Detlef Weigel

Summary

Publications

  1. ncbi request reprint A tiny helper lightens the maternal load
    Detlef Weigel
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 124:1117-8. 2006
  2. doi request reprint Population Genomics for Understanding Adaptation in Wild Plant Species
    Detlef Weigel
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany email
    Annu Rev Genet 49:315-38. 2015
  3. pmc Comparative analysis of non-autonomous effects of tasiRNAs and miRNAs in Arabidopsis thaliana
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nucleic Acids Res 39:2880-9. 2011
  4. pmc A collection of target mimics for comprehensive analysis of microRNA function in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 6:e1001031. 2010
  5. pmc The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
    Tina T Hu
    Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA
    Nat Genet 43:476-81. 2011
  6. pmc Natural variation in Arabidopsis. How do we find the causal genes?
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Physiol 138:567-8. 2005
  7. pmc The 1001 genomes project for Arabidopsis thaliana
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genome Biol 10:107. 2009
  8. pmc On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development
    Heike Wollmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Development 137:3633-42. 2010
  9. ncbi request reprint The evolution of selfing in Arabidopsis thaliana
    Chunlao Tang
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    Science 317:1070-2. 2007
  10. pmc Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nature 465:632-6. 2010

Research Grants

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint A tiny helper lightens the maternal load
    Detlef Weigel
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 124:1117-8. 2006
    ..The mysterious agent is not a protein but rather a microRNA that is transcribed at this transition point...
  2. doi request reprint Population Genomics for Understanding Adaptation in Wild Plant Species
    Detlef Weigel
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany email
    Annu Rev Genet 49:315-38. 2015
    ..We conclude with thoughts on opportunities with other plant species and the impact of expected progress in sequencing technology and genome engineering for studying adaptation in nature. ..
  3. pmc Comparative analysis of non-autonomous effects of tasiRNAs and miRNAs in Arabidopsis thaliana
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nucleic Acids Res 39:2880-9. 2011
    ..In agreement with this hypothesis, the silencing signals initiated by different sRNAs differ in their genetic requirements...
  4. pmc A collection of target mimics for comprehensive analysis of microRNA function in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 6:e1001031. 2010
    ..In addition to insight into modes of miRNA action, this study provides an important resource for the study of miRNA function in plants...
  5. pmc The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
    Tina T Hu
    Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA
    Nat Genet 43:476-81. 2011
    ..The high-quality reference genome sequence for A. lyrata will be an important resource for functional, evolutionary and ecological studies in the genus Arabidopsis...
  6. pmc Natural variation in Arabidopsis. How do we find the causal genes?
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Physiol 138:567-8. 2005
  7. pmc The 1001 genomes project for Arabidopsis thaliana
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genome Biol 10:107. 2009
    ..We advocate here a 1001 Genomes project for Arabidopsis thaliana, the workhorse of plant genetics, which will provide an enormous boost for plant research with a modest financial investment...
  8. pmc On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development
    Heike Wollmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Development 137:3633-42. 2010
    ..We present a model in which the decision whether stamens or petals develop is based on the balance between AP2 and AG activities, rather than the two being mutually exclusive...
  9. ncbi request reprint The evolution of selfing in Arabidopsis thaliana
    Chunlao Tang
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    Science 317:1070-2. 2007
    ..An analysis of the genome-wide pattern of linkage disequilibrium suggests that selfing most likely evolved roughly a million years ago or more...
  10. pmc Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nature 465:632-6. 2010
    ..This allele segregates at intermediate frequency both throughout the worldwide range of A. thaliana and within local populations, consistent with this allele providing substantial fitness benefits despite its marked impact on growth...
  11. ncbi request reprint Recombination and linkage disequilibrium in Arabidopsis thaliana
    Sung Kim
    Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:1151-5. 2007
    ..LD also reflects the action of selection, and it is more extensive between nonsynonymous polymorphisms than between synonymous polymorphisms...
  12. doi request reprint Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Cell 151:859-70. 2012
    ..In the absence of CPL1, HYL1 dephosphorylation and hence accurate processing and strand selection from miRNA duplexes are compromised. Our findings thus define a new regulatory step in plant miRNA biogenesis...
  13. pmc Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:17466-73. 2010
    ..Furthermore, our results suggest that the DCL1 is not only involved in miRNA action but also contributes to silencing of a subset of transposons, apparently through an effect on DNA methylation...
