi request reprint N-myc regulates parkin expression
    Andrew B West
    Morris K Udall Center for Parkinson s Disease Research, UCLA Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Biol Chem 279:28896-902. 2004
  4. pmc Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
    Wanli W Smith
    Department of Psychiatry, Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:18676-81. 2005
  5. doi request reprint Parkin mediates the degradation-independent ubiquitination of Hsp70
    Darren J Moore
    Institute for Cell Engineering, and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 105:1806-19. 2008
  6. ncbi request reprint Genetics of parkin-linked disease
    Andrew B West
    Neuropsychiatric Institute and Hospital, University of California at Los Angeles, 90024, USA
    Hum Genet 114:327-36. 2004
  7. ncbi request reprint To die or grow: Parkinson's disease and cancer
    Andrew B West
    Institute for Cell Engineering, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Neurosci 28:348-52. 2005
  8. ncbi request reprint Parkin is not regulated by the unfolded protein response in human neuroblastoma cells
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, 32224, Jacksonville, FL, USA
    Neurosci Lett 341:139-42. 2003
  9. pmc Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    Andrew B West
    Institute for Cell Engineering, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:16842-7. 2005
  10. ncbi request reprint Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
    Andrew B West
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 16:223-32. 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Functional association of the parkin gene promoter with idiopathic Parkinson's disease
    Andrew B West
    Laboratories of Neurogenetics, Department of Neuroscience, Mayo Clinic Jacksonville, FL 32224, USA
    Hum Mol Genet 11:2787-92. 2002
    ..Our results further implicate the parkin gene in the development of Parkinson's disease...
  2. ncbi request reprint Identification of a novel gene linked to parkin via a bi-directional promoter
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Biol 326:11-9. 2003
    ..Although PACRG protein lacks known functional domains, in silico prediction suggests a potential link to the ubiquitin/proteasome system...
  3. ncbi request reprint N-myc regulates parkin expression
    Andrew B West
    Morris K Udall Center for Parkinson s Disease Research, UCLA Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Biol Chem 279:28896-902. 2004
    ..Our results, in combination with functional knowledge of the proteins encoded by these genes, suggest a common pathway linking together PD, the ubiquitin-proteasome system, and cell cycle control...
  4. pmc Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
    Wanli W Smith
    Department of Psychiatry, Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:18676-81. 2005
    ....
  5. doi request reprint Parkin mediates the degradation-independent ubiquitination of Hsp70
    Darren J Moore
    Institute for Cell Engineering, and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 105:1806-19. 2008
    ....
  6. ncbi request reprint Genetics of parkin-linked disease
    Andrew B West
    Neuropsychiatric Institute and Hospital, University of California at Los Angeles, 90024, USA
    Hum Genet 114:327-36. 2004
    ..Future studies that address the issues in question should have a far-reaching impact in downstream biochemical studies and our understanding of parkin's role in PD...
  7. ncbi request reprint To die or grow: Parkinson's disease and cancer
    Andrew B West
    Institute for Cell Engineering, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Neurosci 28:348-52. 2005
    ..When considering the normal function of these PD-linked genes in the periphery and their potential role in cancer, further emphasis might be placed on protein handling relating to cell-cycle control in the etiology of PD...
  8. ncbi request reprint Parkin is not regulated by the unfolded protein response in human neuroblastoma cells
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, 32224, Jacksonville, FL, USA
    Neurosci Lett 341:139-42. 2003
    ..These data suggest a lack of association between parkin and the unfolded protein response in SH-SY5Y cells...
  9. pmc Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    Andrew B West
    Institute for Cell Engineering, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:16842-7. 2005
    ..These results suggest a gain-of-function mechanism for LRRK2-linked disease with a central role for kinase activity in the development of PD...
  10. ncbi request reprint Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
    Andrew B West
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 16:223-32. 2007
    ..These results suggest a link between LRRK2 kinase activity and pathogenic mechanisms relating to neurodegeneration, further supporting a gain-of-function role for LRRK2 mutations...
  11. pmc Dynamic and redundant regulation of LRRK2 and LRRK1 expression
    Saskia Biskup
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Neurosci 8:102. 2007
    ..The expression profiles of the murine LRRK proteins have not been fully described and insufficiently characterized antibodies have produced conflicting results in the literature...
  12. ncbi request reprint Molecular pathophysiology of Parkinson's disease
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:57-87. 2005
    ....