Keith Wesnes

Summary

Publications

  1. pmc A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Behav Brain Funct 4:24. 2008
  2. ncbi request reprint Cognitive function testing: the case for standardization and automation
    Keith A Wesnes
    Cognitive Drug Research, Goring on Thames, UK
    J Br Menopause Soc 12:158-63. 2006
  3. doi request reprint Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system
    Keith A Wesnes
    Cognitive Drug Research Ltd, Goring on Thames, UK
    Neurodegener Dis 5:261-3. 2008
  4. ncbi request reprint Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease
    Keith Wesnes
    Cognitive Drug Research, Ltd, Goring on Thames, and Human Cognitive Neuroscience Unit, Northumbria University, Newcastle on Tyne, UK
    Drugs Today (Barc) 43:349-59. 2007
  5. doi request reprint Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg
    Keith A Wesnes
    Cognitive Drug Research Ltd, Goring on Thames, UK
    Expert Opin Drug Saf 8:615-26. 2009
  6. doi request reprint Cognition assessment in paediatric clinical trials
    Chris J Edgar
    Cognitive Drug Research Ltd, CDR House, Goring on Thames, UK
    Drug Discov Today 13:79-85. 2008
  7. ncbi request reprint The effects of L-theanine, caffeine and their combination on cognition and mood
    Crystal F Haskell
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Biol Psychol 77:113-22. 2008
  8. ncbi request reprint Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine
    Crystal F Haskell
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Psychopharmacology (Berl) 179:813-25. 2005
  9. ncbi request reprint A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning
    Jeanet Ingwersen
    Cognition and Communication Research Centre, Division of Psychology, University of Northumbria, Newcastle upon Tyne NE1 8ST, UK
    Appetite 49:240-4. 2007
  10. ncbi request reprint Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: a prospective study
    Romola S Bucks
    University of Southampton, UK
    Brain Behav Immun 22:399-407. 2008

