RhoG signals in parallel with Rac1 and Cdc42Krister Wennerberg
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
J Biol Chem 277:47810-7. 2002
..Together, these data argue that RhoG function is mediated by signals independent of Rac1 and Cdc42 activation and instead by direct utilization of a subset of common effectors...
- The Ras superfamily at a glance
Krister Wennerberg
Cytoskeleton Inc, 1830 S. Acoma Street, Denver, CO 80223, USA
J Cell Sci 118:843-6. 2005
- Rho and Rac take center stage
Keith Burridge
Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Cell 116:167-79. 2004
..Additionally, we will discuss how there is signaling crosstalk between family members and how various bacterial pathogens have developed strategies to manipulate Rho protein activity so as to enhance their own survival...
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosisShawn M Ellerbroek
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Biol Cell 15:3309-19. 2004
..Together, this work establishes SGEF as a RhoG exchange factor and provides evidence that both SGEF and RhoG regulate membrane dynamics in promotion of macropinocytosis...
- Rho-family GTPases: it's not only Rac and Rho (and I like it)
Krister Wennerberg
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
J Cell Sci 117:1301-12. 2004
..Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation...
- XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
William T Arthur
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Biol Chem 277:42964-72. 2002
..In conclusion, here we describe a Rho family GEF that can discriminate between the closely related RhoA, RhoB, and RhoC, possibly giving insight to the divergent functions of these three proteins...
- Integrin signaling to the actin cytoskeleton
Kris A DeMali
Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Curr Opin Cell Biol 15:572-82. 2003
..Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion...
- Rnd proteins function as RhoA antagonists by activating p190 RhoGAP
Krister Wennerberg
Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Curr Biol 13:1106-15. 2003
..However, effector molecules of Rnd proteins with such properties have not been identified...
- Serine phosphorylation negatively regulates RhoA in vivo
Shawn M Ellerbroek
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:19023-31. 2003
....
- Analysis of activated GAPs and GEFs in cell lysates
Rafael Garcia-Mata
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
Methods Enzymol 406:425-37. 2006
..This assay can be used to identify GEFs, GAPs, and effectors involved in specific cellular pathways to determine their GTPase specificity and to monitor the temporal activation of GEFs and GAPs in response to upstream signals...
