Matthew R Weir

Summary

Publications

  1. ncbi request reprint Combination therapy with Renin-Angiotensin-aldosterone receptor blockers for hypertension: how far have we come?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 10:146-52. 2008
  2. ncbi request reprint Newer combination therapies in the management of hypertension: an update
    Alan H Gradman
    Western Pennsylvania Hospital, Temple University School of Medicine Clinical Campus, Pittsburgh, PA, USA
    J Clin Hypertens (Greenwich) 10:398-405. 2008
  3. doi request reprint Beta-blockers in the treatment of hypertension: are there clinically relevant differences?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 121:90-8. 2009
  4. doi request reprint Renal outcomes in hypertensive Black patients at high cardiovascular risk
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 81:568-76. 2012
  5. doi request reprint Anemia after kidney transplantation; its prevalence, risk factors, and independent association with graft and patient survival: a time-varying analysis
    Heather Jones
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 93:923-8. 2012
  6. doi request reprint The independent association between serum uric acid and graft outcomes after kidney transplantation
    Abdolreza Haririan
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W143, Baltimore, MD 21201, USA
    Transplantation 89:573-9. 2010
  7. pmc Erythropoiesis-stimulating agents increase the risk of acute stroke in patients with chronic kidney disease
    Stephen L Seliger
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 80:288-94. 2011
  8. doi request reprint A study of renal outcomes in obese living kidney donors
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 90:993-9. 2010
  9. ncbi request reprint Time to achieve blood-pressure goal: influence of dose of valsartan monotherapy and valsartan and hydrochlorothiazide combination therapy
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Hypertens 20:807-15. 2007
  10. doi request reprint Antibody-mediated allograft rejection: morphologic spectrum and serologic correlations in surveillance and for cause biopsies
    John C Papadimitriou
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 95:128-36. 2013

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Combination therapy with Renin-Angiotensin-aldosterone receptor blockers for hypertension: how far have we come?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 10:146-52. 2008
    ..Studies are now under way to determine the relative benefits of an RAAS blocker/diuretic compared with an RAAS blocker/calcium channel blocker as initial therapy...
  2. ncbi request reprint Newer combination therapies in the management of hypertension: an update
    Alan H Gradman
    Western Pennsylvania Hospital, Temple University School of Medicine Clinical Campus, Pittsburgh, PA, USA
    J Clin Hypertens (Greenwich) 10:398-405. 2008
    ..Participants included Matthew R. Weir, MD, University of Maryland School of Medicine, Baltimore, MD, and George L. Bakris, MD, University of Chicago, Chicago, IL...
  3. doi request reprint Beta-blockers in the treatment of hypertension: are there clinically relevant differences?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 121:90-8. 2009
    ....
  4. doi request reprint Renal outcomes in hypertensive Black patients at high cardiovascular risk
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 81:568-76. 2012
    ..Blacks have a modestly higher increased risk for more advanced increases in serum creatinine than non-Blacks...
  5. doi request reprint Anemia after kidney transplantation; its prevalence, risk factors, and independent association with graft and patient survival: a time-varying analysis
    Heather Jones
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 93:923-8. 2012
    ..Posttransplant anemia and its association with transplant outcomes have not been properly studied...
  6. doi request reprint The independent association between serum uric acid and graft outcomes after kidney transplantation
    Abdolreza Haririan
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W143, Baltimore, MD 21201, USA
    Transplantation 89:573-9. 2010
    ..We sought to evaluate the predictive value of mean uric acid (UA) level during the first 6 months posttransplant for graft survival and function...
  7. pmc Erythropoiesis-stimulating agents increase the risk of acute stroke in patients with chronic kidney disease
    Stephen L Seliger
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 80:288-94. 2011
    ..Hence, in a large national sample of anemic patients with CKD, ESA treatment was associated with an increased risk of acute stroke with the greatest effect among patients with cancer...
  8. doi request reprint A study of renal outcomes in obese living kidney donors
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 90:993-9. 2010
    ..Little is known about the long-term outcomes of obese living kidney donors (OLKDs). We undertook this study to describe renal outcomes of OLKDs several years after donation...