  14. pmc Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
    Susanna Atwell
    Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
    Nature 465:627-31. 2010
    ..Our study demonstrates the feasibility of GWA studies in A. thaliana and suggests that the approach will be appropriate for many other organisms...
  15. pmc QTL mapping in new Arabidopsis thaliana advanced intercross-recombinant inbred lines
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 4:e4318. 2009
    ..One strategy to increase the power of precisely localizing small effect QTL, is the use of an intercross approach before inbreeding to produce Advanced Intercross RILs (AI-RILs)...
  16. ncbi request reprint Integration of spatial and temporal information during floral induction in Arabidopsis
    Philip A Wigge
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 309:1056-9. 2005
    ..A complex of FT and FD proteins in turn can activate floral identity genes such as APETALA1 (AP1)...
  17. pmc Dual effects of miR156-targeted SPL genes and CYP78A5/KLUH on plastochron length and organ size in Arabidopsis thaliana
    Jia wei Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Plant Cell 20:1231-43. 2008
    ..The effects of both miR156-targeted SPL genes and CYP78A5 on organ size are correlated with changes in plastochron length, suggesting a potential compensatory mechanism that links the rate at which leaves are produced to final leaf size...
  18. pmc Genetic architecture of flowering-time variation in Arabidopsis thaliana
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genetics 188:421-33. 2011
    ..While this finding parallels results obtained for maize, in contrast to maize much of the variation in flowering time in A. thaliana appears to be due to large-effect alleles...
  19. pmc STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings
    Anna Skylar
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    Development 137:541-9. 2010
    ..These findings identify a new branch of the cytokinin signaling network, linking cytokinin to the process of meristem and seedling establishment...
  20. pmc At-TAX: a whole genome tiling array resource for developmental expression analysis and transcript identification in Arabidopsis thaliana
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstr, 37 39, 72076 Tubingen, Germany
    Genome Biol 9:R112. 2008
    ..Visualizations of gene expression estimates, transcribed regions, and tiling probe measurements are accessible online at the At-TAX homepage...
  21. pmc Sequencing of natural strains of Arabidopsis thaliana with short reads
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genome Res 18:2024-33. 2008
    ..Our pipeline for aligning reads and predicting SNPs and indels, SHORE, is available for download at http://1001genomes.org...
  22. doi request reprint Stress-induced changes in the Arabidopsis thaliana transcriptome analyzed using whole-genome tiling arrays
    Georg Zeller
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 58:1068-82. 2009
    ....
  23. doi request reprint Comparative analysis of the MIR319a microRNA locus in Arabidopsis and related Brassicaceae
    Norman Warthmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Mol Biol Evol 25:892-902. 2008
    ..More broadly, we find that the foldback diverges less rapidly than the remainder of the primary transcript. To understand the molecular evolution of miRNA genes, investigations at different levels of phylogenetic divergence are required...
  24. ncbi request reprint Sequence and expression differences underlie functional specialization of Arabidopsis microRNAs miR159 and miR319
    Javier F Palatnik
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Dev Cell 13:115-25. 2007
    ..Together, our findings reveal that functional specialization of miR159 and miR319 is achieved through both expression and sequence differences...
  25. pmc Control of jasmonate biosynthesis and senescence by miR319 targets
    Carla Schommer
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Biol 6:e230. 2008
    ..We propose that miR319-controlled TCP transcription factors coordinate two sequential processes in leaf development: leaf growth, which they negatively regulate, and leaf senescence, which they positively regulate...
  26. doi request reprint Genome-wide single nucleotide polymorphisms reveal population history and adaptive divergence in wild guppies
    Eva Maria Willing
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen D72076, Germany
    Mol Ecol 19:968-84. 2010
    ..Overall, this study demonstrates the power of a genome-wide SNP data set to inform for studies on natural variation, adaptation and evolution of wild populations...
  27. pmc Tissue-specific silencing of Arabidopsis SU(VAR)3-9 HOMOLOG8 by miR171a
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Physiol 161:805-12. 2013
    ..Our study demonstrates that each miR171a strand can be loaded onto RISC with separate regulatory outcomes...
