R H Weisler

Summary

Publications

  1. ncbi request reprint Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment
    Kathryn M Connor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3812, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:21-5. 2006
  2. pmc Clinical response and symptomatic remission in short- and long-term trials of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Greg W Mattingly
    St Charles Psychiatric Associates Midwest Research, 4801 Weldon Spring Pkwy, Suite 300, St Charles, MO, USA
    BMC Psychiatry 13:39. 2013
  3. pmc Effect of lisdexamfetamine dimesylate on sleep in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry and Child and Adolescent Psychiatry, New York University School of Medicine, NY, USA
    Behav Brain Funct 5:34. 2009
  4. ncbi request reprint Review of long-acting stimulants in the treatment of attention deficit hyperactivity disorder
    Richard H Weisler
    Duke University Medical Center, Durham, NC, USA
    Expert Opin Pharmacother 8:745-58. 2007
  5. ncbi request reprint Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder
    Richard H Weisler
    Duke University, Department of Psychiatry and Behavioral Science, University of North Carolina at Chapel Hill, 700 Spring Forest, Suite 125, Raleigh, NC 27609, USA
    Expert Rev Neurother 5:587-95. 2005
  6. ncbi request reprint Long-term cardiovascular effects of mixed amphetamine salts extended release in adults with ADHD
    Richard H Weisler
    Duke University Medical Center, University of North Carilina, Chapel Hill, Raleigh 27609, USA
    CNS Spectr 10:35-43. 2005
  7. ncbi request reprint Extended-release carbamazepine capsules as monotherapy in bipolar disorder : pooled results from two randomised, double-blind, placebo-controlled trials
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University, Raleigh, North Carolina 27609, USA
    CNS Drugs 20:219-31. 2006
  8. ncbi request reprint Efficacy of quetiapine monotherapy for the treatment of depressive episodes in bipolar I disorder: a post hoc analysis of combined results from 2 double-blind, randomized, placebo-controlled studies
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, University of North Carolina at Chapel Hill, Raleigh, NC 27609, USA
    J Clin Psychiatry 69:769-82. 2008
  9. ncbi request reprint Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk taking, and persistence
    Richard H Weisler
    University of North Carolina at Chapel Hill and Duke University Medical Center, United States
    J Affect Disord 108:1-9. 2008
  10. ncbi request reprint Mixed amphetamine salts extended-release in the treatment of adult ADHD: a randomized, controlled trial
    Richard H Weisler
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    CNS Spectr 11:625-39. 2006

Detail Information

Publications44

  1. ncbi request reprint Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment
    Kathryn M Connor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3812, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:21-5. 2006
    ..Preliminary results suggest a potential benefit of agents that enhance gamma-aminobutyric acid (GABA) neurotransmission in treating posttraumatic stress disorder (PTSD)...
  2. pmc Clinical response and symptomatic remission in short- and long-term trials of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Greg W Mattingly
    St Charles Psychiatric Associates Midwest Research, 4801 Weldon Spring Pkwy, Suite 300, St Charles, MO, USA
    BMC Psychiatry 13:39. 2013
    ..This study examined clinical response and symptomatic remission in analyses of 2 studies of lisdexamfetamine dimesylate (LDX) in adults with ADHD...
  3. pmc Effect of lisdexamfetamine dimesylate on sleep in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry and Child and Adolescent Psychiatry, New York University School of Medicine, NY, USA
    Behav Brain Funct 5:34. 2009
    ..abstract:..
  4. ncbi request reprint Review of long-acting stimulants in the treatment of attention deficit hyperactivity disorder
    Richard H Weisler
    Duke University Medical Center, Durham, NC, USA
    Expert Opin Pharmacother 8:745-58. 2007
    ..Distinctions can be made among the long-acting medications with regard to the onset, magnitude and duration of their clinical effects. Recognition of these differences is important for individualizing treatment for patients with ADHD...
  5. ncbi request reprint Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder
    Richard H Weisler
    Duke University, Department of Psychiatry and Behavioral Science, University of North Carolina at Chapel Hill, 700 Spring Forest, Suite 125, Raleigh, NC 27609, USA
    Expert Rev Neurother 5:587-95. 2005
    ..Recent data collected based on this new formulation of carbamazepine illustrate the need for education about the utility of this compound in bipolar disorder...
  6. ncbi request reprint Long-term cardiovascular effects of mixed amphetamine salts extended release in adults with ADHD
    Richard H Weisler
    Duke University Medical Center, University of North Carilina, Chapel Hill, Raleigh 27609, USA
    CNS Spectr 10:35-43. 2005
    ..To assess long-term cardiovascular effects of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) combined subtype...
