M Weis

Summary

Publications

  1. ncbi request reprint Simvastatin treatment is associated with improvement in coronary endothelial function and decreased cytokine activation in patients after heart transplantation
    M Weis
    Stanford University Medical School, Falk Cardiovascular Research Center, Stanford, California 94305, USA
    J Am Coll Cardiol 38:814-8. 2001
  2. ncbi request reprint Vasodilator response to nifedipine in human coronary arteries with endothelial dysfunction
    Michael Weis
    Medizinische Klinik I, University Hospital Grosshadern, LM University of Munich, Munich, Germany
    J Cardiovasc Pharmacol 39:172-80. 2002
  3. ncbi request reprint An association between microvascular endothelial dysfunction, transcardiac nitric oxide production and pro-inflammatory cytokines after heart transplantation in humans
    S M Wildhirt
    Department of Cardiac Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
    Transpl Int 13:S228-34. 2000
  4. ncbi request reprint Coronary flow reserve and nitric oxide synthases after cardiac transplantation in humans
    S M Wildhirt
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Eur J Cardiothorac Surg 19:840-7. 2001
  5. ncbi request reprint Coronary vasomotor dysfunction in the cardiac allograft: impact of different immunosuppressive regimens
    M Weis
    Medizinische Klinik I, University of Munich, Germany
    J Cardiovasc Pharmacol 36:776-84. 2000
  6. ncbi request reprint Effects of Celsior and University of Wisconsin preservation solutions on hemodynamics and endothelial function after cardiac transplantation in humans: a single-center, prospective, randomized trial
    S M Wildhirt
    Department of Cardiac Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
    Transpl Int 13:S203-11. 2000
  7. ncbi request reprint Modulation of coronary vasomotor tone by cytokines in cardiac transplant recipients
    M Weis
    Medizinische Klinik und Poliklinik I, Institut fur Klinische Chemie, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplantation 68:1263-7. 1999
  8. ncbi request reprint Expression of endomyocardial nitric oxide synthase and coronary endothelial function in human cardiac allografts
    S M Wildhirt
    Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany
    Circulation 104:I336-43. 2001
  9. ncbi request reprint Levosimendan for primary graft failure after heart transplantation: a 3-year follow-up
    A Beiras-Fernandez
    Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplant Proc 43:2260-2. 2011
  10. ncbi request reprint Endothelin immunocytochemistry: indications of false-positive labeling patterns and non-detectable antigen concentrations
    W P Wolf
    Medizinische Klinik I, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Histochem Cell Biol 116:411-26. 2001

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Simvastatin treatment is associated with improvement in coronary endothelial function and decreased cytokine activation in patients after heart transplantation
    M Weis
    Stanford University Medical School, Falk Cardiovascular Research Center, Stanford, California 94305, USA
    J Am Coll Cardiol 38:814-8. 2001
    ....
  2. ncbi request reprint Vasodilator response to nifedipine in human coronary arteries with endothelial dysfunction
    Michael Weis
    Medizinische Klinik I, University Hospital Grosshadern, LM University of Munich, Munich, Germany
    J Cardiovasc Pharmacol 39:172-80. 2002
    ..The association between microvascular response to nifedipine and endothelin levels in the coronary sinus needs further clarification...
  3. ncbi request reprint An association between microvascular endothelial dysfunction, transcardiac nitric oxide production and pro-inflammatory cytokines after heart transplantation in humans
    S M Wildhirt
    Department of Cardiac Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
    Transpl Int 13:S228-34. 2000
    ....
  4. ncbi request reprint Coronary flow reserve and nitric oxide synthases after cardiac transplantation in humans
    S M Wildhirt
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Eur J Cardiothorac Surg 19:840-7. 2001
    ..We therefore investigated the potential relationship between the expression of nitric oxide synthases (NOS) and coronary endothelial function in human cardiac transplant recipients over time...
  5. ncbi request reprint Coronary vasomotor dysfunction in the cardiac allograft: impact of different immunosuppressive regimens
    M Weis
    Medizinische Klinik I, University of Munich, Germany
    J Cardiovasc Pharmacol 36:776-84. 2000
    ..This may have an important impact on subsequent development of transplant coronary atherosclerosis...
  6. ncbi request reprint Effects of Celsior and University of Wisconsin preservation solutions on hemodynamics and endothelial function after cardiac transplantation in humans: a single-center, prospective, randomized trial
    S M Wildhirt
    Department of Cardiac Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
    Transpl Int 13:S203-11. 2000
    ..The positive correlation between impaired endothelial function and total ischemic time in the Celsior group requires longitudinal investigation in particular with regard to the development of allograft vasculopathy...
  7. ncbi request reprint Modulation of coronary vasomotor tone by cytokines in cardiac transplant recipients
    M Weis
    Medizinische Klinik und Poliklinik I, Institut fur Klinische Chemie, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplantation 68:1263-7. 1999
    ..In this study, we characterized the relationship between coronary epicardial and microvascular vasomotor function and expression of specific cytokine patterns in human heart transplant recipients...