  28. doi request reprint A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana
    Sridevi Sureshkumar
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Science 323:1060-3. 2009
    ..The Bur-0 IIL1 defect thus presents a genetically tractable model for triplet repeat expansions and their variability in natural populations...
  29. pmc Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella rubella
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genetics 192:729-39. 2012
    ..rubella is complex, despite this very young species having undergone an extreme genetic bottleneck when it split from C. grandiflora a few tens of thousands of years ago...
  30. doi request reprint Natural variation in biogenesis efficiency of individual Arabidopsis thaliana microRNAs
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Curr Biol 22:166-70. 2012
    ..Our results suggest that natural variation in miRNA biogenesis resulting from cis mutations is a common contributor to phenotypic variation in plants...
  31. ncbi request reprint Specific effects of microRNAs on the plant transcriptome
    Rebecca Schwab
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Dev Cell 8:517-27. 2005
    ..This finding unifies the view of plant miRNA action...
  32. doi request reprint Whole-genome sequencing of multiple Arabidopsis thaliana populations
    Jun Cao
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Nat Genet 43:956-63. 2011
    ..thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations...
  33. doi request reprint Regulation and functional specialization of small RNA-target nodes during plant development
    Ignacio Rubio-Somoza
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Curr Opin Plant Biol 12:622-7. 2009
    ..Here, we focus on the idea of distinct small RNA-target transcript pairs as nodes within biological networks, and review progress toward understanding the role of small RNA-target nodes in the context of auxin signaling...
  34. pmc Complex evolutionary events at a tandem cluster of Arabidopsis thaliana genes resulting in a single-locus genetic incompatibility
    Lisa M Smith
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 7:e1002164. 2011
    ..Our work provides insights into how tandem arrays, which are particularly prone to frequent, complex rearrangements, can produce genetic novelty...
  35. pmc Simultaneous alignment of short reads against multiple genomes
    Korbinian Schneeberger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Genome Biol 10:R98. 2009
    ..Demonstrated benefits include access to polymorphisms that cannot be identified by alignments against the reference alone. Download GenomeMapper at http://1001genomes.org...
  36. pmc The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of Arabidopsis thaliana
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Nat Genet 38:711-5. 2006
    ..thaliana. Our work, together with previous findings, suggests that photoreceptor genes are major agents of natural variation in plant flowering and growth response...
  37. pmc ESTs and EST-linked polymorphisms for genetic mapping and phylogenetic reconstruction in the guppy, Poecilia reticulata
    Christine Dreyer
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, D72076, Germany
    BMC Genomics 8:269. 2007
    ..However, genomic resources for studying this important model were not previously widely available...
  38. doi request reprint Synteny-based mapping-by-sequencing enabled by targeted enrichment
    Vinicius C Galvão
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 71:517-26. 2012
    ....
  39. doi request reprint MIGS: miRNA-induced gene silencing
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 70:541-7. 2012
    ..MIGS can be reliably used for the knockdown of a single gene or of multiple unrelated genes. In addition, we show that MIGS can be applied to other species by co-expression of miR173...
  40. pmc Genome-wide comparison of nucleotide-binding site-leucine-rich repeat-encoding genes in Arabidopsis
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tuebingen, Germany
    Plant Physiol 157:757-69. 2011
    ..Finally, in contrast to Drosophila, there is a clearly positive relationship between interspecific divergence and intraspecific polymorphisms...
  41. pmc Dual roles of the bZIP transcription factor PERIANTHIA in the control of floral architecture and homeotic gene expression
    Annette T Maier
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Development 136:1613-20. 2009
    ..Finally, we show that PAN expression persists in ag mutant flowers, suggesting that PAN and AG are engaged in a negative-feedback loop, which might be mediated by the stem-cell-inducing transcription factor WUSCHEL (WUS)...
  42. doi request reprint Structure determinants for accurate processing of miR172a in Arabidopsis thaliana
    Schallum Werner
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Curr Biol 20:42-8. 2010
    ..Our ability to engineer de novo a functional minimal miRNA precursor highlights that we have discovered several elements both necessary and sufficient for accurate miRNA processing...
  43. ncbi request reprint Control of leaf morphogenesis by microRNAs
    Javier F Palatnik
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Nature 425:257-63. 2003
    ..TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms...
  44. pmc The rate and molecular spectrum of spontaneous mutations in Arabidopsis thaliana
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 327:92-4. 2010
    ..We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis...