  7. ncbi request reprint Extended-release carbamazepine capsules as monotherapy in bipolar disorder : pooled results from two randomised, double-blind, placebo-controlled trials
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University, Raleigh, North Carolina 27609, USA
    CNS Drugs 20:219-31. 2006
    ..By pooling data from these two trials, a more highly powered analysis of the efficacy and safety of CBZ-ERC in bipolar I disorder could be conducted...
  8. ncbi request reprint Efficacy of quetiapine monotherapy for the treatment of depressive episodes in bipolar I disorder: a post hoc analysis of combined results from 2 double-blind, randomized, placebo-controlled studies
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, University of North Carolina at Chapel Hill, Raleigh, NC 27609, USA
    J Clin Psychiatry 69:769-82. 2008
    ....
  9. ncbi request reprint Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk taking, and persistence
    Richard H Weisler
    University of North Carolina at Chapel Hill and Duke University Medical Center, United States
    J Affect Disord 108:1-9. 2008
    ..The development of lamotrigine provides one example of the importance of prescience, patience and persistence in bringing a novel idea to clinical fruition...
  10. ncbi request reprint Mixed amphetamine salts extended-release in the treatment of adult ADHD: a randomized, controlled trial
    Richard H Weisler
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    CNS Spectr 11:625-39. 2006
    ..Functional impairments, underachievement, and difficult interpersonal relationships illustrate the need for effective treatment of ADHD through adulthood...
  11. ncbi request reprint Mental health and recovery in the Gulf Coast after Hurricanes Katrina and Rita
    Richard H Weisler
    Department of Psychiatry, University of North Carolina at Chapel Hill, and Duke University Medical Center, Durham 27609, USA
    JAMA 296:585-8. 2006
  12. ncbi request reprint The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials
    Richard H Weisler
    University of North Carolina at Chapel Hill, NC, USA
    CNS Spectr 11:788-99. 2006
    ..This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling...
  13. ncbi request reprint Emerging drugs for attention-deficit/hyperactivity disorder
    Richard H Weisler
    Duke University Medical Center, Durham, NC, USA
    Expert Opin Emerg Drugs 12:423-34. 2007
    ..Potential therapies such as adrenergic receptor agonists, glutamatergic agents, GABA receptor antagonists and nicotine receptor agonists are being explored as future pharmacotherapies for ADHD...
  14. ncbi request reprint Extended release quetiapine fumarate monotherapy for major depressive disorder: results of a double-blind, randomized, placebo-controlled study
    Richard Weisler
    Department of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, NC, USA
    CNS Spectr 14:299-313. 2009
    ..Once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy was evaluated in major depressive disorder (MDD)...
  15. doi request reprint Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: a randomized controlled study)
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC, USA
    J Clin Psychiatry 72:1452-64. 2011
    ..This study investigated the efficacy and safety of quetiapine monotherapy as maintenance treatment in bipolar I disorder compared with switching to placebo or lithium...
  16. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled trial of extended-release carbamazepine capsules as monotherapy for bipolar disorder patients with manic or mixed episodes
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University, 700 Spring Forest, Suite 125, Raleigh, N C 27609, USA
    J Clin Psychiatry 65:478-84. 2004
    ..We assessed the efficacy and safety of monotherapy with beaded, extended-release carbamazepine capsules (ERC-CBZ; SPD417) in bipolar disorder patients with manic or mixed episodes...
  17. doi request reprint Analysis of suicidality in pooled data from 2 double-blind, placebo-controlled aripiprazole adjunctive therapy trials in major depressive disorder
    R H Weisler
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, University of North Carolina at Chapel Hill, 700 Spring Forest, Ste 125, Raleigh, NC 27609, USA
    J Clin Psychiatry 72:548-55. 2011
    ..To assess the impact of adjunctive aripiprazole versus adjunctive placebo treatment on suicidality in patients with major depressive disorder...
  18. ncbi request reprint Extended-release carbamazepine capsules as monotherapy for acute mania in bipolar disorder: a multicenter, randomized, double-blind, placebo-controlled trial
    Richard H Weisler
    Department of Psychiatry and Behavioral Sciences, Duke University, 700 Spring Forest, Suite 125, Raleigh, NC 27609, USA
    J Clin Psychiatry 66:323-30. 2005
    ..In the present study, we further evaluated the efficacy and safety of monotherapy with beaded, extended-release carbamazepine capsules (ERC-CBZ) in patients with bipolar I disorder experiencing manic or mixed episodes...
  19. ncbi request reprint Long-term safety and effectiveness of lisdexamfetamine dimesylate in adults with attention-deficit/ hyperactivity disorder
    Richard Weisler
    Department of Psychiatry, University of North Carolina, Chapel Hill, USA
    CNS Spectr 14:573-85. 2009
    ..To evaluate the long-term safety and effectiveness of lisdexamfetamine dimesylate (LDX) in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD)...