  8. ncbi request reprint Expression of endomyocardial nitric oxide synthase and coronary endothelial function in human cardiac allografts
    S M Wildhirt
    Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany
    Circulation 104:I336-43. 2001
    ..The data from the present study suggest an important role for the iNOS/nitric oxide pathway in the regulation of microvascular function in the absence of preexisting atherosclerotic lesions...
  9. ncbi request reprint Levosimendan for primary graft failure after heart transplantation: a 3-year follow-up
    A Beiras-Fernandez
    Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplant Proc 43:2260-2. 2011
    ..Levosimendan increases the 30-day survival among patients with PGF. Herein we have reported a 3-year follow-up at a single center of a patient cohort including PGF cases treated with levosimendan...
  10. ncbi request reprint Endothelin immunocytochemistry: indications of false-positive labeling patterns and non-detectable antigen concentrations
    W P Wolf
    Medizinische Klinik I, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Histochem Cell Biol 116:411-26. 2001
    ..Discrepancies in endothelin immunocytochemistry may originate from false-positive results and from expression levels of endothelin below the detection limit of immunocytochemical methods...
  11. ncbi request reprint Prognostic significance of coronary flow reserve on left ventricular ejection fraction in cardiac transplant recipients
    M Weis
    Department of Internal Medicine I, University Hospital Grosshadern, Munich, Germany
    Transplantation 65:103-8. 1998
    ..The present study tested the impact of microvascular vasomotor function on changes in left ventricular systolic function in the long-term follow-up after cardiac transplantation...
  12. ncbi request reprint Coronary artery disease in the transplanted heart
    M Weis
    Medizinische Klinik und Poliklinik I, University Hospital Grosshadern, Munich, Germany
    Annu Rev Med 51:81-100. 2000
    ..Revascularization procedures have a limited role in treating significant focal lesions. Retransplantation, the only definitive treatment, remains ethically controversial...
  13. doi request reprint Modulation of dendritic cells and toll-like receptors by marathon running
    Thomas Nickel
    Medizinische Klinik und Poliklinik 1, Campus Grosshadern, Ludwig Maximilians Universitat Munchen, Marchioninistr 15, 81377 Munich, Germany
    Eur J Appl Physiol 112:1699-708. 2012
    ..Myeloid and plasmacytoid DCs are differently affected by the excessive physical stress. Immunomodulatory mechanisms seem to play a key role in the response and adaptation to acute excessive exercise...
  14. doi request reprint Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
    H Hanssen
    Department of Prevention and Sports Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Atherosclerosis 216:433-9. 2011
    ..Here, we investigate the effect of regular exercise on retinal vessel diameters in lean and obese runners. We analyze a possible link to alterations of the nitric oxide (NO)-asymmetric dimethylarginine (ADMA) pathway...
  15. ncbi request reprint Multidrug-resistant gram-positive infections in patients with ventricular assist devices: the role of daptomycin
    A Beiras-Fernandez
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplant Proc 41:2589-91. 2009
    ..We report the successful use of daptomycin in patients presenting with MDR gram-positive infections after VAD implantation...
  16. ncbi request reprint Primary graft failure and Ca2+ sensitizers after heart transplantation
    A Beiras-Fernandez
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplant Proc 40:951-2. 2008
    ..Acute graft failure after cardiac transplantation is associated with poor short- and long-term outcomes. Among our patients, levosimendan reduced the need for catecholamine support as well as improved ventricular performance...
  17. ncbi request reprint Coronary endothelial vasomotor function and vascular remodeling in heart transplant recipients randomized for tacrolimus or cyclosporine immunosuppression
    Paraskevi Petrakopoulou
    Medizinische Klinik und Poliklinik I, Ludwig Maximilians University of Munich, Munich, Germany
    J Am Coll Cardiol 47:1622-9. 2006
    ..This study aimed to compare changes in coronary endothelial function, systemic endothelin-1 (ET-1) levels, and vascular remodeling in heart transplant recipients randomized to cyclosporin A (CyA) or tacrolimus (Tac) immunosuppression...
  18. doi request reprint Graft-infiltrating dendritic cells and coronary endothelial dysfunction after human heart transplantation
    Sieglinde Kofler
    Medizinische Klinik und Poliklinik I, University Medical Center Munich Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    J Heart Lung Transplant 27:387-93. 2008
    ....
  19. doi request reprint Cardiac allograft vasculopathy: recent developments
    Daniel Schmauss
    Medizinische Klinik und Poliklinik I, University Hospital Munich Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Circulation 117:2131-41. 2008
    ..However, because individual responses to an allograft change over time, assays to monitor the recipient's immune response and individualized methods for therapeutic immune modulation are clearly needed...
  20. ncbi request reprint Impact of coronary endothelial dysfunction on adverse long-term outcome after heart transplantation
    Marion Kübrich
    Divisions of Cardiology and Cardiovascular Surgery, University Hospital Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Transplantation 85:1580-7. 2008
    ..The present prospective study tested whether endothelial dysfunction independently predicts cardiovascular-related events and death after heart transplantation (HTx)...