  45. ncbi request reprint Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana
    Richard M Clark
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 317:338-42. 2007
    ..Analyzing the polymorphisms we describe in larger sets of accessions will enable a detailed understanding of forces shaping population-wide sequence variation in A. thaliana...
  46. pmc Distinct expression patterns of natural antisense transcripts in Arabidopsis
    Stefan R Henz
    Max Planck Institute for Developmental Biology, Department of Molecular Biology, Tuebingen, Germany
    Plant Physiol 144:1247-55. 2007
    ..Our results demonstrate that there is a trend toward anticorrelated expression of cis-NAT pairs in Arabidopsis, but currently available data do not produce a strong signature of small RNA-mediated silencing for this process...
  47. ncbi request reprint MSQT for choosing SNP assays from multiple DNA alignments
    Norman Warthmann
    Max Planck Institute for Developmental Biology, Department of Molecular Biology, 72076 Tubingen, Germany
    Bioinformatics 23:2784-7. 2007
    ..One challenging aspect of genotyping and association mapping projects is often the identification of markers that are informative between groups of individuals and to convert these into genotyping assays...
  48. pmc Linkage analysis reveals the independent origin of Poeciliid sex chromosomes and a case of atypical sex inheritance in the guppy (Poecilia reticulata)
    Namita Tripathi
    Max Plank Institute for Developmental Biology, 72076 Tubingen, Germany
    Genetics 182:365-74. 2009
    ..In one mapping cross, we observed sex ratio and male phenotype deviations and propose an atypical mode of genetic sex inheritance as its basis...
  49. pmc Reference-guided assembly of four diverse Arabidopsis thaliana genomes
    Korbinian Schneeberger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:10249-54. 2011
    ..Genome assemblies, raw reads, and further information are accessible through http://1001genomes.org/projects/assemblies.html...
  50. pmc Local-scale patterns of genetic variability, outcrossing, and spatial structure in natural stands of Arabidopsis thaliana
    Kirsten Bomblies
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 6:e1000890. 2010
    ..Our findings have important implications for sampling and interpreting diversity among A. thaliana accessions...
  51. pmc Haplotype structure and phenotypic associations in the chromosomal regions surrounding two Arabidopsis thaliana flowering time loci
    Jenny Hagenblad
    Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA
    Genetics 168:1627-38. 2004
    ..No clear evidence for previously unknown alleles at either locus was found, but the effect of population structure in causing false positives was evident...
  52. pmc Evolution of Arabidopsis thaliana microRNAs from random sequences
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    RNA 14:2455-9. 2008
    ..Subsequent stabilization through coevolution with initially fortuitous targets may lead to fixation of a small subset of these proto-miRNA genes...
  53. doi request reprint Artificial microRNAs for specific gene silencing in rice
    Norman Warthmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Methods Mol Biol 956:131-49. 2013
    ..In addition, beneficial knockout phenotypes can easily be transferred between varieties and across incompatibility barriers. This chapter describes the generation and application of amiRNAs as a gene silencing tool in rice...
  54. doi request reprint Paired-end RAD-seq for de novo assembly and marker design without available reference
    Eva Maria Willing
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, University of Tubingen, Sand 14, 72076 Tubingen, Germany
    Bioinformatics 27:2187-93. 2011
    ..Single-end RAD-seq has proven to provide a large number of informative genetic markers in reference as well as non-reference organisms...
  55. doi request reprint Spontaneous epigenetic variation in the Arabidopsis thaliana methylome
    Claude Becker
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nature 480:245-9. 2011
    ..The biased distribution and frequent reversion of epimutations have important implications for the potential contribution of sequence-independent epialleles to plant evolution...
  56. pmc Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 105:8795-800. 2008
    ..Taken together, our results uncover dual roles in splicing and miRNA processing that distinguish SE and the cap-binding complex from specialized miRNA processing factors such as DCL1 and HYL1...
  57. pmc Arabidopsis and relatives as models for the study of genetic and genomic incompatibilities
    Kirsten Bomblies
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Philos Trans R Soc Lond B Biol Sci 365:1815-23. 2010
    ..In the near future, all these studies will be greatly empowered by complete genome sequences not only for all members of this relatively small genus, but also for many different individuals within each species...