  20. ncbi request reprint Safety, efficacy and extended duration of action of mixed amphetamine salts extended-release capsules for the treatment of ADHD
    Richard H Weisler
    Department of Psychiatry, Duke University Medical Center, 700 Spring Forest Rd Suite 125, Raleigh, NC 27609, USA
    Expert Opin Pharmacother 6:1003-18. 2005
    ..d. MAS XR has a rapid onset of action--within 1.5 h--and provides 12 h coverage. The efficacy, safety and extended duration of action of MAS XR have been established through clinical studies in school-age children, adolescents and adults...
  21. doi request reprint Efficacy of extended release quetiapine fumarate monotherapy in patients with major depressive disorder: a pooled analysis of two 6-week, double-blind, placebo-controlled studies
    Richard H Weisler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Raleigh, NC 27609, USA
    Int Clin Psychopharmacol 27:27-39. 2012
    ..In patients with MDD, quetiapine XR (150 and 300 mg/day) monotherapy reduced depressive symptoms, with significant improvements compared with placebo from week 1 onward...
  22. ncbi request reprint Quetiapine in the treatment of anxiety in patients with bipolar I or II depression: a secondary analysis from a randomized, double-blind, placebo-controlled study
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, USA
    J Clin Psychiatry 67:355-62. 2006
    ..The analyses in this multicenter, double-blind, randomized, fixed-dose, placebo-controlled study evaluated effects of quetiapine monotherapy on anxiety symptoms in bipolar depression...
  23. ncbi request reprint Triple-bead mixed amphetamine salts (SPD465), a novel, enhanced extended-release amphetamine formulation for the treatment of adults with ADHD: a randomized, double-blind, multicenter, placebo-controlled study
    Thomas J Spencer
    Department of Psychiatry, Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, 55 Fruit St, Warren 705, Boston, MA 02114, USA
    J Clin Psychiatry 69:1437-48. 2008
    ....
  24. doi request reprint Short-term effects of lisdexamfetamine dimesylate on cardiovascular parameters in a 4-week clinical trial in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Clin Psychiatry 70:1652-61. 2009
    ..To evaluate the short-term impact of lisdexamfetamine dimesylate on cardiovascular parameters in adults with attention-deficit/hyperactivity disorder (ADHD)...
  25. ncbi request reprint Extended-release carbamazepine capsules: a viewpoint
    Richard H Weisler
    Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
    CNS Drugs 19:717-8. 2005
  26. ncbi request reprint Dimensions of self-rated mood in depressed, manic, and normal subjects
    E P Ahearn
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Compr Psychiatry 42:196-201. 2001
    ..Normal subjects exhibit megalothymic (hyperthymia) on most dimensions of subjective mood. The negative MVAS scores of depressed patients are even more deviant from normal than the conventional scoring system would suggest...
  27. ncbi request reprint A pilot study of mirtazapine in post-traumatic stress disorder
    K M Connor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int Clin Psychopharmacol 14:29-31. 1999
    ..Mirtazapine was associated with clinical improvement in 50% of subjects with severe, chronic PTSD, suggesting a need for further investigation in double-blind, placebo-controlled trials...
  28. ncbi request reprint Relationship of mania symptomatology to maintenance treatment response with divalproex, lithium, or placebo
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuropsychopharmacology 30:1932-9. 2005
    ..Dysphoric mania appeared to predispose patients to more side effects when treated with either divalproex or lithium during maintenance therapy...
  29. ncbi request reprint Psychometric properties of the Social Phobia Inventory (SPIN). New self-rating scale
    K M Connor
    Department of Psychiatry and Behavioral Sciences, Duke University, Medical Center, Durham, NC 27710, USA
    Br J Psychiatry 176:379-86. 2000
    ..Of available self-rated social phobia scales, none assesses the spectrum of fear, avoidance, and physiological symptoms, all of which are clinically important. Because of this limitation, we developed the Social Phobia Inventory (SPIN)...
  30. ncbi request reprint Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry, New York University School of Medicine, 530 First Ave 7D, New York, NY 10016, USA
    J Clin Psychiatry 69:1364-73. 2008
    ..To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD)...
  31. ncbi request reprint Mirtazapine vs. placebo in posttraumatic stress disorder: a pilot trial
    Jonathan R T Davidson
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 53:188-91. 2003
    ..Based on an earlier pilot study, as well as a theoretical consideration of its mechanism of action, we undertook a placebo-controlled, double-blind trial of mirtazapine in posttraumatic stress disorder...
