Mark Welch

Summary

Publications

  1. pmc Design parameters to control synthetic gene expression in Escherichia coli
    Mark Welch
    DNA2 0, Menlo Park, CA, USA
    PLoS ONE 4:e7002. 2009
  2. doi request reprint Designing genes for successful protein expression
    Mark Welch
    DNA2 0, Inc, Suite A, Menlo Park, California, USA
    Methods Enzymol 498:43-66. 2011
  3. pmc Engineering genes for predictable protein expression
    Claes Gustafsson
    DNA2 0 Inc, 1140 O Brien Drive, Menlo Park, CA 94025, USA
    Protein Expr Purif 83:37-46. 2012
  4. pmc You're one in a googol: optimizing genes for protein expression
    Mark Welch
    DNA 2 0, Inc, 1430 O Brien Drive, Menlo Park, CA 94025, USA
    J R Soc Interface 6:S467-76. 2009
  5. doi request reprint In silico design of functional DNA constructs
    Alan Villalobos
    DNA2 0, Inc, Menlo Park, CA, USA
    Methods Mol Biol 852:197-213. 2012
  6. doi request reprint Mapping of amino Acid substitutions conferring herbicide resistance in wheat glutathione transferase
    Sridhar Govindarajan
    DNA2 0, Inc, 1140 O Brien Drive, Suite A, Menlo Park, California 94025, United States
    ACS Synth Biol 4:221-7. 2015
  7. ncbi request reprint Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster
    Hugo G Menzella
    Kosan Biosciences, Inc, 3832 Bay Center Place, Hayward, CA, 94545, USA
    J Ind Microbiol Biotechnol 33:22-8. 2006

Collaborators

Detail Information

Publications7

  1. pmc Design parameters to control synthetic gene expression in Escherichia coli
    Mark Welch
    DNA2 0, Menlo Park, CA, USA
    PLoS ONE 4:e7002. 2009
    ..Protein-coding sequences are commonly re-designed to enhance expression, but there are no experimentally supported design principles...
  2. doi request reprint Designing genes for successful protein expression
    Mark Welch
    DNA2 0, Inc, Suite A, Menlo Park, California, USA
    Methods Enzymol 498:43-66. 2011
    ..Finally, we show how many of these methods can be accomplished using the synthetic biology software tool Gene Designer...
  3. pmc Engineering genes for predictable protein expression
    Claes Gustafsson
    DNA2 0 Inc, 1140 O Brien Drive, Menlo Park, CA 94025, USA
    Protein Expr Purif 83:37-46. 2012
    ..We here discuss how these new tools are being applied and how they circumvent the constraints of previous approaches, highlighting some of the surprising and promising results emerging from the developing field of gene engineering...
  4. pmc You're one in a googol: optimizing genes for protein expression
    Mark Welch
    DNA 2 0, Inc, 1430 O Brien Drive, Menlo Park, CA 94025, USA
    J R Soc Interface 6:S467-76. 2009
    ....
  5. doi request reprint In silico design of functional DNA constructs
    Alan Villalobos
    DNA2 0, Inc, Menlo Park, CA, USA
    Methods Mol Biol 852:197-213. 2012
    ..Together, the functions in Gene Designer provide a complete capability to design functional genetic constructs...
  6. doi request reprint Mapping of amino Acid substitutions conferring herbicide resistance in wheat glutathione transferase
    Sridhar Govindarajan
    DNA2 0, Inc, 1140 O Brien Drive, Suite A, Menlo Park, California 94025, United States
    ACS Synth Biol 4:221-7. 2015
    ..Predictive quantitative models like those presented here have broad applicability for bioengineering. ..
  7. ncbi request reprint Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster
    Hugo G Menzella
    Kosan Biosciences, Inc, 3832 Bay Center Place, Hayward, CA, 94545, USA
    J Ind Microbiol Biotechnol 33:22-8. 2006
    ..Indeed, for optimal polyketide production, PKS expression had to be down-regulated by promoter attenuation to achieve balance with expression of the accessory proteins needed to support polyketide biosynthesis...