Levosimendan improves cardiopulmonary resuscitation and survival by K(ATP) channel activationGianluca A A M Cammarata
J Am Coll Cardiol 47:1083-5. 2006
- Levosimendan improves postresuscitation myocardial dysfunction after beta-adrenergic blockade
Jinglan Wang
Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
J Lab Clin Med 146:179-83. 2005
..When levosimendan was added, postresuscitation myocardial contractile function was improved even more...
Time-dependent interventionsMax Harry Weil
Institute of Critical Care Medicine, Palm Springs, California, USA
Crit Care 8:11-2. 2004
..It is increasingly apparent that neither epinephrine whether in conventional or high doses nor vasopressin improve ultimate survival. To the contrary, there is evidence favoring beta1-adrenergic blockade...
- Clinical decision making during resuscitation and guidelines for termination of the resuscitation effort
M H Weil
Institute of Critical Care Medicine, Palm Springs, CA 92262, USA
Minerva Anestesiol 69:180-3. 2003
..In some condition, transferring the patient with terminal diseases to an alternate physician or institution is ultimately respectful both for the patient and of physician...
- Levosimendan improves postresuscitation outcomes in a rat model of CPR
Lei Huang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA 92270, USA
J Lab Clin Med 146:256-61. 2005
..Levosimendan and dobutamine both improved postresuscitation myocardial function. However, levosimendan produced more favorable postresuscitation myocardial function and increased the duration of postresuscitation survival...
Coronary blood flow produced by muscle contractions induced by intracardiac electrical CPR during ventricular fibrillationHao Wang
Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
Pacing Clin Electrophysiol 32:S223-7. 2009
..It has been reported that transthoracic electrical cardiopulmonary resuscitation (ECPR) generates coronary perfusion pressures (CPP) similar to manual chest compressions (MCC). We hypothesized that intracardiac ECPR produces similar CPP...
- Microcirculation during cardiac arrest and resuscitation
Michael Fries
Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
Crit Care Med 34:S454-7. 2006
..Administration of epinephrine dramatically decreased microcirculatory blood flow...
- Effects of biphasic waveforms on outcomes of cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest
Yun-Te Chang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 34:3024-8. 2006
..Dual-path sequential defibrillation had less postresuscitation myocardial dysfunction than rectilinear biphasic and dual-path simultaneous defibrillation, but at 72 hrs these differences were no longer significant...
- Microvascular blood flow during cardiopulmonary resuscitation is predictive of outcome
Michael Fries
The Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, United States
Resuscitation 71:248-53. 2006
..82, p<0.01). Microvascular blood flow in the sublingual mucosa is therefore closely related to coronary perfusion pressure during cardiopulmonary resuscitation and both are predictive of outcome...
- Cardiopulmonary resuscitation in a rat model of chronic myocardial ischemia
Xiangshao Fang
Weil Institute of Critical Care Medicine, 35100 Bob Hope Dr, Rancho Mirage, CA 92270, USA
J Appl Physiol 101:1091-6. 2006
..This model would suggest further clinically relevant investigation on cardiac arrest and CPR...
- The characteristics of postcountershock pulseless electrical activity may indicate the outcome of CPR
Xiangshao Fang
Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA, USA
Resuscitation 69:303-9. 2006
..Fisher's discriminant analysis is helpful in predicting the likelihood of ROSC for an individual animal presenting with postcountershock PEA...
- Nonselective beta-blocking agent improves the outcome of cardiopulmonary resuscitation in a rat model
Lei Huang
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 32:S378-80. 2004
..CONCLUSION: Nonselective beta-blockade improved the outcome of cardiopulmonary resuscitation in a rat model and deserves further evaluation in settings of cardiopulmonary resuscitation...
- In-hospital cardiac arrest
Max Harry Weil
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 33:2825-30. 2005
..Outcomes are therefore improved in critical care settings and especially in coronary care units in which patients are continuously monitored...
