Detlef Weigel

Summary

Publications

  1. ncbi request reprint A tiny helper lightens the maternal load
    Detlef Weigel
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 124:1117-8. 2006
  2. pmc Natural variation in Arabidopsis. How do we find the causal genes?
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Physiol 138:567-8. 2005
  3. pmc The 1001 genomes project for Arabidopsis thaliana
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genome Biol 10:107. 2009
  4. pmc On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development
    Heike Wollmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Development 137:3633-42. 2010
  5. pmc Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nature 465:632-6. 2010
  6. pmc Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:17466-73. 2010
  7. doi request reprint Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Cell 151:859-70. 2012
  8. pmc Genetic architecture of flowering-time variation in Arabidopsis thaliana
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genetics 188:421-33. 2011
  9. pmc QTL mapping in new Arabidopsis thaliana advanced intercross-recombinant inbred lines
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 4:e4318. 2009
  10. ncbi request reprint Integration of spatial and temporal information during floral induction in Arabidopsis
    Philip A Wigge
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 309:1056-9. 2005

Research Grants

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint A tiny helper lightens the maternal load
    Detlef Weigel
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 124:1117-8. 2006
    ..The mysterious agent is not a protein but rather a microRNA that is transcribed at this transition point...
  2. pmc Natural variation in Arabidopsis. How do we find the causal genes?
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Physiol 138:567-8. 2005
  3. pmc The 1001 genomes project for Arabidopsis thaliana
    Detlef Weigel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genome Biol 10:107. 2009
    ..We advocate here a 1001 Genomes project for Arabidopsis thaliana, the workhorse of plant genetics, which will provide an enormous boost for plant research with a modest financial investment...
  4. pmc On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development
    Heike Wollmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Development 137:3633-42. 2010
    ..We present a model in which the decision whether stamens or petals develop is based on the balance between AP2 and AG activities, rather than the two being mutually exclusive...
  5. pmc Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nature 465:632-6. 2010
    ..This allele segregates at intermediate frequency both throughout the worldwide range of A. thaliana and within local populations, consistent with this allele providing substantial fitness benefits despite its marked impact on growth...
  6. pmc Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:17466-73. 2010
    ..Furthermore, our results suggest that the DCL1 is not only involved in miRNA action but also contributes to silencing of a subset of transposons, apparently through an effect on DNA methylation...
  7. doi request reprint Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Cell 151:859-70. 2012
    ..In the absence of CPL1, HYL1 dephosphorylation and hence accurate processing and strand selection from miRNA duplexes are compromised. Our findings thus define a new regulatory step in plant miRNA biogenesis...
  8. pmc Genetic architecture of flowering-time variation in Arabidopsis thaliana
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genetics 188:421-33. 2011
    ..While this finding parallels results obtained for maize, in contrast to maize much of the variation in flowering time in A. thaliana appears to be due to large-effect alleles...
  9. pmc QTL mapping in new Arabidopsis thaliana advanced intercross-recombinant inbred lines
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 4:e4318. 2009
    ..One strategy to increase the power of precisely localizing small effect QTL, is the use of an intercross approach before inbreeding to produce Advanced Intercross RILs (AI-RILs)...
  10. ncbi request reprint Integration of spatial and temporal information during floral induction in Arabidopsis
    Philip A Wigge
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 309:1056-9. 2005
    ..A complex of FT and FD proteins in turn can activate floral identity genes such as APETALA1 (AP1)...
  11. pmc Dual effects of miR156-targeted SPL genes and CYP78A5/KLUH on plastochron length and organ size in Arabidopsis thaliana
    Jia wei Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Plant Cell 20:1231-43. 2008
    ..The effects of both miR156-targeted SPL genes and CYP78A5 on organ size are correlated with changes in plastochron length, suggesting a potential compensatory mechanism that links the rate at which leaves are produced to final leaf size...
  12. doi request reprint Stress-induced changes in the Arabidopsis thaliana transcriptome analyzed using whole-genome tiling arrays
    Georg Zeller
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 58:1068-82. 2009
    ....
  13. pmc Sequencing of natural strains of Arabidopsis thaliana with short reads
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Genome Res 18:2024-33. 2008
    ..Our pipeline for aligning reads and predicting SNPs and indels, SHORE, is available for download at http://1001genomes.org...