  58. pmc Genetic linkage map of the guppy, Poecilia reticulata, and quantitative trait loci analysis of male size and colour variation
    Namita Tripathi
    Department of Molecular Biology, Max Plank Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Biol Sci 276:2195-208. 2009
    ..We have used the linkage data to predict quantitative trait loci for a set of variable male traits including size and colour pattern. Contributing loci map to the sex LG for many of these traits...
  59. doi request reprint Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata)
    Verena A Kottler
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Pigment Cell Melanoma Res 28:545-58. 2015
    ..We find that some components of the male orange pattern are particularly sensitive to loss of Adcy5 function. Our work thus reveals a function for Adcy5 in patterning of fish color ornaments...
  60. pmc Opsin gene duplication and diversification in the guppy, a model for sexual selection
    Margarete Hoffmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen D72076, Germany
    Proc Biol Sci 274:33-42. 2007
    ..Since opsin variability parallels the extreme male colour polymorphism within guppy populations, we suggest that mate choice has been a major factor driving the coevolution of opsins and male ornaments in this species...
  61. pmc Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants
    Kirsten Bomblies
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Biol 5:e236. 2007
    ..Moreover, our finding that plant immune-system genes are involved in hybrid necrosis suggests that selective pressures related to host-pathogen conflict might cause the evolution of gene flow barriers in plants...
  62. pmc Highly specific gene silencing by artificial microRNAs in Arabidopsis
    Rebecca Schwab
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant Cell 18:1121-33. 2006
    ..The design principles for amiRNAs have been generalized and integrated into a Web-based tool (http://wmd.weigelworld.org)...
  63. pmc LOCAS--a low coverage assembly tool for resequencing projects
    Juliane D Klein
    University of Tubingen, Tubingen, Germany
    PLoS ONE 6:e23455. 2011
    ..However, computational methods capable of discovering other variations such as novel insertions or highly diverged sequence from low coverage NGS data are still lacking...
  64. ncbi request reprint Arabidopsis: a model genus for speciation
    Kirsten Bomblies
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076, Tubingen, Germany
    Curr Opin Genet Dev 17:500-4. 2007
    ..thaliana and improvements in tools and technology applied to its close relatives are opening doors for combining experimental and comparative analyses to elucidate fundamental mechanisms of evolution...
  65. pmc Coordination of flower maturation by a regulatory circuit of three microRNAs
    Ignacio Rubio-Somoza
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 9:e1003374. 2013
    ..Our observations reveal how different miRNA-TF pairs can be organized into modules that coordinate successive steps in the plant life cycle...
  66. doi request reprint Fast-forward genetics enabled by new sequencing technologies
    Korbinian Schneeberger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Trends Plant Sci 16:282-8. 2011
    ..Deployment of such genes to improve crops or engineer microbes that produce valuable compounds heralds a potential paradigm shift for plant biology...
  67. pmc Evolution of the S-locus region in Arabidopsis relatives
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tuebingen, Germany
    Plant Physiol 157:937-46. 2011
    ..rubella is likely to be an old S-locus haplotype that only very recently became fixed when C. rubella split off from its SI ancestor, Capsella grandiflora...
  68. doi request reprint Small RNAs in flower development
    Heike Wollmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Eur J Cell Biol 89:250-7. 2010
    ..Here we provide an overview about generation and action of miRNAs and other small RNAs, and their contribution to an important developmental process in plants, flower formation...
  69. pmc Highly specific gene silencing by artificial miRNAs in rice
    Norman Warthmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 3:e1829. 2008
    ..Artificial miRNAs (amiRNAs)-designed to target one or several genes of interest-provide a new and highly specific approach for effective post-transcriptional gene silencing (PTGS) in plants...
  70. doi request reprint Gene silencing in plants using artificial microRNAs and other small RNAs
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 53:674-90. 2008
    ..A recently introduced approach is the use of artificial microRNAs (amiRNAs). Here, we review various strategies for small RNA-based gene silencing, and describe in detail the design and application of amiRNAs in many plant species...
  71. pmc Transposon variants and their effects on gene expression in Arabidopsis
    Xi Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 9:e1003255. 2013
    ..Overall, our work indicates that siRNA-targeting of TEs may influence removal of sequences from the genome and hence evolution of gene expression in plants...
