H Weiler Guettler

Summary

Publications

  1. pmc A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 101:1983-91. 1998
  2. ncbi request reprint Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos
    H Weiler-Guettler
    Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA
    Development 122:2271-81. 1996
  3. ncbi request reprint Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development
    E M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Blood 93:3442-50. 1999
  4. pmc A murine model of myocardial microvascular thrombosis
    P D Christie
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 104:533-9. 1999
  5. ncbi request reprint Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Circ Res 78:180-7. 1996

Collaborators

Detail Information

Publications5

  1. pmc A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 101:1983-91. 1998
    ..The thrombomodulin-deficient animals provide a murine model to examine known or identify unknown genetic and environmental factors that lead to the development of thrombosis...
  2. ncbi request reprint Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos
    H Weiler-Guettler
    Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA
    Development 122:2271-81. 1996
    ..The thrombomodulin promoter as defined in this study will allow the targeting of gene expression to the parietal yolk sac of transgenic mice and the initiation of investigations into the role of parietal endoderm in placental function...
  3. ncbi request reprint Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development
    E M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Blood 93:3442-50. 1999
    ..In conclusion, these studies exclude the cytoplasmic domain of TM from playing a role in the early embryonic lethality of TM-null mice and support its function in regulating plasmin generation in plasma...
  4. pmc A murine model of myocardial microvascular thrombosis
    P D Christie
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 104:533-9. 1999
    ..The data were fit to a statistical model that may offer a foundation for examination of hemostasis-regulating gene interactions...
  5. ncbi request reprint Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Circ Res 78:180-7. 1996
    ....