  32. doi request reprint How do you choose a second-line treatment option for depression?
    Richard H Weisler
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
    J Clin Psychiatry 71:21-6. 2010
    ..Comorbid medical conditions, especially cardiac and cerebrovascular complications, and potential drug-drug interactions should be considered when making treatment decisions...
  33. ncbi request reprint Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype
    Eileen P Ahearn
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Med Genet 114:652-8. 2002
    ..Multipoint linkage analysis yielded negative results except for Model 1a, in which a maximal LOD score was -1.24. A mutation screen of Exons 3 and 4 was negative. Notch3 does not appear to be a candidate gene for BPD in this family...
  34. ncbi request reprint Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study
    Jonathan R T Davidson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychopharmacol 25:166-9. 2005
    ..02, log-rank statistic). The odds ratio for relapse on PBO relative to FLU was 3.50. No significant differences were found on other measures. Fluoxetine was well tolerated during double-blind treatment...
  35. ncbi request reprint Bipolar II disorder: current and future treatment options
    Rif El-Mallakh
    Dept of Psychiatry, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Ann Clin Psychiatry 18:259-66. 2006
    ..This review attempts to summarize available data on agents useful in treating patients with the disease...
  36. ncbi request reprint A 6-month, multicenter, open-label evaluation of beaded, extended-release carbamazepine capsule monotherapy in bipolar disorder patients with manic or mixed episodes
    Terence A Ketter
    Stanford University School of Medicine, Stanford, California 94305 5723, USA
    J Clin Psychiatry 65:668-73. 2004
    ..We evaluated open-label monotherapy with beaded extended-release carbamazepine capsules (ERC-CBZ; SPD417) as continuation and short-term maintenance therapy in bipolar disorder patients with manic and mixed episodes...
  37. ncbi request reprint Effectiveness and medical costs of divalproex versus lithium in the treatment of bipolar disorder: results of a naturalistic clinical trial
    Dennis A Revicki
    Center for Health Outcomes Research, MEDTAP International, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
    J Affect Disord 86:183-93. 2005
    ..The clinical, quality of life (QOL), and medical cost outcomes of treatment with divalproex were compared with lithium in patients with bipolar I disorder over 1 year...
  38. ncbi request reprint A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression
    Joseph R Calabrese
    University Hospitals of Cleveland and Case University School of Medicine, 11400 Euclid Ave, Suite 200, Cleveland, OH 44106, USA
    Am J Psychiatry 162:1351-60. 2005
    ..There is a major unmet need for effective options in the treatment of bipolar depression...
  39. ncbi request reprint Reassessing carbamazepine in the treatment of bipolar disorder: clinical implications of new data
    Hagop S Akiskal
    University of California, San Diego, USA
    CNS Spectr 10:suppl 1-11; discuss 12-3; quiz 14-5. 2005
    ..Further efforts are needed to update physicians on the use of carbamazepine relative to other medications in the treatment of bipolar disorder...
  40. ncbi request reprint Long-term safety and effectiveness of mixed amphetamine salts extended release in adults with ADHD
    Joseph Biederman
    Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    CNS Spectr 10:16-25. 2005
    ..Assess the long-term safety and effectiveness of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) combined subtype...
  41. ncbi request reprint An interim analysis of the Quality of Life, Effectiveness, Safety, and Tolerability (QU.E.S.T.) evaluation of mixed amphetamine salts extended release in adults with ADHD
    David W Goodman
    Adult Attention Deficit Disorder Center of Maryland, Johns Hopkins at Green Spring Station, Lutherville, MD 21093, USA
    CNS Spectr 10:26-34. 2005
    ..Evaluate safety and efficacy of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD)...
  42. ncbi request reprint Efficacy and safety of mixed amphetamine salts extended release (Adderall XR) in the management of attention-deficit/hyperactivity disorder in adolescent patients: a 4-week, randomized, double-blind, placebo-controlled, parallel-group study
    Thomas J Spencer
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Ther 28:266-79. 2006
    ..The ability to recognize and diagnose attention-deficit/hyperactivity disorder (ADHD) has increased in recent years. The persistence of ADHD symptoms puts adolescents with ADHD at risk for long-term adverse psychosocial outcomes...
  43. ncbi request reprint Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study)
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    J Clin Psychopharmacol 26:600-9. 2006
    ..This study demonstrates that quetiapine monotherapy is an effective and well-tolerated treatment for depressive episodes in bipolar disorder, confirming the results observed from a previous study (BipOLar DEpRession [BOLDER] I)...
  44. ncbi request reprint Rapid onset of antidepressant activity with venlafaxine
    Richard H Weisler
    J Clin Psychiatry 63:534-5; author reply 535-6. 2002