  9. ncbi request reprint Time to achieve blood-pressure goal: influence of dose of valsartan monotherapy and valsartan and hydrochlorothiazide combination therapy
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Hypertens 20:807-15. 2007
    ..Our objective was to assess time to achieve blood-pressure (BP) goal with incremental doses of valsartan alone, and together with hydrochlorothiazide (HCTZ), in patients with uncomplicated hypertension...
  10. doi request reprint Antibody-mediated allograft rejection: morphologic spectrum and serologic correlations in surveillance and for cause biopsies
    John C Papadimitriou
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 95:128-36. 2013
    ..Subclinical antibody-mediated allograft rejection (AMR) has been characterized in serial biopsies from presensitized recipients but has not been systematically studied in conventional renal transplants...
  11. ncbi request reprint An in-depth review of the evidence linking dietary salt intake and progression of chronic kidney disease
    Charlotte Jones-Burton
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 26:268-75. 2006
    ..Dietary salt has been debated for decades as having a potentially deleterious influence on human health...
  12. doi request reprint Potassium homeostasis and renin-angiotensin-aldosterone system inhibitors
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 5:531-48. 2010
    ..Moreover, these patients are likely to derive benefit from RAAS inhibition. Rather than denying them an effective treatment, electrolyte levels should be closely monitored in these patients...
  13. ncbi request reprint Early steroid withdrawal in solitary pancreas transplantation results in equivalent graft and patient survival compared with maintenance steroid therapy
    Ghazal Vessal
    School of Pharmacy, University of Maryland, Baltimore, MD, USA
    Clin Transplant 21:491-7. 2007
    ..We conclude that early corticosteroid withdrawal in isolated pancreas transplantation results in fewer infections and can be achieved without an increased risk of rejection or graft loss over the first year...
  14. doi request reprint Varying patterns of the antihypertensive and antialbuminuric response to higher doses of renin-angiotensin-aldosterone system blockade in albuminuric hypertensive type 2 diabetes mellitus patients
    Matthew R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Hypertens 29:2031-7. 2011
    ..Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...
  15. doi request reprint Antihypertensive effects of double the maximum dose of valsartan in African-American patients with type 2 diabetes mellitus and albuminuria
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    J Hypertens 28:186-93. 2010
    ..To determine whether higher than conventional doses of renin-angiotensin-aldosterone system blockade can improve BP reduction in African-American patients...
  16. ncbi request reprint Predictors of compliance with antihypertensive therapy in a high-risk medicaid population
    Fadia T Shaya
    Pharmaceutical Health Services Research Department, University of Maryland School of Pharmacy, 220 Arch St, 12th Floor, Baltimore, MD 21201, USA
    J Natl Med Assoc 101:34-9. 2009
    ..To identify predictors of compliance with antihypertensive combination therapy in a Medicaid population...
  17. doi request reprint A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil ± hydrochlorothiazide
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 13:404-12. 2011
    ....
  18. pmc A study of renal outcomes in African American living kidney donors
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 88:1371-6. 2009
    ..Little is known about the long-term outcomes of African American living kidney donors (AALKDs). We undertook this study to describe renal outcomes of AALKDs several years after donation...
  19. doi request reprint Cigarette smoking, kidney function, and mortality after live donor kidney transplant
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Kidney Dis 55:907-15. 2010
    ..The role of smoking as a risk factor for adverse renal outcomes after kidney transplant has not been well studied. We therefore undertook this investigation to assess the association of smoking with transplant outcomes...
  20. pmc Influence of creatinine versus glomerular filtration rate on non-steroidal anti-inflammatory drug prescriptions in chronic kidney disease
    Krupa Patel
    Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Nephrol 36:19-26. 2012
    ..This investigation sought to identify the frequency of NSAID/COX-2 prescription and to determine the influence of serum creatinine (Cr) versus estimated glomerular filtration rate (eGFR) on this practice pattern...
  21. pmc Genotype-based changes in serum uric acid affect blood pressure
    Afshin Parsa
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 81:502-7. 2012
    ..2 and 1.5 mm Hg on the high- and low-sodium diet, respectively. Thus, a Mendelian randomization analysis using variants in the GLUT9 gene indicates that a decrease in serum uric acid has a causal effect of lowering blood pressure...
