Simvastatin treatment is associated with improvement in coronary endothelial function and decreased cytokine activation in patients after heart transplantationM Weis
Stanford University Medical School, Falk Cardiovascular Research Center, Stanford, California 94305, USA
J Am Coll Cardiol 38:814-8. 2001
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- Vasodilator response to nifedipine in human coronary arteries with endothelial dysfunction
Michael Weis
Medizinische Klinik I, University Hospital Grosshadern, LM University of Munich, Munich, Germany
J Cardiovasc Pharmacol 39:172-80. 2002
..The association between microvascular response to nifedipine and endothelin levels in the coronary sinus needs further clarification...
- An association between microvascular endothelial dysfunction, transcardiac nitric oxide production and pro-inflammatory cytokines after heart transplantation in humans
S M Wildhirt
Department of Cardiac Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
Transpl Int 13:S228-34. 2000
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- Coronary flow reserve and nitric oxide synthases after cardiac transplantation in humans
S M Wildhirt
Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
Eur J Cardiothorac Surg 19:840-7. 2001
..We therefore investigated the potential relationship between the expression of nitric oxide synthases (NOS) and coronary endothelial function in human cardiac transplant recipients over time...
- Coronary vasomotor dysfunction in the cardiac allograft: impact of different immunosuppressive regimens
M Weis
Medizinische Klinik I, University of Munich, Germany
J Cardiovasc Pharmacol 36:776-84. 2000
..This may have an important impact on subsequent development of transplant coronary atherosclerosis...
- Effects of Celsior and University of Wisconsin preservation solutions on hemodynamics and endothelial function after cardiac transplantation in humans: a single-center, prospective, randomized trial
S M Wildhirt
Department of Cardiac Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
Transpl Int 13:S203-11. 2000
..The positive correlation between impaired endothelial function and total ischemic time in the Celsior group requires longitudinal investigation in particular with regard to the development of allograft vasculopathy...
- Modulation of coronary vasomotor tone by cytokines in cardiac transplant recipients
M Weis
Medizinische Klinik und Poliklinik I, Institut fur Klinische Chemie, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Transplantation 68:1263-7. 1999
..In this study, we characterized the relationship between coronary epicardial and microvascular vasomotor function and expression of specific cytokine patterns in human heart transplant recipients...
- Expression of endomyocardial nitric oxide synthase and coronary endothelial function in human cardiac allografts
S M Wildhirt
Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany
Circulation 104:I336-43. 2001
..The data from the present study suggest an important role for the iNOS/nitric oxide pathway in the regulation of microvascular function in the absence of preexisting atherosclerotic lesions...
Levosimendan for primary graft failure after heart transplantation: a 3-year follow-upA Beiras-Fernandez
Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Transplant Proc 43:2260-2. 2011
..Levosimendan increases the 30-day survival among patients with PGF. Herein we have reported a 3-year follow-up at a single center of a patient cohort including PGF cases treated with levosimendan...
- Endothelin immunocytochemistry: indications of false-positive labeling patterns and non-detectable antigen concentrations
W P Wolf
Medizinische Klinik I, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Histochem Cell Biol 116:411-26. 2001
..Discrepancies in endothelin immunocytochemistry may originate from false-positive results and from expression levels of endothelin below the detection limit of immunocytochemical methods...
- Prognostic significance of coronary flow reserve on left ventricular ejection fraction in cardiac transplant recipients
M Weis
Department of Internal Medicine I, University Hospital Grosshadern, Munich, Germany
Transplantation 65:103-8. 1998
..The present study tested the impact of microvascular vasomotor function on changes in left ventricular systolic function in the long-term follow-up after cardiac transplantation...
- Coronary artery disease in the transplanted heart
M Weis
Medizinische Klinik und Poliklinik I, University Hospital Grosshadern, Munich, Germany
Annu Rev Med 51:81-100. 2000
..Revascularization procedures have a limited role in treating significant focal lesions. Retransplantation, the only definitive treatment, remains ethically controversial...
- Modulation of dendritic cells and toll-like receptors by marathon running
Thomas Nickel
Medizinische Klinik und Poliklinik 1, Campus Grosshadern, Ludwig Maximilians Universitat Munchen, Marchioninistr 15, 81377 Munich, Germany
Eur J Appl Physiol 112:1699-708. 2012
..Myeloid and plasmacytoid DCs are differently affected by the excessive physical stress. Immunomodulatory mechanisms seem to play a key role in the response and adaptation to acute excessive exercise...
- Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
H Hanssen
Department of Prevention and Sports Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Atherosclerosis 216:433-9. 2011
..Here, we investigate the effect of regular exercise on retinal vessel diameters in lean and obese runners. We analyze a possible link to alterations of the nitric oxide (NO)-asymmetric dimethylarginine (ADMA) pathway...
- Multidrug-resistant gram-positive infections in patients with ventricular assist devices: the role of daptomycin
A Beiras-Fernandez
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Transplant Proc 41:2589-91. 2009
..We report the successful use of daptomycin in patients presenting with MDR gram-positive infections after VAD implantation...
- Primary graft failure and Ca2+ sensitizers after heart transplantation
A Beiras-Fernandez
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Transplant Proc 40:951-2. 2008
..Acute graft failure after cardiac transplantation is associated with poor short- and long-term outcomes. Among our patients, levosimendan reduced the need for catecholamine support as well as improved ventricular performance...
- Coronary endothelial vasomotor function and vascular remodeling in heart transplant recipients randomized for tacrolimus or cyclosporine immunosuppression
Paraskevi Petrakopoulou
Medizinische Klinik und Poliklinik I, Ludwig-Maximilians University of Munich, Munich, Germany
J Am Coll Cardiol 47:1622-9. 2006
..The mean vessel area in the Tac group increased over time, indicating positive vascular remodeling. Tac is superior to CyA with respect to microvascular endothelial function, intimal thickening, and vascular remodeling...