  14. pmc At-TAX: a whole genome tiling array resource for developmental expression analysis and transcript identification in Arabidopsis thaliana
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstr, 37 39, 72076 Tubingen, Germany
    Genome Biol 9:R112. 2008
    ..Visualizations of gene expression estimates, transcribed regions, and tiling probe measurements are accessible online at the At-TAX homepage...
  15. doi request reprint Comparative analysis of the MIR319a microRNA locus in Arabidopsis and related Brassicaceae
    Norman Warthmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Mol Biol Evol 25:892-902. 2008
    ..More broadly, we find that the foldback diverges less rapidly than the remainder of the primary transcript. To understand the molecular evolution of miRNA genes, investigations at different levels of phylogenetic divergence are required...
  16. pmc Control of jasmonate biosynthesis and senescence by miR319 targets
    Carla Schommer
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Biol 6:e230. 2008
    ..We propose that miR319-controlled TCP transcription factors coordinate two sequential processes in leaf development: leaf growth, which they negatively regulate, and leaf senescence, which they positively regulate...
  17. doi request reprint Genome-wide single nucleotide polymorphisms reveal population history and adaptive divergence in wild guppies
    Eva Maria Willing
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen D72076, Germany
    Mol Ecol 19:968-84. 2010
    ..Overall, this study demonstrates the power of a genome-wide SNP data set to inform for studies on natural variation, adaptation and evolution of wild populations...
  18. pmc Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella rubella
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Genetics 192:729-39. 2012
    ..rubella is complex, despite this very young species having undergone an extreme genetic bottleneck when it split from C. grandiflora a few tens of thousands of years ago...
  19. doi request reprint Natural variation in biogenesis efficiency of individual Arabidopsis thaliana microRNAs
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Curr Biol 22:166-70. 2012
    ..Our results suggest that natural variation in miRNA biogenesis resulting from cis mutations is a common contributor to phenotypic variation in plants...
  20. ncbi request reprint Sequence and expression differences underlie functional specialization of Arabidopsis microRNAs miR159 and miR319
    Javier F Palatnik
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Dev Cell 13:115-25. 2007
    ..Together, our findings reveal that functional specialization of miR159 and miR319 is achieved through both expression and sequence differences...
  21. doi request reprint A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana
    Sridevi Sureshkumar
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Science 323:1060-3. 2009
    ..The Bur-0 IIL1 defect thus presents a genetically tractable model for triplet repeat expansions and their variability in natural populations...
  22. ncbi request reprint Specific effects of microRNAs on the plant transcriptome
    Rebecca Schwab
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Dev Cell 8:517-27. 2005
    ..This finding unifies the view of plant miRNA action...
  23. pmc Tissue-specific silencing of Arabidopsis SU(VAR)3-9 HOMOLOG8 by miR171a
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Physiol 161:805-12. 2013
    ..Our study demonstrates that each miR171a strand can be loaded onto RISC with separate regulatory outcomes...
  24. doi request reprint Synteny-based mapping-by-sequencing enabled by targeted enrichment
    Vinicius C Galvão
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 71:517-26. 2012
    ....
  25. doi request reprint MIGS: miRNA-induced gene silencing
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 70:541-7. 2012
    ..MIGS can be reliably used for the knockdown of a single gene or of multiple unrelated genes. In addition, we show that MIGS can be applied to other species by co-expression of miR173...
  26. pmc Genome-wide comparison of nucleotide-binding site-leucine-rich repeat-encoding genes in Arabidopsis
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tuebingen, Germany
    Plant Physiol 157:757-69. 2011
    ..Finally, in contrast to Drosophila, there is a clearly positive relationship between interspecific divergence and intraspecific polymorphisms...
  27. pmc Simultaneous alignment of short reads against multiple genomes
    Korbinian Schneeberger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Genome Biol 10:R98. 2009
    ..Demonstrated benefits include access to polymorphisms that cannot be identified by alignments against the reference alone. Download GenomeMapper at http://1001genomes.org...
  28. pmc Complex evolutionary events at a tandem cluster of Arabidopsis thaliana genes resulting in a single-locus genetic incompatibility
    Lisa M Smith
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 7:e1002164. 2011
    ..Our work provides insights into how tandem arrays, which are particularly prone to frequent, complex rearrangements, can produce genetic novelty...
  29. doi request reprint Whole-genome sequencing of multiple Arabidopsis thaliana populations
    Jun Cao
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Nat Genet 43:956-63. 2011
    ..thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations...