  22. pmc Hemodynamic correlates of proteinuria in chronic kidney disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine Medical Center, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 6:2403-10. 2011
    ..Whether central measures of BP or vascular stiffness are associated with increased risk of proteinuria in patients with chronic kidney disease (CKD) is unknown...
  23. pmc Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease
    Julia J Scialla
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 6:2612-9. 2011
    ..Osteoprotegerin (OPG), a cytokine that regulates bone resorption, has been implicated in the process of vascular calcification and stiffness...
  24. ncbi request reprint Risk-based classification of hypertension and the role of combination therapy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    J Clin Hypertens (Greenwich) 10:4-12. 2008
    ..All 3 sets of guidelines acknowledge the necessity of using > or =2 antihypertensive agents to attain BP goals in many patients...
  25. ncbi request reprint Acute kidney injury and cardiovascular outcomes in acute severe hypertension
    Lynda A Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Circulation 121:2183-91. 2010
    ....
  26. ncbi request reprint Calcium channel blockers: their pharmacologic and therapeutic role in hypertension
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Cardiovasc Drugs 7:5-15. 2007
    ....
  27. doi request reprint Minimizing the risk of chronic allograft nephropathy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Transplantation 87:S14-8. 2009
    ..The avoidance of clinical inertia in pursuing subtle changes in graft function is critical. Modification in maintenance immunosuppression may benefit many patients with early evidence of graft deterioration...
  28. ncbi request reprint Chronic allograft dysfunction: can we use mammalian target of rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?
    Ravinder K Wali
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Organ Transplant 13:614-21. 2008
    ..Protocol biopsies have demonstrated that histological lesions of CNI toxicity can develop as early as 3 months posttransplantation...
  29. ncbi request reprint BK virus-associated nephropathy in renal allograft recipients: rescue therapy by sirolimus-based immunosuppression
    Ravinder K Wali
    Division of Nephrology, Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transplantation 78:1069-73. 2004
    ..BK virus nephritis (BKN) in recipients of renal allografts has reemerged during the past 5 years. Despite increased incidence, therapeutic options remain limited and progression of the disease often leads to allograft failure...
  30. pmc Performance of chronic kidney disease epidemiology collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis
    Ayse L Mindikoglu
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD
    Hepatology 59:1532-42. 2014
    ..However, its diagnostic performance was substantially worse than reported in subjects without cirrhosis...
  31. doi request reprint Efficacy of amlodipine/olmesartan medoxomil ± hydrochlorothiazide in patients aged ≥ 65 or < 65 years with uncontrolled hypertension on prior monotherapy
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 125:124-34. 2013
    ..The treatment regimen was well tolerated irrespective of patient age. ..
  32. ncbi request reprint Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medidne, Baltimore, Maryland 21201 1595, USA
    Clin Ther 29:1803-24. 2007
    ..Angiotensin receptor blockers (ARBs) selectively antagonize angiotensin II at AT 1 receptors and may also increase activation of the AT 2 receptor and modulate the effects of angiotensin II breakdown products...
  33. ncbi request reprint Safety and feasibility of achieving lower systolic blood pressure goals in persons with type 2 diabetes: the SANDS trial
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 11:540-8. 2009
    ..The authors conclude that both standard and more aggressive systolic blood pressure reduction can be achieved with excellent safety and good tolerability in patients with type 2 diabetes mellitus...
  34. ncbi request reprint The efficacy and safety of initial use of irbesartan/hydrochlorothiazide fixed-dose combination in hypertensive patients with and without high cardiovascular risk
    Matthew R Weir
    University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 9:23-30. 2007
    ..Irbesartan/HCTZ provided consistent blood pressure lowering and tolerability regardless of age, obesity, and type 2 diabetes and greater efficacy in patients with high cardiovascular risk...
  35. doi request reprint Readmissions after unauthorized discharges in the cardiovascular setting
    Eberechukwu Onukwugha
    Department of Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Med Care 49:215-24. 2011
    ....
