Use of over-the-counter medications during pregnancyMartha M Werler
Slone Epidemiology Center at Boston University, Boston, MA, USA
Am J Obstet Gynecol 193:771-7. 2005
..We describe the patterns of over-the-counter medication use among pregnant women...
- First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects
Carol Louik
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
N Engl J Med 356:2675-83. 2007
..The risk of birth defects after antenatal exposure to selective serotonin-reuptake inhibitors (SSRIs) remains controversial...
Drug certainty-response in interview-based studiesWai Ping Yau
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Pharmacoepidemiol Drug Saf 20:1210-6. 2011
..Imperfect recall of exposure timing challenges the ascertainment of medications in interview-based studies...
- Demographic and reproductive factors associated with hemifacial microsomia
Martha M Werler
Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Cleft Palate Craniofac J 41:494-50. 2004
..To identify demographic and reproductive risk factors for hemifacial microsomia in offspring...
- Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restriction
Sengwee Toh
Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Ave 6th Floor, Boston, MA 02215, USA
J Clin Psychopharmacol 29:555-60. 2009
..The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes...
- Selective serotonin reuptake inhibitor use and risk of gestational hypertension
Sengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Psychiatry 166:320-8. 2009
..The purpose of this study was to assess the effects of treatment with selective serotonin reuptake inhibitors (SSRIs) on the risks of gestational hypertension and preeclampsia...
- Asthma in pregnancy and its pharmacologic treatment
Carol Louik
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Ann Allergy Asthma Immunol 105:110-7. 2010
..Asthma is among the most common serious medical problems in pregnancy, and its prevalence may be increasing. Management is problematic because asthma may harm the fetus, yet little is known about fetal risks of asthma medications...
- Is there epidemiologic evidence to support vascular disruption as a pathogenesis of gastroschisis?
Martha M Werler
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Am J Med Genet A 149:1399-406. 2009
..However, the observation that increased ORs for some vasoactive exposures were confined to older women raises the question of whether inherent maternal factors might influence risk...
- Can folic acid protect against congenital heart defects in Down syndrome?
Willemijn M Meijer
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215 1201, USA
Birth Defects Res A Clin Mol Teratol 76:714-7. 2006
..Our objectives were to investigate whether first-trimester FA use protects against heart anomalies among DS children...
- Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension
Sonia Hernandez-Diaz
Slone Epidemiology Center, Boston University School of Public Health, Boston, MA, USA
Epidemiology 16:628-34. 2005
..It is also unknown whether the fetal genotype is relevant, or whether folic acid supplementation modifies this association...
- Trends and predictors of folic acid awareness and periconceptional use in pregnant women
Lolkje T W de Jong-van den Berg
Slone Epidemiology Center, Boston University School of Public Health, Boston, Mass, USA
Am J Obstet Gynecol 192:121-8. 2005
..The purpose of this study was to describe recent trends in folic acid awareness and use in the periconceptional period among pregnant women in relation to maternal sociodemographic and other relevant factors...
- Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects
Marlene Anderka
Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, Massachusetts 02108, USA
Birth Defects Res A Clin Mol Teratol 94:22-30. 2012
..Several medications are used for the treatment of NVP; however, data are limited on their possible associations with birth defects...
- Fruit and vegetable intake and risk of upper respiratory tract infection in pregnant women
Lin Li
Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA
Public Health Nutr 13:276-82. 2010
..The present study evaluated the association between fruit and vegetable intake and the incidence of upper respiratory tract infection (URTI) during pregnancy...
U.S. provider reported folic acid or multivitamin ordering for non-pregnant women of childbearing age: NAMCS and NHAMCS, 2005-2006Heather H Burris
Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard University, 330 Brookline Avenue, Boston, MA 02215, USA
Matern Child Health J 15:352-9. 2011
..Our findings suggest that annually there may be over 29 million missed opportunities to recommend folic acid to non-pregnant women seeking preventive care...
- Association of vasoconstrictive exposures with risks of gastroschisis and small intestinal atresia
Martha M Werler
Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Epidemiology 14:349-54. 2003
..The present study examined risks of gastroschisis and small intestinal atresia associated with combined exposure to vasoconstrictive drugs and cigarette smoking...
- Case-crossover and case-time-control designs in birth defects epidemiology
Sonia Hernandez-Diaz
Slone Epidemiology Center, Boston University School of Public Health, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Am J Epidemiol 158:385-91. 2003
..9 (95% CI: 1.2, 7.2), but it requires controls. In the presence of gestational time trends of exposure, the new designs do not offer clear advantages over the case-control design...
- Periconceptional multivitamin use and infant birth weight disparities
Heather H Burris
Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard University, 330 Brookline Ave, Boston, MA 02215, USA
Ann Epidemiol 20:233-40. 2010
..Our objective was to determine whether maternal periconceptional multivitamin (MVI) use is associated with this disparity...