- One-shock versus three-shock defibrillation protocol significantly improves outcome in a porcine model of prolonged ventricular fibrillation cardiac arrest
Wanchun Tang
Weil Institute of Critical Care Medicine, 35 100 Bob Hope Dr, Rancho Mirage, California 92270, USA
Circulation 113:2683-9. 2006
..The success of resuscitation with a 1-shock versus the conventional 3-shock defibrillation protocol was investigated subject to the range of treatment variation imposed by automated external defibrillators (AEDs)...
- Mechanism by which activation of delta-opioid receptor reduces the severity of postresuscitation myocardial dysfunction
Xiangshao Fang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 34:2607-12. 2006
..CONCLUSIONS: The postresuscitation myocardial protective effects provided by activation of delta-opioid receptor may be mediated via opening KATP channels...
- Simultaneous blockade of alpha1- and beta-actions of epinephrine during cardiopulmonary resuscitation
Lei Huang
Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
Crit Care Med 34:S483-5. 2006
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- Minimal interruption of cardiopulmonary resuscitation for a single shock as mandated by automated external defibrillations does not compromise outcomes in a porcine model of cardiac arrest and resuscitation
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 36:3048-53. 2008
..We hypothesized that an 8-sec interruption of chest compressions for a single shock, as mandated by automated external defibrillations, would not impair initial resuscitation and outcomes of cardiopulmonary resuscitation...
- Rapid head cooling initiated coincident with cardiopulmonary resuscitation improves success of defibrillation and post-resuscitation myocardial function in a porcine model of prolonged cardiac arrest
Min-Shan Tsai
J Am Coll Cardiol 51:1988-90. 2008
- Cerebral cortical microvascular flow during and following cardiopulmonary resuscitation after short duration of cardiac arrest
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, CA 92270, USA
Resuscitation 77:229-34. 2008
..To examine changes in cerebral cortical macro- and microcirculation and their relationship to the severity of brain ischaemia during and following resuscitation from a short duration of cardiac arrest...
- Postresuscitation myocardial diastolic dysfunction following prolonged ventricular fibrillation and cardiopulmonary resuscitation
Tingyan Xu
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 36:188-92. 2008
..We therefore investigated the postresuscitation left ventricular diastolic function following prolonged cardiac arrest and subsequent cardiopulmonary resuscitation...
- Electrocardiogram waveforms for monitoring effectiveness of chest compression during cardiopulmonary resuscitation
Yongqin Li
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 36:211-5. 2008
..We therefore sought a readily available option for monitoring the effectiveness of chest compressions, specifically using the electrocardiogram...
- Miniaturized mechanical chest compressor: a new option for cardiopulmonary resuscitation
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, CA 92270, United States
Resuscitation 76:191-7. 2008
..We hypothesized that the 2 kg, low profile, portable device will be as effective as the standard pneumatic Thumper for restoring circulation during CPR...
- Exclusion of a patient assessment interval and extension of the CPR interval both mitigate post-resuscitation myocardial dysfunction in a swine model of cardiac arrest
Yun Te Chang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA 92270 1761, USA
Resuscitation 76:285-90. 2008
..Interruptions of CPR may be reduced by eliminating repetition of shocks between periods of CPR, elimination of the interval for patient assessment before CPR, and extension of the periods of CPR...
- Comparison of rectilinear biphasic waveform with biphasic truncated exponential waveform in a pediatric defibrillation model
Jinglan Wang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 35:1961-5. 2007
..To compare the rectilinear biphasic waveform with a biphasic truncated exponential waveform for pediatric defibrillation...
- Outcomes of CPR in the presence of partial occlusion of left anterior descending coronary artery
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, United States
Resuscitation 75:357-65. 2007
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- The quality of chest compressions during cardiopulmonary resuscitation overrides importance of timing of defibrillation
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, 35100 Bob Hope Dr, Rancho Mirage, CA 92270, USA
Chest 132:70-5. 2007
..We address the quality of chest compressions and the impact on initial defibrillation or initial chest compressions after sudden death...