  36. ncbi request reprint Providing end-organ protection with renin-angiotensin system inhibition: the evidence so far
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    J Clin Hypertens (Greenwich) 8:99-105; quiz 106-7. 2006
    ..This includes composite or specific end points involving reduction of stroke, myocardial infarction, or development of end-stage renal disease...
  37. doi request reprint Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled Spare-the-Nephron trial
    Matthew R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 79:897-907. 2011
    ..Thus, compared with MMF/CNI treatment, a 2-year regimen of MMF/SRL resulted in similar measures of renal function but with fewer deaths and a trend to less BPAR and graft loss...
  38. ncbi request reprint Urinary sodium is a potent correlate of proteinuria: lessons from the chronic renal insufficiency cohort study
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Nephrol 36:397-404. 2012
    ....
  39. doi request reprint Acute fall in glomerular filtration rate with renin-angiotensin system inhibition: a biomeasure of therapeutic success?
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 80:235-7. 2011
    ..This response is functional, not anatomical, and varies with volume status. The reduction in GFR with renin-angiotensin system inhibition may serve as a biomeasure of future therapeutic benefit...
  40. pmc Renal function and cardiovascular response to mental stress
    Stephen L Seliger
    University of Maryland School of Medicine, Maryland VA Healthcare System, Baltimore County, Baltimore, MD 21201, USA
    Am J Nephrol 28:304-10. 2008
    ..Chronic kidney disease (CKD) is also associated with sympathetic hyperactivity and vascular risk, but its relationship with CVR is unknown...
  41. ncbi request reprint Renin inhibitors: novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Nephrol Hypertens 16:416-21. 2007
    ..Direct renin inhibitors are the newest antihypertensive therapeutic class. The review describes their antihypertensive and antiproteinuric effects and possible renoprotective capabilities...
  42. doi request reprint The renoprotective effects of RAS inhibition: focus on prevention and treatment of chronic kidney disease
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA
    Postgrad Med 121:96-103. 2009
    ..Ongoing clinical trials assessing treatment and prevention of CKD may resolve unanswered questions about RAS inhibition in patients with hypertension and/or diabetes...
  43. ncbi request reprint Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease
    Ravinder K Wali
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Am Coll Cardiol 45:1051-60. 2005
    ..We examined the impact of kidney transplantation on left ventricular ejection fraction (LVEF) in end-stage renal disease (ESRD) patients with congestive heart failure (CHF)...
  44. pmc Dry-weight: a concept revisited in an effort to avoid medication-directed approaches for blood pressure control in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street, 111N, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 5:1255-60. 2010
    ..Achieving and maintaining dry-weight appears to be an effective but forgotten strategy in controlling and maintaining normotension among hypertensive patients on hemodialysis...
  45. ncbi request reprint Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 24:379-86. 2004
    ..Its etiology is multifactorial and may include both immunologic and nonimmunologic causes. In this observational cohort study we set out to see if calcineurin inhibitor withdrawal would reduce the likelihood of graft loss...
  46. ncbi request reprint Evaluation of the dose response with valsartan and valsartan/hydrochlorothiazide in patients with essential hypertension
    Matthew R Weir
    Department of Medicine, Division of Nephrology, Univesity of Maryland School of Medicine, MD 21201, USA
    J Clin Hypertens (Greenwich) 9:103-12. 2007
    ..The rate of discontinuation due to adverse events was low with both monotherapy and combination treatment. Higher starting doses may enable patients to achieve greater initial BP reductions and reach BP goal more rapidly...
  47. doi request reprint Does blockade of the Renin-Angiotensin-aldosterone system slow progression of all forms of kidney disease?
    Michael R Lattanzio
    Division of Nephrology, University of Maryland School of Medicine Medical Center, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    Curr Hypertens Rep 12:369-77. 2010
    ..The aim of this review is to provide the most current evidence available for the use of RAAS blockade as a method of slowing the progression of the various forms of CKD...
  48. pmc Current concepts in the diagnosis and classification of renal dysfunction in cirrhosis
    Ayse L Mindikoglu
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Nephrol 38:345-54. 2013
    ..Renal dysfunction is one of the most common complications of cirrhosis with high morbidity and mortality...