  30. pmc Dual roles of the bZIP transcription factor PERIANTHIA in the control of floral architecture and homeotic gene expression
    Annette T Maier
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Development 136:1613-20. 2009
    ..Finally, we show that PAN expression persists in ag mutant flowers, suggesting that PAN and AG are engaged in a negative-feedback loop, which might be mediated by the stem-cell-inducing transcription factor WUSCHEL (WUS)...
  31. doi request reprint Structure determinants for accurate processing of miR172a in Arabidopsis thaliana
    Schallum Werner
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Curr Biol 20:42-8. 2010
    ..Our ability to engineer de novo a functional minimal miRNA precursor highlights that we have discovered several elements both necessary and sufficient for accurate miRNA processing...
  32. doi request reprint Regulation and functional specialization of small RNA-target nodes during plant development
    Ignacio Rubio-Somoza
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Curr Opin Plant Biol 12:622-7. 2009
    ..Here, we focus on the idea of distinct small RNA-target transcript pairs as nodes within biological networks, and review progress toward understanding the role of small RNA-target nodes in the context of auxin signaling...
  33. pmc ESTs and EST-linked polymorphisms for genetic mapping and phylogenetic reconstruction in the guppy, Poecilia reticulata
    Christine Dreyer
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, D72076, Germany
    BMC Genomics 8:269. 2007
    ..However, genomic resources for studying this important model were not previously widely available...
  34. doi request reprint The rate and molecular spectrum of spontaneous mutations in Arabidopsis thaliana
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 327:92-4. 2010
    ..We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light-induced mutagenesis...
  35. doi request reprint Artificial microRNAs for specific gene silencing in rice
    Norman Warthmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Methods Mol Biol 956:131-49. 2013
    ..In addition, beneficial knockout phenotypes can easily be transferred between varieties and across incompatibility barriers. This chapter describes the generation and application of amiRNAs as a gene silencing tool in rice...
  36. doi request reprint Spontaneous epigenetic variation in the Arabidopsis thaliana methylome
    Claude Becker
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nature 480:245-9. 2011
    ..The biased distribution and frequent reversion of epimutations have important implications for the potential contribution of sequence-independent epialleles to plant evolution...
  37. doi request reprint Paired-end RAD-seq for de novo assembly and marker design without available reference
    Eva Maria Willing
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, University of Tubingen, Sand 14, 72076 Tubingen, Germany
    Bioinformatics 27:2187-93. 2011
    ..Single-end RAD-seq has proven to provide a large number of informative genetic markers in reference as well as non-reference organisms...
  38. pmc Linkage analysis reveals the independent origin of Poeciliid sex chromosomes and a case of atypical sex inheritance in the guppy (Poecilia reticulata)
    Namita Tripathi
    Max Plank Institute for Developmental Biology, 72076 Tubingen, Germany
    Genetics 182:365-74. 2009
    ..In one mapping cross, we observed sex ratio and male phenotype deviations and propose an atypical mode of genetic sex inheritance as its basis...
  39. pmc Local-scale patterns of genetic variability, outcrossing, and spatial structure in natural stands of Arabidopsis thaliana
    Kirsten Bomblies
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 6:e1000890. 2010
    ..Our findings have important implications for sampling and interpreting diversity among A. thaliana accessions...
  40. pmc Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 105:8795-800. 2008
    ..Taken together, our results uncover dual roles in splicing and miRNA processing that distinguish SE and the cap-binding complex from specialized miRNA processing factors such as DCL1 and HYL1...
  41. pmc Distinct expression patterns of natural antisense transcripts in Arabidopsis
    Stefan R Henz
    Max Planck Institute for Developmental Biology, Department of Molecular Biology, Tuebingen, Germany
    Plant Physiol 144:1247-55. 2007
    ..Our results demonstrate that there is a trend toward anticorrelated expression of cis-NAT pairs in Arabidopsis, but currently available data do not produce a strong signature of small RNA-mediated silencing for this process...
  42. pmc Reference-guided assembly of four diverse Arabidopsis thaliana genomes
    Korbinian Schneeberger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:10249-54. 2011
    ..Genome assemblies, raw reads, and further information are accessible through http://1001genomes.org/projects/assemblies.html...