- A comparison of electrically induced cardiac arrest with cardiac arrest produced by coronary occlusion
Jinglan Wang
The Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, United States
Resuscitation 72:477-83. 2007
..Accordingly, a potentially more clinically relevant model was investigated in which spontaneous VF followed acute myocardial ischemia...
- delta-Opioid-induced pharmacologic myocardial hibernation during cardiopulmonary resuscitation
Xiangshao Fang
Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
Crit Care Med 34:S486-9. 2006
..CONCLUSIONS: delta-Opioid-induced pharmacologic myocardial hibernation is an option to minimize the myocardial ischemia and reperfusion injury during cardiac arrest and cardiopulmonary resuscitation...
- Spontaneous gasping produces carotid blood flow during untreated cardiac arrest
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, United States
Resuscitation 75:366-71. 2007
..In the present study, we tested the hypothesis that gasps also increase carotid blood flow (CBF) during untreated cardiac arrest...
- Evolution of the stone heart after prolonged cardiac arrest
Kada Klouche
Institute of Critical Care Medicine, Palm Springs, CA, USA
Chest 122:1006-11. 2002
..CONCLUSION: Progressive impairment in diastolic function terminates in a stone heart after prolonged intervals of cardiac arrest...
- Stroke volumes and end-tidal carbon dioxide generated by precordial compression during ventricular fibrillation
Andrej Pernat
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 31:1819-23. 2003
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- A comparison of alpha-methylnorepinephrine, vasopressin and epinephrine for cardiac resuscitation
Kada Klouche
The Institute of Critical Care Medicine, 1695 North Sunrise Way, Bldg 3, 92262 5309, Palm Springs, CA, USA
Resuscitation 57:93-100. 2003
..Both post-resuscitation myocardial function and survival were most improved after administration of the selective alpha(2)-adrenergic agonist, intermediate after vasopressin and least after epinephrine and saline placebo...
- Fixed-energy biphasic waveform defibrillation in a pediatric model of cardiac arrest and resuscitation
Wanchun Tang
The Institute of Critical Care Medicine, 1695 North Sunrise Way, Building 3, Palm Springs, CA 92262 5309, USA
Crit Care Med 30:2736-41. 2002
..Accordingly, we investigated a method by which adult automated defibrillators may be adapted to deliver a 50-J ICBTE shock for pediatric defibrillation...
- Stroke volumes generated by precordial compression during cardiac resuscitation
Kada Klouche
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 30:2626-31. 2002
..CONCLUSION: These observations support the concept that stroke volumes generated by precordial compression are quantitatively related to the coronary perfusion pressure and to the success of cardiopulmonary resuscitation...
- Effects of epinephrine and vasopressin on cerebral microcirculatory flows during and after cardiopulmonary resuscitation
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 35:2145-9. 2007
..Accordingly, we compared the effects of nonadrenergic vasopressin with those of epinephrine on cerebral cortical microvascular flow together with cortical tissue Po2 and Pco2 as indicators of cortical tissue ischemia...
- Adverse outcomes of interrupted precordial compression during automated defibrillation
Ting Yu
Institute of Critical Care Medicine, Palm Springs, Calif 92262-5309, USA
Circulation 106:368-72. 2002
..CONCLUSIONS: Interruptions of precordial compression for rhythm analyses that exceed 15 seconds before each shock compromise the outcome of CPR and increase the severity of postresuscitation myocardial dysfunction...
- A selective alpha(2)-adrenergic agonist for cardiac resuscitation
Kada Klouche
Institute of Critical Care Medicine, Palm Springs, CA 92262 5309, USA
J Lab Clin Med 140:27-34. 2002
..alpha-MNE, a selective alpha-adrenergic agonist, was as effective as epinephrine in restoring spontaneous circulation after 7 minutes of untreated VF in a porcine model for CPR and demonstrated lesser postresuscitation myocardial injury...