  72. pmc Century-scale methylome stability in a recently diverged Arabidopsis thaliana lineage
    Jörg Hagmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 11:e1004920. 2015
    ....
  73. pmc Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis
    Eunyoung Chae
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Cell 159:1341-51. 2014
    ..Our findings suggest that deleterious interactions of immune receptors limit the combinations of favorable disease resistance alleles accessible to plant genomes. ..
  74. pmc Potent induction of Arabidopsis thaliana flowering by elevated growth temperature
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 2:e106. 2006
    ..This response has a genetic basis that is distinct from the known genetic pathways of floral transition, and appears to correlate with changes in RNA processing...
  75. doi request reprint miR156-regulated SPL transcription factors define an endogenous flowering pathway in Arabidopsis thaliana
    Jia wei Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 138:738-49. 2009
    ....
  76. ncbi request reprint The floral regulator LEAFY evolves by substitutions in the DNA binding domain
    Alexis Maizel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Science 308:260-3. 2005
    ..We report that the DNA binding domain of LEAFY, although largely conserved, has diverged in activity. On the contrary, other, more rapidly evolving portions of the protein have few effects on LEAFY activity...
  77. pmc Triggering the formation of tasiRNAs in Arabidopsis thaliana: the role of microRNA miR173
    Felipe F Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    EMBO Rep 10:264-70. 2009
    ..We show that tasiRNAs can be produced from heterologous transcripts containing miR173 or miR390 target sites, indicating that these trigger sequences are the only cis sequences essential for tasiRNA formation...
  78. ncbi request reprint Dissection of floral induction pathways using global expression analysis
    Markus Schmid
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Development 130:6001-12. 2003
    ..These and related findings on SPL genes suggest that microRNAs play an important role in the regulation of flowering...
  79. pmc The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Cell 22:3650-61. 2010
    ..Together, our results reveal a role of PRR7 and PRR9 in regulating CCA1 and LHY activities in response to ambient temperature...
  80. ncbi request reprint Move on up, it's time for change--mobile signals controlling photoperiod-dependent flowering
    Yasushi Kobayashi
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076, Tubingen, Germany
    Genes Dev 21:2371-84. 2007
    ....
  81. ncbi request reprint A gene expression map of Arabidopsis thaliana development
    Markus Schmid
    Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, 72076 Tubingen, Germany
    Nat Genet 37:501-6. 2005
    ..Examining the expression patterns of large gene families, we found that they are often more similar than would be expected by chance, indicating that many gene families have been co-opted for specific developmental processes...
  82. pmc Plant secondary siRNA production determined by microRNA-duplex structure
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 109:2461-6. 2012
    ..We propose that the RNA-induced silencing complex reprogramming occurs during the early steps of miRNA loading, before the miRNA duplex is disassembled and the guide strand is selected...
  83. ncbi request reprint Temporally and spatially controlled induction of gene expression in Arabidopsis thaliana
    Alexis Maizel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Plant J 38:164-71. 2004
    ..Apart from facilitating the investigation of temporal and spatial requirements of gene activity, this technology will permit new types of genetic modifier screens starting with mutations that otherwise confer lethality or sterility...
  84. pmc Recent speciation of Capsella rubella from Capsella grandiflora, associated with loss of self-incompatibility and an extreme bottleneck
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 106:5246-51. 2009
    ..The presence of phenotypic diversity within modern C. rubella suggests that this species will be an interesting model to understand divergence and adaptation, starting from very limited standing genetic variation...
  85. pmc miRNA control of vegetative phase change in trees
    Jia wei Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 7:e1002012. 2011
    ..Our results indicate that miR156 is an evolutionarily conserved regulator of vegetative phase change in both annual herbaceous plants and perennial trees...
  86. doi request reprint Transient assays for the analysis of miRNA processing and function
    Felipe F de Felippes
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Methods Mol Biol 592:255-64. 2010
    ..Agroinfiltration has been used successfully in many different applications, including the analysis of small RNAs. We describe here a protocol for analysis of miRNA processing using agroinfiltration of N. benthamiana leaves...
  87. ncbi request reprint From tough nuts to touch-me-nots
    Jan U Lohmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 116:763-4. 2004
    ..Liljegren and colleagues (2004 [this issue of Cell]) describe a nonlinear network of transcription factor genes controlling this process...