  49. ncbi request reprint Does dietary salt increase the risk for progression of kidney disease?
    Shiraz I Mishra
    Division of Nephrology, University of Maryland School of Medicine, 22 S Greene Street, Room N3W143, Baltimore, MD 21201, USA
    Curr Hypertens Rep 7:385-91. 2005
    ..Further clinical trials are needed to evaluate the relationship between dietary salt and risk for progression of chronic kidney disease...
  50. ncbi request reprint Ethnic disparities, hospital quality, and discharges against medical advice among patients with cardiovascular disease
    Ebere Chukwu Onukwugha
    Pharmaceutical Health Services Research Department, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Ethn Dis 19:172-8. 2009
    ..Disparities in discharges AMA have not been examined among patients with cardiovascular disease, nor has the moderating role of hospital quality been studied...
  51. ncbi request reprint The tissue renin-angiotensin-aldosterone system in diabetes mellitus
    Donna S Hanes
    University of Maryland Hospital, Renal Division, N3W 143, 22 S Greene Street, Baltimore, MD 21202, USA
    Curr Hypertens Rep 6:98-105. 2004
    ..The purpose of this review is to highlight our current understanding of the role of the tissue RAS in the pathogenesis of diabetic end-organ damage and ongoing strategies to interfere pharmacologically...
  52. ncbi request reprint Microalbuminuria in type 2 diabetics: an important, overlooked cardiovascular risk factor
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    J Clin Hypertens (Greenwich) 6:134-41; quiz 142-3. 2004
    ..Consequently, the identification and normalization of urine microalbumin excretion should be an important consideration in patients with diabetes...
  53. ncbi request reprint Angiotensin II receptor blockers: the importance of dose in cardiovascular and renal risk reduction
    Matthew R Weir
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 6:315-23; quiz 324-5. 2004
    ..Data from ongoing trials will provide additional insight...
  54. ncbi request reprint Selective cyclooxygenase-2 inhibition and cardiovascular effects: an observational study of a Medicaid population
    Fadia T Shaya
    Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Arch Intern Med 165:181-6. 2005
    ..This observational cohort study examines the cardiovascular risk of COX-2 inhibitors compared with nonspecific NSAIDs in Maryland Medicaid enrollees, a high-risk population...
  55. ncbi request reprint Usefulness of ARBs and ACE inhibitors in the prevention of vascular dementia in the elderly
    Donna S Hanes
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Geriatr Cardiol 16:175-82. 2007
    ..The use of angiotensin receptor blockers as first-line therapy for hypertension and cognitive protection in the elderly should be strongly considered...
  56. doi request reprint Efficacy and safety of carvedilol in treatment of heart failure with chronic kidney disease: a meta-analysis of randomized trials
    Ravinder K Wali
    University of Maryland School of Medicine, Baltimore, MD, USA
    Circ Heart Fail 4:18-26. 2011
    ..We assessed whether treatment of systolic HF with carvedilol is efficacious and safe in adults with CKD...
  57. doi request reprint Renin inhibition and microalbuminuria development: meaningful predictor of kidney disease progression
    Lalitha De Silva
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Nephrol Hypertens 19:437-43. 2010
    ..We evaluate the data on the use of direct renin inhibitors (DRIs) for treatment of hypertension with microalbuminuria...
  58. pmc Determinants of blood pressure response to low-salt intake in a healthy adult population
    May E Montasser
    Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 13:795-800. 2011
    ..Our results suggest that salt reduction may have greater BP-lowering effects on women, older individuals, individuals with higher SBP, and individuals with higher SBP response to CPT...
  59. pmc Benefits Improvement and Protection Act's impact on transplantation rates among elderly MEDICARE beneficiaries with end-stage renal disease
    C Daniel Mullins
    Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Transplantation 95:463-9. 2013
    ..Our objective was to determine BIPA's impact on renal transplantation among elderly patients (age ≥65 years) affected by BIPA...