- Predicting the success of defibrillation by electrocardiographic analysis
Heitor P Povoas
The Institute of Critical Care Medicine, 1695 North Sunrise Way, Building #3, Palm Springs, CA 92262-5309, USA
Resuscitation 53:77-82. 2002
..This method potentially fulfills the need for minimizing ineffective defibrillation attempts and their attendant adverse effects on the myocardium...
- Vasopressor agents for cardiopulmonary resuscitation
Lan Cao
The Institute of Critical Care Medicine, Palm Springs, California 92262, USA
J Cardiovasc Pharmacol Ther 8:115-21. 2003
..Accordingly, myocardial ischemic injury during cardiopulmonary resuscitation is minimized, and postresuscitation myocardial function is preserved with improved survival...
- Evidence favoring the use of an alpha2-selective vasopressor agent for cardiopulmonary resuscitation
Tommaso Pellis
The Institute of Critical Care Medicine, Palm Springs, Calif 92262, USA
Circulation 108:2716-21. 2003
..However, combined alpha1- and beta-adrenergic blockade, which represented a predominantly selective alpha2-vasopressor effect, resulted in improved postresuscitation cardiac and neurological recovery...
- Carvedilol mitigates adverse effects of epinephrine during cardiopulmonary resuscitation
Lei Huang
The Institute of Critical Care Medicine, Palm Springs, CA, USA
J Cardiovasc Pharmacol Ther 10:113-20. 2005
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- Increases in both buccal and sublingual partial pressure of carbon dioxide reflect decreases of tissue blood flows in a porcine model during hemorrhagic shock
Tommaso Pellis
Institute of Critical Care Medicine, Rancho Mirage, California, USA
J Trauma 58:817-24. 2005
..CONCLUSION: The current study extends the rationale for noninvasive measurements to both buccal and sublingual mucosa for diagnosis and quantitation of hemorrhagic shock severity...
- Comparison between dobutamine and levosimendan for management of postresuscitation myocardial dysfunction
Lei Huang
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 33:487-91. 2005
..CONCLUSIONS: Levosimendan has the potential of improving postresuscitation myocardial function. It is likely to serve as an alternative to dobutamine as an inotropic agent for management of postresuscitation myocardial dysfunction...
- Beta1-adrenergic blockade during cardiopulmonary resuscitation improves survival
Gianluca Cammarata
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 32:S440-3. 2004
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- Miniaturized chest compressor
Carlos Castillo
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 32:S366-8. 2004
..To the contrary, it is potentially more effective than the much larger and heavier industry standard for maintaining circulation...
- The effects of biphasic waveform design on post-resuscitation myocardial function
Wanchun Tang
Insitute of Critical Care Medicine, Palm Springs, California 92262 5309, USA
J Am Coll Cardiol 43:1228-35. 2004
..This study examined the effects of biphasic truncated exponential waveform design on survival and post-resuscitation myocardial function after prolonged ventricular fibrillation (VF)...
- Spontaneous gasping generates cardiac output during cardiac arrest
Jing Xie
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 32:238-40. 2004
..001) and coronary perfusion pressure from 4 +/- 3 to 13 +/- 7 mm Hg (p <.001). CONCLUSIONS: Our studies confirm that preterminal gasping during ventricular fibrillation increases both ventilation and forward blood flow...
- Cardiopulmonary resuscitation: one size does not fit all
Max Harry Weil
Circulation 107:794. 2003
- Role of buccal PCO2 in the management of fluid resuscitation during hemorrhagic shock
Giuseppe Ristagno
Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
Crit Care Med 34:S442-6. 2006
..Buccal PCO2 measurement therefore emerges as a useful predictor for survival and outcome and a useful guide to manage fluid resuscitation during hemorrhagic shock...
- Pharmacologic defibrillation
Shue-Ren Wann
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 30:S154-6. 2002
..Therefore, sodium-hydrogen exchanger inhibitors may provide new options in settings of cardiopulmonary resuscitation to facilitate defibrillation...