Collaborators

Detail Information

Publications25

  1. pmc A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Behav Brain Funct 4:24. 2008
    ..abstract:..
  2. ncbi request reprint Cognitive function testing: the case for standardization and automation
    Keith A Wesnes
    Cognitive Drug Research, Goring on Thames, UK
    J Br Menopause Soc 12:158-63. 2006
    ....
  3. doi request reprint Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system
    Keith A Wesnes
    Cognitive Drug Research Ltd, Goring on Thames, UK
    Neurodegener Dis 5:261-3. 2008
    ..Finally, the CDR system has a large normative database which allows treatment effects in dementia to be put into an unambiguous clinical perspective...
  4. ncbi request reprint Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease
    Keith Wesnes
    Cognitive Drug Research, Ltd, Goring on Thames, and Human Cognitive Neuroscience Unit, Northumbria University, Newcastle on Tyne, UK
    Drugs Today (Barc) 43:349-59. 2007
    ..A treatment is now available for a previously unmet medical need...
  5. doi request reprint Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg
    Keith A Wesnes
    Cognitive Drug Research Ltd, Goring on Thames, UK
    Expert Opin Drug Saf 8:615-26. 2009
    ..To assess the cognitive effects of single doses of solifenacin 10 mg compared with placebo (primary objective) and oxybutynin immediate release (IR) 10 mg (secondary objective) in elderly subjects...
  6. doi request reprint Cognition assessment in paediatric clinical trials
    Chris J Edgar
    Cognitive Drug Research Ltd, CDR House, Goring on Thames, UK
    Drug Discov Today 13:79-85. 2008
    ..This requirement to evaluate cognition in children and adolescents, and new legislation for paediatric clinical trials, has created an increased demand for suitable assessment methods...
  7. ncbi request reprint The effects of L-theanine, caffeine and their combination on cognition and mood
    Crystal F Haskell
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Biol Psychol 77:113-22. 2008
    ..These results suggest that beverages containing L-theanine and caffeine may have a different pharmacological profile to those containing caffeine alone...
  8. ncbi request reprint Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine
    Crystal F Haskell
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Psychopharmacology (Berl) 179:813-25. 2005
    ..It is therefore unclear whether any beneficial findings are due to the positive effects of caffeine or to the alleviation of caffeine withdrawal...
  9. ncbi request reprint A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning
    Jeanet Ingwersen
    Cognition and Communication Research Centre, Division of Psychology, University of Northumbria, Newcastle upon Tyne NE1 8ST, UK
    Appetite 49:240-4. 2007
    ..742 and -13.510, respectively, p<0.05) and secondary memory (M=-30.675 and -47.183, respectively, p<0.05)...
  10. ncbi request reprint Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: a prospective study
    Romola S Bucks
    University of Southampton, UK
    Brain Behav Immun 22:399-407. 2008
    ..URTIs also affect mood. Future studies need to examine the role of inflammatory molecules and the brain regions implicated in mediating these findings...
  11. ncbi request reprint The cognitive effects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls
    Colin Palmer
    Behavioural Neuroscience Laboratory, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Victoria, Australia
    Hum Psychopharmacol 23:151-9. 2008
    ....
  12. doi request reprint An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
    Andrew B Scholey
    Brain Sciences Institute, Swinburne University, Melbourne, Vic, 3122, Australia
    Psychopharmacology (Berl) 198:127-39. 2008
    ..In recent controlled trials, administration of sage extracts with established cholinergic properties improved cognitive function in young adults...
  13. ncbi request reprint Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers
    Jaymin Shah
    Elan Pharmaceuticals, Inc, San Diego, California, USA
    Clin Ther 28:1308-17. 2006
    ..A multiparticulate capsule formulation of the alpha2-adrenergic agonist tizanidine has been developed to decrease C(max), AUC, and associated somnolence, while maintaining efficacy...
  14. ncbi request reprint Orthostatic hypotension in Parkinson's disease: association with cognitive decline?
    Liesl M Allcock
    Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital, Sunderland, UK
    Int J Geriatr Psychiatry 21:778-83. 2006
    ..We therefore hypothesize that PD patients with orthostatic hypotension (OH) have a different cognitive profile compared to PD patients without OH...
  15. ncbi request reprint Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients
    James M Ferguson
    University of Utah, Salt Lake City, Utah, USA
    Int Clin Psychopharmacol 18:9-14. 2003
    ..The results of the present study provide objective data to support the possibility that reboxetine favourably affects cognitive processes in depressed patients...
  16. ncbi request reprint Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers
    Harumi Kitagawa
    Quintiles, Inc, Tokyo, Japan
    Neuropsychopharmacology 28:542-51. 2003
    ..These data indicate that GTS-21 may represent a novel treatment for dementia...
  17. ncbi request reprint Basal activity of the HPA axis and cognitive function in anorexia nervosa
    Julie A Seed
    Division of Psychology, University of Northumbria, New Castle upon Tyne, UK
    Int J Neuropsychopharmacol 5:17-25. 2002
    ..The limitations of cortisol as an indicator of HPA axis activity are discussed...
  18. ncbi request reprint Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 18:94-100. 2004
    ..This may reflect the greater cholinergic deficits in areas of the brain responsible for visual hallucinations, offering greater potential for attentional improvement...
  19. ncbi request reprint Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory
    Cathy Matrenza
    Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    J Psychopharmacol 18:21-31. 2004
    ..These findings suggest that simultaneously depleting the availability of brain serotonin and catecholamines in healthy female subjects selectively impairs sustained attention, without affecting other cognitive domains...
  20. ncbi request reprint Selective effects of acute serotonin and catecholamine depletion on memory in healthy women
    Ben J Harrison
    Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Melbourne Australia
    J Psychopharmacol 18:32-40. 2004
    ..This may shed light on the role of these neurotransmitters in disorders that are characterized by significant memory impairment...
  21. ncbi request reprint Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial
    C V Russell Blacker
    Department of Health and Social Sciences, University of Exeter, Exeter, England
    JAMA 292:1195-204. 2004
    ..There is no established pharmacological treatment for the core symptoms of chronic fatigue syndrome (CFS). Galantamine hydrobromide, an acetyl cholesterone inhibitor, has pharmacological properties that might benefit patients with CFS...
  22. ncbi request reprint Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly
    Nunzio Pomara
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 29:2311-5. 2004
    ..Plasma GABA concentration does not appear to be a useful marker of susceptibility to benzodiazepine-induced cognitive toxicity in the elderly. Other approaches to estimating central GABA activity should be pursued...
  23. ncbi request reprint Short-term transdermal estradiol therapy, cognition and depressive symptoms in healthy older women. A randomised placebo controlled pilot cross-over study
    Rebekah Schiff
    Department of Medicine for the Elderly, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Psychoneuroendocrinology 30:309-15. 2005
    ..However, the results do support the concept that depressive symptoms may be reduced by estradiol, and not simply due to the relief of climacteric symptoms...
  24. ncbi request reprint Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers
    Gary G Kay
    Washington Neuropsychological Institute, Washington, DC 20008, USA
    BJU Int 96:1055-62. 2005
    ..To evaluate the pharmacodynamic effects of darifenacin (a muscarinic M(3) selective receptor antagonist) and dicyclomine (an M(1) selective receptor antagonist) in healthy male volunteers...
  25. ncbi request reprint Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease
    Daniel M Forton
    Hepatology Section, Division of Medicine A, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    Hepatology 35:433-9. 2002
    ..The findings on MRS suggest that a biological cause underlies this abnormality...