- Maternal dietary glycemic intake and the risk of neural tube defects
Mahsa M Yazdy
Slone Epidemiology Center, Boston University, Boston, MA02215, USA
Am J Epidemiol 171:407-14. 2010
..0); for high DGL, it was 1.8 (95% confidence interval: 0.8, 4.0). Diets with proportionally high DGI or DGL may put the developing fetus at risk of an NTD, adding further evidence that hyperglycemia lies within the pathogenic pathway...
- Folic acid intake and spina bifida in the era of dietary folic acid fortification
Katherine Ahrens
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
Epidemiology 22:731-7. 2011
..We evaluated whether intake of folic acid from supplements and diet was associated with a reduction in spina bifida in the setting of folic acid fortification...
- Maternal dietary glycaemic intake during pregnancy and the risk of birth defects
Mahsa M Yazdy
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
Paediatr Perinat Epidemiol 25:340-6. 2011
..0; 95% CI: 1.1, 8.1]. Because this is the first paper (to our knowledge) to explore dGI and dGL in relation to a spectrum of birth defects, additional studies are needed...
- Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestations
Sonia Hernandez-Diaz
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Fertil Steril 88:438-45. 2007
..To investigate the association between infertility treatments and gestational hypertension and preeclampsia...
- Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008
Allen A Mitchell
Slone Epidemiology Center at Boston University, Boston, MA, USA
Am J Obstet Gynecol 205:51.e1-8. 2011
..The objective of the study was to provide information on overall medication use throughout pregnancy, with particular focus on the first trimester and specific prescription medications...
- Vasoactive exposures, vascular events, and hemifacial microsomia
Martha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 70:389-95. 2004
..We collected data in a case-control study to identify whether vasoactive exposures or vascular events during early pregnancy affect the risk of HFM...
- Gulf War veterans and hemifacial microsomia
Martha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 73:50-2. 2005
..We used data collected from a case-control study of HFM to estimate risk in relation to parental military service and, in particular, Gulf War service...
- Sensitivity and specificity of computerized algorithms to classify gestational periods in the absence of information on date of conception
Sengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 167:633-40. 2008
..However, the sensitivity of this algorithm is lower for preterm deliveries, suggesting limited validity to assess drug safety for pregnancy outcomes associated with prematurity...
- Decongestant use during pregnancy and its association with preterm delivery
Rohini K Hernandez
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Birth Defects Res A Clin Mol Teratol 88:715-21. 2010
..Despite the frequent intake of decongestants during pregnancy, only one study to date has evaluated the association of decongestants with preterm delivery, and it identified a reduced risk. We examined this association in more detail...
- Nonsteroidal antiinflammatory drug use among women and the risk of birth defects
Rohini K Hernandez
Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA, USA
Am J Obstet Gynecol 206:228.e1-8. 2012
..We examined whether the use of nonsteroidal antiinflammatory drugs (NSAIDs) in early pregnancy was associated with a range of structural birth defects...
- Maternal medication use and risks of gastroschisis and small intestinal atresia
Martha M Werler
Slone Epidemiology Unit, Boston University School of Public Health, Boston, MA, USA
Am J Epidemiol 155:26-31. 2002
..Although pseudoephedrine has previously been shown to increase gastroschisis risk, findings of this study raise questions about interactions between medications and possible confounding by underlying illness...
- Risk factors for persistent pulmonary hypertension of the newborn
Sonia Hernandez diaz
Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
Pediatrics 120:e272-82. 2007
..We performed a case-control study to determine possible antenatal and perinatal predictors of persistent pulmonary hypertension of the newborn...
- Hypothesis: could Epstein-Barr virus play a role in the development of gastroschisis?
Martha M Werler
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 88:71-5. 2010
..There is both anecdotal and published evidence showing that gastroschisis sometimes (but not always) occurs in clusters, raising the possibility that an infectious agent might be involved in its pathogenesis...
- Alcohol consumption and time to recognition of pregnancy
Erika M Edwards
Data Coordinating Center, Boston University School of Public Health, 715 Albany St, 580, Boston, MA 02118, USA
Matern Child Health J 10:467-72. 2006
..This study evaluates whether women who consume alcohol are at an increased risk of recognizing pregnancy later than women who do not, adjusting for confounding factors that have been associated with alcohol consumption during pregnancy...
- Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis
Rachel L Badovinac
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
Birth Defects Res A Clin Mol Teratol 79:8-15. 2007
..We undertook this meta-analysis to test the hypothesis that nonsyndromic oral cleft birth prevalences are different for those whose mothers took folic acid-containing supplements and for those whose mothers did not...