  60. doi request reprint Eosinophilia as an early indicator of pancreatic allograft rejection
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Transplant 26:238-41. 2012
    ..A pancreas allograft biopsy indicated eosinophilic acute cellular rejection. Peripheral eosinophilia may be a useful early indicator of pancreas graft rejection preceding changes in serum pancreatic enzymes by approximately one month...
  61. pmc Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish
    Patrick F McArdle
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arthritis Rheum 58:2874-81. 2008
    ..This study was undertaken to investigate associations between uric acid levels and single-nucleotide polymorphisms (SNPs)...
  62. doi request reprint Acute kidney injury following cardiac surgery: role of perioperative blood pressure control
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 33:438-52. 2011
    ..Although factors that predispose to postoperative renal dysfunction have been identified, this knowledge has not been associated with a substantial reduction in the incidence of this serious adverse event...
  63. doi request reprint A randomized, double-blind, forced-titration study to compare olmesartan medoxomil versus losartan potassium in patients with stage 1 and 2 hypertension
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Postgrad Med 123:80-7. 2011
    ..To evaluate the comparative efficacy and safety of once-daily olmesartan medoxomil (OM) and losartan potassium (LOS) in patients with hypertension...
  64. ncbi request reprint Renin angiotensin system inhibition in the older person: a review
    Maha A Mohamed
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, N3W143, Baltimore, MD 21201, USA
    Clin Geriatr Med 25:245-57. 2009
    ..Herein, the author's review the mechanism of action of the renin angiotensin cascade and then discuss the clinical evidence surrounding the use of RAS-blocking drugs in the older population...
  65. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....
  66. ncbi request reprint A noninferiority comparison of valsartan/hydrochlorothiazide combination versus amlodipine in black hypertensives
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Hypertension 46:508-13. 2005
    ..5 mg) is as effective as high-dose amlodipine (10 mg) in reducing blood pressure in blacks with stage 1 and stage 2 hypertension, and valsartan/hydrochlorothiazide is better tolerated...
  67. ncbi request reprint The role of combination antihypertensive therapy in the prevention and treatment of chronic kidney disease
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Hypertens 18:100S-105S. 2005
    ..Fixed-dose combination agents are useful in bringing high-risk hypertensive patients to appropriate BP goals, primarily by simplifying the complex medical regimens in these patients...
  68. ncbi request reprint Blood pressure management in the kidney transplant recipient
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, 22 South Greene Street, Suite N3W143, Baltimore, MD 21201, USA
    Adv Chronic Kidney Dis 11:172-83. 2004
    ....
  69. ncbi request reprint COX-2 inhibitors and cardiovascular risk
    Daniel J Salzberg
    Division of Nephrology, University of Maryland School of Medicine, 22 S Greene Street, Room N3W143 Baltimore, MD 21201 1595, USA
    Subcell Biochem 42:159-74. 2007
    ..Finally, modest dietary salt restriction may help lessen the effects of COX-inhibitors on blood pressure...
  70. ncbi request reprint Drug therapy persistence and stroke recurrence
    Fadia T Shaya
    Department of Epidemiology and Preventive Medicine, University of Maryland, 515 West Lombard St, Baltimore, MD 21201, USA
    Am J Manag Care 12:313-9. 2006
    ..To assess the effect of persistence of use of warfarin sodium, aspirin, or clopidogrel bisulfate on stroke recurrence in a Medicaid high-risk, largely female, African American population...
  71. ncbi request reprint Cigarette smoking and incident chronic kidney disease: a systematic review
    Charlotte Jones-Burton
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Nephrol 27:342-51. 2007
    ..Several studies have examined the role of cigarette smoking in the development of renal disease in human populations. However, there have been no systematic reviews on the evidence linking smoking with incident renal disease...
  72. pmc Clinical commentary: how to choose blood pressure goals and treatment: influence of estimated glomerular filtration rate and albuminuria
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Trans Am Clin Climatol Assoc 119:53-61; discussion 61-3. 2008
    ....
  73. doi request reprint A single center comparison of long-term outcomes of renal allografts procured laparoscopically versus historic controls procured by the open approach
    Joseph M Nogueira
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transpl Int 21:908-14. 2008
    ..We conclude that, despite having suffered early renal dysfunction, the lapNx cohort of renal allograft recipients enjoys similar long-term renal allograft survival as compared to openNx...
