Robert C Welsh

Summary

Publications

  1. doi request reprint A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PC
    Robert C Welsh
    University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
    Circ Cardiovasc Interv 5:336-46. 2012
  2. doi request reprint Anticoagulation after subcutaneous enoxaparin is time sensitive in STEMI patients treated with tenecteplase
    Robert C Welsh
    2C2 Cardiology, WMC, University of Alberta, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada
    J Thromb Thrombolysis 34:126-31. 2012
  3. doi request reprint Cardiovascular assessment of diabetic end-stage renal disease patients before renal transplantation
    Robert C Welsh
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Transplantation 91:213-8. 2011
  4. ncbi request reprint Does fitness level modulate the cardiovascular hemodynamic response to exercise?
    Michael K Stickland
    Faculty of Physiucal Education and Recreation, University of Alberta, Edmonton, Canada
    J Appl Physiol (1985) 100:1895-901. 2006
  5. ncbi request reprint A novel enoxaparin regime for ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a WEST sub-study
    Robert C Welsh
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Catheter Cardiovasc Interv 70:341-8. 2007
  6. ncbi request reprint Effect of acute increases in pulmonary vascular pressures on exercise pulmonary gas exchange
    Michael K Stickland
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada
    J Appl Physiol (1985) 100:1910-7. 2006
  7. doi request reprint Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction
    Paul W Armstrong
    Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research, University of Alberta, Edmonton, Canada
    N Engl J Med 368:1379-87. 2013
  8. doi request reprint Incidence of heart failure and mortality after acute coronary syndromes
    Padma Kaul
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 165:379-85.e2. 2013
  9. ncbi request reprint Effects of prolonged exercise to exhaustion on left-ventricular function and pulmonary gas exchange
    Michael K Stickland
    Faculty of Physical Education and Recreation, University of Alberta, E 424 Van Vliet Center, Edmonton, Alta, Canada T6G 2H9
    Respir Physiol Neurobiol 142:197-209. 2004
  10. ncbi request reprint A marriage of enhancement: fibrinolysis and conjunctive therapy
    Robert C Welsh
    The University of Alberta, Department of Medicine, Division of Cardiology, Edmonton, AB T6G 2H7 Canada
    Thromb Haemost 92:1194-200. 2004

Detail Information

Publications41

  1. doi request reprint A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PC
    Robert C Welsh
    University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
    Circ Cardiovasc Interv 5:336-46. 2012
    ....
  2. doi request reprint Anticoagulation after subcutaneous enoxaparin is time sensitive in STEMI patients treated with tenecteplase
    Robert C Welsh
    2C2 Cardiology, WMC, University of Alberta, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada
    J Thromb Thrombolysis 34:126-31. 2012
    ..3 mg/kg IV enoxaparin at time of PCI reliably achieved anti-Xa ≥ 0.5 U/ml. Our findings provide a rational novel strategy for anti-thrombotic management in STEMI patients undergoing a pharmacoinvasive reperfusion strategy...
  3. doi request reprint Cardiovascular assessment of diabetic end-stage renal disease patients before renal transplantation
    Robert C Welsh
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Transplantation 91:213-8. 2011
    ....
  4. ncbi request reprint Does fitness level modulate the cardiovascular hemodynamic response to exercise?
    Michael K Stickland
    Faculty of Physiucal Education and Recreation, University of Alberta, Edmonton, Canada
    J Appl Physiol (1985) 100:1895-901. 2006
    ....
  5. ncbi request reprint A novel enoxaparin regime for ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a WEST sub-study
    Robert C Welsh
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Catheter Cardiovasc Interv 70:341-8. 2007
    ..To evaluate the anticoagulation effect of subcutaneous (SQ) and intravenous (IV) enoxaparin through systematic anti-Xa sampling during primary PCI for acute STEMI...
  6. ncbi request reprint Effect of acute increases in pulmonary vascular pressures on exercise pulmonary gas exchange
    Michael K Stickland
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada
    J Appl Physiol (1985) 100:1910-7. 2006
    ..Minute ventilation and arterial PcO2 were not consistently affected by LBPP. Therefore, small acute increases in pulmonary vascular pressures do not widen exercise A-aDO2 or consistently affect IP shunt recruitment or ventilation...