- Maternal vasoactive exposures, amniotic bands, and terminal transverse limb defects
Martha M Werler
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA mwerler slone bu edu
Birth Defects Res A Clin Mol Teratol 85:52-7. 2009
..If amniotic bands are secondary to vascular disruption, then a shared pathogenesis for each case group might be exhibited by similar risk factors...
- Hemifacial microsomia: from gestation to childhood
Martha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
J Craniofac Surg 20:664-9. 2009
..When data on the full study sample are available, further analyses will determine whether the preliminary findings remain and if they vary by HFM phenotype, parenting style, or indicators of social risk...
- Correcting for exposure misclassification using survival analysis with a time-varying exposure
Katherine Ahrens
Slone Epidemiology Center at Boston University, MA, USA
Ann Epidemiol 22:799-806. 2012
..Here we show how quantitative correction for exposure misclassification can be applied to a Cox regression model with a time-varying dichotomous exposure...
- Socioeconomic status as a modifier of the relationship between antibiotic use during pregnancy and birthweight
Jessica W Nelson
Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
Birth 35:196-203. 2008
....
- Epidemiologic analysis of maternal factors and amniotic band defects
Martha M Werler
Slone Epidemiology Center, Boston University School of Public Health, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 67:68-72. 2003
..Little is known about risk factors for either ARS or BWC, except that maternal age has been shown to affect risk inversely...
- Case-control studies for identifying novel teratogens
Martha M Werler
Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Am J Med Genet C Semin Med Genet 157:201-8. 2011
..Examples of case-control studies and their contributions to the field are presented. © 2011 Wiley-Liss, Inc...
- Use of antiepileptic medications in pregnancy in relation to risks of birth defects
Martha M Werler
Slone Epidemiology Center at Boston University, Boston, MA, USA
Ann Epidemiol 21:842-50. 2011
..To evaluate use of specific antiepileptic drugs (AEDs) in pregnancy in relation to specific birth defects...
- Vasoactive exposures during pregnancy and risk of microtia
Carla M Van Bennekom
Slone Epidemiology Center at Boston University, Boston, Massachusetts
Birth Defects Res A Clin Mol Teratol 97:53-9. 2013
..Little is known about the etiology of nonsyndromic microtia. This study investigated the hypothesis that microtia is caused by vascular disruption...
- Maternal tea consumption during early pregnancy and the risk of spina bifida
Mahsa M Yazdy
Slone Epidemiology Center at Boston University, Boston, MA, USA
Birth Defects Res A Clin Mol Teratol 94:756-61. 2012
..13; 95% CI, 0.87-11.33). Our data do not support an overall association between tea consumption and spina bifida, but there is a suggestion of a possible interaction between higher levels of folic acid intake and tea consumption...
- Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiology
Miguel A Hernán
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 155:176-84. 2002
..65 (95% confidence interval: 0.46, 0.94) should be used because the adjusted odds ratio is invalid. Causal diagrams are used to encode qualitative a priori subject matter knowledge...
- Gender differences in the professional and private lives of plastic surgeons
Terri J Halperin
Department of Plastic Surgery, Children s Hospital, Harvard Medical School and Slone Epidemiology Center, Boston University, Boston, MA, USA
Ann Plast Surg 64:775-9. 2010
..Nevertheless, female plastic surgeons appear to have similar career satisfaction and are no more likely to retire earlier or more frequently than male plastic surgeons...
- Predictors of recall certainty of dates of analgesic medication use in pregnancy
Rose G Radin
Slone Epidemiology Center, Boston University, Boston, MA, USA
Pharmacoepidemiol Drug Saf 22:25-32. 2013
..Recalled dates of medication use are difficult to validate, particularly for over-the-counter (OTC) medications. We evaluated mothers' recall certainty as an approximation of the accuracy of their recalled exposures...
- Short interpregnancy interval and gastroschisis risk in the National Birth Defects Prevention Study
Kelly D Getz
Massachusetts Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, Massachusetts 02108, USA
Birth Defects Res A Clin Mol Teratol 94:714-20. 2012
..Short interpregnancy intervals (IPI) have been associated with an increased risk for several adverse pregnancy outcomes, but an association with gastroschisis risk has not been previously explored...
- Teratogen update: pseudoephedrine
Martha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02115, USA
Birth Defects Res A Clin Mol Teratol 76:445-52. 2006
..In addition, the majority of decongestant use is in oral form and the question of whether intranasal formulations carry risk has not been adequately addressed...
- Maternal use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), and muscular ventricular septal defects
Mario A Cleves
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Arkansas Center for Birth Defects Research and Prevention, 11219 Financial Centre Parkway, Little Rock, AR 72211, USA
Birth Defects Res A Clin Mol Teratol 70:107-13. 2004
..CONCLUSIONS: Significant associations were not detected between the occurrence of mVSDs and maternal use of NSAIDs or acetaminophen adjusting for maternal fever, nor were they detected between maternal fever and mVSDs...