  74. doi request reprint Effects of high- and low-sodium diets on ambulatory blood pressure in patients with hypertension receiving aliskiren
    Matthew R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cardiovasc Pharmacol Ther 15:356-63. 2010
    ..6%; P < .0001). Overall, 40.9% patients had ≥ 1 adverse event and the rates were similar between groups. In this study, aliskiren was well tolerated and a low-sodium diet accentuated its antihypertensive effect...
  75. doi request reprint Renal consequences of prostaglandin inhibition in heart failure
    Ayoola O Akinbamowo
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Heart Fail Clin 4:505-10. 2008
    ..This review summarizes the renal consequences of using prostaglandin inhibitors in subjects who have congestive heart failure...
  76. ncbi request reprint Salt intake and progression of chronic kidney disease: an overlooked modifiable exposure? A commentary
    Matthew R Weir
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 45:176-88. 2005
    ..Increased salt intake also attenuates the antihypertensive effects of most antihypertensive drugs. Consequently, salt intake must be considered a potential modifiable risk factor for the progression of kidney disease...
  77. ncbi request reprint Incidence of pedal edema formation with dihydropyridine calcium channel blockers: issues and practical significance
    Matthew R Weir
    Division of Nephrology, University of Maryland Hopsital, Baltimore, MD 21201, USA
    J Clin Hypertens (Greenwich) 5:330-5. 2003
    ..A favorable tolerability profile is of particular importance for an antihypertensive medication, since hypertension is a chronic disorder necessitating long-term treatment and patient compliance...
  78. pmc The frequency of hyperkalemia and its significance in chronic kidney disease
    Lisa M Einhorn
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arch Intern Med 169:1156-62. 2009
    ..Hyperkalemia is a potential threat to patient safety in chronic kidney disease (CKD). This study determined the incidence of hyperkalemia in CKD and whether it is associated with excess mortality...
  79. doi request reprint Have we fallen off target with concerns surrounding dual RAAS blockade?
    Michael R Lattanzio
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 78:539-45. 2010
    ....
  80. ncbi request reprint Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program
    Matthew R Weir
    Nephrology Division, University of Maryland Hospital, Baltimore, MD 21201, USA
    Am Heart J 146:591-604. 2003
    ..The totality of data is not consistent with an increased CV risk among patients taking rofecoxib...
  81. ncbi request reprint Opportunities for cardiovascular risk reduction with angiotensin II receptor blockers
    Matthew R Weir
    University of Maryland Hospital, Renal Division, N3W 143, Baltimore, MD 21202, USA
    Curr Hypertens Rep 4:333-5. 2002
  82. ncbi request reprint Dietary salt, blood pressure, and microalbuminuria
    Matthew R Weir
    Division of Nephrology, University of Maryland Hospital, 22 South Greene Street, Baltimore, MD 21201 1595, USA
    J Clin Hypertens (Greenwich) 6:23-6. 2004
    ....
  83. ncbi request reprint Progressive renal and cardiovascular disease: optimal treatment strategies
    Matthew R Weir
    University of Maryland Medical System, 22 South Greene Street, Room N3W143, Baltimore, MD 21201 1595, USA
    Kidney Int 62:1482-92. 2002
  84. ncbi request reprint RAAS escape: a real clinical entity that may be important in the progression of cardiovascular and renal disease
    Jay Lakkis
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Suite N3W143, Baltimore, MD 21201, USA
    Curr Hypertens Rep 5:408-17. 2003
    ..Consequently, aldosterone receptor antagonists may have specific benefits for reducing target-organ injury, particularly if there is evidence of RAAS escape...
  85. ncbi request reprint Pharmacological strategies for kidney function preservation: are there differences by ethnicity?
    Jay Lakkis
    Department of Medicine, Division of Nephrology, University of Maryland, School of Medicine, Baltimore, MD, USA
    Adv Ren Replace Ther 11:24-40. 2004
    ..The obesity and diabetes epidemics are unlikely to abate without innovative and ultimately effective public health approaches...