- Graft-infiltrating dendritic cells and coronary endothelial dysfunction after human heart transplantation
Sieglinde Kofler
Medizinische Klinik und Poliklinik I, University Medical Center Munich Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
J Heart Lung Transplant 27:387-93. 2008
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- Cardiac allograft vasculopathy: recent developments
Daniel Schmauss
Medizinische Klinik und Poliklinik I, University Hospital Munich Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
Circulation 117:2131-41. 2008
..However, because individual responses to an allograft change over time, assays to monitor the recipient's immune response and individualized methods for therapeutic immune modulation are clearly needed...
- Impact of coronary endothelial dysfunction on adverse long-term outcome after heart transplantation
Marion Kübrich
Divisions of Cardiology and Cardiovascular Surgery, University Hospital Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
Transplantation 85:1580-7. 2008
..The present prospective study tested whether endothelial dysfunction independently predicts cardiovascular-related events and death after heart transplantation (HTx)...
- Cytomegalovirus infection in heart transplant recipients is associated with impaired endothelial function
Paraskevi Petrakopoulou
Medizinische Klinik und Poliklinik I, University Medical Center, Munich-Grosshadern, Germany
Circulation 110:II207-12. 2004
..CMV infection may contribute to allograft failure by accelerating coronary endothelial dysfunction...
- Beneficial effects of quinaprilat on coronary vasomotor function, endothelial oxidative stress, and endothelin activation after human heart transplantation
Silke Steinhauff
Division of Cardiology, University Hospital Munich-Grosshadern, 81377 Munich, Germany
Transplantation 77:1859-65. 2004
..Quinaprilat reduces vascular oxidative stress and ET-1 activity and mediates formation of nitrosoglutathione, effects that might contribute to long-term vasculoprotective effects of ACEI after heart transplantation...
- Cardiac allograft vasculopathy: prevention and treatment options
Michael Weis
Stanford University School of Medicine, Division of Cardiovascular Medicine, Stanford, California, USA
Transplant Proc 34:1847-9. 2002
- Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway
Michael Weis
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305-5406, USA
Arterioscler Thromb Vasc Biol 23:567-75. 2003
..In addition, the alteration in endothelial function contributes to vascular inflammation and progression of the disease...
- Statins have biphasic effects on angiogenesis
Michael Weis
Stanford University School of Medicine, Division of Cardiovascular Medicine, Stanford, Calif 94305, USA
Circulation 105:739-45. 2002
..At clinically relevant doses, statins may modulate angiogenesis in humans via effects on geranylated proteins...
- Dual mode of HMG-CoA reductase inhibition on dendritic cell invasion
Sieglinde Kofler
Medizinische Klinik und Poliklinik I, University Medical Center Munich Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
Atherosclerosis 197:105-10. 2008
..As DCs control immunity, regulating DC/endothelial cell interaction by statins may have relevance to inflammation and atherogenesis...
- Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious
Bruno Meiser
Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
J Heart Lung Transplant 26:598-603. 2007
..97 at 1 and 2 years. The regimen was well tolerated with only 3 patients requiring a change of study medication. Mean serum creatinine increased during the first year but returned to baseline at 2 years...
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptorsChristopher Heeschen
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Invest 110:527-36. 2002
..To our knowledge, this is the first description of a cholinergic angiogenic pathway, and it suggests a novel avenue for therapeutic modulation of angiogenesis...
- Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes
Heiko Methe
Department of Cardiology, Ludwig Maximilians University, Munich, Germany
Arterioscler Thromb Vasc Biol 25:1439-45. 2005
..Molecular mechanisms underlying these effects have not been well explored. Because statins attenuate lipopolysaccharide (LPS) responsiveness, we hypothesized that part of the pleiotropic effects are mediated through innate immunity...
- The impact of immunosuppression on endothelial function
Anja Trapp
Medizinische Klinik und Poliklinik I, University Hospital Munich-Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany
J Cardiovasc Pharmacol 45:81-7. 2005
..MP and MMF induced minor changes in endothelial function compared with CS, Rapa, and Tac...
- Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation
Sieglinde Kofler
Department of Cardiology, University Hospital Munich-Grosshadern, Ludwig-Maximilians University of Munich, 81377 Munich, Germany
Clin Sci (Lond) 108:205-13. 2005
..This review will focus on the vascular mechanisms orchestrated by cytokines and summarizes the current knowledge concerning the contribution of cytokines to cardiovascular diseases...
- Tacrolimus or cyclosporine: which is the better partner for mycophenolate mofetil in heart transplant recipients?
Bruno M Meiser
Department of Cardiac Surgery, University of Munich, Grosshadern Medical Center, Marchioninistrasse 15, 81366 Munich, Germany
Transplantation 78:591-8. 2004
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- Nicotine promotes arteriogenesis
Christopher Heeschen
Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5406, USA
J Am Coll Cardiol 41:489-96. 2003
..CONCLUSIONS: In the short term, nicotine promotes angiogenesis and arteriogenesis in the setting of ischemia. The effect of nicotine may be mediated in part by activation of endothelial-monocyte interactions involved in arteriogenesis...
- Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases
Michael Weis
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif, USA
Arterioscler Thromb Vasc Biol 22:1817-23. 2002
..A fundamental aspect of DC function is their capacity to adhere and migrate through vascular endothelial cells (ECs). We investigated the role of endothelial activation and dysregulation of the NO pathway on DC adhesion and migration...
- Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis
Michael Weis
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305-5406, USA
Circulation 109:500-5. 2004
..CMV infection may contribute to endothelial dysfunction and TA by dysregulation of the endothelial nitric oxide synthase pathway...