  88. ncbi request reprint The role of JAGGED in shaping lateral organs
    JOSE R DINNENY
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 131:1101-10. 2004
    ..If misexpressed, JAGGED can induce the formation of bracts, suggesting that the exclusion of JAGGED from the cryptic bract is a cause of bractless flowers in Arabidopsis...
  89. pmc Independent control of gibberellin biosynthesis and flowering time by the circadian clock in Arabidopsis
    Miguel A Blázquez
    Instituto de Biología Molecular y Celular de Plantas Consejo Superior de Investigaciones Científicas Universidad Politécnica de Valencia, 46022 Valencia, Spain
    Plant Physiol 130:1770-5. 2002
    ..We show that toc1 affects expression of several floral regulators and a GA biosynthetic gene, but that these effects are independent...
  90. pmc Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development
    Xuelin Wu
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Biol 309:306-16. 2007
    ..These findings show that combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development...
  91. ncbi request reprint Target mimicry provides a new mechanism for regulation of microRNA activity
    José Manuel Franco-Zorrilla
    Department of Plant Molecular Genetics, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    Nat Genet 39:1033-7. 2007
    ..We coin the term 'target mimicry' to define this mechanism of inhibition of miRNA activity. Target mimicry can be generalized beyond the control of Pi homeostasis, as demonstrated using artificial target mimics...
  92. pmc Comprehensive interaction map of the Arabidopsis MADS Box transcription factors
    Stefan de Folter
    Business Unit Bioscience, Plant Research International, 6700 AA Wageningen, The Netherlands
    Plant Cell 17:1424-33. 2005
    ..Heterodimers between flower induction and floral organ identity proteins were observed, which point to (auto)regulatory mechanisms that prevent the activity of flower induction proteins in the flower...
  93. ncbi request reprint NUBBIN and JAGGED define stamen and carpel shape in Arabidopsis
    JOSE R DINNENY
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Development 133:1645-55. 2006
    ....
  94. ncbi request reprint Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
    ..Insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene...
  95. ncbi request reprint A thermosensory pathway controlling flowering time in Arabidopsis thaliana
    Miguel A Blázquez
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 33:168-71. 2003
    ..As with vernalization and photoperiod, ambient temperature ultimately affects expression of the floral pathway integrator FT...
  96. ncbi request reprint The extent of linkage disequilibrium in Arabidopsis thaliana
    Magnus Nordborg
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 30:190-3. 2002
    ..The combination of a relatively high level of polymorphism and extensive haplotype structure bodes well for developing a genome-wide LD map in A. thaliana...
  97. pmc Quantitative trait loci controlling light and hormone response in two accessions of Arabidopsis thaliana
    Justin O Borevitz
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genetics 160:683-96. 2002
    ..The phenotype and map position of LIGHT2 suggest the photoreceptor PHYB as a candidate gene. Natural variation in light and hormone response thus defines both new genes and known genes that control light response in wild accessions...
  98. ncbi request reprint Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux
    Marta Michniewicz
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, Tubingen, Germany
    Cell 130:1044-56. 2007
    ..In the case of PIN proteins, this mechanism enables switches in the direction of intercellular auxin fluxes, which mediate differential growth, tissue patterning, and organogenesis...
  99. ncbi request reprint Building beauty: the genetic control of floral patterning
    Jan U Lohmann
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Cell 2:135-42. 2002
    ..This review discusses recent progress in our understanding of floral homeotic genes, with an emphasis on how their region-specific expression is regulated...
  100. ncbi request reprint Ectopic expression of SUPERMAN suppresses development of petals and stamens
    Jae Young Yun
    School of Biological Sciences, Seoul National University, Seoul, 151 742 Korea
    Plant Cell Physiol 43:52-7. 2002
    ..Together, these results suggest that SUP has both indirect and direct effects on the expression of B function homeotic genes...
  101. ncbi request reprint HUA2 caused natural variation in shoot morphology of A. thaliana
    Qing Wang
    Department of Biology, University of Western Ontario, London, Ontario, Canada
    Curr Biol 17:1513-9. 2007
    ..Natural variation in HUA2 activity thus coordinates changes in two important life-history traits, flowering time and shoot morphology...

Research Grants1

  1. Variation and Quantitative Genetics in Model Organisms
    Detlef Weigel; Fiscal Year: 2004
    ..A second focus will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. ..