  43. pmc Arabidopsis and relatives as models for the study of genetic and genomic incompatibilities
    Kirsten Bomblies
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Philos Trans R Soc Lond B Biol Sci 365:1815-23. 2010
    ..In the near future, all these studies will be greatly empowered by complete genome sequences not only for all members of this relatively small genus, but also for many different individuals within each species...
  44. pmc Genetic linkage map of the guppy, Poecilia reticulata, and quantitative trait loci analysis of male size and colour variation
    Namita Tripathi
    Department of Molecular Biology, Max Plank Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Biol Sci 276:2195-208. 2009
    ..We have used the linkage data to predict quantitative trait loci for a set of variable male traits including size and colour pattern. Contributing loci map to the sex LG for many of these traits...
  45. pmc Coordination of flower maturation by a regulatory circuit of three microRNAs
    Ignacio Rubio-Somoza
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 9:e1003374. 2013
    ..Our observations reveal how different miRNA-TF pairs can be organized into modules that coordinate successive steps in the plant life cycle...
  46. doi request reprint Fast-forward genetics enabled by new sequencing technologies
    Korbinian Schneeberger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Trends Plant Sci 16:282-8. 2011
    ..Deployment of such genes to improve crops or engineer microbes that produce valuable compounds heralds a potential paradigm shift for plant biology...
  47. pmc Evolution of the S-locus region in Arabidopsis relatives
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tuebingen, Germany
    Plant Physiol 157:937-46. 2011
    ..rubella is likely to be an old S-locus haplotype that only very recently became fixed when C. rubella split off from its SI ancestor, Capsella grandiflora...
  48. pmc Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants
    Kirsten Bomblies
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Biol 5:e236. 2007
    ..Moreover, our finding that plant immune-system genes are involved in hybrid necrosis suggests that selective pressures related to host-pathogen conflict might cause the evolution of gene flow barriers in plants...
  49. pmc Highly specific gene silencing by artificial miRNAs in rice
    Norman Warthmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 3:e1829. 2008
    ..Artificial miRNAs (amiRNAs)-designed to target one or several genes of interest-provide a new and highly specific approach for effective post-transcriptional gene silencing (PTGS) in plants...
  50. doi request reprint Gene silencing in plants using artificial microRNAs and other small RNAs
    Stephan Ossowski
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 53:674-90. 2008
    ..A recently introduced approach is the use of artificial microRNAs (amiRNAs). Here, we review various strategies for small RNA-based gene silencing, and describe in detail the design and application of amiRNAs in many plant species...
  51. ncbi request reprint MSQT for choosing SNP assays from multiple DNA alignments
    Norman Warthmann
    Max Planck Institute for Developmental Biology, Department of Molecular Biology, 72076 Tubingen, Germany
    Bioinformatics 23:2784-7. 2007
    ..One challenging aspect of genotyping and association mapping projects is often the identification of markers that are informative between groups of individuals and to convert these into genotyping assays...
  52. pmc Highly specific gene silencing by artificial microRNAs in Arabidopsis
    Rebecca Schwab
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant Cell 18:1121-33. 2006
    ..The design principles for amiRNAs have been generalized and integrated into a Web-based tool (http://wmd.weigelworld.org)...
  53. doi request reprint Small RNAs in flower development
    Heike Wollmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Eur J Cell Biol 89:250-7. 2010
    ..Here we provide an overview about generation and action of miRNAs and other small RNAs, and their contribution to an important developmental process in plants, flower formation...
  54. pmc Evolution of Arabidopsis thaliana microRNAs from random sequences
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    RNA 14:2455-9. 2008
    ..Subsequent stabilization through coevolution with initially fortuitous targets may lead to fixation of a small subset of these proto-miRNA genes...
  55. pmc Transposon variants and their effects on gene expression in Arabidopsis
    Xi Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 9:e1003255. 2013
    ..Overall, our work indicates that siRNA-targeting of TEs may influence removal of sequences from the genome and hence evolution of gene expression in plants...
  56. ncbi request reprint The floral regulator LEAFY evolves by substitutions in the DNA binding domain
    Alexis Maizel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Science 308:260-3. 2005
    ..We report that the DNA binding domain of LEAFY, although largely conserved, has diverged in activity. On the contrary, other, more rapidly evolving portions of the protein have few effects on LEAFY activity...
  57. doi request reprint miR156-regulated SPL transcription factors define an endogenous flowering pathway in Arabidopsis thaliana
    Jia wei Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 138:738-49. 2009
    ....