  7. doi request reprint Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction
    Paul W Armstrong
    Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research, University of Alberta, Edmonton, Canada
    N Engl J Med 368:1379-87. 2013
    ....
  8. doi request reprint Incidence of heart failure and mortality after acute coronary syndromes
    Padma Kaul
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 165:379-85.e2. 2013
    ..We examined the 1-year incidence of HF and its association with mortality among patients surviving their first acute coronary syndrome (ACS) hospitalization...
  9. ncbi request reprint Effects of prolonged exercise to exhaustion on left-ventricular function and pulmonary gas exchange
    Michael K Stickland
    Faculty of Physical Education and Recreation, University of Alberta, E 424 Van Vliet Center, Edmonton, Alta, Canada T6G 2H9
    Respir Physiol Neurobiol 142:197-209. 2004
    ..Gas exchange was not related to cardiovascular function at the onset, or at end exercise. The results indicate that the widening A-aD(O(2)) during exercise is due to a readily reversible change in gas exchange function...
  10. ncbi request reprint A marriage of enhancement: fibrinolysis and conjunctive therapy
    Robert C Welsh
    The University of Alberta, Department of Medicine, Division of Cardiology, Edmonton, AB T6G 2H7 Canada
    Thromb Haemost 92:1194-200. 2004
    ..The future is likely to emphasize greater application of the already effective therapies at our disposal and the development of novel anti-platelet and anti-thrombin agents as well as those directed toward inflammation...
  11. doi request reprint Use and timing of coronary angiography and associated in-hospital outcomes in Canadian non-ST-segment elevation myocardial infarction patients: insights from the Canadian Global Registry of Acute Coronary Events
    Gabor T Gyenes
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 29:1429-35. 2013
    ..Although an early invasive approach has become standard strategy for the management of non-ST-segment elevation myocardial infarction (NSTEMI), the frequency and timing in Canada is uncertain...
  12. doi request reprint Prior coronary artery bypass graft patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention
    Robert C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    JACC Cardiovasc Interv 3:343-51. 2010
    ..We sought to compare outcomes in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) with or without previous coronary artery bypass grafts (CABG)...
  13. doi request reprint Mode of hospital presentation in patients with non-ST-elevation myocardial infarction: implications for strategic management
    Wayne Tymchak
    Division of Cardiology, Department of Medicine, University of Alberta, Alberta, Canada
    Am Heart J 162:436-43. 2011
    ..To assess the feasibility of initiating this strategy in the prehospital environment, we examined how such patients are transported to hospital, their risk profile, and the proportion potentially eligible for such a strategy...
  14. doi request reprint Refining clinical trial composite outcomes: an application to the Assessment of the Safety and Efficacy of a New Thrombolytic-3 (ASSENT-3) trial
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    Am Heart J 161:848-54. 2011
    ..Traditional time-to-event analysis assigns equal weight to the first event in the composite end point. This is counterintuitive to many stakeholders...
  15. doi request reprint Evaluation of early percutaneous coronary intervention vs. standard therapy after fibrinolysis for ST-segment elevation myocardial infarction: contribution of weighting the composite endpoint
    Jeffrey A Bakal
    Division of Cardiology, 2 132 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, Alberta, Canada T6G 2E1
    Eur Heart J 34:903-8. 2013
    ..The selection of optimal endpoints for cardiovascular clinical trials continues to be challenging. We examined an alternative interpretation of a series of trials when the individual event severity is considered...
  16. pmc The effects of dobutamine and dopamine on intrapulmonary shunt and gas exchange in healthy humans
    Tracey L Bryan
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    J Appl Physiol (1985) 113:541-8. 2012
    ..In addition, given the deleterious effect on Qs/Qt and the risk of neurological complications with intrapulmonary shunts, these findings could have important implications for use of dobutamine and dopamine in the clinical setting...
  17. pmc Prolonged strenuous exercise alters the cardiovascular response to dobutamine stimulation in male athletes
    Robert C Welsh
    Division of Cardiology, University of Alberta Hospital, Edmonton, Alberta, Canada
    J Physiol 569:325-30. 2005
    ..This study supports the hypothesis that beta-receptor downregulation and/or desensitization may play a major role in prolonged-strenuous-exercise-mediated cardiac fatigue...