- Expanding automatic external defibrillators to include automated detection of cardiac, respiratory, and cardiorespiratory arrest
Tommaso Pellis
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 30:S176-8. 2002
..The cardiac arrest detector is therefore likely to augment the current information provided by automated defibrillators and to allow for more precise verbal prompting of lay rescuers...
- Comparison of buccal microcirculation between septic and hemorrhagic shock
Xiangshao Fang
Weil Institute of Critical Care Medicine, Rancho Mirage, California, USA
Crit Care Med 34:S447-53. 2006
..CONCLUSIONS: Impaired microcirculatory alteration in septic shock is more severe than hemorrhagic shock; microcirculation is relatively independent of improved systemic hemodynamics, in contrast to those in hemorrhagic shock...
- Letter by Tang et al regarding article, "BIPHASIC trial: a randomized comparison of fixed lower versus escalating higher energy levels for defibrillation in out-of-hospital cardiac arrest"
Wanchun Tang
Circulation 116:e522; author reply e523. 2007
- Cardiopulmonary resuscitation for pulseless rhythms and asystole
Max Harry Weil
Crit Care Med 30:245. 2002
- Intravenous infusion of bone marrow mesenchymal stem cells improves myocardial function in a rat model of myocardial ischemia
Tong Wang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 35:2587-93. 2007
..We investigated the effects of three different sites for delivery of bone marrow mesenchymal stem cells (MSCs) in a rat model of myocardial ischemia...
- Automated detection of ventricular fibrillation to guide cardiopulmonary resuscitation
Yongqin Li
Weil Institute of Critical Care Medicine, Rancho Mirage, California 92270, USA
Crit Pathw Cardiol 6:131-4. 2007
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- A comparison of myocardial function after primary cardiac and primary asphyxial cardiac arrest
Max Harry Weil
Am J Respir Crit Care Med 166:774. 2002
- Myocardial injury in children following resuscitation after cardiac arrest
Paul A Checchia
Division of Pediatric Critical Care Medicine, Loma Linda University Children s Hospital, Loma Linda, CA, USA
Resuscitation 57:131-7. 2003
..Our purpose was to determine whether measurement of cardiac troponin I in children with acute out-of-hospital cardiac arrest predicts the severity of myocardial injury...
- Myocardial performance index following electrically induced or ischemically induced cardiac arrest
Tingyan Xu
The Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, United States
Resuscitation 76:103-7. 2008
..We sought to investigate the echocardiographic myocardial performance index (MPI) to assess post-resuscitation myocardial function following electrically and ischemically induced ventricular fibrillation (VF)...
- Cariporide for pharmacologic defibrillation after prolonged cardiac arrest
Shue-Ren Wann
Institute of Critical Care Medicine, Palm Springs, CA 92264, USA
J Cardiovasc Pharmacol Ther 7:161-9. 2002
..CONCLUSIONS: Cariporide, when administered prior to and during cardiac arrest, improved both the success of resuscitation and postresuscitation myocardial function...
- Cardiopulmonary resuscitation in the mouse
Lei Song
Institute of Critical Care Medicine, Palm Springs, 92262, California, USA
J Appl Physiol 93:1222-6. 2002
..As in rats, swine, and human patients, threshold levels of mean aortic pressure, CPP, and PET(CO(2)) were critical determinates of resuscitability in this murine model of threshold level of cardiac arrest and resuscitation...
- Amplitude spectrum area: measuring the probability of successful defibrillation as applied to human data
Clayton Young
Institute of Critical Care Medicine, Palm Springs, CA, USA
Crit Care Med 32:S356-8. 2004
..AMSA therefore serves to minimize interruptions of precordial compression and the myocardial damage caused by delivery of repetitive and ineffective electrical shocks...
- Clinical review: Devices and drugs for cardiopulmonary resuscitation -- opportunities and restraints
Max Harry Weil
Institute of Critical Care Medicine, Palm Springs, California, USA
Crit Care 9:287-90. 2005
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