  58. pmc Triggering the formation of tasiRNAs in Arabidopsis thaliana: the role of microRNA miR173
    Felipe F Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    EMBO Rep 10:264-70. 2009
    ..We show that tasiRNAs can be produced from heterologous transcripts containing miR173 or miR390 target sites, indicating that these trigger sequences are the only cis sequences essential for tasiRNA formation...
  59. pmc Opsin gene duplication and diversification in the guppy, a model for sexual selection
    Margarete Hoffmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen D72076, Germany
    Proc Biol Sci 274:33-42. 2007
    ..Since opsin variability parallels the extreme male colour polymorphism within guppy populations, we suggest that mate choice has been a major factor driving the coevolution of opsins and male ornaments in this species...
  60. pmc Potent induction of Arabidopsis thaliana flowering by elevated growth temperature
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 2:e106. 2006
    ..This response has a genetic basis that is distinct from the known genetic pathways of floral transition, and appears to correlate with changes in RNA processing...
  61. ncbi request reprint Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana
    Richard M Clark
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 317:338-42. 2007
    ..Analyzing the polymorphisms we describe in larger sets of accessions will enable a detailed understanding of forces shaping population-wide sequence variation in A. thaliana...
  62. ncbi request reprint Arabidopsis: a model genus for speciation
    Kirsten Bomblies
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076, Tubingen, Germany
    Curr Opin Genet Dev 17:500-4. 2007
    ..thaliana and improvements in tools and technology applied to its close relatives are opening doors for combining experimental and comparative analyses to elucidate fundamental mechanisms of evolution...
  63. pmc The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation
    Patrice A Salome
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tuebingen, Germany
    Plant Cell 22:3650-61. 2010
    ..Together, our results reveal a role of PRR7 and PRR9 in regulating CCA1 and LHY activities in response to ambient temperature...
  64. ncbi request reprint A gene expression map of Arabidopsis thaliana development
    Markus Schmid
    Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, 72076 Tubingen, Germany
    Nat Genet 37:501-6. 2005
    ..Examining the expression patterns of large gene families, we found that they are often more similar than would be expected by chance, indicating that many gene families have been co-opted for specific developmental processes...
  65. pmc The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of Arabidopsis thaliana
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Nat Genet 38:711-5. 2006
    ..thaliana. Our work, together with previous findings, suggests that photoreceptor genes are major agents of natural variation in plant flowering and growth response...
  66. ncbi request reprint Move on up, it's time for change--mobile signals controlling photoperiod-dependent flowering
    Yasushi Kobayashi
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076, Tubingen, Germany
    Genes Dev 21:2371-84. 2007
    ....
  67. ncbi request reprint Control of leaf morphogenesis by microRNAs
    Javier F Palatnik
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Nature 425:257-63. 2003
    ..TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms...
  68. ncbi request reprint Dissection of floral induction pathways using global expression analysis
    Markus Schmid
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Development 130:6001-12. 2003
    ..These and related findings on SPL genes suggest that microRNAs play an important role in the regulation of flowering...
  69. pmc Plant secondary siRNA production determined by microRNA-duplex structure
    Pablo A Manavella
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 109:2461-6. 2012
    ..We propose that the RNA-induced silencing complex reprogramming occurs during the early steps of miRNA loading, before the miRNA duplex is disassembled and the guide strand is selected...
  70. pmc A collection of target mimics for comprehensive analysis of microRNA function in Arabidopsis thaliana
    Marco Todesco
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 6:e1001031. 2010
    ..In addition to insight into modes of miRNA action, this study provides an important resource for the study of miRNA function in plants...
  71. ncbi request reprint Temporally and spatially controlled induction of gene expression in Arabidopsis thaliana
    Alexis Maizel
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Plant J 38:164-71. 2004
    ..Apart from facilitating the investigation of temporal and spatial requirements of gene activity, this technology will permit new types of genetic modifier screens starting with mutations that otherwise confer lethality or sterility...
  72. doi request reprint Transient assays for the analysis of miRNA processing and function
    Felipe F de Felippes
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Methods Mol Biol 592:255-64. 2010
    ..Agroinfiltration has been used successfully in many different applications, including the analysis of small RNAs. We describe here a protocol for analysis of miRNA processing using agroinfiltration of N. benthamiana leaves...