  18. doi request reprint The pre-hospital fibrinolysis experience in Europe and North America and implications for wider dissemination
    Thao Huynh
    Division of Cardiology, Department of Medicine, McGill Health University Center, Montreal, Quebec, Canada
    JACC Cardiovasc Interv 4:877-83. 2011
    ..A secondary objective is to report the outcome data of the PHL programs surveyed...
  19. doi request reprint Temporal trends in patient and treatment delay among men and women presenting with ST-elevation myocardial infarction
    Padma Kaul
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 161:91-7. 2011
    ..Whether these have resulted in changes in sex differences in time to treatment is unknown. We examined temporal trends in time to reperfusion therapy among men and women with STEMI...
  20. doi request reprint Treatment and outcomes of patients with suspected acute coronary syndromes in relation to initial diagnostic impressions (insights from the Canadian Global Registry of Acute Coronary Events [GRACE] and Canadian Registry of Acute Coronary Events [CANRACE])
    Ravi R Bajaj
    Department of Medicine, Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Cardiol 111:202-7. 2013
    ..The GRACE risk score provided accurate risk assessment, regardless of the initial diagnostic impression...
  21. ncbi request reprint Variations in pre-hospital fibrinolysis process of care: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic 3 Plus international acute myocardial infarction pre-hospital care survey
    Robert C Welsh
    University of Albert, Edmonton, Canada
    Eur J Emerg Med 11:134-40. 2004
    ....
  22. ncbi request reprint Feasibility and applicability of paramedic-based prehospital fibrinolysis in a large North American center
    Robert C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 152:1007-14. 2006
    ....
  23. doi request reprint Complete vs culprit-only revascularization for patients with multivessel disease undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a systematic review and meta-analysis
    Kevin R Bainey
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada Electronic address
    Am Heart J 167:1-14.e2. 2014
    ..Whether a strategy of complete revascularization in these patients is superior is unknown. We performed a meta-analysis comparing the benefits and risks of routine culprit-only PCI vs multivessel PCI in STEMI...
  24. doi request reprint Bridging the gap for nonmetropolitan STEMI patients through implementation of a pharmacoinvasive reperfusion strategy
    Jay Shavadia
    University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 29:951-9. 2013
    ....
  25. doi request reprint Contemporary pharmacological reperfusion in ST elevation myocardial infarction
    Robert C Welsh
    Division of Cardiology, Department of Medicine, University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
    Curr Opin Cardiol 27:340-6. 2012
    ..This review focuses on recent data that will further enhance the clinician's ability to deliver a pharmacological reperfusion strategy to this patient population...
  26. pmc Clinical risk scoring beyond initial troponin values: results from a large, prospective, unselected acute chest pain population
    Michael A McDonald
    Department of Medicine, University of Alberta, Edmonton
    Can J Cardiol 23:287-92. 2007
    ..Current clinical risk models, typically derived from selected populations, are limited by their relative complexity and the absence of a well-defined role of troponin...
  27. doi request reprint Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction
    Justin A Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
    J Am Coll Cardiol 53:13-20. 2009
    ..The purpose of this study was to examine the long-term incidence of heart failure (HF) in elderly patients with myocardial infarction (MI)...
  28. doi request reprint Acute management of ST-elevation myocardial infarction patients taking dabigatran
    Jay Shavadia
    Mazankowski Alberta Heart Institute and University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 29:1531.e13-4. 2013
    ..Additionally we propose suggestions for urgent percutaneous coronary intervention while taking dabigatran, a strategy that should be implemented cautiously and adapted as further evidence becomes available. ..
  29. doi request reprint Outcomes of consecutive patients referred for consideration for transcatheter aortic valve implantation from an encompassing health-care region
    Steven R Meyer
    Division of Cardiac Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada Electronic address
    Am J Cardiol 112:1450-4. 2013
    ..With expansion of clinical experience and the evidence supporting TAVI, the Heart Teams defined to assess this patient population will be burdened with increased clinical commitment and require appropriate support...