  86. pmc The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study
    Braxton D Mitchell
    Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Heart J 155:823-8. 2008
    ..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
  87. ncbi request reprint Achieving goal blood pressure in patients with type 2 diabetes: conventional versus fixed-dose combination approaches
    George L Bakris
    Department of Preventive Medicine, Rush Presbyterian St Lukes Medical Center, Chicago, IL 60612, USA
    J Clin Hypertens (Greenwich) 5:202-9. 2003
    ..A fixed-dose combination approach appears as safe as the current conventional approaches...
  88. doi request reprint Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial
    Barbara V Howard
    MedStar Research Institute, 6495 New Hampshire Ave, Suite 201, Hyattsville, MD 20783, USA
    JAMA 299:1678-89. 2008
    ..Individuals with diabetes are at increased risk for cardiovascular disease (CVD), but more aggressive targets for risk factor control have not been tested...
  89. ncbi request reprint Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study
    George L Bakris
    Department of Preventive Medicine, Rush Presbyterian St Luke s Medical Center, Rush Medical College, Chicago, IL 60612, USA
    Arch Intern Med 163:1555-65. 2003
    ..Clinical trials of nephropathy in people with type 2 diabetes mellitus have not examined the effects of systolic blood pressure (SBP) or pulse pressure (PP) on the time to end-stage renal disease (ESRD) or death...
  90. ncbi request reprint How big a role should JNC 7 play in the care of hypertensive patients?
    Matthew R Weir
    J Fam Pract 56:E7-9; author reply E9-10. 2007
  91. ncbi request reprint Treatment of prehypertension: how soon is soon enough? What therapy should be used?
    Matthew R Weir
    Curr Hypertens Rep 8:393-4. 2006
  92. ncbi request reprint Combination therapy of amlodipine/benazepril versus monotherapy of amlodipine in a practice-based setting
    Franz H Messerli
    Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 15:550-6. 2002
    ..This large practice-based clinical trial assessed the efficacy and tolerability of fixed-dose combination therapy with amlodipine/benazepril, compared with amlodipine monotherapy, in patients with mild-to-moderate hypertension...
  93. ncbi request reprint Optimizing target-organ protection in patients with diabetes mellitus: angiotensin-converting enzyme inhibitors or angiotensin receptor blockers?
    Wei X Lu
    Curr Hypertens Rep 5:192-8. 2003
    ....
  94. ncbi request reprint Treatment of diabetic hypertensive patients: results of a national survey
    Marvin Moser
    Yale University School of Medicine, New Haven, CT, USA
    J Clin Hypertens (Greenwich) 7:110. 2005
  95. ncbi request reprint Antihypertensive drugs for CVD
    Matthew R Weir
    J Fam Pract 55:889-91; author reply 891-2. 2006
  96. ncbi request reprint Blood pressure and cardiovascular risks: implications of the presence or absence of a nocturnal dip in blood pressure
    Matthew R Weir
    Curr Opin Nephrol Hypertens 12:57-60. 2003
  97. doi request reprint Comparison of dual RAAS blockade and higher-dose RAAS inhibition on nephropathy progression
    George L Bakris
    University of Chicago, Pritzker School of Medicine, Hypertensive Diseases Unit, Chicago, IL, USA
    Postgrad Med 120:33-42. 2008
    ..Clinical data and ongoing trials will be discussed in the context of this hypothesis...
  98. ncbi request reprint Is activated vitamin D supplementation renoprotective?
    Matthew R Weir
    Hypertension 52:211-2. 2008
  99. pmc Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study
    Marie Hélène Roy-Gagnon
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    J Hypertens 26:729-36. 2008
    ..Additionally, to our knowledge, no study has examined the genetics of BP recovery from the CPT, including whether shared genetic factors influence both reactivity and recovery...
  100. ncbi request reprint Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 18:1540-6. 2007
    ..Antihypertensive treatment that is aimed at improving renal outcomes in patients with diabetic nephropathy may therefore require a dual strategy, targeting both SBP and albuminuria reduction...
  101. ncbi request reprint How do you define "hypertension" in a patient with type 1 diabetes?
    Matthew R Weir
    Hypertension 49:13-4. 2007