E J Weinman

Summary

Publications

  1. pmc Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
    Yong Pan
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Fannin Street, Houston, Texas 77054, USA
    Breast Cancer Res 10:R5. 2008
  2. pmc Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:37216-21. 2011
  3. pmc Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:13454-60. 2010
  4. pmc Increased renal dopamine and acute renal adaptation to a high-phosphate diet
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Physiol Renal Physiol 300:F1123-9. 2011
  5. ncbi request reprint Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA
    E J Weinman
    Departments of Medicine and Physiology, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 279:F393-9. 2000
  6. pmc Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:25134-8. 2010
  7. ncbi request reprint Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 281:F374-80. 2001
  8. ncbi request reprint cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor
    M Zizak
    Department of Medicine, Gl Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 274:24753-8. 1999
  9. pmc Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
    E J Weinman
    Department of Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Clin Invest 101:2199-206. 1998
  10. ncbi request reprint Regulation of the Na/H exchanger regulatory factor in OK cells
    E J Weinman
    Department of Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Miner Electrolyte Metab 25:135-42. 1999

Detail Information

Publications19

  1. pmc Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
    Yong Pan
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Fannin Street, Houston, Texas 77054, USA
    Breast Cancer Res 10:R5. 2008
    ....
  2. pmc Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:37216-21. 2011
    ..In addition, FGF-23 synergizes with PTH to inhibit phosphate transport by facilitating the activation of the PTH signal transduction pathway...
  3. pmc Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:13454-60. 2010
    ..These studies suggest a novel role for the PDZ adapter protein NHERF-1 in coordinating dopamine signals that inhibit renal phosphate transport...
  4. pmc Increased renal dopamine and acute renal adaptation to a high-phosphate diet
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Physiol Renal Physiol 300:F1123-9. 2011
    ....
  5. ncbi request reprint Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA
    E J Weinman
    Departments of Medicine and Physiology, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 279:F393-9. 2000
    ..Thus NHERF and related PDZ-containing proteins appear to be essential adapters for regulation of renal transporters in the mammalian kidney that maintain salt and water balance...
  6. pmc Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:25134-8. 2010
    ..The phosphorylation of Thr(95) facilitates the phosphorylation of Ser(77). This, in turn, results in the dissociation of NHERF-1 from Npt2a and a decrease in phosphate transport in renal proximal tubule cells...
  7. ncbi request reprint Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 281:F374-80. 2001
    ....
  8. ncbi request reprint cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor
    M Zizak
    Department of Medicine, Gl Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 274:24753-8. 1999
    ..This study shows that members of the regulatory factor gene family, NHE-RF and E3KARP, are necessary for cAMP inhibition of NHE3 by allowing NHE3 to be phosphorylated. This inhibition is not dependent on the phosphorylation of NHE-RF...
  9. pmc Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
    E J Weinman
    Department of Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Clin Invest 101:2199-206. 1998
    ..One or more of the serine residues at positions 287, 289, and/or 290 represent the critical PKA phosphorylation site(s) on the NHE-RF protein that mediates the physiologic effect of cAMP on the renal BBM Na/H exchanger...
  10. ncbi request reprint Regulation of the Na/H exchanger regulatory factor in OK cells
    E J Weinman
    Department of Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Miner Electrolyte Metab 25:135-42. 1999
    ..The results indicate that serum is associated with a decrease in NHE-RF mRNA and protein, while chronic exposure to cAMP is associated with an altered distribution of NHE-RF between the cytosolic and membrane fractions of OK cells...
  11. ncbi request reprint The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998
    ..Our findings indicate that agonist-dependent beta2-adrenergic receptor binding of NHERF plays a role in beta2-adrenergic receptor-mediated regulation of Na+/H+ exchange...
  12. pmc cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein
    C H Yun
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:3010-5. 1997
    ..Transfection in PS120/NHE3 fibroblasts with either NHERF or E3KARP reconstituted cAMP-induced inhibition of NHE3, resulting in 25-30% inhibition in these cells...
  13. ncbi request reprint Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine and the Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    J Biol Chem 276:42339-46. 2001
    ....
  14. ncbi request reprint Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK
    J B Wade
    Department of Physiology, Division of Nephrology, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Physiol Cell Physiol 280:C192-8. 2001
    ..The finding that NHERF isoforms occur in different cell types suggests that NHERF and NHERF2 may subserve different functions in the kidney...
  15. ncbi request reprint Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor
    E J Weinman
    Department of Medicine, West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV, USA
    Biochim Biophys Acta 1447:71-6. 1999
    ....
  16. pmc Basolateral Na(+)/HCO(3)(-) cotransport activity is regulated by the dissociable Na(+)/H(+) exchanger regulatory factor
    A A Bernardo
    Section of Nephrology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612 7315, USA
    J Clin Invest 104:195-201. 1999
    ....
  17. pmc Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger
    E J Weinman
    Department of Medicine, University of California, Los Angeles School of Medicine, USA
    J Clin Invest 95:2143-9. 1995
    ..Reverse transcription/PCR studies in the kidney indicate the presence of mRNA for NHE-RF in several distinct nephron segments including the proximal tubule...
  18. pmc Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3
    X Li
    Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2195, USA
    J Physiol 537:537-52. 2001
    ....
  19. ncbi request reprint Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex
    E J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Kidney Int 60:450-4. 2001
    ..NHERF and related PDZ-containing proteins may serve as adapters for regulation of renal transporters...