  21. ncbi request reprint Cytomegalovirus infection in heart transplant recipients is associated with impaired endothelial function
    Paraskevi Petrakopoulou
    Medizinische Klinik und Poliklinik I, University Medical Center, Munich Grosshadern, Germany
    Circulation 110:II207-12. 2004
    ..Cardiac allograft vasculopathy (CAV) is initiated by allograft endothelial injury. We hypothesized that a major mechanism by which cytomegalovirus (CMV) could contribute to CAV is by dysregulation of the endothelial vasomotor response...
  22. ncbi request reprint Beneficial effects of quinaprilat on coronary vasomotor function, endothelial oxidative stress, and endothelin activation after human heart transplantation
    Silke Steinhauff
    Division of Cardiology, University Hospital Munich Grosshadern, 81377 Munich, Germany
    Transplantation 77:1859-65. 2004
    ....
  23. ncbi request reprint Cardiac allograft vasculopathy: prevention and treatment options
    Michael Weis
    Stanford University School of Medicine, Division of Cardiovascular Medicine, Stanford, California, USA
    Transplant Proc 34:1847-9. 2002
  24. ncbi request reprint Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway
    Michael Weis
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305 5406, USA
    Arterioscler Thromb Vasc Biol 23:567-75. 2003
    ..In addition, the alteration in endothelial function contributes to vascular inflammation and progression of the disease...
  25. ncbi request reprint Statins have biphasic effects on angiogenesis
    Michael Weis
    Stanford University School of Medicine, Division of Cardiovascular Medicine, Stanford, Calif 94305, USA
    Circulation 105:739-45. 2002
    ..Statins inhibit HMG-CoA reductase to reduce the synthesis of cholesterol and isoprenoids that modulate diverse cell functions. We investigated the effect of the statins cerivastatin and atorvastatin on angiogenesis in vitro and in vivo...
  26. ncbi request reprint Dual mode of HMG-CoA reductase inhibition on dendritic cell invasion
    Sieglinde Kofler
    Medizinische Klinik und Poliklinik I, University Medical Center Munich Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Atherosclerosis 197:105-10. 2008
    ..As DCs control immunity, regulating DC/endothelial cell interaction by statins may have relevance to inflammation and atherogenesis...
  27. ncbi request reprint Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious
    Bruno Meiser
    Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
    J Heart Lung Transplant 26:598-603. 2007
    ..97 at 1 and 2 years. The regimen was well tolerated with only 3 patients requiring a change of study medication. Mean serum creatinine increased during the first year but returned to baseline at 2 years...
  28. pmc A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors
    Christopher Heeschen
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 110:527-36. 2002
    ..To our knowledge, this is the first description of a cholinergic angiogenic pathway, and it suggests a novel avenue for therapeutic modulation of angiogenesis...
  29. ncbi request reprint Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes
    Heiko Methe
    Department of Cardiology, Ludwig Maximilians University, Munich, Germany
    Arterioscler Thromb Vasc Biol 25:1439-45. 2005
    ..Molecular mechanisms underlying these effects have not been well explored. Because statins attenuate lipopolysaccharide (LPS) responsiveness, we hypothesized that part of the pleiotropic effects are mediated through innate immunity...
  30. ncbi request reprint The impact of immunosuppression on endothelial function
    Anja Trapp
    Medizinische Klinik und Poliklinik I, University Hospital Munich Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    J Cardiovasc Pharmacol 45:81-7. 2005
    ..MP and MMF induced minor changes in endothelial function compared with CS, Rapa, and Tac...
  31. ncbi request reprint Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation
    Sieglinde Kofler
    Department of Cardiology, University Hospital Munich Grosshadern, Ludwig Maximilians University of Munich, 81377 Munich, Germany
    Clin Sci (Lond) 108:205-13. 2005
    ..This review will focus on the vascular mechanisms orchestrated by cytokines and summarizes the current knowledge concerning the contribution of cytokines to cardiovascular diseases...
  32. ncbi request reprint Tacrolimus or cyclosporine: which is the better partner for mycophenolate mofetil in heart transplant recipients?
    Bruno M Meiser
    Department of Cardiac Surgery, University of Munich, Grosshadern Medical Center, Marchioninistrasse 15, 81366 Munich, Germany
    Transplantation 78:591-8. 2004
    ....
  33. ncbi request reprint Nicotine promotes arteriogenesis
    Christopher Heeschen
    Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
    J Am Coll Cardiol 41:489-96. 2003
    ....
  34. ncbi request reprint Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases
    Michael Weis
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    Arterioscler Thromb Vasc Biol 22:1817-23. 2002
    ..A fundamental aspect of DC function is their capacity to adhere and migrate through vascular endothelial cells (ECs). We investigated the role of endothelial activation and dysregulation of the NO pathway on DC adhesion and migration...
  35. ncbi request reprint Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis
    Michael Weis
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305 5406, USA
    Circulation 109:500-5. 2004
    ..We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the adverse vascular effect of CMV...