  73. ncbi request reprint From tough nuts to touch-me-nots
    Jan U Lohmann
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    Cell 116:763-4. 2004
    ..Liljegren and colleagues (2004 [this issue of Cell]) describe a nonlinear network of transcription factor genes controlling this process...
  74. pmc Comparative analysis of non-autonomous effects of tasiRNAs and miRNAs in Arabidopsis thaliana
    Felipe Fenselau de Felippes
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Nucleic Acids Res 39:2880-9. 2011
    ..In agreement with this hypothesis, the silencing signals initiated by different sRNAs differ in their genetic requirements...
  75. pmc miRNA control of vegetative phase change in trees
    Jia wei Wang
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Genet 7:e1002012. 2011
    ..Our results indicate that miR156 is an evolutionarily conserved regulator of vegetative phase change in both annual herbaceous plants and perennial trees...
  76. pmc Recent speciation of Capsella rubella from Capsella grandiflora, associated with loss of self-incompatibility and an extreme bottleneck
    Ya Long Guo
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 106:5246-51. 2009
    ..The presence of phenotypic diversity within modern C. rubella suggests that this species will be an interesting model to understand divergence and adaptation, starting from very limited standing genetic variation...
  77. pmc Comprehensive interaction map of the Arabidopsis MADS Box transcription factors
    Stefan de Folter
    Business Unit Bioscience, Plant Research International, 6700 AA Wageningen, The Netherlands
    Plant Cell 17:1424-33. 2005
    ..Heterodimers between flower induction and floral organ identity proteins were observed, which point to (auto)regulatory mechanisms that prevent the activity of flower induction proteins in the flower...
  78. ncbi request reprint Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
    ..Insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene...
  79. ncbi request reprint NUBBIN and JAGGED define stamen and carpel shape in Arabidopsis
    JOSE R DINNENY
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Development 133:1645-55. 2006
    ....
  80. ncbi request reprint Target mimicry provides a new mechanism for regulation of microRNA activity
    José Manuel Franco-Zorrilla
    Department of Plant Molecular Genetics, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    Nat Genet 39:1033-7. 2007
    ..We coin the term 'target mimicry' to define this mechanism of inhibition of miRNA activity. Target mimicry can be generalized beyond the control of Pi homeostasis, as demonstrated using artificial target mimics...
  81. pmc Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development
    Xuelin Wu
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Biol 309:306-16. 2007
    ..These findings show that combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development...
  82. pmc Independent control of gibberellin biosynthesis and flowering time by the circadian clock in Arabidopsis
    Miguel A Blázquez
    Instituto de Biología Molecular y Celular de Plantas Consejo Superior de Investigaciones Científicas Universidad Politécnica de Valencia, 46022 Valencia, Spain
    Plant Physiol 130:1770-5. 2002
    ..We show that toc1 affects expression of several floral regulators and a GA biosynthetic gene, but that these effects are independent...
  83. ncbi request reprint The role of JAGGED in shaping lateral organs
    JOSE R DINNENY
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 131:1101-10. 2004
    ..If misexpressed, JAGGED can induce the formation of bracts, suggesting that the exclusion of JAGGED from the cryptic bract is a cause of bractless flowers in Arabidopsis...
  84. ncbi request reprint A thermosensory pathway controlling flowering time in Arabidopsis thaliana
    Miguel A Blázquez
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 33:168-71. 2003
    ..As with vernalization and photoperiod, ambient temperature ultimately affects expression of the floral pathway integrator FT...
  85. pmc Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for natural flowering-time variation
    Jonathan D Werner
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2460-5. 2005
    ..Analysis of near isogenic lines and quantitative transgenic complementation experiments confirmed that the FLM deletion is, in large part, responsible for the early flowering of the Nd accession...
  86. pmc Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light
    Daniele L Filiault
    Section of Plant Biology, College of Biological Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:3157-62. 2008
    ..Together with earlier studies linking variation in light sensitivity to photoreceptor genes, our work suggests that photoreceptors may be a common target of natural selection...
  87. ncbi request reprint The 35S promoter used in a selectable marker gene of a plant transformation vector affects the expression of the transgene
    So Yeon Yoo
    Plant Signaling Network Research Center, School of Life Sciences and Biotechnology, Korea University, Seoul, 136 701, Korea
    Planta 221:523-30. 2005
    ....