  30. ncbi request reprint Meta-analysis of randomized trials comparing enoxaparin versus unfractionated heparin as adjunctive therapy to fibrinolysis in ST-elevation acute myocardial infarction
    Pierre Theroux
    Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Am J Cardiol 91:860-4. 2003
  31. pmc Tailoring therapy to best suit ST-segment elevation myocardial infarction: searching for the right fit
    Paul W Armstrong
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 169:925-7. 2003
  32. pmc Evaluating the views of paramedics, cardiologists, emergency department physicians and nurses on advanced prehospital management of acute ST elevation myocardial infarction
    Naheed A Rajabali
    Walter C Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada
    Can J Cardiol 25:e323-8. 2009
    ..Understanding perceived barriers to and facilitators of PHM implementation may support the expansion of programs, with associated patient benefit...
  33. doi request reprint Determining the cost economic "tipping point" for the addition of a regional percutaneous coronary intervention facility
    Jeffrey A Bakal
    Canadian VIGOUR Centre, Edmonton, Alberta, Canada
    Can J Cardiol 27:567-72. 2011
    ..A new regional PCI facility could be economically viable if implementation costs are at least comparable to urgent transportation and interventional team clinical competency is maintained...
  34. doi request reprint The influence of time from symptom onset and reperfusion strategy on 1-year survival in ST-elevation myocardial infarction: a pooled analysis of an early fibrinolytic strategy versus primary percutaneous coronary intervention from CAPTIM and WEST
    Cynthia M Westerhout
    University of Alberta, Edmonton, Canada
    Am Heart J 161:283-90. 2011
    ..We examined the relationship between reperfusion strategy and time from symptom onset on 1-year mortality in a combined analysis of 1,168 patients with STEMI...
  35. ncbi request reprint Prehospital management of acute ST-elevation myocardial infarction: a time for reappraisal in North America
    Robert C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 145:1-8. 2003
    ..We review past research in prehospital therapy for STEMI and practical impediments to implementation to establish a framework for interpretation of future developments...
  36. pmc Intra-pulmonary shunt and pulmonary gas exchange during exercise in humans
    Michael K Stickland
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    J Physiol 561:321-9. 2004
    ..These results indicate that anatomical I-P shunts develop during exercise and we suggest that shunt recruitment may contribute to the widened A-aDO(2) during exercise...
  37. ncbi request reprint Coronary artery disease is common in nonuremic, asymptomatic type 1 diabetic islet transplant candidates
    Peter A Senior
    Clinical Islet Transplant Program, University of Alberta, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes Care 28:866-72. 2005
    ..The prevalence of CAD was determined by coronary angiography and the performance of noninvasive cardiac investigation evaluated in type 1 diabetic islet transplant (ITX) candidates with preserved renal function...
  38. ncbi request reprint Low cardiorespiratory fitness is associated with elevated C-reactive protein levels in women with type 2 diabetes
    Jonathan M McGavock
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Care 27:320-5. 2004
    ..The purpose of this study was to examine differences in novel markers of cardiovascular disease (CVD) in women with type 2 diabetes stratified according to cardiorespiratory fitness...
  39. ncbi request reprint Late potentials in female triathletes before and after prolonged strenuous exercise
    Darren E R Warburton
    Faculty of Physical Education and Recreation, Div of Cardiology, Faculty of Medicine, Univ of Alberta, Edmonton, AB, T6G 2M7
    Can J Appl Physiol 28:153-64. 2003
    ..In conclusion, a small portion of female triathletes display LP before and after PSE, which are not worsened by PSE nor related to increased LV dimensions and/or mass...
  40. ncbi request reprint Tumour on the tricuspid valve: metastatic osteosarcoma and the heart
    Michael A Platonov
    University of Alberta, Edmonton, Canada
    Can J Cardiol 21:63-7. 2005
    ..Cardiac involvement is a strong predictor of disease elsewhere and mandates careful surveillance, with surgical management likely providing the best outcome...
  41. ncbi request reprint Clinical in-stent restenosis with bare metal stents: is it truly a benign phenomenon?
    Kevin R Bainey
    University of Alberta, Edmonton, Alberta, Canada
    Int J Cardiol 128:378-82. 2008
    ..The aim of this study was to define the incidence, predictors, timing and clinical presentation of patients with ISR requiring repeat catheterization...