  88. pmc Haplotype structure and phenotypic associations in the chromosomal regions surrounding two Arabidopsis thaliana flowering time loci
    Jenny Hagenblad
    Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA
    Genetics 168:1627-38. 2004
    ..No clear evidence for previously unknown alleles at either locus was found, but the effect of population structure in causing false positives was evident...
  89. ncbi request reprint Acceleration of flowering by overexpression of MFT (MOTHER OF FT AND TFL1)
    So Yeon Yoo
    Plant Signaling Network Research Center, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Mol Cells 17:95-101. 2004
    ..Taken together, we suggest that MFT functions as a floral inducer and that it may act redundantly in determination of flowering time in Arabidopsis...
  90. ncbi request reprint Building beauty: the genetic control of floral patterning
    Jan U Lohmann
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Cell 2:135-42. 2002
    ..This review discusses recent progress in our understanding of floral homeotic genes, with an emphasis on how their region-specific expression is regulated...
  91. ncbi request reprint Modes of intercellular transcription factor movement in the Arabidopsis apex
    Xuelin Wu
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 130:3735-45. 2003
    ..This hypothesis raises the possibility that diffusion is the default state for many macromolecules in the Arabidopsis apex, unless they are specifically retained...
  92. pmc Quantitative trait loci controlling light and hormone response in two accessions of Arabidopsis thaliana
    Justin O Borevitz
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genetics 160:683-96. 2002
    ..The phenotype and map position of LIGHT2 suggest the photoreceptor PHYB as a candidate gene. Natural variation in light and hormone response thus defines both new genes and known genes that control light response in wild accessions...
  93. pmc The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis
    Tim Durfee
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:8571-6. 2003
    ..These results are combined into a genetic model explaining early second whorl initiation/proliferation, in which UFO functions to inhibit an AG-dependent activity...
  94. ncbi request reprint Interaction of LEAFY, AGAMOUS and TERMINAL FLOWER1 in maintaining floral meristem identity in Arabidopsis
    Francois Parcy
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 129:2519-27. 2002
    ..These observations contrast with previous findings that LEAFY acts as a direct activator of floral homeotic genes, supporting the hypothesis that the transcriptional activity of LEAFY is dependent on specific co-regulators...
  95. pmc Regulatory elements of the floral homeotic gene AGAMOUS identified by phylogenetic footprinting and shadowing
    Ray L Hong
    Plant Biology Laboratory, The Salk Institute for Biological Sciences, La Jolla, California 92037, USA
    Plant Cell 15:1296-309. 2003
    ....
  96. pmc Large-scale identification of single-feature polymorphisms in complex genomes
    Justin O Borevitz
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genome Res 13:513-23. 2003
    ..The extension of these tools to organisms with complex genomes, such as Arabidopsis, will greatly increase our ability to map and clone quantitative trait loci (QTL)...
  97. ncbi request reprint Requirement of homeobox gene STIMPY/WOX9 for Arabidopsis meristem growth and maintenance
    Xuelin Wu
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Curr Biol 15:436-40. 2005
    ..Taken together, our findings suggest that STIP identifies a new genetic pathway integrating developmental signals with cell-cycle control...
  98. ncbi request reprint Genetics: hotheaded healer
    Detlef Weigel
    Nature 434:443. 2005
  99. pmc The impact of Arabidopsis on human health: diversifying our portfolio
    Alan M Jones
    Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 133:939-43. 2008
    ..Many discoveries with direct relevance to human health and disease have been elaborated using Arabidopsis, and several processes important to human biology are more easily studied in this versatile model plant...
  100. doi request reprint Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..The elucidation of a natural strategy for metal hyperaccumulation enables the rational design of technologies for the clean-up of metal-contaminated soils and for bio-fortification...
  101. pmc Detecting polymorphic regions in Arabidopsis thaliana with resequencing microarrays
    Georg Zeller
    Friedrich Miescher Laboratory of the Max Planck Society, Tübingen 72070, Germany
    Genome Res 18:918-29. 2008
    ..thaliana, and our method is applicable to similar data sets in other species. More broadly, our computational approach can be applied to other segmentation tasks related to the analysis of genomic variation...

Research Grants2

  1. Transcriptional Regulation in Early Flower Development
    Detlef Weigel; Fiscal Year: 2001
    ..The experiments will also reveal how different stem cells communicate to effect coordinated development of the flower. ..
  2. Variation and Quantitative Genetics in Model Organisms
    Detlef Weigel; Fiscal Year: 2004
    ..A second focus will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. ..